KEGG PATHWAY: apln04142

KEGG

PATHWAY: apln04142

Entry

apln04142                   Pathway

Name

Lysosome - Agrilus planipennis (emerald ash borer)

Description

Lysosomes are membrane-delimited organelles in animal cells serving as the cell's main digestive compartment to which all sorts of macromolecules are delivered for degradation. They contain more than 40 hydrolases in an acidic environment (pH of about 5). After synthesis in the ER, lysosomal enzymes are decorated with mannose-6-phosphate residues, which are recognized by mannose-6-phosphate receptors in the trans-Golgi network. They are packaged into clathrin-coated vesicles and are transported to late endosomes. Substances for digestion are acquired by the lysosomes via a series of processes including endocytosis, phagocytosis, and autophagy.

Class

Cellular Processes; Transport and catabolism

Pathway map

Lysosome

Other DBs

GO:

Organism

Agrilus planipennis (emerald ash borer) [GN:apln]

Gene

V-type proton ATPase 116 kDa subunit a isoform X1 [KO:K02154]

V-type proton ATPase 116 kDa subunit a [KO:K02154]

V-type proton ATPase subunit d [KO:K02146]

V-type proton ATPase subunit d [KO:K02146]

V-type proton ATPase subunit H isoform X1 [KO:K02144]

V-type proton ATPase subunit S1 [KO:K03662]

V-type proton ATPase 16 kDa proteolipid subunit [KO:K02155]

V-type proton ATPase 21 kDa proteolipid subunit-like [KO:K03661]

V-type proton ATPase 21 kDa proteolipid subunit [KO:K03661]

dmX-like protein 2 isoform X1 [KO:K24155]

WD repeat-containing protein 7 [KO:K24738]

oxidation resistance protein 1 isoform X1 [KO:K25442]

cathepsin B [KO:K01363] [EC:3.4.22.1]

lysosomal aspartic protease [KO:K01379] [EC:3.4.23.5]

lysosomal aspartic protease-like [KO:K01379] [EC:3.4.23.5]

cathepsin L-like isoform X1 [KO:K01365] [EC:3.4.22.15]

cathepsin L [KO:K01365] [EC:3.4.22.15]

cathepsin O-like [KO:K01374] [EC:3.4.22.42]

lysosomal alpha-glucosidase isoform X1 [KO:K12316] [EC:3.2.1.20]

glucosylceramidase-like [KO:K01201] [EC:3.2.1.45]

alpha-N-acetylgalactosaminidase [KO:K01204] [EC:3.2.1.49]

alpha-N-acetylglucosaminidase isoform X1 [KO:K01205] [EC:3.2.1.50]

beta-glucuronidase [KO:K01195] [EC:3.2.1.31]

LOW QUALITY PROTEIN: tissue alpha-L-fucosidase-like [KO:K01206] [EC:3.2.1.51]

tissue alpha-L-fucosidase [KO:K01206] [EC:3.2.1.51]

plasma alpha-L-fucosidase-like isoform X1 [KO:K01206] [EC:3.2.1.51]

chitooligosaccharidolytic beta-N-acetylglucosaminidase [KO:K12373] [EC:3.2.1.52]

beta-hexosaminidase subunit alpha [KO:K12373] [EC:3.2.1.52]

chitooligosaccharidolytic beta-N-acetylglucosaminidase isoform X1 [KO:K12373] [EC:3.2.1.52]

beta-mannosidase-like [KO:K01192] [EC:3.2.1.25]

beta-mannosidase-like [KO:K01192] [EC:3.2.1.25]

lysosomal alpha-mannosidase-like [KO:K12311] [EC:3.2.1.24]

lysosomal alpha-mannosidase-like isoform X1 [KO:K12311] [EC:3.2.1.24]

hyaluronidase-like [KO:K01197] [EC:3.2.1.35]

arylsulfatase B-like [KO:K01135] [EC:3.1.6.12]

arylsulfatase B-like [KO:K01135] [EC:3.1.6.12]

arylsulfatase B [KO:K01135] [EC:3.1.6.12]

arylsulfatase B [KO:K01135] [EC:3.1.6.12]

arylsulfatase B isoform X1 [KO:K01135] [EC:3.1.6.12]

arylsulfatase B-like [KO:K01135] [EC:3.1.6.12]

N-acetylglucosamine-6-sulfatase-like isoform X3 [KO:K01137] [EC:3.1.6.14]

iduronate 2-sulfatase isoform X1 [KO:K01136] [EC:3.1.6.13]

N-sulphoglucosamine sulphohydrolase [KO:K01565] [EC:3.10.1.1]

gastric triacylglycerol lipase-like [KO:K01052] [EC:3.1.1.13]

lipase 3-like [KO:K01052] [EC:3.1.1.13]

lysosomal acid lipase/cholesteryl ester hydrolase-like [KO:K01052] [EC:3.1.1.13]

lipase 3-like [KO:K01052] [EC:3.1.1.13]

lipase 3-like [KO:K01052] [EC:3.1.1.13]

lipase 3-like [KO:K01052] [EC:3.1.1.13]

group XV phospholipase A2 isoform X1 [KO:K06129] [EC:3.1.1.5]

plancitoxin-1 [KO:K01158] [EC:3.1.22.1]

plancitoxin-1-like [KO:K01158] [EC:3.1.22.1]

prostatic acid phosphatase [KO:K14410] [EC:3.1.3.2]

venom acid phosphatase Acph-1-like [KO:K14410] [EC:3.1.3.2]

venom acid phosphatase Acph-1 [KO:K14410] [EC:3.1.3.2]

sphingomyelin phosphodiesterase isoform X1 [KO:K12350] [EC:3.1.4.12]

sphingomyelin phosphodiesterase [KO:K12350] [EC:3.1.4.12]

N(4)-(Beta-N-acetylglucosaminyl)-L-asparaginase- like [KO:K01444] [EC:3.5.1.26]

prosaposin [KO:K12382]

ganglioside GM2 activator-like [KO:K12383]

lysosomal thioesterase PPT2 homolog isoform X1 [KO:K01074] [EC:3.1.2.22]

palmitoyl-protein thioesterase 1 [KO:K01074] [EC:3.1.2.22]

lysosome-associated membrane glycoprotein 1 isoform X1 [KO:K06528]

CD63 antigen [KO:K06497]

CD63 antigen-like [KO:K06497]

tetraspanin-9-like [KO:K06497]

CD63 antigen [KO:K06497]

NPC intracellular cholesterol transporter 1 isoform X1 [KO:K12385]

NPC intracellular cholesterol transporter 1 homolog 1b-like [KO:K12385]

NPC intracellular cholesterol transporter 2 [KO:K13443]

ecdysteroid-regulated 16 kDa protein-like isoform X1 [KO:K13443]

NPC intracellular cholesterol transporter 2-like [KO:K13443]

cystinosin homolog [KO:K12386]

putative inorganic phosphate cotransporter [KO:K12301]

protein Malvolio isoform X1 [KO:K21398]

protein Malvolio-like [KO:K21398]

uncharacterized protein LOC112903937 [KO:K12387]

lysosomal-associated transmembrane protein 4B [KO:K12387]

sialomucin core protein 24 isoform X1 [KO:K06546]

battenin [KO:K12389]

heparan-alpha-glucosaminide N-acetyltransferase-like [KO:K10532] [EC:2.3.1.78]

heparan-alpha-glucosaminide N-acetyltransferase [KO:K10532] [EC:2.3.1.78]

formylglycine-generating enzyme-like isoform X1 [KO:K13444] [EC:1.8.3.7]

formylglycine-generating enzyme-like isoform X2 [KO:K13444] [EC:1.8.3.7]

N-acetylglucosamine-1-phosphotransferase subunits alpha/beta [KO:K08239] [EC:2.7.8.17]

uncharacterized protein LOC108734927 [KO:K10089]

clathrin heavy chain [KO:K04646]

AP-1 complex subunit gamma-1 isoform X1 [KO:K12391]

AP-1 complex subunit beta-1 [KO:K12392]

AP-1 complex subunit mu-1 [KO:K12393]

AP-1 complex subunit sigma-2 isoform X1 [KO:K12394]

AP-3 complex subunit delta isoform X1 [KO:K12396]

AP-3 complex subunit beta-2 isoform X1 [KO:K12397]

AP-3 complex subunit mu-1 [KO:K12398]

ADP-ribosylation factor-binding protein GGA1 isoform X1 [KO:K12404]

lipopolysaccharide-induced tumor necrosis factor-alpha factor homolog [KO:K19363]

lipopolysaccharide-induced tumor necrosis factor-alpha factor homolog [KO:K19363]

lipopolysaccharide-induced tumor necrosis factor-alpha factor [KO:K19363]

Compound

ATP

ADP

D-Mannose

D-Mannose 6-phosphate

Reference

Authors

Eskelinen EL, Tanaka Y, Saftig P

Title

At the acidic edge: emerging functions for lysosomal membrane proteins.

Journal

Trends Cell Biol 13:137-45 (2003)
DOI:10.1016/S0962-8924(03)00005-9

Reference

Authors

Neufeld EF

Title

Lysosomal storage diseases.

Journal

Annu Rev Biochem 60:257-80 (1991)
DOI:10.1146/annurev.bi.60.070191.001353

Reference

Authors

von Figura K, Hasilik A

Title

Lysosomal enzymes and their receptors.

Journal

Annu Rev Biochem 55:167-93 (1986)
DOI:10.1146/annurev.bi.55.070186.001123

Reference

Authors

Janvier K, Bonifacino JS

Title

Role of the endocytic machinery in the sorting of lysosome-associated membrane proteins.

Journal

Mol Biol Cell 16:4231-42 (2005)
DOI:10.1091/mbc.E05-03-0213

Reference

Authors

Vergarajauregui S, Puertollano R

Title

Mucolipidosis type IV: the importance of functional lysosomes for efficient autophagy.

Journal

Autophagy 4:832-4 (2008)
DOI:10.4161/auto.6567

Reference

Authors

Jaskolka MC, Winkley SR, Kane PM

Title

RAVE and Rabconnectin-3 Complexes as Signal Dependent Regulators of Organelle Acidification.

Journal

Front Cell Dev Biol 9:698190 (2021)
DOI:10.3389/fcell.2021.698190

Reference

Authors

Majdoul S, Compton AA

Title

Lessons in self-defence: inhibition of virus entry by intrinsic immunity.

Journal

Nat Rev Immunol 10.1038/s41577-021-00626-8 (2021)
DOI:10.1038/s41577-021-00626-8

Related
pathway

Other glycan degradation

Glycosaminoglycan degradation

SNARE interactions in vesicular transport

Autophagy - animal

Endocytosis

KO pathway

LinkDB

DBGET integrated database retrieval system