PATHWAY: ahf00020 Help
Entry
Name
Citrate cycle (TCA cycle) - Arachis hypogaea (peanut)
Description
The citrate cycle (TCA cycle, Krebs cycle) is an important aerobic pathway for the final steps of the oxidation of carbohydrates and fatty acids. The cycle starts with acetyl-CoA, the activated form of acetate, derived from glycolysis and pyruvate oxidation for carbohydrates and from beta oxidation of fatty acids. The two-carbon acetyl group in acetyl-CoA is transferred to the four-carbon compound of oxaloacetate to form the six-carbon compound of citrate. In a series of reactions two carbons in citrate are oxidized to CO2 and the reaction pathway supplies NADH for use in the oxidative phosphorylation and other metabolic processes. The pathway also supplies important precursor metabolites including 2-oxoglutarate. At the end of the cycle the remaining four-carbon part is transformed back to oxaloacetate. According to the genome sequence data, many organisms seem to lack genes for the full cycle [MD:
M00009 ], but contain genes for specific segments [MD:
M00010 M00011 ].
Class
Metabolism; Carbohydrate metabolism
BRITE hierarchy
Pathway map
Ortholog table
Module
ahf_M00010 Citrate cycle, first carbon oxidation, oxaloacetate => 2-oxoglutarate [PATH:ahf00020 ]
ahf_M00011 Citrate cycle, second carbon oxidation, 2-oxoglutarate => oxaloacetate [PATH:ahf00020 ]
Other DBs
Organism
Arachis hypogaea (peanut) [GN:
ahf ]
Gene
112747664 isocitrate dehydrogenase [NAD] regulatory subunit 1, mitochondrial-like isoform X1 [KO:K00030 ] [EC:1.1.1.41 ]
112797153 isocitrate dehydrogenase [NAD] regulatory subunit 1, mitochondrial-like isoform X1 [KO:K00030 ] [EC:1.1.1.41 ]
112800273 isocitrate dehydrogenase [NAD] regulatory subunit 1, mitochondrial-like isoform X1 [KO:K00030 ] [EC:1.1.1.41 ]
112751820 dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex 2, mitochondrial-like [KO:K00658 ] [EC:2.3.1.61 ]
112795926 dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex 1, mitochondrial isoform X1 [KO:K00658 ] [EC:2.3.1.61 ]
112701941 dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex 2, mitochondrial [KO:K00658 ] [EC:2.3.1.61 ]
112720976 dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex 2, mitochondrial-like [KO:K00658 ] [EC:2.3.1.61 ]
112741227 dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex 1, mitochondrial isoform X1 [KO:K00658 ] [EC:2.3.1.61 ]
112764089 dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex 2, mitochondrial [KO:K00658 ] [EC:2.3.1.61 ]
112714326 pyruvate dehydrogenase E1 component subunit beta-3, chloroplastic isoform X1 [KO:K00162 ] [EC:1.2.4.1 ]
112792528 pyruvate dehydrogenase E1 component subunit beta-3, chloroplastic isoform X1 [KO:K00162 ] [EC:1.2.4.1 ]
112797447 pyruvate dehydrogenase E1 component subunit beta-1, mitochondrial isoform X1 [KO:K00162 ] [EC:1.2.4.1 ]
112744078 pyruvate dehydrogenase E1 component subunit beta-1, mitochondrial isoform X1 [KO:K00162 ] [EC:1.2.4.1 ]
112710461 dihydrolipoyllysine-residue acetyltransferase component 2 of pyruvate dehydrogenase complex, mitochondrial isoform X1 [KO:K00627 ] [EC:2.3.1.12 ]
112711538 dihydrolipoyllysine-residue acetyltransferase component 1 of pyruvate dehydrogenase complex, mitochondrial isoform X1 [KO:K00627 ] [EC:2.3.1.12 ]
112712103 dihydrolipoyllysine-residue acetyltransferase component 4 of pyruvate dehydrogenase complex, chloroplastic [KO:K00627 ] [EC:2.3.1.12 ]
112712551 dihydrolipoyllysine-residue acetyltransferase component 5 of pyruvate dehydrogenase complex, chloroplastic [KO:K00627 ] [EC:2.3.1.12 ]
112775659 dihydrolipoyllysine-residue acetyltransferase component 2 of pyruvate dehydrogenase complex, mitochondrial isoform X1 [KO:K00627 ] [EC:2.3.1.12 ]
112775662 dihydrolipoyllysine-residue acetyltransferase component 1 of pyruvate dehydrogenase complex, mitochondrial isoform X1 [KO:K00627 ] [EC:2.3.1.12 ]
112775881 dihydrolipoyllysine-residue acetyltransferase component 4 of pyruvate dehydrogenase complex, chloroplastic [KO:K00627 ] [EC:2.3.1.12 ]
112780004 dihydrolipoyllysine-residue acetyltransferase component 5 of pyruvate dehydrogenase complex, chloroplastic [KO:K00627 ] [EC:2.3.1.12 ]
Compound
C05125 2-(alpha-Hydroxyethyl)thiamine diphosphate
C05381 3-Carboxy-1-hydroxypropyl-ThPP
C15972 Enzyme N6-(lipoyl)lysine
C15973 Enzyme N6-(dihydrolipoyl)lysine
C16254 [Dihydrolipoyllysine-residue succinyltransferase] S-succinyldihydrolipoyllysine
C16255 [Dihydrolipoyllysine-residue acetyltransferase] S-acetyldihydrolipoyllysine
Reference
Authors
Nishizuka Y (ed).
Title
[Metabolic Maps] (In Japanese)
Journal
Tokyo Kagaku Dojin (1980)
Reference
Authors
Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).
Title
[Cellular Functions and Metabolic Maps] (In Japanese)
Journal
Tokyo Kagaku Dojin (1997)
Reference
Authors
Michal G.
Title
Biochemical Pathways
Journal
Wiley (1999)
Related pathway
ahf00053 Ascorbate and aldarate metabolism
ahf00250 Alanine, aspartate and glutamate metabolism
ahf00280 Valine, leucine and isoleucine degradation
ahf00630 Glyoxylate and dicarboxylate metabolism
KO pathway
LinkDB
All DBs