KEGG   PATHWAY: bmor04142
Entry
bmor04142                   Pathway                                
Name
Lysosome - Bombyx mori (domestic silkworm)
Description
Lysosomes are membrane-delimited organelles in animal cells serving as the cell's main digestive compartment to which all sorts of macromolecules are delivered for degradation. They contain more than 40 hydrolases in an acidic environment (pH of about 5). After synthesis in the ER, lysosomal enzymes are decorated with mannose-6-phosphate residues, which are recognized by mannose-6-phosphate receptors in the trans-Golgi network. They are packaged into clathrin-coated vesicles and are transported to late endosomes. Substances for digestion are acquired by the lysosomes via a series of processes including endocytosis, phagocytosis, and autophagy.
Class
Cellular Processes; Transport and catabolism
Pathway map
bmor04142  Lysosome
bmor04142

Other DBs
GO: 0005764
Organism
Bombyx mori (domestic silkworm) [GN:bmor]
Gene
105841262  V-type proton ATPase 116 kDa subunit a1 [KO:K02154]
101736898  V-type proton ATPase 116 kDa subunit a1 [KO:K02154]
101738141  V-type proton ATPase 116 kDa subunit a1 isoform X1 [KO:K02154]
101742516  V-type proton ATPase 116 kDa subunit a1 [KO:K02154]
732966  H+ transporting ATPase V0 subunit D [KO:K02146]
733031  vacuolar ATP synthase subunit H [KO:K02144]
101741915  V-type proton ATPase subunit S1 [KO:K03662]
101740835  uncharacterized protein LOC101740835 [KO:K03662]
778463  VATPc; vacuolar H+ ATP synthase 16 kDa proteolipid subunit [KO:K02155]
692859  vacuolar ATP synthase 21 kDa proteolipid subunit [KO:K03661]
101742988  dmX-like protein 2 isoform X1 [KO:K24155]
110384750  WD repeat-containing protein 7 isoform X1 [KO:K24738]
100271726  oxr1; oxygen resistance gene 1 [KO:K25442]
692390  cathepsin B precursor [KO:K01363] [EC:3.4.22.1]
692768  CatD; cathepsin D precursor [KO:K01379] [EC:3.4.23.5]
693031  Bcp; fibroinase precursor [KO:K01365] [EC:3.4.22.15]
101741653  uncharacterized protein LOC101741653 [KO:K01374] [EC:3.4.22.42]
100302607  Gal; beta-galactosidase [KO:K12309] [EC:3.2.1.23]
101736905  uncharacterized protein LOC101736905 [KO:K12316] [EC:3.2.1.20]
101744138  probable alpha-glucosidase Os06g0675700 isoform X1 [KO:K12316] [EC:3.2.1.20]
101742496  lysosomal acid glucosylceramidase isoform X1 [KO:K01201] [EC:3.2.1.45]
101742640  lysosomal acid glucosylceramidase [KO:K01201] [EC:3.2.1.45]
101742786  lysosomal acid glucosylceramidase isoform X2 [KO:K01201] [EC:3.2.1.45]
101741392  lysosomal acid glucosylceramidase [KO:K01201] [EC:3.2.1.45]
101736031  alpha-N-acetylgalactosaminidase isoform X2 [KO:K01204] [EC:3.2.1.49]
110384698  alpha-N-acetylglucosaminidase [KO:K01205] [EC:3.2.1.50]
101736859  beta-glucuronidase isoform X1 [KO:K01195] [EC:3.2.1.31]
101743490  putative alpha-L-fucosidase [KO:K01206] [EC:3.2.1.51]
101745028  beta-hexosaminidase subunit beta [KO:K12373] [EC:3.2.1.52]
692647  GlcNAcase3; beta-N-acetylglucosaminidase 3 precursor [KO:K12373] [EC:3.2.1.52]
100101196  GlcNAcase2; beta-N-acetylglucosaminidase 2 precursor [KO:K12373] [EC:3.2.1.52]
100038345  GlcNAcase1; beta-N-acetylglucosaminidase 1 precursor [KO:K12373] [EC:3.2.1.52]
693032  chitooligosaccharidolytic beta-N-acetylglucosaminidase [KO:K12373] [EC:3.2.1.52]
101741798  beta-mannosidase [KO:K01192] [EC:3.2.1.25]
101743573  lysosomal alpha-mannosidase isoform X1 [KO:K12311] [EC:3.2.1.24]
101736644  lysosomal alpha-mannosidase [KO:K12311] [EC:3.2.1.24]
101738761  lysosomal alpha-mannosidase isoform X1 [KO:K12311] [EC:3.2.1.24]
101735594  hyaluronidase isoform X2 [KO:K01197] [EC:3.2.1.35]
101737480  arylsulfatase B [KO:K01135] [EC:3.1.6.12]
101737544  arylsulfatase B [KO:K01135] [EC:3.1.6.12]
101737902  arylsulfatase B [KO:K01135] [EC:3.1.6.12]
101745680  N-acetylglucosamine-6-sulfatase [KO:K01137] [EC:3.1.6.14]
101744799  iduronate 2-sulfatase [KO:K01136] [EC:3.1.6.13]
101737423  N-sulphoglucosamine sulphohydrolase [KO:K01565] [EC:3.10.1.1]
101737242  lipase 3 [KO:K01052] [EC:3.1.1.13]
105841519  lipase 1-like [KO:K01052] [EC:3.1.1.13]
101737372  lipase 3 [KO:K01052] [EC:3.1.1.13]
101739546  lipase 1 [KO:K01052] [EC:3.1.1.13]
101739402  lipase 3-like precursor [KO:K01052] [EC:3.1.1.13]
693022  egg-specific protein precursor [KO:K01052] [EC:3.1.1.13]
101737859  lipase 1 [KO:K01052] [EC:3.1.1.13]
101737626  lipase 1 [KO:K01052] [EC:3.1.1.13]
119629039  lipase 3-like [KO:K01052] [EC:3.1.1.13]
119630212  gastric triacylglycerol lipase-like [KO:K01052] [EC:3.1.1.13]
101737816  phospholipase A2 group XV [KO:K06129] [EC:3.1.1.5]
101746575  LOW QUALITY PROTEIN: uncharacterized protein LOC101746575 [KO:K01158] [EC:3.1.22.1]
105842703  prostatic acid phosphatase isoform X1 [KO:K14410] [EC:3.1.3.2]
101740485  prostatic acid phosphatase [KO:K14410] [EC:3.1.3.2]
101744890  sphingomyelin phosphodiesterase 1 [KO:K12350] [EC:3.1.4.12]
101746583  sphingomyelin phosphodiesterase isoform X3 [KO:K12350] [EC:3.1.4.12]
751092  aspartylglucosaminidase [KO:K01444] [EC:3.5.1.26]
692367  Sap-r; saposin-related precursor [KO:K12382]
101739036  lysosomal thioesterase PPT2 homolog isoform X2 [KO:K01074] [EC:3.1.2.22]
101736903  palmitoyl-protein thioesterase 1 isoform X1 [KO:K01074] [EC:3.1.2.22]
101745433  endochitinase A [KO:K06528]
101743758  CD63 antigen [KO:K06497]
101745131  23 kDa integral membrane protein isoform X7 [KO:K06497]
693101  tetraspanin D107 [KO:K06497]
692847  tetraspanin E [KO:K06497]
732926  tetraspanin E118 [KO:K06497]
101738907  leukocyte surface antigen CD53 [KO:K06497]
101743908  CD63 antigen [KO:K06497]
101746805  sensory neuron membrane protein 2 isoform X1 [KO:K12384]
101742149  NPC intracellular cholesterol transporter 1 isoform X1 [KO:K12385]
119629863  NPC intracellular cholesterol transporter 1 homolog 1b-like [KO:K12385]
119629864  NPC intracellular cholesterol transporter 1 homolog 1b-like [KO:K12385]
100101154  ecdysteroid-regulated 16 kDa protein precursor [KO:K13443]
101736837  ecdysteroid-regulated 16 kDa protein [KO:K13443]
101744032  uncharacterized protein LOC101744032 [KO:K13443]
101736896  uncharacterized protein LOC101736896 [KO:K13443]
692685  promoting protein precursor [KO:K13443]
732993  ML-domain containing secreted protein precursor [KO:K13443]
101742843  uncharacterized protein LOC101742843 [KO:K13443]
101745483  uncharacterized protein LOC101745483 [KO:K13443]
101747227  cystinosin homolog isoform X2 [KO:K12386]
101741883  sialin [KO:K12301]
101737295  putative inorganic phosphate cotransporter [KO:K12301]
101737438  putative inorganic phosphate cotransporter [KO:K12301]
101746615  putative inorganic phosphate cotransporter isoform X1 [KO:K12301]
101746043  putative inorganic phosphate cotransporter [KO:K12301]
101746186  putative inorganic phosphate cotransporter isoform X1 [KO:K12301]
101745899  putative inorganic phosphate cotransporter [KO:K12301]
692451  Pi-t1; inorganic phosphate transporter 1 [KO:K12301]
100500932  inorganic phosphate co-transporter [KO:K12301]
692592  lysosomal-associated transmembrane protein [KO:K12387]
101735445  porimin [KO:K06546]
101744899  major facilitator superfamily domain-containing protein 8 isoform X2 [KO:K12307]
101742059  heparan-alpha-glucosaminide N-acetyltransferase [KO:K10532] [EC:2.3.1.78]
101742351  heparan-alpha-glucosaminide N-acetyltransferase [KO:K10532] [EC:2.3.1.78]
101741318  formylglycine-generating enzyme [KO:K13444] [EC:1.8.3.7]
100233163  Chc; clathrin heavy chain [KO:K04646]
101742239  AP-1 complex subunit gamma-1 isoform X1 [KO:K12391]
101740876  AP-1 complex subunit beta-1 [KO:K12392]
101737012  AP-1 complex subunit mu-1 [KO:K12393]
692921  AP1S; adaptin [KO:K12394]
101743409  AP-3 complex subunit delta [KO:K12396]
101743168  AP-3 complex subunit beta-2 [KO:K12397]
101740461  AP-3 complex subunit mu-1 [KO:K12398]
101739762  AP-3 complex subunit sigma-2 isoform X1 [KO:K12399]
101738631  ADP-ribosylation factor-binding protein GGA1 isoform X1 [KO:K12404]
101735961  lipopolysaccharide-induced tumor necrosis factor-alpha factor homolog [KO:K19363]
101740969  lipopolysaccharide-induced tumor necrosis factor-alpha factor homolog isoform X1 [KO:K19363]
101740545  lipopolysaccharide-induced tumor necrosis factor-alpha factor homolog isoform X2 [KO:K19363]
101741211  lipopolysaccharide-induced tumor necrosis factor-alpha factor homolog [KO:K19363]
101745140  lipopolysaccharide-induced tumor necrosis factor-alpha factor homolog [KO:K19363]
101737114  lipopolysaccharide-induced tumor necrosis factor-alpha factor [KO:K19363]
101736893  lipopolysaccharide-induced tumor necrosis factor-alpha factor homolog isoform X1 [KO:K19363]
101741110  lipopolysaccharide-induced tumor necrosis factor-alpha factor homolog isoform X1 [KO:K19363]
101738899  LITAF domain-containing protein [KO:K19363]
101740416  lipopolysaccharide-induced tumor necrosis factor-alpha factor homolog [KO:K19363]
110385505  lipopolysaccharide-induced tumor necrosis factor-alpha factor homolog [KO:K19363]
110386644  lipopolysaccharide-induced tumor necrosis factor-alpha factor homolog isoform X1 [KO:K19363]
119628365  lipopolysaccharide-induced tumor necrosis factor-alpha factor homolog [KO:K19363]
119628382  lipopolysaccharide-induced tumor necrosis factor-alpha factor homolog [KO:K19363]
119629359  lipopolysaccharide-induced tumor necrosis factor-alpha factor homolog isoform X1 [KO:K19363]
119630888  uncharacterized protein LOC119630888 [KO:K19363]
119631108  uncharacterized protein LOC119631108 isoform X1 [KO:K19363]
119631109  lipopolysaccharide-induced tumor necrosis factor-alpha factor homolog [KO:K19363]
119631196  uncharacterized protein LOC119631196 isoform X1 [KO:K19363]
Compound
C00002  ATP
C00008  ADP
C00159  D-Mannose
C00275  D-Mannose 6-phosphate
Reference
PMID:12628346
  Authors
Eskelinen EL, Tanaka Y, Saftig P
  Title
At the acidic edge: emerging functions for lysosomal membrane proteins.
  Journal
Trends Cell Biol 13:137-45 (2003)
DOI:10.1016/S0962-8924(03)00005-9
Reference
PMID:1883197
  Authors
Neufeld EF
  Title
Lysosomal storage diseases.
  Journal
Annu Rev Biochem 60:257-80 (1991)
DOI:10.1146/annurev.bi.60.070191.001353
Reference
PMID:2943218
  Authors
von Figura K, Hasilik A
  Title
Lysosomal enzymes and their receptors.
  Journal
Annu Rev Biochem 55:167-93 (1986)
DOI:10.1146/annurev.bi.55.070186.001123
Reference
PMID:15987739
  Authors
Janvier K, Bonifacino JS
  Title
Role of the endocytic machinery in the sorting of lysosome-associated membrane proteins.
  Journal
Mol Biol Cell 16:4231-42 (2005)
DOI:10.1091/mbc.E05-03-0213
Reference
PMID:18635948
  Authors
Vergarajauregui S, Puertollano R
  Title
Mucolipidosis type IV: the importance of functional lysosomes for efficient autophagy.
  Journal
Autophagy 4:832-4 (2008)
DOI:10.4161/auto.6567
Reference
PMID:34249946
  Authors
Jaskolka MC, Winkley SR, Kane PM
  Title
RAVE and Rabconnectin-3 Complexes as Signal Dependent Regulators of Organelle Acidification.
  Journal
Front Cell Dev Biol 9:698190 (2021)
DOI:10.3389/fcell.2021.698190
Reference
PMID:34646033
  Authors
Majdoul S, Compton AA
  Title
Lessons in self-defence: inhibition of virus entry by intrinsic immunity.
  Journal
Nat Rev Immunol 10.1038/s41577-021-00626-8 (2021)
DOI:10.1038/s41577-021-00626-8
Related
pathway
bmor00511  Other glycan degradation
bmor00531  Glycosaminoglycan degradation
bmor04130  SNARE interactions in vesicular transport
bmor04140  Autophagy - animal
bmor04144  Endocytosis
KO pathway
ko04142   
LinkDB

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