KEGG   PATHWAY: bbis03013
Entry
bbis03013                   Pathway                                
Name
Nucleocytoplasmic transport - Bison bison bison (American bison)
Description
The exchange of molecules between the nucleus and cytoplasm is mediated through nuclear pore complexes (NPCs) embedded in the nuclear envelope. The NPC is composed of highly conserved, distinct structural modules: the inner pore ring, the cytoplasmic and nuclear rings as well as the cytoplasmic filaments and the nuclear basket. Nuclear transport receptors (e.g. importins and exportins) mediate translocation of cargos through the NPC. Cargo proteins harbouring a nuclear export signal (NES) bind to exportins and Ran-GTP to form an export complex in the nucleoplasm. Nuclear export of bulk mRNA is provided by the non-karyopherin transport proteins TAP-p15 in a Ran-GTP-independent manner. Several EJC factors are known to function in mRNA export.
Class
Genetic Information Processing; Translation
Pathway map
bbis03013  Nucleocytoplasmic transport
bbis03013

Other DBs
GO: 0050658
Organism
Bison bison bison (American bison) [GN:bbis]
Gene
105001579  AAAS; aladin isoform X1 [KO:K14320]
104987942  NUPL2; nucleoporin-like protein 2 isoform X1 [KO:K14321]
105000816  GLE1; nucleoporin GLE1 [KO:K18723]
104980725  ATP-dependent RNA helicase DDX19A-like [KO:K18655] [EC:5.6.2.7]
104996463  DDX19B; ATP-dependent RNA helicase DDX19B [KO:K18655] [EC:5.6.2.7]
104989960  RAE1; mRNA export factor [KO:K14298]
104995553  NUP98; nuclear pore complex protein Nup98-Nup96 isoform X1 [KO:K14297]
105000785  NUP214; nuclear pore complex protein Nup214 isoform X1 [KO:K14317]
104993976  NUP88; nuclear pore complex protein Nup88 isoform X1 [KO:K14318]
105005116  RANBP2; E3 SUMO-protein ligase RanBP2 isoform X1 [KO:K12172] [EC:2.3.2.-]
104981221  RANGAP1; ran GTPase-activating protein 1 [KO:K14319]
104986103  UBE2I; SUMO-conjugating enzyme UBC9 [KO:K10577]
104980551  small ubiquitin-related modifier 3 [KO:K12160]
105000544  SUMO2; small ubiquitin-related modifier 2 [KO:K12160]
104994425  small ubiquitin-related modifier 1-like [KO:K12160]
105001223  small ubiquitin-related modifier 2 [KO:K12160]
105003665  SUMO1; small ubiquitin-related modifier 1 [KO:K12160]
104990364  NUP160; nuclear pore complex protein Nup160 [KO:K14303]
105000340  NUP85; nuclear pore complex protein Nup85 isoform X1 [KO:K14304]
105004723  SEC13; protein SEC13 homolog [KO:K14004]
104989773  NUP107; nuclear pore complex protein Nup107 isoform X1 [KO:K14301]
104987267  NUP133; nuclear pore complex protein Nup133 [KO:K14300]
105002477  SEH1L; nucleoporin SEH1 [KO:K14299]
105004810  NUP43; nucleoporin Nup43 [KO:K14305]
104998323  NUP37; nucleoporin Nup37 [KO:K14302]
104997910  AHCTF1; protein ELYS isoform X1 [KO:K25129]
104995739  NUP62; nuclear pore glycoprotein p62 [KO:K14306]
104996861  NUPL1; nucleoporin p58/p45 [KO:K14307]
104987290  NUP54; nucleoporin p54 [KO:K14308]
104982286  NUP205; nuclear pore complex protein Nup205 [KO:K14310]
105000892  NUP188; nucleoporin NUP188 homolog [KO:K14311]
104998546  NUP155; nuclear pore complex protein Nup155 [KO:K14312]
105004316  NUP93; nuclear pore complex protein Nup93 isoform X1 [KO:K14309]
105002898  NUP35; nucleoporin NUP53 [KO:K14313]
104993763  NDC1; nucleoporin NDC1 [KO:K14315]
105004800  NUP210; LOW QUALITY PROTEIN: nuclear pore membrane glycoprotein 210 [KO:K14314]
104987446  NUP210L; nuclear pore membrane glycoprotein 210-like [KO:K14314]
104998913  POM121C; nuclear envelope pore membrane protein POM 121C isoform X1 [KO:K14316]
104984342  POM121L2; POM121-like protein 2 [KO:K14316]
105002307  TMEM33; transmembrane protein 33 [KO:K20724]
104998060  TPR; nucleoprotein TPR [KO:K09291]
104986896  NUP50; nuclear pore complex protein Nup50 [KO:K14295]
104995095  NUP153; nuclear pore complex protein Nup153 [KO:K14296]
104998612  SENP2; sentrin-specific protease 2 isoform X1 [KO:K03345] [EC:3.4.22.68]
104984506  KPNA1; importin subunit alpha-5 [KO:K23940]
104992754  KPNA7; importin subunit alpha-8 [KO:K15043]
105000481  KPNA2; importin subunit alpha-1 [KO:K15043]
104988496  KPNA4; importin subunit alpha-3 [KO:K23583]
104985491  KPNA3; importin subunit alpha-4 [KO:K23583]
105004262  KPNA5; importin subunit alpha-6 [KO:K15042]
104986367  KPNA6; importin subunit alpha-7 [KO:K15042]
104990564  KPNB1; importin subunit beta-1 [KO:K14293]
104998412  TNPO1; transportin-1 [KO:K18752]
104999856  TNPO2; transportin-2 isoform X1 [KO:K18727]
104982337  TNPO3; transportin-3 isoform X1 [KO:K15436]
104982032  IPO4; importin-4 [KO:K20221]
104982177  IPO5; importin-5 [KO:K20222]
104980557  IPO7; importin-7 [KO:K20223]
105003437  IPO8; LOW QUALITY PROTEIN: importin-8 [KO:K18755]
104981818  IPO9; importin-9 isoform X1 [KO:K20224]
104992580  IPO11; importin-11 [KO:K25201]
105004851  IPO13; importin-13 isoform X1 [KO:K25202]
104990970  SNUPN; snurportin-1 [KO:K13151]
105005322  XPO1; exportin-1 [KO:K14290]
104985063  CSE1L; exportin-2 [KO:K18423]
104989800  XPOT; exportin-T [KO:K14288]
104996807  XPO4; exportin-4 isoform X1 [KO:K25203]
105005213  XPO5; exportin-5 [KO:K14289]
104986603  XPO6; exportin-6 isoform X1 [KO:K25204]
104992535  XPO7; LOW QUALITY PROTEIN: exportin-7 [KO:K18460]
104996892  ran-binding protein 17-like [KO:K24115]
104998379  LOW QUALITY PROTEIN: GTP-binding nuclear protein Ran-like [KO:K07936]
104999607  GTP-binding nuclear protein Ran-like [KO:K07936]
104995572  GTP-binding nuclear protein Ran-like [KO:K07936]
104989697  GTP-binding nuclear protein Ran-like [KO:K07936]
104996777  GTP-binding nuclear protein Ran-like [KO:K07936]
104997597  RAN; GTP-binding nuclear protein Ran [KO:K07936]
104986195  EEF1A2; elongation factor 1-alpha 2 [KO:K03231]
104993152  elongation factor 1-alpha 1-like [KO:K03231]
104993322  elongation factor 1-alpha 1-like [KO:K03231]
105001149  elongation factor 1-alpha 1-like [KO:K03231]
104996877  elongation factor 1-alpha 1 [KO:K03231]
104993182  PHAX; phosphorylated adapter RNA export protein [KO:K14291]
104993698  NCBP1; nuclear cap-binding protein subunit 1 [KO:K12882]
104984557  NCBP2; nuclear cap-binding protein subunit 2 [KO:K12883]
104988490  NMD3; 60S ribosomal export protein NMD3 [KO:K07562]
104983747  RBM8A; RNA-binding protein 8A [KO:K12876]
104993768  MAGOH; protein mago nashi homolog [KO:K12877]
105002150  MAGOHB; protein mago nashi homolog 2 [KO:K12877]
104990513  CASC3; protein CASC3 [KO:K14323]
105000412  EIF4A3; eukaryotic initiation factor 4A-III [KO:K13025] [EC:5.6.2.7]
104982091  ACIN1; apoptotic chromatin condensation inducer in the nucleus [KO:K12875]
104996808  SAP18; histone deacetylase complex subunit SAP18 [KO:K14324]
104992075  RNPS1; RNA-binding protein with serine-rich domain 1 isoform X1 [KO:K14325]
104979946  RNA-binding protein with serine-rich domain 1-like [KO:K14325]
104985257  PNN; pinin [KO:K13114]
105000589  ALYREF; THO complex subunit 4 [KO:K12881]
104993896  UPF1; regulator of nonsense transcripts 1 [KO:K14326] [EC:5.6.2.5 5.6.2.3]
104998766  UPF2; regulator of nonsense transcripts 2 [KO:K14327]
104982115  UPF3A; regulator of nonsense transcripts 3A isoform X1 [KO:K14328]
105000904  UPF3B; LOW QUALITY PROTEIN: regulator of nonsense transcripts 3B [KO:K14328]
104998673  NXF1; nuclear RNA export factor 1 [KO:K14284]
104987828  nuclear RNA export factor 3-like [KO:K14284]
105000909  LOW QUALITY PROTEIN: nuclear RNA export factor 3-like [KO:K14284]
104983070  LOW QUALITY PROTEIN: nuclear RNA export factor 3-like [KO:K14284]
105001872  nuclear RNA export factor 2-like [KO:K14284]
104985956  NXT1; NTF2-related export protein 1 [KO:K14285]
104983767  DDX39B; spliceosome RNA helicase DDX39B [KO:K12812] [EC:5.6.2.7]
104981124  SRRM1; serine/arginine repetitive matrix protein 1 isoform X1 [KO:K13171]
104988049  WIBG; partner of Y14 and mago isoform X1 [KO:K14294]
104980277  THOC1; THO complex subunit 1 [KO:K12878]
104980959  LOW QUALITY PROTEIN: THO complex subunit 2-like [KO:K12879]
104985316  THOC2; THO complex subunit 2 [KO:K12879]
104980128  THOC5; THO complex subunit 5 homolog isoform X1 [KO:K13174]
104988882  THOC6; THO complex subunit 6 homolog [KO:K13175]
104997064  THOC7; THO complex subunit 7 homolog isoform X1 [KO:K13176]
105004475  THOC3; THO complex subunit 3 isoform X1 [KO:K12880]
Reference
PMID:16777596
  Authors
Tran EJ, Wente SR
  Title
Dynamic nuclear pore complexes: life on the edge.
  Journal
Cell 125:1041-53 (2006)
DOI:10.1016/j.cell.2006.05.027
Reference
PMID:15519698
  Authors
Rodriguez MS, Dargemont C, Stutz F
  Title
Nuclear export of RNA.
  Journal
Biol Cell 96:639-55 (2004)
DOI:10.1016/j.biolcel.2004.04.014
Reference
PMID:18313922
  Authors
Palancade B, Doye V
  Title
Sumoylating and desumoylating enzymes at nuclear pores: underpinning their unexpected duties?
  Journal
Trends Cell Biol 18:174-83 (2008)
DOI:10.1016/j.tcb.2008.02.001
Reference
PMID:15901496
  Authors
Reed R, Cheng H
  Title
TREX, SR proteins and export of mRNA.
  Journal
Curr Opin Cell Biol 17:269-73 (2005)
DOI:10.1016/j.ceb.2005.04.011
Reference
PMID:16314458
  Authors
Tange TO, Shibuya T, Jurica MS, Moore MJ
  Title
Biochemical analysis of the EJC reveals two new factors and a stable tetrameric protein core.
  Journal
RNA 11:1869-83 (2005)
DOI:10.1261/rna.2155905
Reference
PMID:28673770
  Authors
Beck M, Schirmacher P, Singer S
  Title
Alterations of the nuclear transport system in hepatocellular carcinoma - New basis for therapeutic strategies.
  Journal
J Hepatol 67:1051-1061 (2017)
DOI:10.1016/j.jhep.2017.06.021
Related
pathway
bbis03015  mRNA surveillance pathway
KO pathway
ko03013   
LinkDB

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