PATHWAY: boe00020 Help
Entry
Name
Citrate cycle (TCA cycle) - Brassica oleracea (wild cabbage)
Description
The citrate cycle (TCA cycle, Krebs cycle) is an important aerobic pathway for the final steps of the oxidation of carbohydrates and fatty acids. The cycle starts with acetyl-CoA, the activated form of acetate, derived from glycolysis and pyruvate oxidation for carbohydrates and from beta oxidation of fatty acids. The two-carbon acetyl group in acetyl-CoA is transferred to the four-carbon compound of oxaloacetate to form the six-carbon compound of citrate. In a series of reactions two carbons in citrate are oxidized to CO2 and the reaction pathway supplies NADH for use in the oxidative phosphorylation and other metabolic processes. The pathway also supplies important precursor metabolites including 2-oxoglutarate. At the end of the cycle the remaining four-carbon part is transformed back to oxaloacetate. According to the genome sequence data, many organisms seem to lack genes for the full cycle [MD:
M00009 ], but contain genes for specific segments [MD:
M00010 M00011 ].
Class
Metabolism; Carbohydrate metabolism
BRITE hierarchy
Pathway map
Ortholog table
Module
boe_M00010 Citrate cycle, first carbon oxidation, oxaloacetate => 2-oxoglutarate [PATH:boe00020 ]
boe_M00011 Citrate cycle, second carbon oxidation, 2-oxoglutarate => oxaloacetate [PATH:boe00020 ]
Other DBs
Organism
Brassica oleracea (wild cabbage) [GN:
boe ]
Gene
106328550 dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex 1, mitochondrial [KO:K00658 ] [EC:2.3.1.61 ]
106309608 dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex 2, mitochondrial-like isoform X1 [KO:K00658 ] [EC:2.3.1.61 ]
106327844 dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex 1, mitochondrial-like [KO:K00658 ] [EC:2.3.1.61 ]
106318395 dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex 1, mitochondrial-like [KO:K00658 ] [EC:2.3.1.61 ]
106306618 succinate dehydrogenase [ubiquinone] flavoprotein subunit 1, mitochondrial isoform X1 [KO:K00234 ] [EC:1.3.5.1 ]
106319350 succinate dehydrogenase [ubiquinone] flavoprotein subunit 1, mitochondrial-like isoform X1 [KO:K00234 ] [EC:1.3.5.1 ]
106327919 succinate dehydrogenase [ubiquinone] flavoprotein subunit 1, mitochondrial-like isoform X1 [KO:K00234 ] [EC:1.3.5.1 ]
106324732 succinate dehydrogenase [ubiquinone] iron-sulfur subunit 1, mitochondrial-like [KO:K00235 ] [EC:1.3.5.1 ]
106318305 succinate dehydrogenase [ubiquinone] iron-sulfur subunit 1, mitochondrial-like [KO:K00235 ] [EC:1.3.5.1 ]
106313249 succinate dehydrogenase subunit 3-1, mitochondrial isoform X1 [KO:K00236 ]
106331401 succinate dehydrogenase subunit 4, mitochondrial-like [KO:K25801 ]
106294721 LOW QUALITY PROTEIN: pyruvate dehydrogenase E1 component subunit alpha-2, mitochondrial [KO:K00161 ] [EC:1.2.4.1 ]
106296243 pyruvate dehydrogenase E1 component subunit alpha-2, mitochondrial-like isoform X1 [KO:K00161 ] [EC:1.2.4.1 ]
106338034 LOW QUALITY PROTEIN: pyruvate dehydrogenase E1 component subunit beta-3, chloroplastic [KO:K00162 ] [EC:1.2.4.1 ]
106335527 pyruvate dehydrogenase E1 component subunit beta-2, chloroplastic-like isoform X1 [KO:K00162 ] [EC:1.2.4.1 ]
106298256 dihydrolipoyllysine-residue acetyltransferase component 5 of pyruvate dehydrogenase complex, chloroplastic isoform X1 [KO:K00627 ] [EC:2.3.1.12 ]
106328125 dihydrolipoyllysine-residue acetyltransferase component 2 of pyruvate dehydrogenase complex, mitochondrial isoform X1 [KO:K00627 ] [EC:2.3.1.12 ]
106343245 dihydrolipoyllysine-residue acetyltransferase component 2 of pyruvate dehydrogenase complex, mitochondrial [KO:K00627 ] [EC:2.3.1.12 ]
106342864 dihydrolipoyllysine-residue acetyltransferase component 1 of pyruvate dehydrogenase complex, mitochondrial [KO:K00627 ] [EC:2.3.1.12 ]
106296395 dihydrolipoyllysine-residue acetyltransferase component 3 of pyruvate dehydrogenase complex, mitochondrial [KO:K00627 ] [EC:2.3.1.12 ]
106317633 dihydrolipoyllysine-residue acetyltransferase component 4 of pyruvate dehydrogenase complex, chloroplastic-like [KO:K00627 ] [EC:2.3.1.12 ]
106320953 dihydrolipoyllysine-residue acetyltransferase component 4 of pyruvate dehydrogenase complex, chloroplastic [KO:K00627 ] [EC:2.3.1.12 ]
106306264 dihydrolipoyllysine-residue acetyltransferase component 4 of pyruvate dehydrogenase complex, chloroplastic [KO:K00627 ] [EC:2.3.1.12 ]
Compound
C05125 2-(alpha-Hydroxyethyl)thiamine diphosphate
C05381 3-Carboxy-1-hydroxypropyl-ThPP
C15972 Enzyme N6-(lipoyl)lysine
C15973 Enzyme N6-(dihydrolipoyl)lysine
C16254 [Dihydrolipoyllysine-residue succinyltransferase] S-succinyldihydrolipoyllysine
C16255 [Dihydrolipoyllysine-residue acetyltransferase] S-acetyldihydrolipoyllysine
Reference
Authors
Nishizuka Y (ed).
Title
[Metabolic Maps] (In Japanese)
Journal
Tokyo Kagaku Dojin (1980)
Reference
Authors
Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).
Title
[Cellular Functions and Metabolic Maps] (In Japanese)
Journal
Tokyo Kagaku Dojin (1997)
Reference
Authors
Michal G.
Title
Biochemical Pathways
Journal
Wiley (1999)
Related pathway
boe00053 Ascorbate and aldarate metabolism
boe00250 Alanine, aspartate and glutamate metabolism
boe00280 Valine, leucine and isoleucine degradation
boe00630 Glyoxylate and dicarboxylate metabolism
KO pathway
LinkDB
All DBs