KEGG   PATHWAY: ahf00020
Entry
ahf00020                    Pathway                                
Name
Citrate cycle (TCA cycle) - Arachis hypogaea (peanut)
Description
The citrate cycle (TCA cycle, Krebs cycle) is an important aerobic pathway for the final steps of the oxidation of carbohydrates and fatty acids. The cycle starts with acetyl-CoA, the activated form of acetate, derived from glycolysis and pyruvate oxidation for carbohydrates and from beta oxidation of fatty acids. The two-carbon acetyl group in acetyl-CoA is transferred to the four-carbon compound of oxaloacetate to form the six-carbon compound of citrate. In a series of reactions two carbons in citrate are oxidized to CO2 and the reaction pathway supplies NADH for use in the oxidative phosphorylation and other metabolic processes. The pathway also supplies important precursor metabolites including 2-oxoglutarate. At the end of the cycle the remaining four-carbon part is transformed back to oxaloacetate. According to the genome sequence data, many organisms seem to lack genes for the full cycle [MD:M00009], but contain genes for specific segments [MD:M00010 M00011].
Class
Metabolism; Carbohydrate metabolism
Pathway map
ahf00020  Citrate cycle (TCA cycle)
ahf00020

Module
ahf_M00003  Gluconeogenesis, oxaloacetate => fructose-6P [PATH:ahf00020]
ahf_M00009  Citrate cycle (TCA cycle, Krebs cycle) [PATH:ahf00020]
ahf_M00010  Citrate cycle, first carbon oxidation, oxaloacetate => 2-oxoglutarate [PATH:ahf00020]
ahf_M00011  Citrate cycle, second carbon oxidation, 2-oxoglutarate => oxaloacetate [PATH:ahf00020]
ahf_M00307  Pyruvate oxidation, pyruvate => acetyl-CoA [PATH:ahf00020]
Other DBs
GO: 0006099
Organism
Arachis hypogaea (peanut) [GN:ahf]
Gene
112770988  citrate synthase, mitochondrial [KO:K01647] [EC:2.3.3.1]
112795415  citrate synthase, glyoxysomal [KO:K01647] [EC:2.3.3.1]
112702017  citrate synthase, glyoxysomal [KO:K01647] [EC:2.3.3.1]
112719781  citrate synthase, glyoxysomal [KO:K01647] [EC:2.3.3.1]
112703011  citrate synthase, mitochondrial [KO:K01647] [EC:2.3.3.1]
112765075  citrate synthase, glyoxysomal [KO:K01647] [EC:2.3.3.1]
112695607  ATP-citrate synthase alpha chain protein 2 [KO:K01648] [EC:2.3.3.8]
112749995  ATP-citrate synthase alpha chain protein 1 [KO:K01648] [EC:2.3.3.8]
112772217  ATP-citrate synthase alpha chain protein 1 [KO:K01648] [EC:2.3.3.8]
112796325  ATP-citrate synthase beta chain protein 1 [KO:K01648] [EC:2.3.3.8]
112703043  ATP-citrate synthase alpha chain protein 1 [KO:K01648] [EC:2.3.3.8]
112703240  ATP-citrate synthase beta chain protein 1 [KO:K01648] [EC:2.3.3.8]
112758001  ATP-citrate synthase alpha chain protein 2 [KO:K01648] [EC:2.3.3.8]
112723172  ATP-citrate synthase beta chain protein 1 [KO:K01648] [EC:2.3.3.8]
112741641  ATP-citrate synthase beta chain protein 1 [KO:K01648] [EC:2.3.3.8]
112801138  ATP-citrate synthase alpha chain protein 1 [KO:K01648] [EC:2.3.3.8]
112747696  aconitate hydratase 1 [KO:K01681] [EC:4.2.1.3]
112789603  aconitate hydratase, cytoplasmic [KO:K01681] [EC:4.2.1.3]
112771496  aconitate hydratase, cytoplasmic [KO:K01681] [EC:4.2.1.3]
112737529  aconitate hydratase, cytoplasmic [KO:K01681] [EC:4.2.1.3]
112800303  aconitate hydratase 1 [KO:K01681] [EC:4.2.1.3]
112707003  aconitate hydratase, cytoplasmic [KO:K01681] [EC:4.2.1.3]
112771957  isocitrate dehydrogenase [NADP] [KO:K00031] [EC:1.1.1.42]
112751403  isocitrate dehydrogenase [NADP] [KO:K00031] [EC:1.1.1.42]
112702582  isocitrate dehydrogenase [NADP] isoform X1 [KO:K00031] [EC:1.1.1.42]
112703040  isocitrate dehydrogenase [NADP] [KO:K00031] [EC:1.1.1.42]
112764704  isocitrate dehydrogenase [NADP] [KO:K00031] [EC:1.1.1.42]
112801952  isocitrate dehydrogenase [NADP] [KO:K00031] [EC:1.1.1.42]
112728964  isocitrate dehydrogenase [NAD] catalytic subunit 5, mitochondrial isoform X1 [KO:K00030] [EC:1.1.1.41]
112709995  isocitrate dehydrogenase [NAD] catalytic subunit 5, mitochondrial [KO:K00030] [EC:1.1.1.41]
112747664  isocitrate dehydrogenase [NAD] regulatory subunit 1, mitochondrial-like isoform X1 [KO:K00030] [EC:1.1.1.41]
112772418  isocitrate dehydrogenase [NAD] catalytic subunit 5, mitochondrial [KO:K00030] [EC:1.1.1.41]
112712808  isocitrate dehydrogenase [NAD] catalytic subunit 5, mitochondrial-like [KO:K00030] [EC:1.1.1.41]
112712810  isocitrate dehydrogenase [NAD] catalytic subunit 5, mitochondrial [KO:K00030] [EC:1.1.1.41]
112776788  isocitrate dehydrogenase [NAD] catalytic subunit 5, mitochondrial [KO:K00030] [EC:1.1.1.41]
112777743  3-isopropylmalate dehydrogenase, chloroplastic [KO:K00030] [EC:1.1.1.41]
112797153  isocitrate dehydrogenase [NAD] regulatory subunit 1, mitochondrial-like isoform X1 [KO:K00030] [EC:1.1.1.41]
112703026  isocitrate dehydrogenase [NAD] catalytic subunit 5, mitochondrial [KO:K00030] [EC:1.1.1.41]
112760462  isocitrate dehydrogenase [NAD] catalytic subunit 5, mitochondrial isoform X1 [KO:K00030] [EC:1.1.1.41]
112800273  isocitrate dehydrogenase [NAD] regulatory subunit 1, mitochondrial-like isoform X1 [KO:K00030] [EC:1.1.1.41]
112784123  isocitrate dehydrogenase [NAD] regulatory subunit 1, mitochondrial-like [KO:K00030] [EC:1.1.1.41]
112765879  isocitrate dehydrogenase [NAD] regulatory subunit 1, mitochondrial [KO:K00030] [EC:1.1.1.41]
112766266  isocitrate dehydrogenase [NAD] regulatory subunit 1, mitochondrial [KO:K00030] [EC:1.1.1.41]
112744858  2-oxoglutarate dehydrogenase, mitochondrial-like [KO:K00164] [EC:1.2.4.2]
112744859  2-oxoglutarate dehydrogenase, mitochondrial-like isoform X1 [KO:K00164] [EC:1.2.4.2]
112712294  2-oxoglutarate dehydrogenase, mitochondrial [KO:K00164] [EC:1.2.4.2]
112776349  2-oxoglutarate dehydrogenase, mitochondrial [KO:K00164] [EC:1.2.4.2]
112798147  2-oxoglutarate dehydrogenase, mitochondrial-like [KO:K00164] [EC:1.2.4.2]
112798148  2-oxoglutarate dehydrogenase, mitochondrial-like isoform X1 [KO:K00164] [EC:1.2.4.2]
112751820  dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex 2, mitochondrial-like [KO:K00658] [EC:2.3.1.61]
112795926  dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex 1, mitochondrial isoform X1 [KO:K00658] [EC:2.3.1.61]
112701941  dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex 2, mitochondrial [KO:K00658] [EC:2.3.1.61]
112720976  dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex 2, mitochondrial-like [KO:K00658] [EC:2.3.1.61]
112741227  dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex 1, mitochondrial isoform X1 [KO:K00658] [EC:2.3.1.61]
112764089  dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex 2, mitochondrial [KO:K00658] [EC:2.3.1.61]
112703358  dihydrolipoyl dehydrogenase 2, chloroplastic [KO:K00382] [EC:1.8.1.4]
112723153  dihydrolipoyl dehydrogenase 2, chloroplastic [KO:K00382] [EC:1.8.1.4]
112723227  dihydrolipoyl dehydrogenase, mitochondrial [KO:K00382] [EC:1.8.1.4]
112723240  dihydrolipoyl dehydrogenase, mitochondrial [KO:K00382] [EC:1.8.1.4]
114927418  succinate--CoA ligase [ADP-forming] subunit alpha-2, mitochondrial-like [KO:K01899] [EC:6.2.1.4 6.2.1.5]
112751504  succinate--CoA ligase [ADP-forming] subunit alpha-2, mitochondrial [KO:K01899] [EC:6.2.1.4 6.2.1.5]
112740606  succinate--CoA ligase [ADP-forming] subunit beta, mitochondrial [KO:K01900] [EC:6.2.1.4 6.2.1.5]
112727102  succinate--CoA ligase [ADP-forming] subunit beta, mitochondrial [KO:K01900] [EC:6.2.1.4 6.2.1.5]
112749153  succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial [KO:K00234] [EC:1.3.5.1]
112800700  succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial [KO:K00234] [EC:1.3.5.1]
112697258  succinate dehydrogenase [ubiquinone] iron-sulfur subunit 2, mitochondrial [KO:K00235] [EC:1.3.5.1]
112755157  succinate dehydrogenase [ubiquinone] iron-sulfur subunit 2, mitochondrial [KO:K00235] [EC:1.3.5.1]
112797690  succinate dehydrogenase [ubiquinone] iron-sulfur subunit 2, mitochondrial [KO:K00235] [EC:1.3.5.1]
112744400  succinate dehydrogenase [ubiquinone] iron-sulfur subunit 2, mitochondrial [KO:K00235] [EC:1.3.5.1]
112789604  uncharacterized protein LOC112789604 [KO:K00236]
112737530  uncharacterized protein LOC112737530 [KO:K00236]
112795578  uncharacterized protein LOC112795578 [KO:K25801]
112702729  succinate dehydrogenase subunit 4, mitochondrial [KO:K25801]
112727261  uncharacterized protein LOC112727261 isoform X2 [KO:K25801]
112740859  uncharacterized protein LOC112740859 [KO:K25801]
112764339  succinate dehydrogenase subunit 4, mitochondrial [KO:K25801]
112720576  fumarate hydratase 1, mitochondrial [KO:K01679] [EC:4.2.1.2]
112800903  fumarate hydratase 1, mitochondrial isoform X1 [KO:K01679] [EC:4.2.1.2]
112711210  malate dehydrogenase, cytoplasmic [KO:K00025] [EC:1.1.1.37]
112711212  malate dehydrogenase [KO:K00025] [EC:1.1.1.37]
112735613  malate dehydrogenase, cytoplasmic isoform X1 [KO:K00025] [EC:1.1.1.37]
112776382  malate dehydrogenase, cytoplasmic [KO:K00025] [EC:1.1.1.37]
112776383  malate dehydrogenase [KO:K00025] [EC:1.1.1.37]
112726743  malate dehydrogenase, cytoplasmic isoform X1 [KO:K00025] [EC:1.1.1.37]
112728667  malate dehydrogenase 2, peroxisomal [KO:K00026] [EC:1.1.1.37]
112710233  malate dehydrogenase, chloroplastic [KO:K00026] [EC:1.1.1.37]
112748103  malate dehydrogenase, glyoxysomal-like [KO:K00026] [EC:1.1.1.37]
112790043  malate dehydrogenase, mitochondrial [KO:K00026] [EC:1.1.1.37]
112791339  malate dehydrogenase 2, peroxisomal [KO:K00026] [EC:1.1.1.37]
112718423  malate dehydrogenase, chloroplastic [KO:K00026] [EC:1.1.1.37]
112737907  malate dehydrogenase, mitochondrial [KO:K00026] [EC:1.1.1.37]
112722502  malate dehydrogenase, chloroplastic [KO:K00026] [EC:1.1.1.37]
112800443  malate dehydrogenase, glyoxysomal-like [KO:K00026] [EC:1.1.1.37]
112747386  phosphoenolpyruvate carboxykinase (ATP)-like isoform X1 [KO:K01610] [EC:4.1.1.49]
112799999  phosphoenolpyruvate carboxykinase (ATP)-like isoform X1 [KO:K01610] [EC:4.1.1.49]
112706288  phosphoenolpyruvate carboxykinase (ATP) isoform X1 [KO:K01610] [EC:4.1.1.49]
112765975  phosphoenolpyruvate carboxykinase (ATP) isoform X1 [KO:K01610] [EC:4.1.1.49]
112695259  pyruvate dehydrogenase E1 component subunit alpha-3, chloroplastic [KO:K00161] [EC:1.2.4.1]
112733985  pyruvate dehydrogenase E1 component subunit alpha, mitochondrial [KO:K00161] [EC:1.2.4.1]
112750108  pyruvate dehydrogenase E1 component subunit alpha-1, mitochondrial [KO:K00161] [EC:1.2.4.1]
112791853  pyruvate dehydrogenase E1 component subunit alpha, mitochondrial [KO:K00161] [EC:1.2.4.1]
112734444  pyruvate dehydrogenase E1 component subunit alpha-3, chloroplastic [KO:K00161] [EC:1.2.4.1]
112758560  pyruvate dehydrogenase E1 component subunit alpha-3, chloroplastic [KO:K00161] [EC:1.2.4.1]
112726596  pyruvate dehydrogenase E1 component subunit alpha-3, chloroplastic [KO:K00161] [EC:1.2.4.1]
112801018  pyruvate dehydrogenase E1 component subunit alpha, mitochondrial [KO:K00161] [EC:1.2.4.1]
112710629  pyruvate dehydrogenase E1 component subunit beta-1, mitochondrial [KO:K00162] [EC:1.2.4.1]
112714326  pyruvate dehydrogenase E1 component subunit beta-3, chloroplastic isoform X1 [KO:K00162] [EC:1.2.4.1]
112792528  pyruvate dehydrogenase E1 component subunit beta-3, chloroplastic isoform X1 [KO:K00162] [EC:1.2.4.1]
112734764  pyruvate dehydrogenase E1 component subunit beta-3, chloroplastic [KO:K00162] [EC:1.2.4.1]
112776472  pyruvate dehydrogenase E1 component subunit beta-1, mitochondrial [KO:K00162] [EC:1.2.4.1]
112797447  pyruvate dehydrogenase E1 component subunit beta-1, mitochondrial isoform X1 [KO:K00162] [EC:1.2.4.1]
112783023  pyruvate dehydrogenase E1 component subunit beta-3, chloroplastic [KO:K00162] [EC:1.2.4.1]
112744078  pyruvate dehydrogenase E1 component subunit beta-1, mitochondrial isoform X1 [KO:K00162] [EC:1.2.4.1]
112710461  dihydrolipoyllysine-residue acetyltransferase component 2 of pyruvate dehydrogenase complex, mitochondrial isoform X1 [KO:K00627] [EC:2.3.1.12]
112711538  dihydrolipoyllysine-residue acetyltransferase component 1 of pyruvate dehydrogenase complex, mitochondrial isoform X1 [KO:K00627] [EC:2.3.1.12]
112712103  dihydrolipoyllysine-residue acetyltransferase component 4 of pyruvate dehydrogenase complex, chloroplastic [KO:K00627] [EC:2.3.1.12]
112712551  dihydrolipoyllysine-residue acetyltransferase component 5 of pyruvate dehydrogenase complex, chloroplastic [KO:K00627] [EC:2.3.1.12]
112775659  dihydrolipoyllysine-residue acetyltransferase component 2 of pyruvate dehydrogenase complex, mitochondrial isoform X1 [KO:K00627] [EC:2.3.1.12]
112775662  dihydrolipoyllysine-residue acetyltransferase component 1 of pyruvate dehydrogenase complex, mitochondrial isoform X1 [KO:K00627] [EC:2.3.1.12]
112775881  dihydrolipoyllysine-residue acetyltransferase component 4 of pyruvate dehydrogenase complex, chloroplastic [KO:K00627] [EC:2.3.1.12]
112780004  dihydrolipoyllysine-residue acetyltransferase component 5 of pyruvate dehydrogenase complex, chloroplastic [KO:K00627] [EC:2.3.1.12]
Compound
C00022  Pyruvate
C00024  Acetyl-CoA
C00026  2-Oxoglutarate
C00036  Oxaloacetate
C00042  Succinate
C00068  Thiamin diphosphate
C00074  Phosphoenolpyruvate
C00091  Succinyl-CoA
C00122  Fumarate
C00149  (S)-Malate
C00158  Citrate
C00311  Isocitrate
C00417  cis-Aconitate
C05125  2-(alpha-Hydroxyethyl)thiamine diphosphate
C05379  Oxalosuccinate
C05381  3-Carboxy-1-hydroxypropyl-ThPP
C15972  Enzyme N6-(lipoyl)lysine
C15973  Enzyme N6-(dihydrolipoyl)lysine
C16254  [Dihydrolipoyllysine-residue succinyltransferase] S-succinyldihydrolipoyllysine
C16255  [Dihydrolipoyllysine-residue acetyltransferase] S-acetyldihydrolipoyllysine
Reference
  Authors
Nishizuka Y (ed).
  Title
[Metabolic Maps] (In Japanese)
  Journal
Tokyo Kagaku Dojin (1980)
Reference
  Authors
Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).
  Title
[Cellular Functions and Metabolic Maps] (In Japanese)
  Journal
Tokyo Kagaku Dojin (1997)
Reference
  Authors
Michal G.
  Title
Biochemical Pathways
  Journal
Wiley (1999)
Related
pathway
ahf00010  Glycolysis / Gluconeogenesis
ahf00053  Ascorbate and aldarate metabolism
ahf00061  Fatty acid biosynthesis
ahf00062  Fatty acid elongation
ahf00071  Fatty acid degradation
ahf00190  Oxidative phosphorylation
ahf00220  Arginine biosynthesis
ahf00250  Alanine, aspartate and glutamate metabolism
ahf00280  Valine, leucine and isoleucine degradation
ahf00350  Tyrosine metabolism
ahf00470  D-Amino acid metabolism
ahf00630  Glyoxylate and dicarboxylate metabolism
KO pathway
ko00020   
LinkDB

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