KEGG   PATHWAY: agra00630
Entry
agra00630                   Pathway                                
Name
Glyoxylate and dicarboxylate metabolism - Actinomadura graeca
Class
Metabolism; Carbohydrate metabolism
Pathway map
agra00630  Glyoxylate and dicarboxylate metabolism
agra00630

Module
agra_M00012  Glyoxylate cycle [PATH:agra00630]
agra_M00621  Glycine cleavage system [PATH:agra00630]
agra_M00741  Propanoyl-CoA metabolism, propanoyl-CoA => succinyl-CoA [PATH:agra00630]
Other DBs
GO: 0046487 0043648
Organism
Actinomadura graeca [GN:agra]
Gene
AGRA3207_007815  aceA; isocitrate lyase [KO:K01637] [EC:4.1.3.1]
AGRA3207_004273  acs; acetate--CoA ligase [KO:K01895] [EC:6.2.1.1]
AGRA3207_004393  AMP-binding protein [KO:K01895] [EC:6.2.1.1]
AGRA3207_003564  aceB; malate synthase A [KO:K01638] [EC:2.3.3.9]
AGRA3207_006484  malate synthase A [KO:K01638] [EC:2.3.3.9]
AGRA3207_003089  malate dehydrogenase [KO:K00024] [EC:1.1.1.37]
AGRA3207_001214  hypothetical protein [KO:K01647] [EC:2.3.3.1]
AGRA3207_001906  citryl-CoA lyase [KO:K01647] [EC:2.3.3.1]
AGRA3207_005380  citrate synthase 2 [KO:K01647] [EC:2.3.3.1]
AGRA3207_007610  citrate synthase [KO:K01647] [EC:2.3.3.1]
AGRA3207_001317  aconitate hydratase [KO:K01681] [EC:4.2.1.3]
AGRA3207_002629  acetyl-CoA C-acetyltransferase [KO:K00626] [EC:2.3.1.9]
AGRA3207_002838  thiolase domain-containing protein [KO:K00626] [EC:2.3.1.9]
AGRA3207_003868  acetyl-CoA C-acetyltransferase [KO:K00626] [EC:2.3.1.9]
AGRA3207_004411  thiolase domain-containing protein [KO:K00626] [EC:2.3.1.9]
AGRA3207_005390  acetyl-CoA C-acetyltransferase [KO:K00626] [EC:2.3.1.9]
AGRA3207_005712  acetyl-CoA C-acetyltransferase [KO:K00626] [EC:2.3.1.9]
AGRA3207_007170  thiolase domain-containing protein [KO:K00626] [EC:2.3.1.9]
AGRA3207_002630  mce; methylmalonyl-CoA epimerase [KO:K05606] [EC:5.1.99.1]
AGRA3207_003048  ATP-grasp domain-containing protein [KO:K11263] [EC:6.4.1.2 6.4.1.3 6.3.4.14]
AGRA3207_004554  biotin/lipoyl-binding protein [KO:K11263] [EC:6.4.1.2 6.4.1.3 6.3.4.14]
AGRA3207_003022  acyl-CoA carboxylase subunit beta [KO:K27094] [EC:6.4.1.3 6.4.1.- 2.1.3.15]
AGRA3207_003023  acyl-CoA carboxylase subunit epsilon [KO:K27095]
AGRA3207_007789  methylmalonyl-CoA mutase small subunit [KO:K01847] [EC:5.4.99.2]
AGRA3207_007790  scpA; methylmalonyl-CoA mutase [KO:K01847] [EC:5.4.99.2]
AGRA3207_001512  FAD-binding protein [KO:K00104] [EC:1.1.99.14]
AGRA3207_006483  FAD-binding protein [KO:K00104] [EC:1.1.99.14]
AGRA3207_006482  FAD-binding oxidoreductase [KO:K11472] [EC:1.1.99.14]
AGRA3207_006481  4Fe-4S dicluster domain-containing protein [KO:K11473] [EC:1.1.99.14]
AGRA3207_004309  catalase [KO:K03781] [EC:1.11.1.6]
AGRA3207_007034  catalase [KO:K03781] [EC:1.11.1.6]
AGRA3207_005366  HAD hydrolase-like protein [KO:K01091] [EC:3.1.3.18]
AGRA3207_001043  glutamine synthetase [KO:K01915] [EC:6.3.1.2]
AGRA3207_001494  glutamine synthetase beta-grasp domain-containing protein [KO:K01915] [EC:6.3.1.2]
AGRA3207_001805  glutamine synthetase [KO:K01915] [EC:6.3.1.2]
AGRA3207_003662  glutamine synthetase [KO:K01915] [EC:6.3.1.2]
AGRA3207_006675  glutamine synthetase [KO:K01915] [EC:6.3.1.2]
AGRA3207_006691  glnA; type I glutamate--ammonia ligase [KO:K01915] [EC:6.3.1.2]
AGRA3207_000639  serine hydroxymethyltransferase [KO:K00600] [EC:2.1.2.1]
AGRA3207_002554  serine hydroxymethyltransferase [KO:K00600] [EC:2.1.2.1]
AGRA3207_000105  gcvP; aminomethyl-transferring glycine dehydrogenase [KO:K00281] [EC:1.4.4.2]
AGRA3207_002552  gcvT; glycine cleavage system aminomethyltransferase GcvT [KO:K00605] [EC:2.1.2.10]
AGRA3207_002497  lpdA; dihydrolipoyl dehydrogenase [KO:K00382] [EC:1.8.1.4]
AGRA3207_006700  lpdA; dihydrolipoyl dehydrogenase [KO:K00382] [EC:1.8.1.4]
AGRA3207_002553  gcvH; glycine cleavage system protein GcvH [KO:K02437]
AGRA3207_000581  glycerate kinase [KO:K00865] [EC:2.7.1.165]
AGRA3207_006640  glycerate kinase [KO:K00865] [EC:2.7.1.165]
AGRA3207_001331  eda; bifunctional 4-hydroxy-2-oxoglutarate aldolase/2-dehydro-3-deoxy-phosphogluconate aldolase [KO:K01625] [EC:4.1.2.14 4.1.3.42]
AGRA3207_006045  multifunctional oxoglutarate decarboxylase/oxoglutarate dehydrogenase thiamine pyrophosphate-binding subunit/dihydrolipoyllysine-residue succinyltransferase subunit [KO:K01616] [EC:2.2.1.5 4.1.1.71 1.2.4.2 2.3.1.61]
AGRA3207_001785  molybdopterin-dependent oxidoreductase [KO:K00123] [EC:1.17.1.9]
AGRA3207_001784  dehydrogenase [KO:K00123] [EC:1.17.1.9]
AGRA3207_000927  4Fe-4S dicluster domain-containing protein [KO:K00124]
AGRA3207_000783  alpha/beta hydrolase [KO:K01432] [EC:3.5.1.9]
AGRA3207_002581  purU; formyltetrahydrofolate deformylase [KO:K01433] [EC:3.5.1.10]
AGRA3207_006841  acetamidase/formamidase family protein [KO:K01455] [EC:3.5.1.49]
Compound
C00007  Oxygen
C00011  CO2
C00014  Ammonia
C00022  Pyruvate
C00024  Acetyl-CoA
C00025  L-Glutamate
C00026  2-Oxoglutarate
C00027  Hydrogen peroxide
C00033  Acetate
C00036  Oxaloacetate
C00037  Glycine
C00042  Succinate
C00048  Glyoxylate
C00058  Formate
C00064  L-Glutamine
C00065  L-Serine
C00091  Succinyl-CoA
C00100  Propanoyl-CoA
C00111  Glycerone phosphate
C00136  Butanoyl-CoA
C00149  (S)-Malate
C00158  Citrate
C00160  Glycolate
C00168  Hydroxypyruvate
C00197  3-Phospho-D-glycerate
C00209  Oxalate
C00258  D-Glycerate
C00266  Glycolaldehyde
C00311  Isocitrate
C00313  Oxalyl-CoA
C00332  Acetoacetyl-CoA
C00417  cis-Aconitate
C00552  meso-Tartaric acid
C00631  2-Phospho-D-glycerate
C00683  (S)-Methylmalonyl-CoA
C00798  Formyl-CoA
C00877  Crotonoyl-CoA
C00888  Pentanoyl-CoA
C00898  (R,R)-Tartaric acid
C00975  Dihydroxyfumarate
C00988  2-Phosphoglycolate
C01127  4-Hydroxy-2-oxoglutarate
C01146  2-Hydroxy-3-oxopropanoate
C01182  D-Ribulose 1,5-bisphosphate
C01213  (R)-Methylmalonyl-CoA
C01380  Ethylene glycol
C01732  Mesaconate
C01989  3-Ethylmalate
C01990  3-Oxalomalate
C02123  3-Propylmalate
C02405  Formyl phosphate
C03217  2-Hydroxy-3-oxoadipate
C03459  2-Hydroxy-3-oxosuccinate
C03548  trans-2,3-Epoxysuccinate
C03561  (R)-3-Hydroxybutanoyl-CoA
C03618  L-threo-3-Methylaspartate
C04348  L-Malyl-CoA
C06027  L-erythro-3-Methylmalyl-CoA
C06028  2-Methylfumaryl-CoA
C06049  N-Formylderivatives
C18026  (2S)-Ethylmalonyl-CoA
C18324  (2S)-Methylsuccinyl-CoA
C20238  (2R)-Ethylmalonyl-CoA
C22337  D-Ribulose 1-phosphate
Reference
PMID:10978349
  Authors
Njau RK, Herndon CA, Hawes JW.
  Title
Novel beta-hydroxyacid dehydrogenases in Escherichia coli and Haemophilus influenzae.
  Journal
J Biol Chem 275:38780-6 (2000)
DOI:10.1074/jbc.M007432200
Reference
PMID:18065535
  Authors
Zarzycki J, Schlichting A, Strychalsky N, Muller M, Alber BE, Fuchs G
  Title
Mesaconyl-coenzyme A hydratase, a new enzyme of two central carbon metabolic pathways in bacteria.
  Journal
J Bacteriol 190:1366-74 (2008)
DOI:10.1128/JB.01621-07
Reference
PMID:18819910
  Authors
Erb TJ, Retey J, Fuchs G, Alber BE
  Title
Ethylmalonyl-CoA mutase from Rhodobacter sphaeroides defines a new subclade of coenzyme B12-dependent acyl-CoA mutases.
  Journal
J Biol Chem 283:32283-93 (2008)
DOI:10.1074/jbc.M805527200
Reference
PMID:9596633
  Authors
Coschigano KT, Melo-Oliveira R, Lim J, Coruzzi GM
  Title
Arabidopsis gls mutants and distinct Fd-GOGAT genes. Implications for photorespiration and primary nitrogen assimilation.
  Journal
Plant Cell 10:741-52 (1998)
DOI:10.1105/tpc.10.5.741
Reference
PMID:16407450
  Authors
Masclaux-Daubresse C, Reisdorf-Cren M, Pageau K, Lelandais M, Grandjean O, Kronenberger J, Valadier MH, Feraud M, Jouglet T, Suzuki A
  Title
Glutamine synthetase-glutamate synthase pathway and glutamate dehydrogenase play distinct roles in the sink-source nitrogen cycle in tobacco.
  Journal
Plant Physiol 140:444-56 (2006)
DOI:10.1104/pp.105.071910
Reference
PMID:21252347
  Authors
Khomyakova M, Bukmez O, Thomas LK, Erb TJ, Berg IA
  Title
A methylaspartate cycle in haloarchaea.
  Journal
Science 331:334-7 (2011)
DOI:10.1126/science.1196544
Reference
PMID:11513957
  Authors
Serrano JA, Bonete MJ
  Title
Sequencing, phylogenetic and transcriptional analysis of the glyoxylate bypass operon (ace) in the halophilic archaeon Haloferax volcanii.
  Journal
Biochim Biophys Acta 1520:154-62 (2001)
DOI:10.1016/S0167-4781(01)00263-9
Related
pathway
agra00010  Glycolysis / Gluconeogenesis
agra00020  Citrate cycle (TCA cycle)
agra00030  Pentose phosphate pathway
agra00053  Ascorbate and aldarate metabolism
agra00071  Fatty acid degradation
agra00230  Purine metabolism
agra00250  Alanine, aspartate and glutamate metabolism
agra00260  Glycine, serine and threonine metabolism
agra00620  Pyruvate metabolism
agra00710  Carbon fixation by Calvin cycle
agra00750  Vitamin B6 metabolism
agra00910  Nitrogen metabolism
KO pathway
ko00630   
LinkDB

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