KEGG   PATHWAY: boe00020
Entry
boe00020                    Pathway                                
Name
Citrate cycle (TCA cycle) - Brassica oleracea (wild cabbage)
Description
The citrate cycle (TCA cycle, Krebs cycle) is an important aerobic pathway for the final steps of the oxidation of carbohydrates and fatty acids. The cycle starts with acetyl-CoA, the activated form of acetate, derived from glycolysis and pyruvate oxidation for carbohydrates and from beta oxidation of fatty acids. The two-carbon acetyl group in acetyl-CoA is transferred to the four-carbon compound of oxaloacetate to form the six-carbon compound of citrate. In a series of reactions two carbons in citrate are oxidized to CO2 and the reaction pathway supplies NADH for use in the oxidative phosphorylation and other metabolic processes. The pathway also supplies important precursor metabolites including 2-oxoglutarate. At the end of the cycle the remaining four-carbon part is transformed back to oxaloacetate. According to the genome sequence data, many organisms seem to lack genes for the full cycle [MD:M00009], but contain genes for specific segments [MD:M00010 M00011].
Class
Metabolism; Carbohydrate metabolism
Pathway map
boe00020  Citrate cycle (TCA cycle)
boe00020

Module
boe_M00003  Gluconeogenesis, oxaloacetate => fructose-6P [PATH:boe00020]
boe_M00009  Citrate cycle (TCA cycle, Krebs cycle) [PATH:boe00020]
boe_M00010  Citrate cycle, first carbon oxidation, oxaloacetate => 2-oxoglutarate [PATH:boe00020]
boe_M00011  Citrate cycle, second carbon oxidation, 2-oxoglutarate => oxaloacetate [PATH:boe00020]
boe_M00307  Pyruvate oxidation, pyruvate => acetyl-CoA [PATH:boe00020]
Other DBs
GO: 0006099
Organism
Brassica oleracea (wild cabbage) [GN:boe]
Gene
106311978  citrate synthase 2, peroxisomal [KO:K01647] [EC:2.3.3.1]
106311979  citrate synthase 2, peroxisomal-like [KO:K01647] [EC:2.3.3.1]
106309187  citrate synthase 2, peroxisomal-like [KO:K01647] [EC:2.3.3.1]
106342856  citrate synthase 4, mitochondrial [KO:K01647] [EC:2.3.3.1]
106339817  citrate synthase 2, peroxisomal-like [KO:K01647] [EC:2.3.3.1]
106328208  citrate synthase 4, mitochondrial-like [KO:K01647] [EC:2.3.3.1]
106301011  citrate synthase 2, peroxisomal-like [KO:K01647] [EC:2.3.3.1]
106342475  citrate synthase 3, peroxisomal [KO:K01647] [EC:2.3.3.1]
106342711  citrate synthase 5, mitochondrial [KO:K01647] [EC:2.3.3.1]
106318884  ATP-citrate synthase beta chain protein 2 [KO:K01648] [EC:2.3.3.8]
106318558  ATP-citrate synthase alpha chain protein 2 [KO:K01648] [EC:2.3.3.8]
106308321  ATP-citrate synthase alpha chain protein 1-like [KO:K01648] [EC:2.3.3.8]
106311783  ATP-citrate synthase alpha chain protein 3 [KO:K01648] [EC:2.3.3.8]
106335251  aconitate hydratase 1 [KO:K01681] [EC:4.2.1.3]
106306006  aconitate hydratase 2, mitochondrial-like [KO:K01681] [EC:4.2.1.3]
106311729  aconitate hydratase 3, mitochondrial [KO:K01681] [EC:4.2.1.3]
106334951  aconitate hydratase 2, mitochondrial [KO:K01681] [EC:4.2.1.3]
106308688  aconitate hydratase 1 [KO:K01681] [EC:4.2.1.3]
106319946  cytosolic isocitrate dehydrogenase [NADP]-like [KO:K00031] [EC:1.1.1.42]
106321172  cytosolic isocitrate dehydrogenase [NADP] [KO:K00031] [EC:1.1.1.42]
106335730  isocitrate dehydrogenase [NADP], chloroplastic/mitochondrial [KO:K00031] [EC:1.1.1.42]
106297733  peroxisomal isocitrate dehydrogenase [NADP] [KO:K00031] [EC:1.1.1.42]
106301072  cytosolic isocitrate dehydrogenase [NADP]-like [KO:K00031] [EC:1.1.1.42]
106328742  isocitrate dehydrogenase [NAD] catalytic subunit 5, mitochondrial [KO:K00030] [EC:1.1.1.41]
106293567  isocitrate dehydrogenase [NAD] catalytic subunit 6, mitochondrial isoform X1 [KO:K00030] [EC:1.1.1.41]
106319236  isocitrate dehydrogenase [NAD] catalytic subunit 5, mitochondrial-like [KO:K00030] [EC:1.1.1.41]
106329085  isocitrate dehydrogenase [NAD] regulatory subunit 3, mitochondrial [KO:K00030] [EC:1.1.1.41]
106318047  isocitrate dehydrogenase [NAD] regulatory subunit 1, mitochondrial [KO:K00030] [EC:1.1.1.41]
106307102  isocitrate dehydrogenase [NAD] regulatory subunit 2, mitochondrial isoform X1 [KO:K00030] [EC:1.1.1.41]
106317063  isocitrate dehydrogenase [NAD] catalytic subunit 5, mitochondrial-like [KO:K00030] [EC:1.1.1.41]
106336440  isocitrate dehydrogenase [NAD] regulatory subunit 1, mitochondrial [KO:K00030] [EC:1.1.1.41]
106334854  2-oxoglutarate dehydrogenase, mitochondrial [KO:K00164] [EC:1.2.4.2]
106300115  2-oxoglutarate dehydrogenase, mitochondrial-like [KO:K00164] [EC:1.2.4.2]
106318243  2-oxoglutarate dehydrogenase, mitochondrial-like [KO:K00164] [EC:1.2.4.2]
106328550  dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex 1, mitochondrial [KO:K00658] [EC:2.3.1.61]
106309608  dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex 2, mitochondrial-like isoform X1 [KO:K00658] [EC:2.3.1.61]
106327844  dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex 1, mitochondrial-like [KO:K00658] [EC:2.3.1.61]
106318395  dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex 1, mitochondrial-like [KO:K00658] [EC:2.3.1.61]
106295598  dihydrolipoyl dehydrogenase 2, mitochondrial [KO:K00382] [EC:1.8.1.4]
106300045  dihydrolipoyl dehydrogenase 1, mitochondrial [KO:K00382] [EC:1.8.1.4]
106328211  dihydrolipoyl dehydrogenase 1, chloroplastic [KO:K00382] [EC:1.8.1.4]
106293072  dihydrolipoyl dehydrogenase 2, chloroplastic [KO:K00382] [EC:1.8.1.4]
106303578  succinyl-CoA ligase [ADP-forming] subunit alpha-2, mitochondrial [KO:K01899] [EC:6.2.1.4 6.2.1.5]
106318619  succinyl-CoA ligase [ADP-forming] subunit alpha-1, mitochondrial [KO:K01899] [EC:6.2.1.4 6.2.1.5]
106321537  succinyl-CoA ligase [ADP-forming] subunit alpha-1, mitochondrial-like [KO:K01899] [EC:6.2.1.4 6.2.1.5]
106328747  succinyl-CoA ligase [ADP-forming] subunit alpha-1, mitochondrial-like [KO:K01899] [EC:6.2.1.4 6.2.1.5]
106315428  succinyl-CoA ligase [ADP-forming] subunit beta, mitochondrial [KO:K01900] [EC:6.2.1.4 6.2.1.5]
106301287  succinyl-CoA ligase [ADP-forming] subunit beta, mitochondrial [KO:K01900] [EC:6.2.1.4 6.2.1.5]
106306618  succinate dehydrogenase [ubiquinone] flavoprotein subunit 1, mitochondrial isoform X1 [KO:K00234] [EC:1.3.5.1]
106333226  succinate dehydrogenase [ubiquinone] flavoprotein subunit 2, mitochondrial [KO:K00234] [EC:1.3.5.1]
106319350  succinate dehydrogenase [ubiquinone] flavoprotein subunit 1, mitochondrial-like isoform X1 [KO:K00234] [EC:1.3.5.1]
106327919  succinate dehydrogenase [ubiquinone] flavoprotein subunit 1, mitochondrial-like isoform X1 [KO:K00234] [EC:1.3.5.1]
106319782  succinate dehydrogenase [ubiquinone] iron-sulfur subunit 3, mitochondrial [KO:K00235] [EC:1.3.5.1]
106324732  succinate dehydrogenase [ubiquinone] iron-sulfur subunit 1, mitochondrial-like [KO:K00235] [EC:1.3.5.1]
106301368  succinate dehydrogenase [ubiquinone] iron-sulfur subunit 1, mitochondrial [KO:K00235] [EC:1.3.5.1]
106318305  succinate dehydrogenase [ubiquinone] iron-sulfur subunit 1, mitochondrial-like [KO:K00235] [EC:1.3.5.1]
106313249  succinate dehydrogenase subunit 3-1, mitochondrial isoform X1 [KO:K00236]
106331401  succinate dehydrogenase subunit 4, mitochondrial-like [KO:K25801]
106342425  fumarate hydratase 1, mitochondrial [KO:K01679] [EC:4.2.1.2]
106336855  fumarate hydratase 1, mitochondrial-like [KO:K01679] [EC:4.2.1.2]
106337783  fumarate hydratase 1, mitochondrial-like [KO:K01679] [EC:4.2.1.2]
106318737  malate dehydrogenase, cytoplasmic [KO:K00025] [EC:1.1.1.37]
106293213  malate dehydrogenase, cytoplasmic 1 [KO:K00025] [EC:1.1.1.37]
106307165  malate dehydrogenase, cytoplasmic 1-like [KO:K00025] [EC:1.1.1.37]
106319444  malate dehydrogenase, cytoplasmic 1 [KO:K00025] [EC:1.1.1.37]
106328331  malate dehydrogenase 1, mitochondrial [KO:K00026] [EC:1.1.1.37]
106344959  malate dehydrogenase, chloroplastic-like [KO:K00026] [EC:1.1.1.37]
106318964  malate dehydrogenase 2, glyoxysomal-like [KO:K00026] [EC:1.1.1.37]
106296346  malate dehydrogenase 1, mitochondrial-like [KO:K00026] [EC:1.1.1.37]
106302879  probable malate dehydrogenase, glyoxysomal [KO:K00026] [EC:1.1.1.37]
106336113  malate dehydrogenase, chloroplastic [KO:K00026] [EC:1.1.1.37]
106301033  malate dehydrogenase 1, mitochondrial-like [KO:K00026] [EC:1.1.1.37]
106336611  probable malate dehydrogenase, glyoxysomal [KO:K00026] [EC:1.1.1.37]
106326868  malate dehydrogenase 2, glyoxysomal [KO:K00026] [EC:1.1.1.37]
106304257  phosphoenolpyruvate carboxykinase [ATP]-like [KO:K01610] [EC:4.1.1.49]
106329348  phosphoenolpyruvate carboxykinase [ATP] [KO:K01610] [EC:4.1.1.49]
106325164  phosphoenolpyruvate carboxykinase [ATP]-like isoform X1 [KO:K01610] [EC:4.1.1.49]
106308910  phosphoenolpyruvate carboxykinase [ATP] [KO:K01610] [EC:4.1.1.49]
106301209  pyruvate dehydrogenase E1 component subunit alpha-2, mitochondrial [KO:K00161] [EC:1.2.4.1]
106294721  LOW QUALITY PROTEIN: pyruvate dehydrogenase E1 component subunit alpha-2, mitochondrial [KO:K00161] [EC:1.2.4.1]
106341916  pyruvate dehydrogenase E1 component subunit alpha-1, mitochondrial-like [KO:K00161] [EC:1.2.4.1]
106309432  pyruvate dehydrogenase E1 component subunit alpha-3, chloroplastic-like [KO:K00161] [EC:1.2.4.1]
106311746  pyruvate dehydrogenase E1 component subunit alpha-3, chloroplastic [KO:K00161] [EC:1.2.4.1]
106296243  pyruvate dehydrogenase E1 component subunit alpha-2, mitochondrial-like isoform X1 [KO:K00161] [EC:1.2.4.1]
106312421  pyruvate dehydrogenase E1 component subunit alpha-1, mitochondrial [KO:K00161] [EC:1.2.4.1]
106295127  pyruvate dehydrogenase E1 component subunit alpha-3, chloroplastic [KO:K00161] [EC:1.2.4.1]
106328315  pyruvate dehydrogenase E1 component subunit beta-1, mitochondrial [KO:K00162] [EC:1.2.4.1]
106294627  pyruvate dehydrogenase E1 component subunit beta-2, chloroplastic [KO:K00162] [EC:1.2.4.1]
106338034  LOW QUALITY PROTEIN: pyruvate dehydrogenase E1 component subunit beta-3, chloroplastic [KO:K00162] [EC:1.2.4.1]
106322635  pyruvate dehydrogenase E1 component subunit beta-1, mitochondrial-like [KO:K00162] [EC:1.2.4.1]
106313357  pyruvate dehydrogenase E1 component subunit beta-1, mitochondrial-like [KO:K00162] [EC:1.2.4.1]
106335527  pyruvate dehydrogenase E1 component subunit beta-2, chloroplastic-like isoform X1 [KO:K00162] [EC:1.2.4.1]
106298256  dihydrolipoyllysine-residue acetyltransferase component 5 of pyruvate dehydrogenase complex, chloroplastic isoform X1 [KO:K00627] [EC:2.3.1.12]
106328125  dihydrolipoyllysine-residue acetyltransferase component 2 of pyruvate dehydrogenase complex, mitochondrial isoform X1 [KO:K00627] [EC:2.3.1.12]
106343245  dihydrolipoyllysine-residue acetyltransferase component 2 of pyruvate dehydrogenase complex, mitochondrial [KO:K00627] [EC:2.3.1.12]
106342864  dihydrolipoyllysine-residue acetyltransferase component 1 of pyruvate dehydrogenase complex, mitochondrial [KO:K00627] [EC:2.3.1.12]
106296395  dihydrolipoyllysine-residue acetyltransferase component 3 of pyruvate dehydrogenase complex, mitochondrial [KO:K00627] [EC:2.3.1.12]
106317633  dihydrolipoyllysine-residue acetyltransferase component 4 of pyruvate dehydrogenase complex, chloroplastic-like [KO:K00627] [EC:2.3.1.12]
106320953  dihydrolipoyllysine-residue acetyltransferase component 4 of pyruvate dehydrogenase complex, chloroplastic [KO:K00627] [EC:2.3.1.12]
106306264  dihydrolipoyllysine-residue acetyltransferase component 4 of pyruvate dehydrogenase complex, chloroplastic [KO:K00627] [EC:2.3.1.12]
Compound
C00022  Pyruvate
C00024  Acetyl-CoA
C00026  2-Oxoglutarate
C00036  Oxaloacetate
C00042  Succinate
C00068  Thiamin diphosphate
C00074  Phosphoenolpyruvate
C00091  Succinyl-CoA
C00122  Fumarate
C00149  (S)-Malate
C00158  Citrate
C00311  Isocitrate
C00417  cis-Aconitate
C05125  2-(alpha-Hydroxyethyl)thiamine diphosphate
C05379  Oxalosuccinate
C05381  3-Carboxy-1-hydroxypropyl-ThPP
C15972  Enzyme N6-(lipoyl)lysine
C15973  Enzyme N6-(dihydrolipoyl)lysine
C16254  [Dihydrolipoyllysine-residue succinyltransferase] S-succinyldihydrolipoyllysine
C16255  [Dihydrolipoyllysine-residue acetyltransferase] S-acetyldihydrolipoyllysine
Reference
  Authors
Nishizuka Y (ed).
  Title
[Metabolic Maps] (In Japanese)
  Journal
Tokyo Kagaku Dojin (1980)
Reference
  Authors
Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).
  Title
[Cellular Functions and Metabolic Maps] (In Japanese)
  Journal
Tokyo Kagaku Dojin (1997)
Reference
  Authors
Michal G.
  Title
Biochemical Pathways
  Journal
Wiley (1999)
Related
pathway
boe00010  Glycolysis / Gluconeogenesis
boe00053  Ascorbate and aldarate metabolism
boe00061  Fatty acid biosynthesis
boe00062  Fatty acid elongation
boe00071  Fatty acid degradation
boe00190  Oxidative phosphorylation
boe00220  Arginine biosynthesis
boe00250  Alanine, aspartate and glutamate metabolism
boe00280  Valine, leucine and isoleucine degradation
boe00350  Tyrosine metabolism
boe00470  D-Amino acid metabolism
boe00630  Glyoxylate and dicarboxylate metabolism
KO pathway
ko00020   
LinkDB

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