KEGG   PATHWAY: afun04142
Entry
afun04142                   Pathway                                
Name
Lysosome - Anopheles funestus (African malaria mosquito)
Description
Lysosomes are membrane-delimited organelles in animal cells serving as the cell's main digestive compartment to which all sorts of macromolecules are delivered for degradation. They contain more than 40 hydrolases in an acidic environment (pH of about 5). After synthesis in the ER, lysosomal enzymes are decorated with mannose-6-phosphate residues, which are recognized by mannose-6-phosphate receptors in the trans-Golgi network. They are packaged into clathrin-coated vesicles and are transported to late endosomes. Substances for digestion are acquired by the lysosomes via a series of processes including endocytosis, phagocytosis, and autophagy.
Class
Cellular Processes; Transport and catabolism
Pathway map
afun04142  Lysosome
afun04142

Other DBs
GO: 0005764
Organism
Anopheles funestus (African malaria mosquito) [GN:afun]
Gene
125762405  V-type proton ATPase 116 kDa subunit a 1 isoform X1 [KO:K02154]
125774837  V-type proton ATPase 116 kDa subunit a 1-like [KO:K02154]
125774839  V-type proton ATPase 116 kDa subunit a 1-like [KO:K02154]
125767057  V-type proton ATPase subunit d [KO:K02146]
125760689  V-type proton ATPase subunit d-like [KO:K02146]
125763449  V-type proton ATPase subunit H isoform X1 [KO:K02144]
125766002  V-type proton ATPase subunit S1 [KO:K03662]
125767550  V-type proton ATPase 16 kDa proteolipid subunit c [KO:K02155]
125763591  V-type proton ATPase 21 kDa proteolipid subunit c'' [KO:K03661]
125769599  dmX-like protein 1 isoform X1 [KO:K24155]
125766225  WD repeat-containing protein 7 isoform X1 [KO:K24738]
125764283  serine-rich adhesin for platelets isoform X1 [KO:K25442]
125763882  cathepsin B [KO:K01363] [EC:3.4.22.1]
125763883  cathepsin B-like [KO:K01363] [EC:3.4.22.1]
125764396  cathepsin B-like [KO:K01363] [EC:3.4.22.1]
125764435  lysosomal aspartic protease [KO:K01379] [EC:3.4.23.5]
125770232  cathepsin L-like [KO:K01365] [EC:3.4.22.15]
125764840  cathepsin O-like [KO:K01374] [EC:3.4.22.42]
125764236  beta-galactosidase-like [KO:K12309] [EC:3.2.1.23]
125764237  beta-galactosidase-like isoform X1 [KO:K12309] [EC:3.2.1.23]
125764238  beta-galactosidase-1-like protein [KO:K12309] [EC:3.2.1.23]
125764950  lysosomal alpha-glucosidase-like [KO:K12316] [EC:3.2.1.20]
125774851  lysosomal acid glucosylceramidase [KO:K01201] [EC:3.2.1.45]
125767205  alpha-L-iduronidase isoform X1 [KO:K01217] [EC:3.2.1.76]
125762438  alpha-N-acetylgalactosaminidase [KO:K01204] [EC:3.2.1.49]
125766976  alpha-N-acetylglucosaminidase [KO:K01205] [EC:3.2.1.50]
125770154  beta-glucuronidase isoform X1 [KO:K01195] [EC:3.2.1.31]
125771314  putative alpha-L-fucosidase [KO:K01206] [EC:3.2.1.51]
125761641  beta-hexosaminidase subunit beta-like [KO:K12373] [EC:3.2.1.52]
125760974  chitooligosaccharidolytic beta-N-acetylglucosaminidase [KO:K12373] [EC:3.2.1.52]
125769209  chitooligosaccharidolytic beta-N-acetylglucosaminidase isoform X1 [KO:K12373] [EC:3.2.1.52]
125766051  beta-mannosidase [KO:K01192] [EC:3.2.1.25]
125765545  lysosomal alpha-mannosidase-like [KO:K12311] [EC:3.2.1.24]
125765547  lysosomal alpha-mannosidase-like isoform X1 [KO:K12311] [EC:3.2.1.24]
125770588  hyaluronidase Tab y 2.0101-like [KO:K01197] [EC:3.2.1.35]
125768372  arylsulfatase B-like [KO:K01135] [EC:3.1.6.12]
125768764  arylsulfatase B-like isoform X1 [KO:K01135] [EC:3.1.6.12]
125768768  arylsulfatase B-like [KO:K01135] [EC:3.1.6.12]
125768716  N-acetylglucosamine-6-sulfatase-like [KO:K01137] [EC:3.1.6.14]
125767732  iduronate 2-sulfatase [KO:K01136] [EC:3.1.6.13]
125763666  N-sulphoglucosamine sulphohydrolase [KO:K01565] [EC:3.10.1.1]
125762276  lipase 3-like [KO:K01052] [EC:3.1.1.13]
125762277  lipase 3-like [KO:K01052] [EC:3.1.1.13]
125762441  lipase 3-like [KO:K01052] [EC:3.1.1.13]
125763076  lipase 3-like [KO:K01052] [EC:3.1.1.13]
125765325  lipase 3-like [KO:K01052] [EC:3.1.1.13]
125766011  lipase 1-like [KO:K01052] [EC:3.1.1.13]
125768191  lipase 1-like [KO:K01052] [EC:3.1.1.13]
125760466  lipase 3-like [KO:K01052] [EC:3.1.1.13]
125760469  lipase 1-like [KO:K01052] [EC:3.1.1.13]
125760474  lipase 1-like [KO:K01052] [EC:3.1.1.13]
125764509  phospholipase A2 group XV-like [KO:K06129] [EC:3.1.1.5]
125762227  deoxyribonuclease-2-alpha [KO:K01158] [EC:3.1.22.1]
125764138  lysosomal acid phosphatase [KO:K14410] [EC:3.1.3.2]
125765069  prostatic acid phosphatase [KO:K14410] [EC:3.1.3.2]
125770155  sphingomyelin phosphodiesterase isoform X1 [KO:K12350] [EC:3.1.4.12]
125769814  N(4)-(Beta-N-acetylglucosaminyl)-L-asparaginase [KO:K01444] [EC:3.5.1.26]
125768384  uncharacterized protein LOC125768384 [KO:K12382]
125762538  lysosomal thioesterase PPT2 homolog [KO:K01074] [EC:3.1.2.22]
125760977  palmitoyl-protein thioesterase 1 [KO:K01074] [EC:3.1.2.22]
125762537  lysosome-associated membrane glycoprotein 1-like [KO:K06528]
125761625  CD63 antigen isoform X1 [KO:K06497]
125770715  23 kDa integral membrane protein-like isoform X1 [KO:K06497]
125764416  CD63 antigen-like [KO:K06497]
125762097  NPC intracellular cholesterol transporter 1 isoform X1 [KO:K12385]
125769947  NPC intracellular cholesterol transporter 1 homolog 1b [KO:K12385]
125763743  patched domain-containing protein 3-like [KO:K12385]
125761459  ecdysteroid-regulated 16 kDa protein [KO:K13443]
125761462  NPC intracellular cholesterol transporter 2-like [KO:K13443]
125761463  NPC intracellular cholesterol transporter 2-like [KO:K13443]
125761464  uncharacterized protein LOC125761464 [KO:K13443]
125769373  MD-2-related lipid-recognition protein-like isoform X1 [KO:K13443]
125768150  NPC intracellular cholesterol transporter 2-like [KO:K13443]
125768426  NPC intracellular cholesterol transporter 2 homolog a [KO:K13443]
125761244  NPC intracellular cholesterol transporter 2 homolog a-like [KO:K13443]
125761245  NPC intracellular cholesterol transporter 2 homolog a-like [KO:K13443]
125761246  uncharacterized protein LOC125761246 [KO:K13443]
125770728  NPC intracellular cholesterol transporter 2-like [KO:K13443]
125774852  cystinosin homolog [KO:K12386]
125769058  putative inorganic phosphate cotransporter isoform X1 [KO:K12301]
125762964  protein Malvolio [KO:K21398]
125767093  integumentary mucin C.1-like [KO:K06546]
125775223  battenin [KO:K12389]
125771792  major facilitator superfamily domain-containing protein 8-like isoform X1 [KO:K12307]
125771805  major facilitator superfamily domain-containing protein 8-like [KO:K12307]
125767730  heparan-alpha-glucosaminide N-acetyltransferase [KO:K10532] [EC:2.3.1.78]
125761439  formylglycine-generating enzyme [KO:K13444] [EC:1.8.3.7]
125770614  N-acetylglucosamine-1-phosphotransferase subunits alpha/beta [KO:K08239] [EC:2.7.8.17]
125767220  cation-independent mannose-6-phosphate receptor [KO:K06564]
125762378  clathrin heavy chain [KO:K04646]
125762880  AP-1 complex subunit gamma-1 isoform X1 [KO:K12391]
125765909  AP-1 complex subunit gamma-1-like [KO:K12391]
125762020  AP-1 complex subunit beta-1 isoform X1 [KO:K12392]
125769435  AP-1 complex subunit mu-1 [KO:K12393]
125774812  AP-1 complex subunit sigma-2 isoform X1 [KO:K12394]
125763343  AP-3 complex subunit delta [KO:K12396]
125764792  AP-3 complex subunit beta-2 [KO:K12397]
125762368  AP-3 complex subunit mu-1 [KO:K12398]
125771494  AP-3 complex subunit sigma-2 [KO:K12399]
125768055  ADP-ribosylation factor-binding protein GGA1 isoform X1 [KO:K12404]
125760865  lipopolysaccharide-induced tumor necrosis factor-alpha factor homolog [KO:K19363]
125760867  lipopolysaccharide-induced tumor necrosis factor-alpha factor homolog isoform X1 [KO:K19363]
125760868  lipopolysaccharide-induced tumor necrosis factor-alpha factor homolog [KO:K19363]
125760869  lipopolysaccharide-induced tumor necrosis factor-alpha factor homolog [KO:K19363]
Compound
C00002  ATP
C00008  ADP
C00159  D-Mannose
C00275  D-Mannose 6-phosphate
Reference
PMID:12628346
  Authors
Eskelinen EL, Tanaka Y, Saftig P
  Title
At the acidic edge: emerging functions for lysosomal membrane proteins.
  Journal
Trends Cell Biol 13:137-45 (2003)
DOI:10.1016/S0962-8924(03)00005-9
Reference
PMID:1883197
  Authors
Neufeld EF
  Title
Lysosomal storage diseases.
  Journal
Annu Rev Biochem 60:257-80 (1991)
DOI:10.1146/annurev.bi.60.070191.001353
Reference
PMID:2943218
  Authors
von Figura K, Hasilik A
  Title
Lysosomal enzymes and their receptors.
  Journal
Annu Rev Biochem 55:167-93 (1986)
DOI:10.1146/annurev.bi.55.070186.001123
Reference
PMID:15987739
  Authors
Janvier K, Bonifacino JS
  Title
Role of the endocytic machinery in the sorting of lysosome-associated membrane proteins.
  Journal
Mol Biol Cell 16:4231-42 (2005)
DOI:10.1091/mbc.E05-03-0213
Reference
PMID:18635948
  Authors
Vergarajauregui S, Puertollano R
  Title
Mucolipidosis type IV: the importance of functional lysosomes for efficient autophagy.
  Journal
Autophagy 4:832-4 (2008)
DOI:10.4161/auto.6567
Reference
PMID:34249946
  Authors
Jaskolka MC, Winkley SR, Kane PM
  Title
RAVE and Rabconnectin-3 Complexes as Signal Dependent Regulators of Organelle Acidification.
  Journal
Front Cell Dev Biol 9:698190 (2021)
DOI:10.3389/fcell.2021.698190
Reference
PMID:34646033
  Authors
Majdoul S, Compton AA
  Title
Lessons in self-defence: inhibition of virus entry by intrinsic immunity.
  Journal
Nat Rev Immunol 10.1038/s41577-021-00626-8 (2021)
DOI:10.1038/s41577-021-00626-8
Related
pathway
afun00511  Other glycan degradation
afun00531  Glycosaminoglycan degradation
afun04130  SNARE interactions in vesicular transport
afun04140  Autophagy - animal
afun04144  Endocytosis
KO pathway
ko04142   
LinkDB

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