KEGG   PATHWAY: ame03013
Entry
ame03013                    Pathway                                
Name
Nucleocytoplasmic transport - Apis mellifera (honey bee)
Description
The exchange of molecules between the nucleus and cytoplasm is mediated through nuclear pore complexes (NPCs) embedded in the nuclear envelope. The NPC is composed of highly conserved, distinct structural modules: the inner pore ring, the cytoplasmic and nuclear rings as well as the cytoplasmic filaments and the nuclear basket. Nuclear transport receptors (e.g. importins and exportins) mediate translocation of cargos through the NPC. Cargo proteins harbouring a nuclear export signal (NES) bind to exportins and Ran-GTP to form an export complex in the nucleoplasm. Nuclear export of bulk mRNA is provided by the non-karyopherin transport proteins TAP-p15 in a Ran-GTP-independent manner. Several EJC factors are known to function in mRNA export.
Class
Genetic Information Processing; Translation
Pathway map
ame03013  Nucleocytoplasmic transport
ame03013

Other DBs
GO: 0050658
Organism
Apis mellifera (honey bee) [GN:ame]
Gene
100576146  aladin [KO:K14320]
412950  nucleoporin GLE1 isoform X1 [KO:K18723]
552567  DEAD-box helicase Dbp80 isoform X2 [KO:K18655] [EC:5.6.2.7]
409169  mRNA export factor [KO:K14298]
408335  nuclear pore complex protein Nup98-Nup96 isoform X2 [KO:K14297]
412464  nuclear pore complex protein Nup214 [KO:K14317]
726354  uncharacterized protein LOC726354 [KO:K14317]
726338  nuclear pore complex protein Nup88 [KO:K14318]
726272  RANBP2-like and GRIP domain-containing protein 5/6 isoform X1 [KO:K12172] [EC:2.3.2.-]
411909  ran GTPase-activating protein 1 isoform X2 [KO:K14319]
551283  SUMO-conjugating enzyme UBC9-B [KO:K10577]
550834  small ubiquitin-related modifier 3 [KO:K12160]
409308  small ubiquitin-related modifier [KO:K12160]
725332  nuclear pore complex protein Nup160 homolog [KO:K14303]
408625  nuclear pore complex protein Nup85 [KO:K14304]
410030  protein SEC13 homolog [KO:K14004]
413675  nuclear pore complex protein Nup107 [KO:K14301]
411735  nuclear pore complex protein Nup133 [KO:K14300]
413365  nucleoporin SEH1 isoform X1 [KO:K14299]
413343  nucleoporin Nup37 [KO:K14302]
726339  protein ELYS isoform X1 [KO:K25129]
409734  nuclear pore glycoprotein p62 isoform X1 [KO:K14306]
725896  nucleoporin p58/p45 isoform X1 [KO:K14307]
410972  nuclear pore complex protein Nup54 isoform X1 [KO:K14308]
411918  nuclear pore complex protein Nup205 [KO:K14310]
411474  nucleoporin NUP188 homolog [KO:K14311]
412721  nuclear pore complex protein Nup154 isoform X1 [KO:K14312]
410343  nuclear pore complex protein Nup93 [KO:K14309]
412835  uncharacterized protein LOC412835 [KO:K14313]
100576125  nucleoporin NDC1 isoform X1 [KO:K14315]
100577501  nuclear pore membrane glycoprotein 210 [KO:K14314]
725957  Krueppel homolog 2 [KO:K20724]
412508  nucleoprotein TPR [KO:K09291]
410864  nuclear pore complex protein Nup50 isoform X1 [KO:K14295]
727447  nuclear pore complex protein Nup153 isoform X1 [KO:K14296]
727561  importin subunit alpha [KO:K15043]
412511  importin subunit alpha-3 [KO:K23583]
409543  importin subunit alpha-7 [KO:K15042]
410447  importin subunit beta-1 isoform X1 [KO:K14293]
408842  transportin-1 [KO:K18752]
726159  transportin-3 [KO:K15436]
412817  importin-4 [KO:K20221]
724927  importin-5 [KO:K20222]
551725  importin-7 [KO:K20223]
413940  importin-9 isoform X1 [KO:K20224]
412834  importin-11 isoform X1 [KO:K25201]
409992  importin-13 [KO:K25202]
551281  snurportin-1 [KO:K13151]
413018  exportin-1 [KO:K14290]
411865  exportin-2 [KO:K18423]
725887  exportin-4 [KO:K25203]
413344  exportin-5 [KO:K14289]
726133  exportin-6 [KO:K25204]
413636  exportin-7 isoform X1 [KO:K18460]
410280  GTP-binding nuclear protein Ran [KO:K07936]
544670  EF1a-F2; elongation factor 1-alpha [KO:K03231]
408385  Ef-1a-f1; elongation factor 1-alpha [KO:K03231]
409229  phosphorylated adapter RNA export protein [KO:K14291]
409476  nuclear cap-binding protein subunit 1 [KO:K12882]
413877  nuclear cap-binding protein subunit 2 [KO:K12883]
552010  60S ribosomal export protein NMD3 [KO:K07562]
411778  RNA-binding protein 8A [KO:K12876]
724628  protein mago nashi homolog [KO:K12877]
100578879  protein CASC3 isoform X1 [KO:K14323]
409866  eukaryotic initiation factor 4A-III [KO:K13025] [EC:5.6.2.7]
100578161  apoptotic chromatin condensation inducer in the nucleus [KO:K12875]
100576967  histone deacetylase complex subunit SAP18 [KO:K14324]
551707  RNA-binding protein with serine-rich domain 1 [KO:K14325]
409672  pinin [KO:K13114]
725396  THO complex subunit 4 [KO:K12881]
409839  regulator of nonsense transcripts 1 [KO:K14326] [EC:5.6.2.5 5.6.2.3]
413146  regulator of nonsense transcripts 2 [KO:K14327]
552225  regulator of nonsense transcripts 3B [KO:K14328]
413650  nuclear RNA export factor 1 [KO:K14284]
725134  nuclear RNA export factor 1 [KO:K14284]
102656258  nuclear RNA export factor 2-like [KO:K14284]
413378  NTF2-related export protein isoform X1 [KO:K14285]
552515  ATP-dependent RNA helicase WM6 [KO:K12812] [EC:5.6.2.7]
725155  serine/arginine repetitive matrix protein 1 isoform X1 [KO:K13171]
410103  partner of Y14 and mago [KO:K14294]
409647  THO complex subunit 1 isoform X1 [KO:K12878]
410099  THO complex subunit 2 isoform X2 [KO:K12879]
412584  THO complex subunit 5 homolog [KO:K13174]
725830  THO complex subunit 6 homolog [KO:K13175]
107964891  THO complex subunit 7 homolog isoform X1 [KO:K13176]
413173  THO complex subunit 3 [KO:K12880]
Reference
PMID:16777596
  Authors
Tran EJ, Wente SR
  Title
Dynamic nuclear pore complexes: life on the edge.
  Journal
Cell 125:1041-53 (2006)
DOI:10.1016/j.cell.2006.05.027
Reference
PMID:15519698
  Authors
Rodriguez MS, Dargemont C, Stutz F
  Title
Nuclear export of RNA.
  Journal
Biol Cell 96:639-55 (2004)
DOI:10.1016/j.biolcel.2004.04.014
Reference
PMID:18313922
  Authors
Palancade B, Doye V
  Title
Sumoylating and desumoylating enzymes at nuclear pores: underpinning their unexpected duties?
  Journal
Trends Cell Biol 18:174-83 (2008)
DOI:10.1016/j.tcb.2008.02.001
Reference
PMID:15901496
  Authors
Reed R, Cheng H
  Title
TREX, SR proteins and export of mRNA.
  Journal
Curr Opin Cell Biol 17:269-73 (2005)
DOI:10.1016/j.ceb.2005.04.011
Reference
PMID:16314458
  Authors
Tange TO, Shibuya T, Jurica MS, Moore MJ
  Title
Biochemical analysis of the EJC reveals two new factors and a stable tetrameric protein core.
  Journal
RNA 11:1869-83 (2005)
DOI:10.1261/rna.2155905
Reference
PMID:28673770
  Authors
Beck M, Schirmacher P, Singer S
  Title
Alterations of the nuclear transport system in hepatocellular carcinoma - New basis for therapeutic strategies.
  Journal
J Hepatol 67:1051-1061 (2017)
DOI:10.1016/j.jhep.2017.06.021
Related
pathway
ame03015  mRNA surveillance pathway
KO pathway
ko03013   
LinkDB

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