KEGG   PATHWAY: aof00480
Entry
aof00480                    Pathway                                
Name
Glutathione metabolism - Asparagus officinalis (garden asparagus)
Class
Metabolism; Metabolism of other amino acids
Pathway map
aof00480  Glutathione metabolism
aof00480

Module
aof_M00118  Glutathione biosynthesis, glutamate => glutathione [PATH:aof00480]
Other DBs
GO: 0006749
Organism
Asparagus officinalis (garden asparagus) [GN:aof]
Gene
109832645  gamma-glutamyltranspeptidase 1-like [KO:K18592] [EC:2.3.2.2 3.4.19.13 3.4.19.14]
109848817  gamma-glutamyltranspeptidase 3-like isoform X1 [KO:K18592] [EC:2.3.2.2 3.4.19.13 3.4.19.14]
109842906  gamma-glutamylcyclotransferase 2-1-like isoform X1 [KO:K22596] [EC:4.3.2.9]
109821597  gamma-glutamylcyclotransferase 2-2-like [KO:K22596] [EC:4.3.2.9]
109848877  gamma-glutamylcyclotransferase 2-3 [KO:K22596] [EC:4.3.2.9]
109823042  5-oxoprolinase [KO:K01469] [EC:3.5.2.9]
109850880  glutamate--cysteine ligase, chloroplastic [KO:K01919] [EC:6.3.2.2]
109827453  glutathione synthetase, chloroplastic [KO:K21456] [EC:6.3.2.3]
109831722  glutathione synthetase, chloroplastic-like isoform X1 [KO:K21456] [EC:6.3.2.3]
109828398  leucine aminopeptidase 2, chloroplastic-like [KO:K01255] [EC:3.4.11.1]
109841248  leucine aminopeptidase 1-like [KO:K01255] [EC:3.4.11.1]
109843997  LOW QUALITY PROTEIN: leucine aminopeptidase 2, chloroplastic-like [KO:K01255] [EC:3.4.11.1]
109837548  puromycin-sensitive aminopeptidase isoform X1 [KO:K01256] [EC:3.4.11.2]
109832808  glutathione transferase GST 23-like isoform X1 [KO:K00799] [EC:2.5.1.18]
109832809  glutathione transferase GST 23-like isoform X1 [KO:K00799] [EC:2.5.1.18]
109832810  glutathione transferase GST 23-like [KO:K00799] [EC:2.5.1.18]
109824756  glutathione transferase GST 23-like [KO:K00799] [EC:2.5.1.18]
109824955  glutathione S-transferase F11-like [KO:K00799] [EC:2.5.1.18]
109826045  glutathione S-transferase F10-like [KO:K00799] [EC:2.5.1.18]
109826347  glutathione S-transferase U17-like isoform X1 [KO:K00799] [EC:2.5.1.18]
109827167  glutathione S-transferase 3-like [KO:K00799] [EC:2.5.1.18]
109827171  glutathione S-transferase 3-like [KO:K00799] [EC:2.5.1.18]
109830515  microsomal glutathione S-transferase 3-like [KO:K00799] [EC:2.5.1.18]
109832214  microsomal glutathione S-transferase 3-like [KO:K00799] [EC:2.5.1.18]
109842044  glutathione S-transferase F11-like [KO:K00799] [EC:2.5.1.18]
109849698  probable glutathione S-transferase [KO:K00799] [EC:2.5.1.18]
109849699  glutathione S-transferase U8-like [KO:K00799] [EC:2.5.1.18]
109821352  glutathione S-transferase F10-like [KO:K00799] [EC:2.5.1.18]
109821359  glutathione S-transferase F10-like [KO:K00799] [EC:2.5.1.18]
109848252  glutathione S-transferase U25-like [KO:K00799] [EC:2.5.1.18]
109822659  glutathione S-transferase U17-like [KO:K00799] [EC:2.5.1.18]
109842915  protein IN2-1 homolog B-like [KO:K00799] [EC:2.5.1.18]
109843961  protein IN2-1 homolog B-like [KO:K00799] [EC:2.5.1.18]
109844905  probable glutathione S-transferase parA [KO:K00799] [EC:2.5.1.18]
109821977  glutathione S-transferase U17-like [KO:K00799] [EC:2.5.1.18]
109821978  glutathione S-transferase U17-like [KO:K00799] [EC:2.5.1.18]
109841952  microsomal glutathione S-transferase 3-like [KO:K00799] [EC:2.5.1.18]
109850425  glutathione S-transferase U8-like [KO:K00799] [EC:2.5.1.18]
109836960  glutathione S-transferase T1-like [KO:K00799] [EC:2.5.1.18]
109836961  glutathione S-transferase T1-like [KO:K00799] [EC:2.5.1.18]
109836963  glutathione S-transferase T1-like [KO:K00799] [EC:2.5.1.18]
109837155  probable glutathione S-transferase [KO:K00799] [EC:2.5.1.18]
109837812  glutathione S-transferase F10-like [KO:K00799] [EC:2.5.1.18]
109845346  glutathione S-transferase F11-like [KO:K00799] [EC:2.5.1.18]
109843086  protein IN2-1 homolog B-like [KO:K00799] [EC:2.5.1.18]
109846829  probable glutathione S-transferase [KO:K00799] [EC:2.5.1.18]
109846830  probable glutathione S-transferase [KO:K00799] [EC:2.5.1.18]
109843821  protein IN2-1 homolog B-like [KO:K00799] [EC:2.5.1.18]
109843822  protein IN2-1 homolog B-like isoform X1 [KO:K00799] [EC:2.5.1.18]
109849655  glutathione transferase GST 23-like [KO:K00799] [EC:2.5.1.18]
109849947  glutathione S-transferase U8-like [KO:K00799] [EC:2.5.1.18]
109820145  microsomal glutathione S-transferase 3-like [KO:K00799] [EC:2.5.1.18]
109832572  glutathione S-transferase U10-like [KO:K00799] [EC:2.5.1.18]
109846831  probable glutathione S-transferase [KO:K00799] [EC:2.5.1.18]
109848814  probable glutathione S-transferase [KO:K00799] [EC:2.5.1.18]
109829920  glutathione S-transferase DHAR2-like [KO:K21888] [EC:1.8.5.1 2.5.1.18]
109849073  glutathione S-transferase DHAR2-like [KO:K21888] [EC:1.8.5.1 2.5.1.18]
109821733  glutathione S-transferase DHAR3, chloroplastic-like [KO:K21888] [EC:1.8.5.1 2.5.1.18]
109848531  glutathione reductase, cytosolic-like [KO:K00383] [EC:1.8.1.7]
109834509  glutathione reductase, chloroplastic [KO:K00383] [EC:1.8.1.7]
109840741  cytosolic isocitrate dehydrogenase [NADP]-like [KO:K00031] [EC:1.1.1.42]
109828859  cytosolic isocitrate dehydrogenase [NADP]-like isoform X1 [KO:K00031] [EC:1.1.1.42]
109847469  cytosolic isocitrate dehydrogenase [NADP] [KO:K00031] [EC:1.1.1.42]
109837351  isocitrate dehydrogenase [NADP]-like [KO:K00031] [EC:1.1.1.42]
109825349  LOW QUALITY PROTEIN: 6-phosphogluconate dehydrogenase, decarboxylating 3-like [KO:K00033] [EC:1.1.1.44 1.1.1.343]
109830565  LOW QUALITY PROTEIN: 6-phosphogluconate dehydrogenase, decarboxylating 2, chloroplastic-like [KO:K00033] [EC:1.1.1.44 1.1.1.343]
109836987  6-phosphogluconate dehydrogenase, decarboxylating 1 [KO:K00033] [EC:1.1.1.44 1.1.1.343]
109830513  LOW QUALITY PROTEIN: glucose-6-phosphate 1-dehydrogenase, cytoplasmic isoform [KO:K00036] [EC:1.1.1.49 1.1.1.363]
109834371  glucose-6-phosphate 1-dehydrogenase 1, chloroplastic-like isoform X1 [KO:K00036] [EC:1.1.1.49 1.1.1.363]
109851040  glucose-6-phosphate 1-dehydrogenase 4, chloroplastic isoform X1 [KO:K00036] [EC:1.1.1.49 1.1.1.363]
109836144  glucose-6-phosphate 1-dehydrogenase, chloroplastic-like [KO:K00036] [EC:1.1.1.49 1.1.1.363]
109837320  glucose-6-phosphate 1-dehydrogenase, chloroplastic-like isoform X1 [KO:K00036] [EC:1.1.1.49 1.1.1.363]
109824662  probable glutathione peroxidase 2 [KO:K00432] [EC:1.11.1.9]
109826840  probable phospholipid hydroperoxide glutathione peroxidase [KO:K00432] [EC:1.11.1.9]
109836967  probable phospholipid hydroperoxide glutathione peroxidase [KO:K00432] [EC:1.11.1.9]
109843758  probable phospholipid hydroperoxide glutathione peroxidase [KO:K00432] [EC:1.11.1.9]
109842952  1-Cys peroxiredoxin PER1 [KO:K11188] [EC:1.11.1.7 1.11.1.27 3.1.1.-]
109828741  ornithine decarboxylase-like [KO:K01581] [EC:4.1.1.17]
109839001  ornithine decarboxylase-like [KO:K01581] [EC:4.1.1.17]
109839022  ornithine decarboxylase-like [KO:K01581] [EC:4.1.1.17]
109840750  spermine synthase-like [KO:K00797] [EC:2.5.1.16]
109847455  spermine synthase-like isoform X1 [KO:K00797] [EC:2.5.1.16]
109848832  spermidine synthase 1 [KO:K00797] [EC:2.5.1.16]
109849120  spermidine synthase 1-like isoform X1 [KO:K00797] [EC:2.5.1.16]
109830309  LOW QUALITY PROTEIN: probable L-ascorbate peroxidase 6, chloroplastic [KO:K00434] [EC:1.11.1.11]
109851292  L-ascorbate peroxidase 2, cytosolic [KO:K00434] [EC:1.11.1.11]
109823240  LOW QUALITY PROTEIN: probable L-ascorbate peroxidase 7, chloroplastic [KO:K00434] [EC:1.11.1.11]
109850069  L-ascorbate peroxidase, cytosolic [KO:K00434] [EC:1.11.1.11]
109848456  probable L-ascorbate peroxidase 4 [KO:K00434] [EC:1.11.1.11]
109845098  putative L-ascorbate peroxidase 6 isoform X1 [KO:K00434] [EC:1.11.1.11]
109833689  ribonucleoside-diphosphate reductase large subunit-like isoform X1 [KO:K10807] [EC:1.17.4.1]
109836553  LOW QUALITY PROTEIN: ribonucleoside-diphosphate reductase large subunit-like [KO:K10807] [EC:1.17.4.1]
109830553  ribonucleoside-diphosphate reductase small chain [KO:K10808] [EC:1.17.4.1]
109830571  ribonucleoside-diphosphate reductase small chain [KO:K10808] [EC:1.17.4.1]
Compound
C00005  NADPH
C00006  NADP+
C00024  Acetyl-CoA
C00025  L-Glutamate
C00037  Glycine
C00051  Glutathione
C00072  Ascorbate
C00077  L-Ornithine
C00097  L-Cysteine
C00127  Glutathione disulfide
C00134  Putrescine
C00151  L-Amino acid
C00315  Spermidine
C00669  gamma-L-Glutamyl-L-cysteine
C00750  Spermine
C01322  RX
C01419  Cys-Gly
C01672  Cadaverine
C01879  5-Oxoproline
C02090  Trypanothione
C02320  R-S-Glutathione
C03170  Trypanothione disulfide
C03646  Bis-gamma-glutamylcystine
C03740  (5-L-Glutamyl)-L-amino acid
C05422  Dehydroascorbate
C05726  S-Substituted L-cysteine
C05727  S-Substituted N-acetyl-L-cysteine
C05729  R-S-Cysteinylglycine
C05730  Glutathionylspermidine
C16562  Glutathionylspermine
C16563  Bis(glutathionyl)spermine
C16564  Bis(glutathionyl)spermine disulfide
C16565  Aminopropylcadaverine
C16566  Glutathionylaminopropylcadaverine
C16567  Homotrypanothione
C16568  Homotrypanothione disulfide
C16663  Tryparedoxin
C16664  Tryparedoxin disulfide
Reference
  Authors
Josch C, Klotz LO, Sies H.
  Title
Identification of cytosolic leucyl aminopeptidase (EC 3.4.11.1) as the major cysteinylglycine-hydrolysing activity in rat liver.
  Journal
Biol Chem 384:213-8 (2003)
DOI:10.1515/BC.2003.023
Reference
  Authors
Chu L, Lai Y, Xu X, Eddy S, Yang S, Song L, Kolodrubetz D.
  Title
A 52-kDa leucyl aminopeptidase from treponema denticola is a cysteinylglycinase that mediates the second step of glutathione metabolism.
  Journal
J Biol Chem 283:19351-8 (2008)
DOI:10.1074/jbc.M801034200
Reference
  Authors
Cappiello M, Lazzarotti A, Buono F, Scaloni A, D'Ambrosio C, Amodeo P, Mendez BL, Pelosi P, Del Corso A, Mura U.
  Title
New role for leucyl aminopeptidase in glutathione turnover.
  Journal
Biochem J 378:35-44 (2004)
DOI:10.1042/BJ20031336
Reference
  Authors
Suzuki H, Kamatani S, Kim ES, Kumagai H.
  Title
Aminopeptidases A, B, and N and dipeptidase D are the four cysteinylglycinases of Escherichia coli K-12.
  Journal
J Bacteriol 183:1489-90 (2001)
DOI:10.1128/JB.183.4.1489-1490.2001
Reference
  Authors
Oza SL, Shaw MP, Wyllie S, Fairlamb AH.
  Title
Trypanothione biosynthesis in Leishmania major.
  Journal
Mol Biochem Parasitol 139:107-16 (2005)
DOI:10.1016/j.molbiopara.2004.10.004
Reference
  Authors
Oza SL, Ariyanayagam MR, Fairlamb AH.
  Title
Characterization of recombinant glutathionylspermidine synthetase/amidase from Crithidia fasciculata.
  Journal
Biochem J 364:679-86 (2002)
DOI:10.1042/BJ20011370
Reference
PMID:9677355
  Authors
Tetaud E, Manai F, Barrett MP, Nadeau K, Walsh CT, Fairlamb AH.
  Title
Cloning and characterization of the two enzymes responsible for trypanothione biosynthesis in Crithidia fasciculata.
  Journal
J Biol Chem 273:19383-90 (1998)
DOI:10.1074/jbc.273.31.19383
Reference
  Authors
Ariyanayagam MR, Oza SL, Mehlert A, Fairlamb AH.
  Title
Bis(glutathionyl)spermine and other novel trypanothione analogues in Trypanosoma cruzi.
  Journal
J Biol Chem 278:27612-9 (2003)
DOI:10.1074/jbc.M302750200
Reference
  Authors
Oza SL, Ariyanayagam MR, Aitcheson N, Fairlamb AH.
  Title
Properties of trypanothione synthetase from Trypanosoma brucei.
  Journal
Mol Biochem Parasitol 131:25-33 (2003)
DOI:10.1016/S0166-6851(03)00176-2
Reference
  Authors
Oza SL, Tetaud E, Ariyanayagam MR, Warnon SS, Fairlamb AH.
  Title
A single enzyme catalyses formation of Trypanothione from glutathione and spermidine in Trypanosoma cruzi.
  Journal
J Biol Chem 277:35853-61 (2002)
DOI:10.1074/jbc.M204403200
Reference
  Authors
Comini M, Menge U, Wissing J, Flohe L.
  Title
Trypanothione synthesis in crithidia revisited.
  Journal
J Biol Chem 280:6850-60 (2005)
DOI:10.1074/jbc.M404486200
Reference
PMID:7813456
  Authors
Hunter KJ, Le Quesne SA, Fairlamb AH.
  Title
Identification and biosynthesis of N1,N9-bis(glutathionyl)aminopropylcadaverine (homotrypanothione) in Trypanosoma cruzi.
  Journal
Eur J Biochem 226:1019-27 (1994)
DOI:10.1111/j.1432-1033.1994.t01-1-01019.x
Reference
  Authors
Krauth-Siegel RL, Meiering SK, Schmidt H.
  Title
The parasite-specific trypanothione metabolism of trypanosoma and leishmania.
  Journal
Biol Chem 384:539-49 (2003)
DOI:10.1515/BC.2003.062
Reference
  Authors
Krauth-Siegel RL, Comini MA.
  Title
Redox control in trypanosomatids, parasitic protozoa with trypanothione-based thiol metabolism.
  Journal
Biochim Biophys Acta 1780:1236-48 (2008)
DOI:10.1016/j.bbagen.2008.03.006
Reference
PMID:8892297
  Authors
Krauth-Siegel RL, Ludemann H.
  Title
Reduction of dehydroascorbate by trypanothione.
  Journal
Mol Biochem Parasitol 80:203-8 (1996)
DOI:10.1016/0166-6851(96)02689-8
Reference
  Authors
Dormeyer M, Reckenfelderbaumer N, Ludemann H, Krauth-Siegel RL.
  Title
Trypanothione-dependent synthesis of deoxyribonucleotides by Trypanosoma brucei ribonucleotide reductase.
  Journal
J Biol Chem 276:10602-6 (2001)
DOI:10.1074/jbc.M010352200
Reference
  Authors
Schmidt H, Krauth-Siegel RL.
  Title
Functional and physicochemical characterization of the thioredoxin system in Trypanosoma brucei.
  Journal
J Biol Chem 278:46329-36 (2003)
DOI:10.1074/jbc.M305338200
Reference
PMID:9851611
  Authors
Tetaud E, Fairlamb AH.
  Title
Cloning, expression and reconstitution of the trypanothione-dependent peroxidase system of Crithidia fasciculata.
  Journal
Mol Biochem Parasitol 96:111-23 (1998)
DOI:10.1016/S0166-6851(98)00120-0
Reference
  Authors
Castro H, Sousa C, Santos M, Cordeiro-da-Silva A, Flohe L, Tomas AM.
  Title
Complementary antioxidant defense by cytoplasmic and mitochondrial peroxiredoxins in Leishmania infantum.
  Journal
Free Radic Biol Med 33:1552-62 (2002)
DOI:10.1016/S0891-5849(02)01089-4
Reference
  Authors
Wilkinson SR, Temperton NJ, Mondragon A, Kelly JM.
  Title
Distinct mitochondrial and cytosolic enzymes mediate trypanothione-dependent peroxide metabolism in Trypanosoma cruzi.
  Journal
J Biol Chem 275:8220-5 (2000)
DOI:10.1074/jbc.275.11.8220
Reference
  Authors
Konig J, Fairlamb AH.
  Title
A comparative study of type I and type II tryparedoxin peroxidases in Leishmania major.
  Journal
FEBS J 274:5643-58 (2007)
DOI:10.1111/j.1742-4658.2007.06087.x
Reference
  Authors
Hillebrand H, Schmidt A, Krauth-Siegel RL.
  Title
A second class of peroxidases linked to the trypanothione metabolism.
  Journal
J Biol Chem 278:6809-15 (2003)
DOI:10.1074/jbc.M210392200
Reference
  Authors
Soksawatmaekhin W, Kuraishi A, Sakata K, Kashiwagi K, Igarashi K.
  Title
Excretion and uptake of cadaverine by CadB and its physiological functions in Escherichia coli.
  Journal
Mol Microbiol 51:1401-12 (2004)
DOI:10.1046/j.1365-2958.2003.03913.x
Reference
PMID:6798961
  Authors
Pegg AE, Shuttleworth K, Hibasami H.
  Title
Specificity of mammalian spermidine synthase and spermine synthase.
  Journal
Biochem J 197:315-20 (1981)
DOI:10.1042/bj1970315
Related
pathway
aof00220  Arginine biosynthesis
aof00250  Alanine, aspartate and glutamate metabolism
aof00270  Cysteine and methionine metabolism
aof00430  Taurine and hypotaurine metabolism
aof00460  Cyanoamino acid metabolism
KO pathway
ko00480   
LinkDB

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