KEGG   PATHWAY: bby00260
Entry
bby00260                    Pathway                                
Name
Glycine, serine and threonine metabolism - Bacillus bombysepticus
Description
Serine is derived from 3-phospho-D-glycerate, an intermediate of glycolysis [MD:M00020], and glycine is derived from serine. Threonine is an essential amino acid, which animals cannot synthesize. In bacteria and plants, threonine is derived from aspartate [MD:M00018].
Class
Metabolism; Amino acid metabolism
Pathway map
bby00260  Glycine, serine and threonine metabolism
bby00260

Module
bby_M00018  Threonine biosynthesis, aspartate => homoserine => threonine [PATH:bby00260]
bby_M00621  Glycine cleavage system [PATH:bby00260]
Other DBs
GO: 0006544 0006563 0070178 0006566
Organism
Bacillus bombysepticus [GN:bby]
Gene
CY96_08230  aspartate kinase [KO:K00928] [EC:2.7.2.4]
CY96_18075  aspartate kinase [KO:K00928] [EC:2.7.2.4]
CY96_10895  aspartate-semialdehyde dehydrogenase [KO:K00133] [EC:1.2.1.11]
CY96_18080  aspartate-semialdehyde dehydrogenase [KO:K00133] [EC:1.2.1.11]
CY96_11800  homoserine dehydrogenase [KO:K00003] [EC:1.1.1.3]
CY96_26145  homoserine dehydrogenase [KO:K00003] [EC:1.1.1.3]
CY96_08920  homoserine dehydrogenase [KO:K00003] [EC:1.1.1.3]
CY96_08930  serine kinase [KO:K00872] [EC:2.7.1.39]
CY96_08925  threonine synthase [KO:K01733] [EC:4.2.3.1]
CY96_25690  serine hydroxymethyltransferase [KO:K00600] [EC:2.1.2.1]
CY96_23690  bifunctional glyoxylate/hydroxypyruvate reductase B [KO:K00090] [EC:1.1.1.79 1.1.1.81 1.1.1.215]
CY96_00010  glycerate kinase [KO:K00865] [EC:2.7.1.165]
CY96_07620  phosphoglycerate mutase [KO:K01834] [EC:5.4.2.11]
CY96_17825  phosphoglycerate mutase [KO:K01834] [EC:5.4.2.11]
CY96_09395  phosphoglycerate mutase [KO:K01834] [EC:5.4.2.11]
CY96_11175  gpmA; phosphoglyceromutase [KO:K01834] [EC:5.4.2.11]
CY96_24045  phosphoglycerate mutase [KO:K01834] [EC:5.4.2.11]
CY96_24675  phosphoglyceromutase [KO:K15633] [EC:5.4.2.12]
CY96_15035  3-phosphoglycerate dehydrogenase [KO:K00058] [EC:1.1.1.95 1.1.1.399]
CY96_15040  MFS transporter [KO:K00831] [EC:2.6.1.52]
CY96_02265  2-amino-3-ketobutyrate CoA ligase [KO:K00639] [EC:2.3.1.29]
CY96_08710  amine oxidase [KO:K00274] [EC:1.4.3.4]
CY96_09165  amine oxidase [KO:K00274] [EC:1.4.3.4]
CY96_20310  glycine dehydrogenase [KO:K00282] [EC:1.4.4.2]
CY96_20305  glycine dehydrogenase [KO:K00283] [EC:1.4.4.2]
CY96_20315  glycine cleavage system protein T [KO:K00605] [EC:2.1.2.10]
CY96_12630  acoL; dihydrolipoamide dehydrogenase [KO:K00382] [EC:1.8.1.4]
CY96_19905  dihydrolipoamide dehydrogenase [KO:K00382] [EC:1.8.1.4]
CY96_18930  dihydrolipoamide dehydrogenase [KO:K00382] [EC:1.8.1.4]
CY96_24135  glycine cleavage system protein H [KO:K02437]
CY96_06250  CDP-diacylglycerol--serine O-phosphatidyltransferase [KO:K17103] [EC:2.7.8.8]
CY96_04160  CDP-diacylglycerol--serine O-phosphatidyltransferase [KO:K17103] [EC:2.7.8.8]
CY96_16510  CDP-diacylglycerol--serine O-phosphatidyltransferase [KO:K17103] [EC:2.7.8.8]
CY96_21035  cystathionine gamma-synthase [KO:K17217] [EC:4.4.1.1 4.4.1.2]
CY96_11350  serine dehydratase [KO:K01752] [EC:4.3.1.17]
CY96_19775  serine dehydratase [KO:K01752] [EC:4.3.1.17]
CY96_19780  serine dehydratase [KO:K01752] [EC:4.3.1.17]
CY96_11355  serine dehydratase [KO:K01752] [EC:4.3.1.17]
CY96_08400  threonine dehydratase [KO:K01754] [EC:4.3.1.19]
CY96_11070  threonine dehydratase [KO:K01754] [EC:4.3.1.19]
CY96_08105  serine ammonia-lyase [KO:K01753] [EC:4.3.1.18]
CY96_29240  serine ammonia-lyase [KO:K01753] [EC:4.3.1.18]
CY96_22920  amino acid racemase [KO:K25316] [EC:5.1.1.10]
CY96_10015  aspartate racemase [KO:K25316] [EC:5.1.1.10]
CY96_05415  tryptophan synthase subunit alpha [KO:K01695] [EC:4.2.1.20]
CY96_05410  tryptophan synthase subunit beta [KO:K01696] [EC:4.2.1.20]
CY96_29745  2,4-diaminobutyrate decarboxylase [KO:K13745] [EC:4.1.1.86]
Compound
C00011  CO2
C00014  Ammonia
C00022  Pyruvate
C00037  Glycine
C00048  Glyoxylate
C00049  L-Aspartate
C00065  L-Serine
C00078  L-Tryptophan
C00097  L-Cysteine
C00101  Tetrahydrofolate
C00109  2-Oxobutanoate
C00114  Choline
C00143  5,10-Methylenetetrahydrofolate
C00168  Hydroxypyruvate
C00188  L-Threonine
C00197  3-Phospho-D-glycerate
C00213  Sarcosine
C00258  D-Glycerate
C00263  L-Homoserine
C00300  Creatine
C00430  5-Aminolevulinate
C00441  L-Aspartate 4-semialdehyde
C00546  Methylglyoxal
C00576  Betaine aldehyde
C00581  Guanidinoacetate
C00631  2-Phospho-D-glycerate
C00719  Betaine
C00740  D-Serine
C00986  1,3-Diaminopropane
C01005  O-Phospho-L-serine
C01026  N,N-Dimethylglycine
C01102  O-Phospho-L-homoserine
C01242  [Protein]-S8-aminomethyldihydrolipoyllysine
C01888  Aminoacetone
C02051  Lipoylprotein
C02291  L-Cystathionine
C02737  Phosphatidylserine
C02972  Dihydrolipoylprotein
C03082  4-Phospho-L-aspartate
C03194  (R)-1-Aminopropan-2-ol
C03232  3-Phosphonooxypyruvate
C03283  L-2,4-Diaminobutanoate
C03508  L-2-Amino-3-oxobutanoic acid
C05519  L-Allothreonine
C06231  Ectoine
C06442  N(gamma)-Acetyldiaminobutyrate
C16432  5-Hydroxyectoine
C19929  N(alpha)-Acetyl-L-2,4-diaminobutyrate
Reference
  Authors
Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).
  Title
[Cellular Functions and Metabolic Maps] (In Japanese)
  Journal
Tokyo Kagaku Dojin (1997)
Reference
PMID:11823218
  Authors
Kuhlmann AU, Bremer E.
  Title
Osmotically regulated synthesis of the compatible solute ectoine in Bacillus pasteurii and related Bacillus spp.
  Journal
Appl Environ Microbiol 68:772-83 (2002)
DOI:10.1128/AEM.68.2.772-783.2002
Reference
PMID:10473374
  Authors
Canovas D, Borges N, Vargas C, Ventosa A, Nieto JJ, Santos H.
  Title
Role of Ngamma-acetyldiaminobutyrate as an enzyme stabilizer and an intermediate in the biosynthesis of hydroxyectoine.
  Journal
Appl Environ Microbiol 65:3774-9 (1999)
DOI:10.1128/AEM.65.9.3774-3779.1999
Reference
PMID:17636255
  Authors
Bursy J, Pierik AJ, Pica N, Bremer E.
  Title
Osmotically induced synthesis of the compatible solute hydroxyectoine is mediated by an evolutionarily conserved ectoine hydroxylase.
  Journal
J Biol Chem 282:31147-55 (2007)
DOI:10.1074/jbc.M704023200
Reference
PMID:16707670
  Authors
Garcia-Estepa R, Argandona M, Reina-Bueno M, Capote N, Iglesias-Guerra F, Nieto JJ, Vargas C.
  Title
The ectD gene, which is involved in the synthesis of the compatible solute hydroxyectoine, is essential for thermoprotection of the halophilic bacterium Chromohalobacter salexigens.
  Journal
J Bacteriol 188:3774-84 (2006)
DOI:10.1128/JB.00136-06
Reference
PMID:15470257
  Authors
Arevalo-Rodriguez M, Pan X, Boeke JD, Heitman J
  Title
FKBP12 controls aspartate pathway flux in Saccharomyces cerevisiae to prevent toxic intermediate accumulation.
  Journal
Eukaryot Cell 3:1287-96 (2004)
DOI:10.1128/EC.3.5.1287-1296.2004
Reference
PMID:7639721
  Authors
Rees WD, Hay SM
  Title
The biosynthesis of threonine by mammalian cells: expression of a complete bacterial biosynthetic pathway in an animal cell.
  Journal
Biochem J 309 ( Pt 3):999-1007 (1995)
DOI:10.1042/bj3090999
Reference
PMID:11341914
  Authors
Jacques SL, Nieman C, Bareich D, Broadhead G, Kinach R, Honek JF, Wright GD
  Title
Characterization of yeast homoserine dehydrogenase, an antifungal target: the invariant histidine 309 is important for enzyme integrity.
  Journal
Biochim Biophys Acta 1544:28-41 (2001)
DOI:10.1016/S0167-4838(00)00203-X
Reference
PMID:15520012
  Authors
Chen X, Jhee KH, Kruger WD
  Title
Production of the neuromodulator H2S by cystathionine beta-synthase via the condensation of cysteine and homocysteine.
  Journal
J Biol Chem 279:52082-6 (2004)
DOI:10.1074/jbc.C400481200
Related
pathway
bby00010  Glycolysis / Gluconeogenesis
bby00020  Citrate cycle (TCA cycle)
bby00230  Purine metabolism
bby00250  Alanine, aspartate and glutamate metabolism
bby00270  Cysteine and methionine metabolism
bby00290  Valine, leucine and isoleucine biosynthesis
bby00300  Lysine biosynthesis
bby00330  Arginine and proline metabolism
bby00460  Cyanoamino acid metabolism
bby00470  D-Amino acid metabolism
bby00564  Glycerophospholipid metabolism
bby00620  Pyruvate metabolism
bby00630  Glyoxylate and dicarboxylate metabolism
bby00640  Propanoate metabolism
bby00680  Methane metabolism
bby00860  Porphyrin metabolism
bby00920  Sulfur metabolism
KO pathway
ko00260   
LinkDB

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