KEGG   PATHWAY: aprc00480
Entry
aprc00480                   Pathway                                
Name
Glutathione metabolism - Abrus precatorius (Indian licorice)
Class
Metabolism; Metabolism of other amino acids
Pathway map
aprc00480  Glutathione metabolism
aprc00480

Module
aprc_M00118  Glutathione biosynthesis, glutamate => glutathione [PATH:aprc00480]
Other DBs
GO: 0006749
Organism
Abrus precatorius (Indian licorice) [GN:aprc]
Gene
113850170  glutathione hydrolase 1-like [KO:K18592] [EC:2.3.2.2 3.4.19.13 3.4.19.14]
113867111  glutathione hydrolase 3 isoform X1 [KO:K18592] [EC:2.3.2.2 3.4.19.13 3.4.19.14]
113847740  gamma-glutamylcyclotransferase 2-3 [KO:K22596] [EC:4.3.2.9]
113865395  gamma-glutamylcyclotransferase 2-1-like [KO:K22596] [EC:4.3.2.9]
113857566  5-oxoprolinase [KO:K01469] [EC:3.5.2.9]
113854610  glutamate--cysteine ligase, chloroplastic [KO:K01919] [EC:6.3.2.2]
113863435  glutathione synthetase, chloroplastic-like [KO:K21456] [EC:6.3.2.3]
113863436  glutathione synthetase, chloroplastic-like [KO:K21456] [EC:6.3.2.3]
113846649  leucine aminopeptidase 1-like [KO:K01255] [EC:3.4.11.1]
113853190  leucine aminopeptidase 1-like [KO:K01255] [EC:3.4.11.1]
113853787  puromycin-sensitive aminopeptidase isoform X1 [KO:K01256] [EC:3.4.11.2]
113871281  probable glutathione S-transferase [KO:K00799] [EC:2.5.1.18]
113871334  glutathione S-transferase L3-like [KO:K00799] [EC:2.5.1.18]
113847730  glutathione S-transferase-like [KO:K00799] [EC:2.5.1.18]
113847983  microsomal glutathione S-transferase 3 [KO:K00799] [EC:2.5.1.18]
113860766  probable glutathione S-transferase [KO:K00799] [EC:2.5.1.18]
113860816  glutathione S-transferase L3-like [KO:K00799] [EC:2.5.1.18]
113860956  glutathione S-transferase L3 isoform X1 [KO:K00799] [EC:2.5.1.18]
113860969  probable glutathione S-transferase [KO:K00799] [EC:2.5.1.18]
113872031  protein IN2-1 homolog B-like isoform X1 [KO:K00799] [EC:2.5.1.18]
113872173  glutathione S-transferase U9-like [KO:K00799] [EC:2.5.1.18]
113872209  glutathione transferase GST 23-like [KO:K00799] [EC:2.5.1.18]
113872365  probable glutathione S-transferase [KO:K00799] [EC:2.5.1.18]
113848182  glutathione S-transferase U19-like [KO:K00799] [EC:2.5.1.18]
113848911  probable glutathione S-transferase [KO:K00799] [EC:2.5.1.18]
113861590  glutathione S-transferase L3-like [KO:K00799] [EC:2.5.1.18]
113861592  glutathione S-transferase L1-like [KO:K00799] [EC:2.5.1.18]
113849078  glutathione S-transferase F12-like [KO:K00799] [EC:2.5.1.18]
113873026  probable glutathione S-transferase [KO:K00799] [EC:2.5.1.18]
113873648  glutathione S-transferase F13-like [KO:K00799] [EC:2.5.1.18]
113849651  probable glutathione S-transferase parA [KO:K00799] [EC:2.5.1.18]
113873825  glutathione S-transferase-like [KO:K00799] [EC:2.5.1.18]
113874112  glutathione S-transferase F9-like [KO:K00799] [EC:2.5.1.18]
113864475  probable glutathione S-transferase parC [KO:K00799] [EC:2.5.1.18]
113864556  glutathione transferase GST 23-like [KO:K00799] [EC:2.5.1.18]
113864569  probable glutathione S-transferase isoform X1 [KO:K00799] [EC:2.5.1.18]
113853574  glutathione S-transferase F10-like [KO:K00799] [EC:2.5.1.18]
113853575  glutathione S-transferase F9-like [KO:K00799] [EC:2.5.1.18]
113853682  glutathione S-transferase T1-like [KO:K00799] [EC:2.5.1.18]
113854049  probable glutathione S-transferase [KO:K00799] [EC:2.5.1.18]
113854050  glutathione S-transferase 3-like [KO:K00799] [EC:2.5.1.18]
113854051  glutathione S-transferase 3-like [KO:K00799] [EC:2.5.1.18]
113855251  glutathione S-transferase T1-like isoform X1 [KO:K00799] [EC:2.5.1.18]
113855538  probable glutathione S-transferase [KO:K00799] [EC:2.5.1.18]
113855539  glutathione S-transferase 3-like [KO:K00799] [EC:2.5.1.18]
113856598  probable glutathione S-transferase isoform X1 [KO:K00799] [EC:2.5.1.18]
113845825  glutathione S-transferase 3-like [KO:K00799] [EC:2.5.1.18]
113857452  glutathione transferase GST 23-like [KO:K00799] [EC:2.5.1.18]
113868838  glutathione S-transferase U10-like [KO:K00799] [EC:2.5.1.18]
113869029  glutathione S-transferase U17-like [KO:K00799] [EC:2.5.1.18]
113857983  glutathione S-transferase U17-like [KO:K00799] [EC:2.5.1.18]
113872224  glutathione S-transferase DHAR2-like [KO:K21888] [EC:1.8.5.1 2.5.1.18]
113849681  glutathione S-transferase DHAR3, chloroplastic-like [KO:K21888] [EC:1.8.5.1 2.5.1.18]
113870753  glutathione reductase, chloroplastic [KO:K00383] [EC:1.8.1.7]
113857401  glutathione reductase, cytosolic isoform X1 [KO:K00383] [EC:1.8.1.7]
113848039  isocitrate dehydrogenase [NADP] isoform X1 [KO:K00031] [EC:1.1.1.42]
113853746  isocitrate dehydrogenase [NADP], chloroplastic-like isoform X1 [KO:K00031] [EC:1.1.1.42]
113867139  isocitrate dehydrogenase [NADP] isoform X1 [KO:K00031] [EC:1.1.1.42]
113861308  6-phosphogluconate dehydrogenase, decarboxylating 2 [KO:K00033] [EC:1.1.1.44 1.1.1.343]
113854942  6-phosphogluconate dehydrogenase, decarboxylating 3, chloroplastic [KO:K00033] [EC:1.1.1.44 1.1.1.343]
113860895  glucose-6-phosphate 1-dehydrogenase, chloroplastic isoform X1 [KO:K00036] [EC:1.1.1.49 1.1.1.363]
113849012  glucose-6-phosphate 1-dehydrogenase, chloroplastic-like isoform X1 [KO:K00036] [EC:1.1.1.49 1.1.1.363]
113861247  inactive glucose-6-phosphate 1-dehydrogenase 4, chloroplastic isoform X1 [KO:K00036] [EC:1.1.1.49 1.1.1.363]
113867213  glucose-6-phosphate 1-dehydrogenase, cytoplasmic isoform [KO:K00036] [EC:1.1.1.49 1.1.1.363]
113870744  probable glutathione peroxidase 4 [KO:K00432] [EC:1.11.1.9]
113863860  probable glutathione peroxidase 5 [KO:K00432] [EC:1.11.1.9]
113853683  probable phospholipid hydroperoxide glutathione peroxidase [KO:K00432] [EC:1.11.1.9]
113854066  probable phospholipid hydroperoxide glutathione peroxidase [KO:K00432] [EC:1.11.1.9]
113854252  probable glutathione peroxidase 8 [KO:K00432] [EC:1.11.1.9]
113868447  probable glutathione peroxidase 8 [KO:K00432] [EC:1.11.1.9]
113845819  phospholipid hydroperoxide glutathione peroxidase, chloroplastic-like [KO:K00432] [EC:1.11.1.9]
113860079  1-Cys peroxiredoxin [KO:K11188] [EC:1.11.1.7 1.11.1.27 3.1.1.-]
113866310  ornithine decarboxylase-like [KO:K01581] [EC:4.1.1.17]
113874828  spermidine synthase 1-like [KO:K00797] [EC:2.5.1.16]
113851419  spermidine synthase 2-like [KO:K00797] [EC:2.5.1.16]
113868436  spermine synthase [KO:K00797] [EC:2.5.1.16]
113868857  spermidine synthase 1 [KO:K00797] [EC:2.5.1.16]
113857909  spermidine synthase 2 [KO:K00797] [EC:2.5.1.16]
113859214  L-ascorbate peroxidase, cytosolic [KO:K00434] [EC:1.11.1.11]
113864980  putative L-ascorbate peroxidase 6 isoform X1 [KO:K00434] [EC:1.11.1.11]
113866037  L-ascorbate peroxidase 3 isoform X1 [KO:K00434] [EC:1.11.1.11]
113866932  probable L-ascorbate peroxidase 6, chloroplastic/mitochondrial isoform X1 [KO:K00434] [EC:1.11.1.11]
113868726  L-ascorbate peroxidase 3-like [KO:K00434] [EC:1.11.1.11]
113846685  ribonucleoside-diphosphate reductase large subunit-like [KO:K10807] [EC:1.17.4.1]
113871171  ribonucleoside-diphosphate reductase large subunit [KO:K10807] [EC:1.17.4.1]
113847568  ribonucleoside-diphosphate reductase small chain A [KO:K10808] [EC:1.17.4.1]
113861100  ribonucleoside-diphosphate reductase small chain-like [KO:K10808] [EC:1.17.4.1]
113862999  ribonucleoside-diphosphate reductase small chain [KO:K10808] [EC:1.17.4.1]
Compound
C00005  NADPH
C00006  NADP+
C00024  Acetyl-CoA
C00025  L-Glutamate
C00037  Glycine
C00051  Glutathione
C00072  Ascorbate
C00077  L-Ornithine
C00097  L-Cysteine
C00127  Glutathione disulfide
C00134  Putrescine
C00151  L-Amino acid
C00315  Spermidine
C00669  gamma-L-Glutamyl-L-cysteine
C00750  Spermine
C01322  RX
C01419  Cys-Gly
C01672  Cadaverine
C01879  5-Oxoproline
C02090  Trypanothione
C02320  R-S-Glutathione
C03170  Trypanothione disulfide
C03646  Bis-gamma-glutamylcystine
C03740  (5-L-Glutamyl)-L-amino acid
C05422  Dehydroascorbate
C05726  S-Substituted L-cysteine
C05727  S-Substituted N-acetyl-L-cysteine
C05729  R-S-Cysteinylglycine
C05730  Glutathionylspermidine
C16562  Glutathionylspermine
C16563  Bis(glutathionyl)spermine
C16564  Bis(glutathionyl)spermine disulfide
C16565  Aminopropylcadaverine
C16566  Glutathionylaminopropylcadaverine
C16567  Homotrypanothione
C16568  Homotrypanothione disulfide
C16663  Tryparedoxin
C16664  Tryparedoxin disulfide
Reference
  Authors
Josch C, Klotz LO, Sies H.
  Title
Identification of cytosolic leucyl aminopeptidase (EC 3.4.11.1) as the major cysteinylglycine-hydrolysing activity in rat liver.
  Journal
Biol Chem 384:213-8 (2003)
DOI:10.1515/BC.2003.023
Reference
  Authors
Chu L, Lai Y, Xu X, Eddy S, Yang S, Song L, Kolodrubetz D.
  Title
A 52-kDa leucyl aminopeptidase from treponema denticola is a cysteinylglycinase that mediates the second step of glutathione metabolism.
  Journal
J Biol Chem 283:19351-8 (2008)
DOI:10.1074/jbc.M801034200
Reference
  Authors
Cappiello M, Lazzarotti A, Buono F, Scaloni A, D'Ambrosio C, Amodeo P, Mendez BL, Pelosi P, Del Corso A, Mura U.
  Title
New role for leucyl aminopeptidase in glutathione turnover.
  Journal
Biochem J 378:35-44 (2004)
DOI:10.1042/BJ20031336
Reference
  Authors
Suzuki H, Kamatani S, Kim ES, Kumagai H.
  Title
Aminopeptidases A, B, and N and dipeptidase D are the four cysteinylglycinases of Escherichia coli K-12.
  Journal
J Bacteriol 183:1489-90 (2001)
DOI:10.1128/JB.183.4.1489-1490.2001
Reference
  Authors
Oza SL, Shaw MP, Wyllie S, Fairlamb AH.
  Title
Trypanothione biosynthesis in Leishmania major.
  Journal
Mol Biochem Parasitol 139:107-16 (2005)
DOI:10.1016/j.molbiopara.2004.10.004
Reference
  Authors
Oza SL, Ariyanayagam MR, Fairlamb AH.
  Title
Characterization of recombinant glutathionylspermidine synthetase/amidase from Crithidia fasciculata.
  Journal
Biochem J 364:679-86 (2002)
DOI:10.1042/BJ20011370
Reference
PMID:9677355
  Authors
Tetaud E, Manai F, Barrett MP, Nadeau K, Walsh CT, Fairlamb AH.
  Title
Cloning and characterization of the two enzymes responsible for trypanothione biosynthesis in Crithidia fasciculata.
  Journal
J Biol Chem 273:19383-90 (1998)
DOI:10.1074/jbc.273.31.19383
Reference
  Authors
Ariyanayagam MR, Oza SL, Mehlert A, Fairlamb AH.
  Title
Bis(glutathionyl)spermine and other novel trypanothione analogues in Trypanosoma cruzi.
  Journal
J Biol Chem 278:27612-9 (2003)
DOI:10.1074/jbc.M302750200
Reference
  Authors
Oza SL, Ariyanayagam MR, Aitcheson N, Fairlamb AH.
  Title
Properties of trypanothione synthetase from Trypanosoma brucei.
  Journal
Mol Biochem Parasitol 131:25-33 (2003)
DOI:10.1016/S0166-6851(03)00176-2
Reference
  Authors
Oza SL, Tetaud E, Ariyanayagam MR, Warnon SS, Fairlamb AH.
  Title
A single enzyme catalyses formation of Trypanothione from glutathione and spermidine in Trypanosoma cruzi.
  Journal
J Biol Chem 277:35853-61 (2002)
DOI:10.1074/jbc.M204403200
Reference
  Authors
Comini M, Menge U, Wissing J, Flohe L.
  Title
Trypanothione synthesis in crithidia revisited.
  Journal
J Biol Chem 280:6850-60 (2005)
DOI:10.1074/jbc.M404486200
Reference
PMID:7813456
  Authors
Hunter KJ, Le Quesne SA, Fairlamb AH.
  Title
Identification and biosynthesis of N1,N9-bis(glutathionyl)aminopropylcadaverine (homotrypanothione) in Trypanosoma cruzi.
  Journal
Eur J Biochem 226:1019-27 (1994)
DOI:10.1111/j.1432-1033.1994.t01-1-01019.x
Reference
  Authors
Krauth-Siegel RL, Meiering SK, Schmidt H.
  Title
The parasite-specific trypanothione metabolism of trypanosoma and leishmania.
  Journal
Biol Chem 384:539-49 (2003)
DOI:10.1515/BC.2003.062
Reference
  Authors
Krauth-Siegel RL, Comini MA.
  Title
Redox control in trypanosomatids, parasitic protozoa with trypanothione-based thiol metabolism.
  Journal
Biochim Biophys Acta 1780:1236-48 (2008)
DOI:10.1016/j.bbagen.2008.03.006
Reference
PMID:8892297
  Authors
Krauth-Siegel RL, Ludemann H.
  Title
Reduction of dehydroascorbate by trypanothione.
  Journal
Mol Biochem Parasitol 80:203-8 (1996)
DOI:10.1016/0166-6851(96)02689-8
Reference
  Authors
Dormeyer M, Reckenfelderbaumer N, Ludemann H, Krauth-Siegel RL.
  Title
Trypanothione-dependent synthesis of deoxyribonucleotides by Trypanosoma brucei ribonucleotide reductase.
  Journal
J Biol Chem 276:10602-6 (2001)
DOI:10.1074/jbc.M010352200
Reference
  Authors
Schmidt H, Krauth-Siegel RL.
  Title
Functional and physicochemical characterization of the thioredoxin system in Trypanosoma brucei.
  Journal
J Biol Chem 278:46329-36 (2003)
DOI:10.1074/jbc.M305338200
Reference
PMID:9851611
  Authors
Tetaud E, Fairlamb AH.
  Title
Cloning, expression and reconstitution of the trypanothione-dependent peroxidase system of Crithidia fasciculata.
  Journal
Mol Biochem Parasitol 96:111-23 (1998)
DOI:10.1016/S0166-6851(98)00120-0
Reference
  Authors
Castro H, Sousa C, Santos M, Cordeiro-da-Silva A, Flohe L, Tomas AM.
  Title
Complementary antioxidant defense by cytoplasmic and mitochondrial peroxiredoxins in Leishmania infantum.
  Journal
Free Radic Biol Med 33:1552-62 (2002)
DOI:10.1016/S0891-5849(02)01089-4
Reference
  Authors
Wilkinson SR, Temperton NJ, Mondragon A, Kelly JM.
  Title
Distinct mitochondrial and cytosolic enzymes mediate trypanothione-dependent peroxide metabolism in Trypanosoma cruzi.
  Journal
J Biol Chem 275:8220-5 (2000)
DOI:10.1074/jbc.275.11.8220
Reference
  Authors
Konig J, Fairlamb AH.
  Title
A comparative study of type I and type II tryparedoxin peroxidases in Leishmania major.
  Journal
FEBS J 274:5643-58 (2007)
DOI:10.1111/j.1742-4658.2007.06087.x
Reference
  Authors
Hillebrand H, Schmidt A, Krauth-Siegel RL.
  Title
A second class of peroxidases linked to the trypanothione metabolism.
  Journal
J Biol Chem 278:6809-15 (2003)
DOI:10.1074/jbc.M210392200
Reference
  Authors
Soksawatmaekhin W, Kuraishi A, Sakata K, Kashiwagi K, Igarashi K.
  Title
Excretion and uptake of cadaverine by CadB and its physiological functions in Escherichia coli.
  Journal
Mol Microbiol 51:1401-12 (2004)
DOI:10.1046/j.1365-2958.2003.03913.x
Reference
PMID:6798961
  Authors
Pegg AE, Shuttleworth K, Hibasami H.
  Title
Specificity of mammalian spermidine synthase and spermine synthase.
  Journal
Biochem J 197:315-20 (1981)
DOI:10.1042/bj1970315
Related
pathway
aprc00220  Arginine biosynthesis
aprc00250  Alanine, aspartate and glutamate metabolism
aprc00270  Cysteine and methionine metabolism
aprc00430  Taurine and hypotaurine metabolism
aprc00460  Cyanoamino acid metabolism
KO pathway
ko00480   
LinkDB

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