KEGG   PATHWAY: bsaf00260
Entry
bsaf00260                   Pathway                                
Name
Glycine, serine and threonine metabolism - Bacillus safensis
Description
Serine is derived from 3-phospho-D-glycerate, an intermediate of glycolysis [MD:M00020], and glycine is derived from serine. Threonine is an essential amino acid, which animals cannot synthesize. In bacteria and plants, threonine is derived from aspartate [MD:M00018].
Class
Metabolism; Amino acid metabolism
Pathway map
bsaf00260  Glycine, serine and threonine metabolism
bsaf00260

Module
bsaf_M00018  Threonine biosynthesis, aspartate => homoserine => threonine [PATH:bsaf00260]
bsaf_M00020  Serine biosynthesis, glycerate-3P => serine [PATH:bsaf00260]
bsaf_M00555  Betaine biosynthesis, choline => betaine [PATH:bsaf00260]
bsaf_M00621  Glycine cleavage system [PATH:bsaf00260]
Other DBs
GO: 0006544 0006563 0070178 0006566
Organism
Bacillus safensis [GN:bsaf]
Gene
BSL056_08200  aspartate kinase [KO:K00928] [EC:2.7.2.4]
BSL056_02090  aspartate kinase [KO:K00928] [EC:2.7.2.4]
BSL056_14240  aspartate kinase [KO:K00928] [EC:2.7.2.4]
BSL056_08195  aspartate-semialdehyde dehydrogenase [KO:K00133] [EC:1.2.1.11]
BSL056_16250  homoserine dehydrogenase [KO:K00003] [EC:1.1.1.3]
BSL056_16240  homoserine kinase [KO:K00872] [EC:2.7.1.39]
BSL056_16245  threonine synthase [KO:K01733] [EC:4.2.3.1]
BSL056_09765  threonine synthase [KO:K01733] [EC:4.2.3.1]
BSL056_18335  serine hydroxymethyltransferase [KO:K00600] [EC:2.1.2.1]
BSL056_17300  bifunctional glyoxylate/hydroxypyruvate reductase B [KO:K00090] [EC:1.1.1.79 1.1.1.81 1.1.1.215]
BSL056_19680  glycerate kinase [KO:K00865] [EC:2.7.1.165]
BSL056_04405  histidine phosphatase family protein [KO:K01834] [EC:5.4.2.11]
BSL056_17045  phosphoglycerate mutase (2,3-diphosphoglycerate-independent) [KO:K15633] [EC:5.4.2.12]
BSL056_11390  phosphoglycerate dehydrogenase [KO:K00058] [EC:1.1.1.95 1.1.1.399]
BSL056_05030  phosphoserine transaminase [KO:K00831] [EC:2.6.1.52]
BSL056_14395  haloacid dehalogenase [KO:K25528] [EC:3.1.3.3]
BSL056_08330  8-amino-7-oxononanoate synthase [KO:K00639] [EC:2.3.1.29]
BSL056_08325  L-threonine 3-dehydrogenase [KO:K00060] [EC:1.1.1.103]
BSL056_12130  glycine dehydrogenase (aminomethyl-transferring) [KO:K00282] [EC:1.4.4.2]
BSL056_12125  glycine dehydrogenase (aminomethyl-transferring) [KO:K00283] [EC:1.4.4.2]
BSL056_12135  glycine cleavage system protein T [KO:K00605] [EC:2.1.2.10]
BSL056_06040  dihydrolipoyl dehydrogenase [KO:K00382] [EC:1.8.1.4]
BSL056_11915  dihydrolipoyl dehydrogenase [KO:K00382] [EC:1.8.1.4]
BSL056_02580  dihydrolipoyl dehydrogenase [KO:K00382] [EC:1.8.1.4]
BSL056_06210  dihydrolipoyl dehydrogenase [KO:K00382] [EC:1.8.1.4]
BSL056_07050  dihydrolipoyl dehydrogenase [KO:K00382] [EC:1.8.1.4]
BSL056_16495  glycine cleavage system protein H [KO:K02437]
BSL056_15495  alcohol dehydrogenase [KO:K11440] [EC:1.1.1.1]
BSL056_15500  betaine-aldehyde dehydrogenase [KO:K00130] [EC:1.2.1.8]
BSL056_12965  cystathionine gamma-synthase [KO:K17217] [EC:4.4.1.1 4.4.1.2]
BSL056_07715  L-serine dehydratase, iron-sulfur-dependent subunit beta [KO:K01752] [EC:4.3.1.17]
BSL056_07720  L-serine dehydratase, iron-sulfur-dependent subunit alpha [KO:K01752] [EC:4.3.1.17]
BSL056_10740  threonine dehydratase [KO:K01754] [EC:4.3.1.19]
BSL056_11155  tryptophan synthase subunit alpha [KO:K01695] [EC:4.2.1.20]
BSL056_11160  tryptophan synthase subunit beta [KO:K01696] [EC:4.2.1.20]
BSL056_05395  diaminobutyrate--2-oxoglutarate transaminase [KO:K00836] [EC:2.6.1.76]
BSL056_05400  aspartate aminotransferase family protein [KO:K13745] [EC:4.1.1.86]
BSL056_03800  aspartate aminotransferase family protein [KO:K13745] [EC:4.1.1.86]
Compound
C00011  CO2
C00014  Ammonia
C00022  Pyruvate
C00037  Glycine
C00048  Glyoxylate
C00049  L-Aspartate
C00065  L-Serine
C00078  L-Tryptophan
C00097  L-Cysteine
C00101  Tetrahydrofolate
C00109  2-Oxobutanoate
C00114  Choline
C00143  5,10-Methylenetetrahydrofolate
C00168  Hydroxypyruvate
C00188  L-Threonine
C00197  3-Phospho-D-glycerate
C00213  Sarcosine
C00258  D-Glycerate
C00263  L-Homoserine
C00300  Creatine
C00430  5-Aminolevulinate
C00441  L-Aspartate 4-semialdehyde
C00546  Methylglyoxal
C00576  Betaine aldehyde
C00581  Guanidinoacetate
C00631  2-Phospho-D-glycerate
C00719  Betaine
C00740  D-Serine
C00986  1,3-Diaminopropane
C01005  O-Phospho-L-serine
C01026  N,N-Dimethylglycine
C01102  O-Phospho-L-homoserine
C01242  [Protein]-S8-aminomethyldihydrolipoyllysine
C01888  Aminoacetone
C02051  Lipoylprotein
C02291  L-Cystathionine
C02737  Phosphatidylserine
C02972  Dihydrolipoylprotein
C03082  4-Phospho-L-aspartate
C03194  (R)-1-Aminopropan-2-ol
C03232  3-Phosphonooxypyruvate
C03283  L-2,4-Diaminobutanoate
C03508  L-2-Amino-3-oxobutanoic acid
C05519  L-Allothreonine
C06231  Ectoine
C06442  N(gamma)-Acetyldiaminobutyrate
C16432  5-Hydroxyectoine
C19929  N(alpha)-Acetyl-L-2,4-diaminobutyrate
Reference
  Authors
Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).
  Title
[Cellular Functions and Metabolic Maps] (In Japanese)
  Journal
Tokyo Kagaku Dojin (1997)
Reference
PMID:11823218
  Authors
Kuhlmann AU, Bremer E.
  Title
Osmotically regulated synthesis of the compatible solute ectoine in Bacillus pasteurii and related Bacillus spp.
  Journal
Appl Environ Microbiol 68:772-83 (2002)
DOI:10.1128/AEM.68.2.772-783.2002
Reference
PMID:10473374
  Authors
Canovas D, Borges N, Vargas C, Ventosa A, Nieto JJ, Santos H.
  Title
Role of Ngamma-acetyldiaminobutyrate as an enzyme stabilizer and an intermediate in the biosynthesis of hydroxyectoine.
  Journal
Appl Environ Microbiol 65:3774-9 (1999)
DOI:10.1128/AEM.65.9.3774-3779.1999
Reference
PMID:17636255
  Authors
Bursy J, Pierik AJ, Pica N, Bremer E.
  Title
Osmotically induced synthesis of the compatible solute hydroxyectoine is mediated by an evolutionarily conserved ectoine hydroxylase.
  Journal
J Biol Chem 282:31147-55 (2007)
DOI:10.1074/jbc.M704023200
Reference
PMID:16707670
  Authors
Garcia-Estepa R, Argandona M, Reina-Bueno M, Capote N, Iglesias-Guerra F, Nieto JJ, Vargas C.
  Title
The ectD gene, which is involved in the synthesis of the compatible solute hydroxyectoine, is essential for thermoprotection of the halophilic bacterium Chromohalobacter salexigens.
  Journal
J Bacteriol 188:3774-84 (2006)
DOI:10.1128/JB.00136-06
Reference
PMID:15470257
  Authors
Arevalo-Rodriguez M, Pan X, Boeke JD, Heitman J
  Title
FKBP12 controls aspartate pathway flux in Saccharomyces cerevisiae to prevent toxic intermediate accumulation.
  Journal
Eukaryot Cell 3:1287-96 (2004)
DOI:10.1128/EC.3.5.1287-1296.2004
Reference
PMID:7639721
  Authors
Rees WD, Hay SM
  Title
The biosynthesis of threonine by mammalian cells: expression of a complete bacterial biosynthetic pathway in an animal cell.
  Journal
Biochem J 309 ( Pt 3):999-1007 (1995)
DOI:10.1042/bj3090999
Reference
PMID:11341914
  Authors
Jacques SL, Nieman C, Bareich D, Broadhead G, Kinach R, Honek JF, Wright GD
  Title
Characterization of yeast homoserine dehydrogenase, an antifungal target: the invariant histidine 309 is important for enzyme integrity.
  Journal
Biochim Biophys Acta 1544:28-41 (2001)
DOI:10.1016/S0167-4838(00)00203-X
Reference
PMID:15520012
  Authors
Chen X, Jhee KH, Kruger WD
  Title
Production of the neuromodulator H2S by cystathionine beta-synthase via the condensation of cysteine and homocysteine.
  Journal
J Biol Chem 279:52082-6 (2004)
DOI:10.1074/jbc.C400481200
Related
pathway
bsaf00010  Glycolysis / Gluconeogenesis
bsaf00020  Citrate cycle (TCA cycle)
bsaf00230  Purine metabolism
bsaf00250  Alanine, aspartate and glutamate metabolism
bsaf00270  Cysteine and methionine metabolism
bsaf00290  Valine, leucine and isoleucine biosynthesis
bsaf00300  Lysine biosynthesis
bsaf00330  Arginine and proline metabolism
bsaf00460  Cyanoamino acid metabolism
bsaf00470  D-Amino acid metabolism
bsaf00564  Glycerophospholipid metabolism
bsaf00600  Sphingolipid metabolism
bsaf00620  Pyruvate metabolism
bsaf00630  Glyoxylate and dicarboxylate metabolism
bsaf00640  Propanoate metabolism
bsaf00680  Methane metabolism
bsaf00860  Porphyrin metabolism
bsaf00920  Sulfur metabolism
KO pathway
ko00260   
LinkDB

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