KEGG   PATHWAY: apro04141
Entry
apro04141                   Pathway                                
Name
Protein processing in endoplasmic reticulum - Auxenochlorella protothecoides
Description
The endoplasmic reticulum (ER) is a subcellular organelle where proteins are folded with the help of lumenal chaperones. Newly synthesized peptides enter the ER via the sec61 pore and are glycosylated. Correctly folded proteins are packaged into transport vesicles that shuttle them to the Golgi complex. Misfolded proteins are retained within the ER lumen in complex with molecular chaperones. Proteins that are terminally misfolded bind to BiP and are directed toward degradation through the proteasome in a process called ER-associated degradation (ERAD). Accumulation of misfolded proteins in the ER causes ER stress and activates a signaling pathway called the unfolded protein response (UPR). In certain severe situations, however, the protective mechanisms activated by the UPR are not sufficient to restore normal ER function and cells die by apoptosis.
Class
Genetic Information Processing; Folding, sorting and degradation
Pathway map
apro04141  Protein processing in endoplasmic reticulum
apro04141

Other DBs
GO: 0030433 0034976
Organism
Auxenochlorella protothecoides [GN:apro]
Gene
F751_1501  Protein transport protein Sec61 subunit gamma-1 [KO:K07342]
F751_4601  Translocation protein sec62 [KO:K12275]
F751_0068  Translocation protein SEC63-like protein [KO:K09540]
F751_5251  Dolichyl-diphosphooligosaccharide-protein glycosyltransferase subunit 1 [KO:K12666]
F751_6619  Dolichyl-diphosphooligosaccharide-protein glycosyltransferase subunit DAD1 [KO:K12668]
F751_6913  Dolichyl-diphosphooligosaccharide-protein glycosyltransferase 48 kDa subunit [KO:K12670]
F751_0618  Dolichyl-diphosphooligosaccharide-protein glycosyltransferase subunit STT3 [KO:K07151] [EC:2.4.99.18]
F751_4268  hypothetical protein [KO:K19478]
F751_4830  Mannosyl-oligosaccharide glucosidase [KO:K01228] [EC:3.2.1.106]
F751_4648  Hypoxia up-regulated protein 1 [KO:K09486]
F751_3275  Luminal-binding protein 5 [KO:K09490] [EC:3.6.4.10]
F751_5041  DnaJ-like protein subfamily B member 11 [KO:K09517]
F751_3274  Endoplasmin-like protein [KO:K09487]
F751_4043  Heat shock protein 83-1 [KO:K09487]
F751_0574  Neutral alpha-glucosidase AB [KO:K05546] [EC:3.2.1.207]
F751_5652  Glucosidase 2 subunit beta [KO:K08288]
F751_5645  Calnexin-like protein 1 [KO:K08054]
F751_5574  Mannosyl-oligosaccharide 1,2-alpha-mannosidase MNS1 [KO:K01230] [EC:3.2.1.113]
F751_6268  Endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase [KO:K23741] [EC:3.2.1.209]
F751_6191  SEC12-like protein 2 [KO:K14003]
F751_1459  SEC13-like protein [KO:K14004]
F751_6771  Protein transport protein SEC31 [KO:K14005]
F751_5708  Protein transport protein SEC23 [KO:K14006]
F751_0368  Protein transport protein Sec24-like CEF [KO:K14007]
F751_5027  Protein transport protein Sec24-like [KO:K14007]
F751_4763  UDP-glucose:glycoprotein glucosyltransferase [KO:K11718] [EC:2.4.1.-]
F751_4086  putative alpha-mannosidase I MNS5 [KO:K10086]
F751_3271  Protein disulfide isomerase-like 1-4 [KO:K09580] [EC:5.3.4.1]
F751_1014  Endoplasmic oxidoreductin-1 [KO:K10950] [EC:1.8.4.-]
F751_4397  Protein OS-9 [KO:K10088]
F751_3829  hypothetical protein [KO:K13249]
F751_6572  Translocon-associated protein subunit beta [KO:K13250]
F751_0500  Derlin-2.1 [KO:K13989]
F751_6215  Derlin-1 [KO:K13989]
F751_6914  UBA and UBX domain-containing protein [KO:K14012]
F751_1800  NPL4-like protein 2 [KO:K14015]
F751_5643  Ubiquitin fusion degradation protein 1-like protein [KO:K14016]
F751_3047  Stromal 70 kDa heat shock-related protein, chloroplastic [KO:K03283]
F751_2616  Heat shock cognate 70 kDa protein [KO:K03283]
F751_4627  DnaJ protein-like protein 2 [KO:K09503]
F751_6270  DnaJ-like protein subfamily B member 14 [KO:K09518]
F751_2447  Heat shock protein 90-2 [KO:K04079]
F751_4216  Hsp70-binding protein 1 [KO:K09562]
F751_3267  18.1 kDa class I heat shock protein [KO:K13993]
F751_6653  17.6 kDa class I heat shock protein 3 [KO:K13993]
F751_5712  Ubiquitin thioesterase OTU1 [KO:K13719] [EC:3.1.2.-]
F751_4120  Phospholipase A-2-activating protein [KO:K14018]
F751_5662  putative ubiquitin receptor RAD23a [KO:K10839]
F751_3657  Ubiquilin-1 [KO:K04523]
F751_3612  Peptide-N(4)-(N-acetyl-beta-glucosaminyl)asparagine amidase [KO:K01456] [EC:3.5.1.52]
F751_3174  putative ubiquitin conjugation factor E4 [KO:K10597] [EC:2.3.2.27]
F751_1357  Eukaryotic translation initiation factor 2 subunit alpha [KO:K03237]
F751_4604  Membrane-bound transcription factor site-1 protease [KO:K08653] [EC:3.4.21.112]
F751_2334  Ubiquitin-conjugating enzyme E2 32 [KO:K10578] [EC:2.3.2.23]
F751_3882  putative ubiquitin-conjugating enzyme E2 33 [KO:K04554] [EC:2.3.2.23]
F751_0271  Ubiquitin-conjugating enzyme E2 14 [KO:K10575] [EC:2.3.2.23]
F751_3543  E3 ubiquitin-protein ligase synoviolin [KO:K10601] [EC:2.3.2.27]
F751_1888  E3 ubiquitin-protein ligase [KO:K10666] [EC:2.3.2.27]
F751_3789  Sel-1-like protein 1 [KO:K14026]
F751_2271  E3 ubiquitin protein ligase RIN2 [KO:K10636] [EC:2.3.2.36]
F751_1431  Ubiquitin-conjugating enzyme E2 28 [KO:K06689] [EC:2.3.2.23]
F751_6626  E3 ubiquitin-protein ligase RBX1 [KO:K03868] [EC:2.3.2.32]
F751_6385  Cullin-1 [KO:K03347]
Compound
C00076  Calcium cation
G00009   
G00010   
G00011   
G00012   
G10694   
Reference
PMID:19491040
  Authors
Naidoo N
  Title
ER and aging-Protein folding and the ER stress response.
  Journal
Ageing Res Rev 8:150-9 (2009)
DOI:10.1016/j.arr.2009.03.001
Reference
PMID:18023214
  Authors
Malhotra JD, Kaufman RJ
  Title
The endoplasmic reticulum and the unfolded protein response.
  Journal
Semin Cell Dev Biol 18:716-31 (2007)
DOI:10.1016/j.semcdb.2007.09.003
Reference
PMID:20347046
  Authors
Maattanen P, Gehring K, Bergeron JJ, Thomas DY
  Title
Protein quality control in the ER: the recognition of misfolded proteins.
  Journal
Semin Cell Dev Biol 21:500-11 (2010)
DOI:10.1016/j.semcdb.2010.03.006
Reference
PMID:20219571
  Authors
Stolz A, Wolf DH
  Title
Endoplasmic reticulum associated protein degradation: a chaperone assisted journey to hell.
  Journal
Biochim Biophys Acta 1803:694-705 (2010)
DOI:10.1016/j.bbamcr.2010.02.005
Reference
PMID:20112977
  Authors
Dejgaard K, Theberge JF, Heath-Engel H, Chevet E, Tremblay ML, Thomas DY
  Title
Organization of the Sec61 translocon, studied by high resolution native electrophoresis.
  Journal
J Proteome Res 9:1763-71 (2010)
DOI:10.1021/pr900900x
Related
pathway
apro00510  N-Glycan biosynthesis
apro03050  Proteasome
apro03060  Protein export
KO pathway
ko04141   
LinkDB

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