Entry
Name
Quorum sensing - Burkholderia pseudomallei K96243
Description
Quorum sensing (QS) is a regulatory system that allows bacteria to share information about cell density and adjust gene expression accordingly. All QS bacteria produce and release chemical signal molecules called autoinducers (AIs) that increase in concentration as a function of cell density. The most commonly studied AIs belong to one of the following three categories: acylated homoserine lactones, also referred to as AI-1, used by Gram-negative bacteria; peptide signals, used by Gram-positive bacteria; and AI-2, used by both Gram-negative and Gram-positive bacteria. QS can be divided into at least 4 steps: production of AIs by the bacterial cell; release of AIs, either actively or passively, into the surrounding environment; recognition of AIs by specific receptors; and leading to changes in gene regulation once they exceed a threshold concentration. The processes controlled by QS include virulence, competence, conjugation, antibiotic production, motility, sporulation, and biofilm formation.
Class
Cellular Processes; Cellular community - prokaryotes
BRITE hierarchy
Pathway map
Ortholog table
Other DBs
Organism
Burkholderia pseudomallei K96243 [GN:
bps ]
Gene
BPSS1352 putative fatty acid biosynthetic protein [KO:K18100 ] [EC:2.4.1.-]
BPSS0536 putative 3-hydroxydecanoyl-ACP:CoA transacylase [KO:K18100 ] [EC:2.4.1.-]
BPSS1351 putative rhamnosyltransferase protein [KO:K18101 ] [EC:2.4.1.-]
BPSS0537 putative UDP-glucoronosyl and UDP-glucosyl transferase [KO:K18101 ] [EC:2.4.1.-]
BPSS0580 subfamily M23A unassigned peptidase [KO:K08642 ] [EC:3.4.24.-]
BPSL3311 flhD; flagellar regulon master regulator subunit FlhD [KO:K02403 ]
BPSL3310 flhC; flagellar regulon master regulator subunit FlhC [KO:K02402 ]
BPSL1175 kdpE; two-component system, regulatory protein KdpE [KO:K07667 ]
BPSL1649 putative ABC transport system, substrate-binding protein [KO:K02055 ]
BPSS0249 putative ABC transport system, substrate-binding exported protein [KO:K02055 ]
BPSL0108 putative extracellular solute-binding lipoprotein [KO:K02055 ]
BPSL1300 putative ABC transport system, ATP-binding protein [KO:K02052 ]
BPSL1652 putative ABC transport system, ATP-binding protein [KO:K02052 ]
BPSS1738 putative ABC transport system ATP-binding protein [KO:K02052 ]
BPSS0248 putative ABC transport system, ATP-binding protein [KO:K02052 ]
BPSS0575 braC; leucine-, isoleucine-, valine-, threonine-, and alanine-binding protein precursor [KO:K01999 ]
BPSL3388 putative periplasmic amino acid binding transport protein [KO:K01999 ]
BPSL3412 putative branched-chain amino acid ABC transporter periplasmic protein [KO:K01999 ]
BPSL3416 putative branched-chain amino acid ABC transporter periplasmic substrate binding protein [KO:K01999 ]
BPSL1205 putative amino acid transport system, exported protein [KO:K01999 ]
BPSL1751 putative amino-acid transport-related exported protein [KO:K01999 ]
BPSL2000 putative branched amino acid transport system, membrane protein [KO:K01997 ]
BPSS0576 braD; high-affinity branched-chain amino acid transport system permease protein [KO:K01997 ]
BPSL3411 putative branched-chain amino acid ABC transporter permease [KO:K01997 ]
BPSL3415 putative branched-chain amino acid ABC transporter permease [KO:K01997 ]
BPSL0049 putative branched-chain amino acid transport system permease protein [KO:K01997 ]
BPSS0577 braE; high-affinity branched-chain amino acid transport system permease protein [KO:K01998 ]
BPSL3414 putative branched-chain amino acid ABC transporter integral membrane subunit [KO:K01998 ]
BPSL1999 putative branched amino acid related transport system, bifunctional protein (membrane and ATP-binding) [KO:K01995 K01998 ]
BPSS0578 braF; high-affinity branched-chain amino acid transport ATP-binding protein [KO:K01995 ]
BPSL3418 putative branched-chain amino acid ABC transporter ATP-binding subunit [KO:K01995 ]
BPSL1998 putative branched amino acid related transport system protein [KO:K01996 ]
BPSS0579 braG; high-affinity branched-chain amino acid transport ATP-binding protein [KO:K01996 ]
BPSL3409 putative branched-chain amino acid ABC transporter ATP-binding subunit [KO:K01996 ]
BPSL3417 putative branched-chain amino acid ABC transporter ATP-binding subunit [KO:K01996 ]
BPSS0887 pmlR; N-acylhomoserine lactone dependent regulatory protein [KO:K19666 ]
BPSS1569 putative N-acylhomoserine lactone-dependent regulatory protein [KO:K19731 ]
BPSL1269 putative IclR-family transcriptional regulatory protein [KO:K20329 ]
BPSL1802 multidrug efflux system putative membrane lipoprotein [KO:K18139 ]
BPSS2141 oppA; putative periplasmic oligopeptide-binding protein precursor [KO:K15580 ]
BPSS2140 oppB; putative oligopeptide transport system permease protein [KO:K15581 ]
BPSS2139 oppC; putative oligopeptide transport system permease protein [KO:K15582 ]
BPSS2138 oppD; putative oligopeptide transport ATP-binding ABC transport protein [KO:K15583 ]
BPSS2137 oppF; putative oligopeptide transport ATP-binding ABC transport protein [KO:K10823 ]
BPSS0953 putative dipeptide transport system permease protein [KO:K02033 ]
BPSS0952 putative dipeptide transport system permease protein [KO:K02034 ]
BPSS1993 mprA; serine metalloprotease precursor [KO:K14645 ] [EC:3.4.21.-]
BPSL1210 secG; general secretory pathway, protein-export membrane protein [KO:K03075 ]
Compound
C11837 N-Butyryl-L-homoserine lactone
C11841 N-(3-Oxooctanoyl)homoserine lactone
C11844 N-Heptanoylhomoserine lactone
C11845 N-(3-Hydroxy-7-cis-tetradecenoyl)homoserine lactone
C11848 2-Heptyl-3-hydroxy-quinolone
C18049 N-Acyl-L-homoserine lactone
C18206 cis-11-Methyl-2-dodecenoic acid
C20643 2-Heptyl-4(1H)-quinolone
C20677 N-(4-Coumaroyl)-L-homoserine lactone
C20959 (4S)-4-Hydroxy-5-phosphooxypentane-2,3-dione
C21195 N-(3-Hydroxybutanoyl)-L-homoserine lactone
C21197 N-Hexanoyl-L-homoserine lactone
C21198 N-(3-Oxohexanoyl)-L-homoserine lactone
C21199 N-Octanoyl-L-homoserine lactone
C21200 N-3-Hydroxyoctanoyl-L-homoserine lactone
C21201 N-3-Oxo-dodecanoyl-L-homoserine lactone
Reference
Authors
Pereira CS, Thompson JA, Xavier KB
Title
AI-2-mediated signalling in bacteria.
Journal
Reference
Authors
Verma SC, Miyashiro T
Title
Quorum sensing in the squid-Vibrio symbiosis.
Journal
Reference
Authors
Norsworthy AN, Visick KL
Title
Gimme shelter: how Vibrio fischeri successfully navigates an animal's multiple environments.
Journal
Reference
Authors
Papaioannou E, Utari PD, Quax WJ
Title
Choosing an appropriate infection model to study quorum sensing inhibition in Pseudomonas infections.
Journal
Reference
Authors
Heeb S, Fletcher MP, Chhabra SR, Diggle SP, Williams P, Camara M
Title
Quinolones: from antibiotics to autoinducers.
Journal
Reference
Authors
Rasamiravaka T, Labtani Q, Duez P, El Jaziri M
Title
The formation of biofilms by Pseudomonas aeruginosa: a review of the natural and synthetic compounds interfering with control mechanisms.
Journal
Reference
Authors
Whiteley M, Greenberg EP
Title
Promoter specificity elements in Pseudomonas aeruginosa quorum-sensing-controlled genes.
Journal
Reference
Authors
Chin-A-Woeng TF, van den Broek D, de Voer G, van der Drift KM, Tuinman S, Thomas-Oates JE, Lugtenberg BJ, Bloemberg GV
Title
Phenazine-1-carboxamide production in the biocontrol strain Pseudomonas chlororaphis PCL1391 is regulated by multiple factors secreted into the growth medium.
Journal
Reference
Authors
Hughes DT, Clarke MB, Yamamoto K, Rasko DA, Sperandio V
Title
The QseC adrenergic signaling cascade in Enterohemorrhagic E. coli (EHEC).
Journal
Reference
Authors
Njoroge J, Sperandio V
Title
Enterohemorrhagic Escherichia coli virulence regulation by two bacterial adrenergic kinases, QseC and QseE.
Journal
Reference
Authors
Pacheco AR, Curtis MM, Ritchie JM, Munera D, Waldor MK, Moreira CG, Sperandio V
Title
Fucose sensing regulates bacterial intestinal colonization.
Journal
Reference
Authors
Hirakawa H, Harwood CS, Pechter KB, Schaefer AL, Greenberg EP
Title
Antisense RNA that affects Rhodopseudomonas palustris quorum-sensing signal receptor expression.
Journal
Reference
Authors
Danino VE, Wilkinson A, Edwards A, Downie JA
Title
Recipient-induced transfer of the symbiotic plasmid pRL1JI in Rhizobium leguminosarum bv. viciae is regulated by a quorum-sensing relay.
Journal
Reference
Authors
Wisniewski-Dye F, Downie JA
Title
Quorum-sensing in Rhizobium.
Journal
Reference
Authors
Rodelas B, Lithgow JK, Wisniewski-Dye F, Hardman A, Wilkinson A, Economou A, Williams P, Downie JA
Title
Analysis of quorum-sensing-dependent control of rhizosphere-expressed (rhi) genes in Rhizobium leguminosarum bv. viciae.
Journal
Reference
Authors
Lang J, Faure D
Title
Functions and regulation of quorum-sensing in Agrobacterium tumefaciens.
Journal
Reference
Authors
Planamente S, Morera S, Faure D
Title
In planta fitness-cost of the Atu4232-regulon encoding for a selective GABA-binding sensor in Agrobacterium.
Journal
Reference
Authors
Barnard AM, Salmond GP
Title
Quorum sensing in Erwinia species.
Journal
Reference
Authors
Barnard AM, Bowden SD, Burr T, Coulthurst SJ, Monson RE, Salmond GP
Title
Quorum sensing, virulence and secondary metabolite production in plant soft-rotting bacteria.
Journal
Reference
Authors
Carlier A, Burbank L, von Bodman SB
Title
Identification and characterization of three novel EsaI/EsaR quorum-sensing controlled stewartan exopolysaccharide biosynthetic genes in Pantoea stewartii ssp. stewartii.
Journal
Reference
Authors
Beck von Bodman S, Farrand SK
Title
Capsular polysaccharide biosynthesis and pathogenicity in Erwinia stewartii require induction by an N-acylhomoserine lactone autoinducer.
Journal
Reference
Authors
O'Grady EP, Viteri DF, Malott RJ, Sokol PA
Title
Reciprocal regulation by the CepIR and CciIR quorum sensing systems in Burkholderia cenocepacia.
Journal
Reference
Authors
Malott RJ, Baldwin A, Mahenthiralingam E, Sokol PA
Title
Characterization of the cciIR quorum-sensing system in Burkholderia cenocepacia.
Journal
Reference
Authors
Deng Y, Schmid N, Wang C, Wang J, Pessi G, Wu D, Lee J, Aguilar C, Ahrens CH, Chang C, Song H, Eberl L, Zhang LH
Title
Cis-2-dodecenoic acid receptor RpfR links quorum-sensing signal perception with regulation of virulence through cyclic dimeric guanosine monophosphate turnover.
Journal
Reference
Authors
Suppiger A, Schmid N, Aguilar C, Pessi G, Eberl L
Title
Two quorum sensing systems control biofilm formation and virulence in members of the Burkholderia cepacia complex.
Journal
Reference
Authors
Deng Y, Wu J, Tao F, Zhang LH
Title
Listening to a new language: DSF-based quorum sensing in Gram-negative bacteria.
Journal
Reference
Authors
Ryan RP, Dow JM
Title
Communication with a growing family: diffusible signal factor (DSF) signaling in bacteria.
Journal
Reference
Authors
Kim J, Kim JG, Kang Y, Jang JY, Jog GJ, Lim JY, Kim S, Suga H, Nagamatsu T, Hwang I
Title
Quorum sensing and the LysR-type transcriptional activator ToxR regulate toxoflavin biosynthesis and transport in Burkholderia glumae.
Journal
Reference
Authors
Kim J, Kang Y, Choi O, Jeong Y, Jeong JE, Lim JY, Kim M, Moon JS, Suga H, Hwang I
Title
Regulation of polar flagellum genes is mediated by quorum sensing and FlhDC in Burkholderia glumae.
Journal
Reference
Authors
Stauff DL, Bassler BL
Title
Quorum sensing in Chromobacterium violaceum: DNA recognition and gene regulation by the CviR receptor.
Journal
Reference
Authors
Chen G, Swem LR, Swem DL, Stauff DL, O'Loughlin CT, Jeffrey PD, Bassler BL, Hughson FM
Title
A strategy for antagonizing quorum sensing.
Journal
Reference
Authors
Hao G, Burr TJ
Title
Regulation of long-chain N-acyl-homoserine lactones in Agrobacterium vitis.
Journal
Reference
Authors
Savka MA, Le PT, Burr TJ
Title
LasR receptor for detection of long-chain quorum-sensing signals: identification of N-acyl-homoserine lactones encoded by the avsI locus of Agrobacterium vitis.
Journal
Reference
Authors
Le KY, Otto M
Title
Quorum-sensing regulation in staphylococci-an overview.
Journal
Reference
Authors
Queck SY, Jameson-Lee M, Villaruz AE, Bach TH, Khan BA, Sturdevant DE, Ricklefs SM, Li M, Otto M
Title
RNAIII-independent target gene control by the agr quorum-sensing system: insight into the evolution of virulence regulation in Staphylococcus aureus.
Journal
Reference
Authors
Darkoh C, DuPont HL, Norris SJ, Kaplan HB
Title
Toxin synthesis by Clostridium difficile is regulated through quorum signaling.
Journal
Reference
Authors
Vidal JE, Shak JR, Canizalez-Roman A
Title
The CpAL quorum sensing system regulates production of hemolysins CPA and PFO to build Clostridium perfringens biofilms.
Journal
Reference
Authors
Ohtani K, Yuan Y, Hassan S, Wang R, Wang Y, Shimizu T
Title
Virulence gene regulation by the agr system in Clostridium perfringens.
Journal
Reference
Authors
Li YH, Tian X
Title
Quorum sensing and bacterial social interactions in biofilms.
Journal
Reference
Authors
Berg KH, Biornstad TJ, Johnsborg O, Havarstein LS
Title
Properties and biological role of streptococcal fratricins.
Journal
Reference
Authors
Conrads G, de Soet JJ, Song L, Henne K, Sztajer H, Wagner-Dobler I, Zeng AP
Title
Comparing the cariogenic species Streptococcus sobrinus and S. mutans on whole genome level.
Journal
Reference
Authors
Jimenez JC, Federle MJ
Title
Quorum sensing in group A Streptococcus.
Journal
Reference
Authors
Cook LC, Federle MJ
Title
Peptide pheromone signaling in Streptococcus and Enterococcus.
Journal
Reference
Authors
Podbielski A, Leonard BA
Title
The group A streptococcal dipeptide permease (Dpp) is involved in the uptake of essential amino acids and affects the expression of cysteine protease.
Journal
Reference
Authors
Podbielski A, Pohl B, Woischnik M, Korner C, Schmidt KH, Rozdzinski E, Leonard BA
Title
Molecular characterization of group A streptococcal (GAS) oligopeptide permease (opp) and its effect on cysteine protease production.
Journal
Reference
Authors
Anbalagan S, Dmitriev A, McShan WM, Dunman PM, Chaussee MS
Title
Growth phase-dependent modulation of Rgg binding specificity in Streptococcus pyogenes.
Journal
Reference
Authors
Clewell DB
Title
Tales of conjugation and sex pheromones: A plasmid and enterococcal odyssey.
Journal
Reference
Authors
Wardal E, Sadowy E, Hryniewicz W
Title
Complex nature of enterococcal pheromone-responsive plasmids.
Journal
Pol J Microbiol 59:79-87 (2010)
Reference
Authors
Roux A, Payne SM, Gilmore MS
Title
Microbial telesensing: probing the environment for friends, foes, and food.
Journal
Reference
Authors
Slamti L, Perchat S, Huillet E, Lereclus D
Title
Quorum sensing in Bacillus thuringiensis is required for completion of a full infectious cycle in the insect.
Journal
Reference
Authors
Lopez D, Kolter R
Title
Extracellular signals that define distinct and coexisting cell fates in Bacillus subtilis.
Journal
Reference
Authors
Stephenson S, Mueller C, Jiang M, Perego M
Title
Molecular analysis of Phr peptide processing in Bacillus subtilis.
Journal
Reference
Authors
Lanigan-Gerdes S, Dooley AN, Faull KF, Lazazzera BA
Title
Identification of subtilisin, Epr and Vpr as enzymes that produce CSF, an extracellular signalling peptide of Bacillus subtilis.
Journal
Reference
Authors
Kleerebezem M
Title
Quorum sensing control of lantibiotic production; nisin and subtilin autoregulate their own biosynthesis.
Journal
Reference
Authors
Rutherford ST, Bassler BL
Title
Bacterial quorum sensing: its role in virulence and possibilities for its control.
Journal
Reference
Authors
LaSarre B, Federle MJ
Title
Exploiting quorum sensing to confuse bacterial pathogens.
Journal
Reference
Authors
Sifri CD
Title
Healthcare epidemiology: quorum sensing: bacteria talk sense.
Journal
Related pathway
KO pathway
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