KEGG   PATHWAY: aor00260
Entry
aor00260                    Pathway                                
Name
Glycine, serine and threonine metabolism - Aspergillus oryzae
Description
Serine is derived from 3-phospho-D-glycerate, an intermediate of glycolysis [MD:M00020], and glycine is derived from serine. Threonine is an essential amino acid, which animals cannot synthesize. In bacteria and plants, threonine is derived from aspartate [MD:M00018].
Class
Metabolism; Amino acid metabolism
Pathway map
aor00260  Glycine, serine and threonine metabolism
aor00260

Module
aor_M00018  Threonine biosynthesis, aspartate => homoserine => threonine [PATH:aor00260]
aor_M00020  Serine biosynthesis, glycerate-3P => serine [PATH:aor00260]
aor_M00338  Cysteine biosynthesis, homocysteine + serine => cysteine [PATH:aor00260]
aor_M00621  Glycine cleavage system [PATH:aor00260]
Other DBs
GO: 0006544 0006563 0070178 0006566
Organism
Aspergillus oryzae [GN:aor]
Gene
AO090009000702  unnamed protein product; aspartate kinase [KO:K00928] [EC:2.7.2.4]
AO090020000314  unnamed protein product; aspartate-semialdehyde dehydrogenase [KO:K00133] [EC:1.2.1.11]
AO090009000136  unnamed protein product; homoserine dehydrogenase [KO:K00003] [EC:1.1.1.3]
AO090003000721  unnamed protein product; homoserine dehydrogenase [KO:K00003] [EC:1.1.1.3]
AO090009000682  unnamed protein product; homoserine kinase [KO:K00872] [EC:2.7.1.39]
AO090038000224  unnamed protein product; pyridoxalphosphate-dependent enzyme/predicted threonine synthase [KO:K01733] [EC:4.2.3.1]
AO090012000408  unnamed protein product; threonine aldolase [KO:K01620] [EC:4.1.2.48]
AO090005000497  unnamed protein product; threonine aldolase [KO:K01620] [EC:4.1.2.48]
AO090005001302  unnamed protein product; glycine/serine hydroxymethyltransferase [KO:K00600] [EC:2.1.2.1]
AO090011000915  unnamed protein product; glycine/serine hydroxymethyltransferase [KO:K00600] [EC:2.1.2.1]
AO090012000926  unnamed protein product; alanine-glyoxylate aminotransferase AGT1 [KO:K00830] [EC:2.6.1.44 2.6.1.45 2.6.1.51]
AO090005001300  unnamed protein product; phosphoglycerate mutase [KO:K15633] [EC:5.4.2.12]
AO090011000325  unnamed protein product; predicted kinase [KO:K15918] [EC:2.7.1.31]
AO090009000711  unnamed protein product; D-3-phosphoglycerate dehydrogenase, D-isomer-specific 2-hydroxy acid dehydrogenase superfamily [KO:K00058] [EC:1.1.1.95 1.1.1.399]
AO090023000099  unnamed protein product; phosphoserine aminotransferase [KO:K00831] [EC:2.6.1.52]
AO090020000345  unnamed protein product; phosphoserine phosphatase [KO:K01079] [EC:3.1.3.3]
AO090124000026  unnamed protein product; predicted dehydrogenase [KO:K16066] [EC:1.1.1.381 1.1.1.-]
AO090026000725  unnamed protein product; predicted dehydrogenase [KO:K16066] [EC:1.1.1.381 1.1.1.-]
AO090009000630  unnamed protein product; 5-aminolevulinate synthase [KO:K00643] [EC:2.3.1.37]
AO090023000744  unnamed protein product; monoamine oxidase [KO:K00274] [EC:1.4.3.4]
AO090113000186  unnamed protein product; amine oxidase [KO:K00274] [EC:1.4.3.4]
AO090103000118  unnamed protein product; amine oxidase [KO:K00274] [EC:1.4.3.4]
AO090103000401  unnamed protein product; copper amine oxidase [KO:K00276] [EC:1.4.3.21]
AO090003000356  unnamed protein product; copper amine oxidase [KO:K00276] [EC:1.4.3.21]
AO090011000229  unnamed protein product; copper amine oxidase [KO:K00276] [EC:1.4.3.21]
AO090701000307  unnamed protein product; copper amine oxidase [KO:K00276] [EC:1.4.3.21]
AO090701000490  unnamed protein product; copper amine oxidase [KO:K00276] [EC:1.4.3.21]
AO090138000079  unnamed protein product; copper amine oxidase [KO:K00276] [EC:1.4.3.21]
AO090005000103  unnamed protein product; copper amine oxidase [KO:K00276] [EC:1.4.3.21]
AO090011000351  unnamed protein product; glycine dehydrogenase (decarboxylating) [KO:K00281] [EC:1.4.4.2]
AO090038000338  unnamed protein product; aminomethyl transferase [KO:K00605] [EC:2.1.2.10]
AO090011000486  unnamed protein product; dihydrolipoamide dehydrogenase [KO:K00382] [EC:1.8.1.4]
AO090001000337  unnamed protein product; glycine cleavage system H protein (lipoate-binding) [KO:K02437]
AO090005000932  unnamed protein product; D-aspartate oxidase [KO:K00273] [EC:1.4.3.3]
AO090113000084  unnamed protein product; D-aspartate oxidase [KO:K00273] [EC:1.4.3.3]
AO090012000898  unnamed protein product; D-aspartate oxidase [KO:K00273] [EC:1.4.3.3]
AO090026000714  unnamed protein product; D-aspartate oxidase [KO:K00273] [EC:1.4.3.3]
AO090009000203  unnamed protein product; predicted protein [KO:K17103] [EC:2.7.8.8]
AO090103000021  unnamed protein product; NAD-dependent aldehyde dehydrogenases [KO:K00130] [EC:1.2.1.8]
AO090023000142  unnamed protein product; dimethylglycine dehydrogenase precursor [KO:K00309] [EC:1.5.3.10]
AO090138000040  unnamed protein product; FAD-dependent oxidoreductase [KO:K00306] [EC:1.5.3.1 1.5.3.7]
AO090001000230  unnamed protein product; FAD-dependent oxidoreductase [KO:K00306] [EC:1.5.3.1 1.5.3.7]
AO090102000313  unnamed protein product; FAD-dependent oxidoreductase [KO:K00306] [EC:1.5.3.1 1.5.3.7]
AO090005000038  unnamed protein product; FAD-dependent oxidoreductase [KO:K00306] [EC:1.5.3.1 1.5.3.7]
AO090003000547  unnamed protein product; FAD-dependent oxidoreductase [KO:K00306] [EC:1.5.3.1 1.5.3.7]
AO090026000204  unnamed protein product; FAD-dependent oxidoreductase [KO:K00306] [EC:1.5.3.1 1.5.3.7]
AO090011000473  unnamed protein product; FAD-dependent oxidoreductase [KO:K00306] [EC:1.5.3.1 1.5.3.7]
AO090011000931  unnamed protein product; cysteine synthase [KO:K01697] [EC:4.2.1.22]
AO090103000051  unnamed protein product; cystathionine beta-lyases/cystathionine gamma-synthases [KO:K01758] [EC:4.4.1.1]
AO090023000756  unnamed protein product; threonine/serine dehydratases [KO:K01754] [EC:4.3.1.19]
AO090701000582  unnamed protein product; serine racemase [KO:K01754] [EC:4.3.1.19]
AO090103000289  unnamed protein product; serine racemase [KO:K01754] [EC:4.3.1.19]
AO090023000790  unnamed protein product; threonine/serine dehydratases [KO:K17989] [EC:4.3.1.17 4.3.1.19]
AO090009000342  unnamed protein product; threonine/serine dehydratases [KO:K17989] [EC:4.3.1.17 4.3.1.19]
AO090026000284  unnamed protein product; tryptophan synthase beta chain [KO:K01694] [EC:4.2.1.20]
AO090005001315  unnamed protein product; tryptophan synthase beta chain [KO:K01694] [EC:4.2.1.20]
AO090023000874  unnamed protein product; tryptophan synthase beta chain [KO:K01694] [EC:4.2.1.20]
AO090010000231  unnamed protein product; tryptophan synthase beta chain [KO:K06001] [EC:4.2.1.20]
Compound
C00011  CO2
C00014  Ammonia
C00022  Pyruvate
C00037  Glycine
C00048  Glyoxylate
C00049  L-Aspartate
C00065  L-Serine
C00078  L-Tryptophan
C00097  L-Cysteine
C00101  Tetrahydrofolate
C00109  2-Oxobutanoate
C00114  Choline
C00143  5,10-Methylenetetrahydrofolate
C00168  Hydroxypyruvate
C00188  L-Threonine
C00197  3-Phospho-D-glycerate
C00213  Sarcosine
C00258  D-Glycerate
C00263  L-Homoserine
C00300  Creatine
C00430  5-Aminolevulinate
C00441  L-Aspartate 4-semialdehyde
C00546  Methylglyoxal
C00576  Betaine aldehyde
C00581  Guanidinoacetate
C00631  2-Phospho-D-glycerate
C00719  Betaine
C00740  D-Serine
C00986  1,3-Diaminopropane
C01005  O-Phospho-L-serine
C01026  N,N-Dimethylglycine
C01102  O-Phospho-L-homoserine
C01242  [Protein]-S8-aminomethyldihydrolipoyllysine
C01888  Aminoacetone
C02051  Lipoylprotein
C02291  L-Cystathionine
C02737  Phosphatidylserine
C02972  Dihydrolipoylprotein
C03082  4-Phospho-L-aspartate
C03194  (R)-1-Aminopropan-2-ol
C03232  3-Phosphonooxypyruvate
C03283  L-2,4-Diaminobutanoate
C03508  L-2-Amino-3-oxobutanoic acid
C05519  L-Allothreonine
C06231  Ectoine
C06442  N(gamma)-Acetyldiaminobutyrate
C16432  5-Hydroxyectoine
C19929  N(alpha)-Acetyl-L-2,4-diaminobutyrate
Reference
  Authors
Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).
  Title
[Cellular Functions and Metabolic Maps] (In Japanese)
  Journal
Tokyo Kagaku Dojin (1997)
Reference
PMID:11823218
  Authors
Kuhlmann AU, Bremer E.
  Title
Osmotically regulated synthesis of the compatible solute ectoine in Bacillus pasteurii and related Bacillus spp.
  Journal
Appl Environ Microbiol 68:772-83 (2002)
DOI:10.1128/AEM.68.2.772-783.2002
Reference
PMID:10473374
  Authors
Canovas D, Borges N, Vargas C, Ventosa A, Nieto JJ, Santos H.
  Title
Role of Ngamma-acetyldiaminobutyrate as an enzyme stabilizer and an intermediate in the biosynthesis of hydroxyectoine.
  Journal
Appl Environ Microbiol 65:3774-9 (1999)
DOI:10.1128/AEM.65.9.3774-3779.1999
Reference
PMID:17636255
  Authors
Bursy J, Pierik AJ, Pica N, Bremer E.
  Title
Osmotically induced synthesis of the compatible solute hydroxyectoine is mediated by an evolutionarily conserved ectoine hydroxylase.
  Journal
J Biol Chem 282:31147-55 (2007)
DOI:10.1074/jbc.M704023200
Reference
PMID:16707670
  Authors
Garcia-Estepa R, Argandona M, Reina-Bueno M, Capote N, Iglesias-Guerra F, Nieto JJ, Vargas C.
  Title
The ectD gene, which is involved in the synthesis of the compatible solute hydroxyectoine, is essential for thermoprotection of the halophilic bacterium Chromohalobacter salexigens.
  Journal
J Bacteriol 188:3774-84 (2006)
DOI:10.1128/JB.00136-06
Reference
PMID:15470257
  Authors
Arevalo-Rodriguez M, Pan X, Boeke JD, Heitman J
  Title
FKBP12 controls aspartate pathway flux in Saccharomyces cerevisiae to prevent toxic intermediate accumulation.
  Journal
Eukaryot Cell 3:1287-96 (2004)
DOI:10.1128/EC.3.5.1287-1296.2004
Reference
PMID:7639721
  Authors
Rees WD, Hay SM
  Title
The biosynthesis of threonine by mammalian cells: expression of a complete bacterial biosynthetic pathway in an animal cell.
  Journal
Biochem J 309 ( Pt 3):999-1007 (1995)
DOI:10.1042/bj3090999
Reference
PMID:11341914
  Authors
Jacques SL, Nieman C, Bareich D, Broadhead G, Kinach R, Honek JF, Wright GD
  Title
Characterization of yeast homoserine dehydrogenase, an antifungal target: the invariant histidine 309 is important for enzyme integrity.
  Journal
Biochim Biophys Acta 1544:28-41 (2001)
DOI:10.1016/S0167-4838(00)00203-X
Reference
PMID:15520012
  Authors
Chen X, Jhee KH, Kruger WD
  Title
Production of the neuromodulator H2S by cystathionine beta-synthase via the condensation of cysteine and homocysteine.
  Journal
J Biol Chem 279:52082-6 (2004)
DOI:10.1074/jbc.C400481200
Related
pathway
aor00010  Glycolysis / Gluconeogenesis
aor00020  Citrate cycle (TCA cycle)
aor00230  Purine metabolism
aor00250  Alanine, aspartate and glutamate metabolism
aor00270  Cysteine and methionine metabolism
aor00290  Valine, leucine and isoleucine biosynthesis
aor00300  Lysine biosynthesis
aor00330  Arginine and proline metabolism
aor00460  Cyanoamino acid metabolism
aor00470  D-Amino acid metabolism
aor00564  Glycerophospholipid metabolism
aor00600  Sphingolipid metabolism
aor00620  Pyruvate metabolism
aor00630  Glyoxylate and dicarboxylate metabolism
aor00640  Propanoate metabolism
aor00680  Methane metabolism
aor00860  Porphyrin metabolism
aor00920  Sulfur metabolism
KO pathway
ko00260   
LinkDB

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