KEGG   PATHWAY: bror04142
Entry
bror04142                   Pathway                                
Name
Lysosome - Bacillus rossius redtenbacheri
Description
Lysosomes are membrane-delimited organelles in animal cells serving as the cell's main digestive compartment to which all sorts of macromolecules are delivered for degradation. They contain more than 40 hydrolases in an acidic environment (pH of about 5). After synthesis in the ER, lysosomal enzymes are decorated with mannose-6-phosphate residues, which are recognized by mannose-6-phosphate receptors in the trans-Golgi network. They are packaged into clathrin-coated vesicles and are transported to late endosomes. Substances for digestion are acquired by the lysosomes via a series of processes including endocytosis, phagocytosis, and autophagy.
Class
Cellular Processes; Transport and catabolism
Pathway map
bror04142  Lysosome
bror04142

Other DBs
GO: 0005764
Organism
Bacillus rossius redtenbacheri [GN:bror]
Gene
134535501  V-type proton ATPase 116 kDa subunit a 1-like [KO:K02154]
134535518  V-type proton ATPase 116 kDa subunit a 1-like isoform X1 [KO:K02154]
134528446  V-type proton ATPase 116 kDa subunit a 1 isoform X1 [KO:K02154]
134540731  V-type proton ATPase subunit d [KO:K02146]
134533729  V-type proton ATPase subunit H isoform X1 [KO:K02144]
134539431  V-type proton ATPase subunit S1-like [KO:K03662]
134539432  V-type proton ATPase subunit S1-like [KO:K03662]
134536977  V-type proton ATPase 16 kDa proteolipid subunit c-like [KO:K02155]
134536976  V-type proton ATPase 16 kDa proteolipid subunit c [KO:K02155]
134534040  V-type proton ATPase 21 kDa proteolipid subunit c'' [KO:K03661]
134537783  dmX-like protein 2 isoform X1 [KO:K24155]
134535543  WD repeat-containing protein 7 isoform X1 [KO:K24738]
134531781  nuclear receptor coactivator 7 isoform X1 [KO:K25442]
134528498  cathepsin B [KO:K01363] [EC:3.4.22.1]
134536570  dipeptidyl peptidase 1-like isoform X1 [KO:K01275] [EC:3.4.14.1]
134538718  dipeptidyl peptidase 1-like [KO:K01275] [EC:3.4.14.1]
134528466  lysosomal aspartic protease-like [KO:K01379] [EC:3.4.23.5]
134528470  lysosomal aspartic protease-like [KO:K01379] [EC:3.4.23.5]
134541908  cathepsin L-like [KO:K01365] [EC:3.4.22.15]
134542332  procathepsin L-like [KO:K01365] [EC:3.4.22.15]
134542372  procathepsin L-like [KO:K01365] [EC:3.4.22.15]
134527488  procathepsin L-like [KO:K01365] [EC:3.4.22.15]
134539430  cathepsin O-like [KO:K01374] [EC:3.4.22.42]
134540718  beta-galactosidase isoform X1 [KO:K12309] [EC:3.2.1.23]
134542140  lysosomal alpha-glucosidase-like [KO:K12316] [EC:3.2.1.20]
134535052  probable maltase-glucoamylase 2 [KO:K12316] [EC:3.2.1.20]
134538376  lysosomal alpha-glucosidase-like [KO:K12316] [EC:3.2.1.20]
134541064  putative glucosylceramidase 4 [KO:K01201] [EC:3.2.1.45]
134541220  lysosomal acid glucosylceramidase-like isoform X1 [KO:K01201] [EC:3.2.1.45]
134541328  lysosomal acid glucosylceramidase-like [KO:K01201] [EC:3.2.1.45]
134541390  putative glucosylceramidase 4 [KO:K01201] [EC:3.2.1.45]
134541440  lysosomal acid glucosylceramidase-like isoform X1 [KO:K01201] [EC:3.2.1.45]
134541441  lysosomal acid glucosylceramidase-like isoform X1 [KO:K01201] [EC:3.2.1.45]
134541443  lysosomal acid glucosylceramidase-like [KO:K01201] [EC:3.2.1.45]
134541444  lysosomal acid glucosylceramidase-like [KO:K01201] [EC:3.2.1.45]
134533706  lysosomal acid glucosylceramidase-like [KO:K01201] [EC:3.2.1.45]
134534712  lysosomal acid glucosylceramidase-like isoform X1 [KO:K01201] [EC:3.2.1.45]
134534714  lysosomal acid glucosylceramidase-like [KO:K01201] [EC:3.2.1.45]
134534717  lysosomal acid glucosylceramidase-like [KO:K01201] [EC:3.2.1.45]
134534842  lysosomal acid glucosylceramidase-like isoform X1 [KO:K01201] [EC:3.2.1.45]
134535352  lysosomal acid glucosylceramidase-like [KO:K01201] [EC:3.2.1.45]
134535958  putative glucosylceramidase 4 [KO:K01201] [EC:3.2.1.45]
134535959  putative glucosylceramidase 4 [KO:K01201] [EC:3.2.1.45]
134535960  putative glucosylceramidase 4 [KO:K01201] [EC:3.2.1.45]
134527206  lysosomal acid glucosylceramidase-like [KO:K01201] [EC:3.2.1.45]
134536661  lysosomal acid glucosylceramidase-like [KO:K01201] [EC:3.2.1.45]
134537345  lysosomal acid glucosylceramidase-like [KO:K01201] [EC:3.2.1.45]
134537416  lysosomal acid glucosylceramidase-like [KO:K01201] [EC:3.2.1.45]
134530895  alpha-L-iduronidase isoform X1 [KO:K01217] [EC:3.2.1.76]
134534230  alpha-N-acetylgalactosaminidase [KO:K01204] [EC:3.2.1.49]
134534231  alpha-N-acetylgalactosaminidase [KO:K01204] [EC:3.2.1.49]
134530105  alpha-N-acetylglucosaminidase isoform X1 [KO:K01205] [EC:3.2.1.50]
134532576  beta-glucuronidase-like isoform X1 [KO:K01195] [EC:3.2.1.31]
134532579  beta-glucuronidase-like isoform X1 [KO:K01195] [EC:3.2.1.31]
134532623  beta-glucuronidase isoform X1 [KO:K01195] [EC:3.2.1.31]
134532987  beta-glucuronidase-like [KO:K01195] [EC:3.2.1.31]
134538543  beta-glucuronidase-like [KO:K01195] [EC:3.2.1.31]
134530293  beta-glucuronidase-like [KO:K01195] [EC:3.2.1.31]
134532893  alpha-L-fucosidase-like [KO:K01206] [EC:3.2.1.51]
134541415  alpha-L-fucosidase-like [KO:K01206] [EC:3.2.1.51]
134541657  alpha-L-fucosidase-like [KO:K01206] [EC:3.2.1.51]
134541772  alpha-L-fucosidase-like [KO:K01206] [EC:3.2.1.51]
134538361  alpha-L-fucosidase-like [KO:K01206] [EC:3.2.1.51]
134541110  chitooligosaccharidolytic beta-N-acetylglucosaminidase [KO:K12373] [EC:3.2.1.52]
134539570  chitooligosaccharidolytic beta-N-acetylglucosaminidase isoform X1 [KO:K12373] [EC:3.2.1.52]
134540474  beta-hexosaminidase subunit alpha-like isoform X1 [KO:K12373] [EC:3.2.1.52]
134540476  beta-hexosaminidase subunit alpha-like [KO:K12373] [EC:3.2.1.52]
134540478  beta-hexosaminidase subunit beta-like isoform X1 [KO:K12373] [EC:3.2.1.52]
134528230  beta-mannosidase-like [KO:K01192] [EC:3.2.1.25]
134531954  beta-mannosidase-like [KO:K01192] [EC:3.2.1.25]
134532641  lysosomal alpha-mannosidase-like [KO:K12311] [EC:3.2.1.24]
134533120  lysosomal alpha-mannosidase-like isoform X1 [KO:K12311] [EC:3.2.1.24]
134533385  lysosomal alpha-mannosidase-like [KO:K12311] [EC:3.2.1.24]
134533428  lysosomal alpha-mannosidase-like [KO:K12311] [EC:3.2.1.24]
134528481  lysosomal alpha-mannosidase-like [KO:K12311] [EC:3.2.1.24]
134537335  lysosomal alpha-mannosidase-like isoform X1 [KO:K12311] [EC:3.2.1.24]
134537422  lysosomal alpha-mannosidase-like [KO:K12311] [EC:3.2.1.24]
134539861  lysosomal alpha-mannosidase-like isoform X1 [KO:K12311] [EC:3.2.1.24]
134529521  hyaluronidase-like [KO:K01197] [EC:3.2.1.35]
134532720  arylsulfatase B-like [KO:K01135] [EC:3.1.6.12]
134535156  arylsulfatase B-like [KO:K01135] [EC:3.1.6.12]
134531714  arylsulfatase B-like [KO:K01135] [EC:3.1.6.12]
134532330  arylsulfatase B-like [KO:K01135] [EC:3.1.6.12]
134530986  arylsulfatase G-like isoform X1 [KO:K12381] [EC:3.1.6.-]
134529740  N-acetylglucosamine-6-sulfatase-like isoform X1 [KO:K01137] [EC:3.1.6.14]
134535764  iduronate 2-sulfatase isoform X1 [KO:K01136] [EC:3.1.6.13]
134541301  N-sulphoglucosamine sulphohydrolase isoform X1 [KO:K01565] [EC:3.10.1.1]
134540933  lipase 1-like [KO:K01052] [EC:3.1.1.13]
134541012  lipase 3-like [KO:K01052] [EC:3.1.1.13]
134541084  lipase 3-like [KO:K01052] [EC:3.1.1.13]
134541947  lipase 3-like [KO:K01052] [EC:3.1.1.13]
134528143  lipase 3-like [KO:K01052] [EC:3.1.1.13]
134539636  lipase 3-like [KO:K01052] [EC:3.1.1.13]
134539637  lipase 3-like [KO:K01052] [EC:3.1.1.13]
134540353  lipase 3-like [KO:K01052] [EC:3.1.1.13]
134540619  lipase 3-like isoform X1 [KO:K01052] [EC:3.1.1.13]
134540621  gastric triacylglycerol lipase-like [KO:K01052] [EC:3.1.1.13]
134538953  phospholipase A2 group XV-like [KO:K06129] [EC:3.1.1.5]
134527349  deoxyribonuclease-2-alpha isoform X1 [KO:K01158] [EC:3.1.22.1]
134541944  prostatic acid phosphatase-like [KO:K14410] [EC:3.1.3.2]
134541946  lysosomal acid phosphatase-like [KO:K14410] [EC:3.1.3.2]
134541948  prostatic acid phosphatase-like [KO:K14410] [EC:3.1.3.2]
134542291  uncharacterized protein LOC134542291 [KO:K14410] [EC:3.1.3.2]
134542293  prostatic acid phosphatase-like [KO:K14410] [EC:3.1.3.2]
134542305  prostatic acid phosphatase-like [KO:K14410] [EC:3.1.3.2]
134542307  prostatic acid phosphatase-like [KO:K14410] [EC:3.1.3.2]
134542414  prostatic acid phosphatase-like [KO:K14410] [EC:3.1.3.2]
134542503  testicular acid phosphatase homolog [KO:K14410] [EC:3.1.3.2]
134528573  prostatic acid phosphatase-like [KO:K14410] [EC:3.1.3.2]
134529155  lysosomal acid phosphatase-like [KO:K14410] [EC:3.1.3.2]
134530821  testicular acid phosphatase homolog [KO:K14410] [EC:3.1.3.2]
134530822  venom acid phosphatase Acph-1-like [KO:K14410] [EC:3.1.3.2]
134530824  lysosomal acid phosphatase-like [KO:K14410] [EC:3.1.3.2]
134530825  prostatic acid phosphatase-like [KO:K14410] [EC:3.1.3.2]
134543099  sphingomyelin phosphodiesterase-like isoform X1 [KO:K12350] [EC:3.1.4.12]
134543100  sphingomyelin phosphodiesterase-like isoform X1 [KO:K12350] [EC:3.1.4.12]
134529317  sphingomyelin phosphodiesterase isoform X1 [KO:K12350] [EC:3.1.4.12]
134537006  N(4)-(Beta-N-acetylglucosaminyl)-L-asparaginase isoform X1 [KO:K01444] [EC:3.5.1.26]
134528118  prosaposin [KO:K12382]
134540825  ganglioside GM2 activator-like isoform X1 [KO:K12383]
134533248  ganglioside GM2 activator-like [KO:K12383]
134537819  lysosomal thioesterase PPT2 homolog isoform X1 [KO:K01074] [EC:3.1.2.22]
134530115  palmitoyl-protein thioesterase 1 [KO:K01074] [EC:3.1.2.22]
134539079  uncharacterized protein LOC134539079 isoform X1 [KO:K06528]
134533507  23 kDa integral membrane protein-like isoform X1 [KO:K06497]
134527415  CD63 antigen-like [KO:K06497]
134530174  CD63 antigen-like [KO:K06497]
134530175  CD63 antigen-like [KO:K06497]
134530564  CD63 antigen-like [KO:K06497]
134532335  tetraspanin-6-like [KO:K06497]
134534940  NPC intracellular cholesterol transporter 1 homolog 1b-like [KO:K12385]
134543322  NPC intracellular cholesterol transporter 1 isoform X1 [KO:K12385]
134543240  uncharacterized protein LOC134543240 [KO:K13443]
134535272  uncharacterized protein LOC134535272 [KO:K13443]
134535656  uncharacterized protein LOC134535656 [KO:K13443]
134528176  MD-2-related lipid-recognition protein-like [KO:K13443]
134528260  ecdysteroid-regulated 16 kDa protein [KO:K13443]
134530620  ecdysteroid-regulated 16 kDa protein [KO:K13443]
134531008  NPC intracellular cholesterol transporter 2 isoform X1 [KO:K13443]
134531470  NPC intracellular cholesterol transporter 2 [KO:K13443]
134528053  cystinosin homolog isoform X1 [KO:K12386]
134532733  putative inorganic phosphate cotransporter isoform X1 [KO:K12301]
134541173  sialin-like isoform X1 [KO:K12301]
134541374  sialin-like [KO:K12301]
134533381  sialin-like [KO:K12301]
134533560  sialin-like isoform X1 [KO:K12301]
134542482  putative inorganic phosphate cotransporter isoform X1 [KO:K12301]
134542879  sialin-like [KO:K12301]
134535484  sialin-like isoform X1 [KO:K12301]
134535912  sialin-like isoform X1 [KO:K12301]
134536673  uncharacterized transporter slc-17.2-like [KO:K12301]
134537175  sialin-like [KO:K12301]
134538253  sialin-like [KO:K12301]
134538546  sialin-like isoform X1 [KO:K12301]
134530320  sialin-like [KO:K12301]
134530567  sialin-like [KO:K12301]
134530787  sialin-like [KO:K12301]
134530788  sialin-like [KO:K12301]
134530789  sialin-like isoform X1 [KO:K12301]
134530816  sialin-like isoform X1 [KO:K12301]
134531039  sialin-like [KO:K12301]
134531449  sialin-like [KO:K12301]
134531450  sialin-like isoform X1 [KO:K12301]
134531451  sialin-like isoform X1 [KO:K12301]
134531452  sialin-like [KO:K12301]
134531453  sialin-like isoform X1 [KO:K12301]
134540711  putative inorganic phosphate cotransporter [KO:K12301]
134529154  protein Malvolio isoform X1 [KO:K21398]
134530523  lysosomal-associated transmembrane protein 4A [KO:K12387]
134537869  integumentary mucin C.1-like [KO:K06546]
134529804  battenin isoform X1 [KO:K12389]
134537478  major facilitator superfamily domain-containing protein 8 [KO:K12307]
134528063  heparan-alpha-glucosaminide N-acetyltransferase-like isoform X1 [KO:K10532] [EC:2.3.1.78]
134539516  heparan-alpha-glucosaminide N-acetyltransferase [KO:K10532] [EC:2.3.1.78]
134533888  formylglycine-generating enzyme [KO:K13444] [EC:1.8.3.7]
134532950  clathrin heavy chain isoform X1 [KO:K04646]
134532652  AP-1 complex subunit gamma-1 isoform X1 [KO:K12391]
134529392  AP-2 complex subunit beta [KO:K12392]
134536748  AP-1 complex subunit mu-1 [KO:K12393]
134537111  AP-1 complex subunit sigma-2 isoform X1 [KO:K12394]
134536101  AP-3 complex subunit delta-1 isoform X1 [KO:K12396]
134534920  AP-3 complex subunit beta-2 [KO:K12397]
134543190  AP-3 complex subunit mu-1 isoform X1 [KO:K12398]
134528271  AP-3 complex subunit sigma-1 [KO:K12399]
134539873  ADP-ribosylation factor-binding protein GGA1 isoform X1 [KO:K12404]
134540909  lipopolysaccharide-induced tumor necrosis factor-alpha factor homolog [KO:K19363]
134534044  LITAF domain-containing protein isoform X1 [KO:K19363]
134534265  lipopolysaccharide-induced tumor necrosis factor-alpha factor homolog [KO:K19363]
134540691  lipopolysaccharide-induced tumor necrosis factor-alpha factor homolog [KO:K19363]
134540727  lipopolysaccharide-induced tumor necrosis factor-alpha factor homolog [KO:K19363]
Compound
C00002  ATP
C00008  ADP
C00159  D-Mannose
C00275  D-Mannose 6-phosphate
Reference
PMID:12628346
  Authors
Eskelinen EL, Tanaka Y, Saftig P
  Title
At the acidic edge: emerging functions for lysosomal membrane proteins.
  Journal
Trends Cell Biol 13:137-45 (2003)
DOI:10.1016/S0962-8924(03)00005-9
Reference
PMID:1883197
  Authors
Neufeld EF
  Title
Lysosomal storage diseases.
  Journal
Annu Rev Biochem 60:257-80 (1991)
DOI:10.1146/annurev.bi.60.070191.001353
Reference
PMID:2943218
  Authors
von Figura K, Hasilik A
  Title
Lysosomal enzymes and their receptors.
  Journal
Annu Rev Biochem 55:167-93 (1986)
DOI:10.1146/annurev.bi.55.070186.001123
Reference
PMID:15987739
  Authors
Janvier K, Bonifacino JS
  Title
Role of the endocytic machinery in the sorting of lysosome-associated membrane proteins.
  Journal
Mol Biol Cell 16:4231-42 (2005)
DOI:10.1091/mbc.E05-03-0213
Reference
PMID:18635948
  Authors
Vergarajauregui S, Puertollano R
  Title
Mucolipidosis type IV: the importance of functional lysosomes for efficient autophagy.
  Journal
Autophagy 4:832-4 (2008)
DOI:10.4161/auto.6567
Reference
PMID:34249946
  Authors
Jaskolka MC, Winkley SR, Kane PM
  Title
RAVE and Rabconnectin-3 Complexes as Signal Dependent Regulators of Organelle Acidification.
  Journal
Front Cell Dev Biol 9:698190 (2021)
DOI:10.3389/fcell.2021.698190
Reference
PMID:34646033
  Authors
Majdoul S, Compton AA
  Title
Lessons in self-defence: inhibition of virus entry by intrinsic immunity.
  Journal
Nat Rev Immunol 10.1038/s41577-021-00626-8 (2021)
DOI:10.1038/s41577-021-00626-8
Related
pathway
bror00511  Other glycan degradation
bror00531  Glycosaminoglycan degradation
bror04130  SNARE interactions in vesicular transport
bror04140  Autophagy - animal
bror04144  Endocytosis
KO pathway
ko04142   
LinkDB

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