KEGG   PATHWAY: bsg00260
Entry
bsg00260                    Pathway                                
Name
Glycine, serine and threonine metabolism - Brucella suis ZW046
Description
Serine is derived from 3-phospho-D-glycerate, an intermediate of glycolysis [MD:M00020], and glycine is derived from serine. Threonine is an essential amino acid, which animals cannot synthesize. In bacteria and plants, threonine is derived from aspartate [MD:M00018].
Class
Metabolism; Amino acid metabolism
Pathway map
bsg00260  Glycine, serine and threonine metabolism
bsg00260

Module
bsg_M00018  Threonine biosynthesis, aspartate => homoserine => threonine [PATH:bsg00260]
bsg_M00020  Serine biosynthesis, glycerate-3P => serine [PATH:bsg00260]
bsg_M00555  Betaine biosynthesis, choline => betaine [PATH:bsg00260]
bsg_M00621  Glycine cleavage system [PATH:bsg00260]
Other DBs
GO: 0006544 0006563 0070178 0006566
Organism
Brucella suis ZW046 [GN:bsg]
Gene
IY72_08930  aspartate kinase [KO:K00928] [EC:2.7.2.4]
IY72_15370  aspartate-semialdehyde dehydrogenase [KO:K00133] [EC:1.2.1.11]
IY72_06045  homoserine dehydrogenase [KO:K00003] [EC:1.1.1.3]
IY72_02155  serine kinase [KO:K02204] [EC:2.7.1.39]
IY72_02195  threonine synthase [KO:K01733] [EC:4.2.3.1]
IY72_10905  threonine aldolase [KO:K01620] [EC:4.1.2.48]
IY72_03560  glyA; serine hydroxymethyltransferase [KO:K00600] [EC:2.1.2.1]
IY72_10770  2-hydroxyacid dehydrogenase [KO:K12972] [EC:1.1.1.79 1.1.1.81]
IY72_01590  hydroxypyruvate reductase [KO:K11529] [EC:2.7.1.165]
IY72_16190  phosphoglyceromutase [KO:K01834] [EC:5.4.2.11]
IY72_08080  3-phosphoglycerate dehydrogenase [KO:K00058] [EC:1.1.1.95 1.1.1.399]
IY72_12890  3-phosphoglycerate dehydrogenase [KO:K00058] [EC:1.1.1.95 1.1.1.399]
IY72_08090  phosphoserine aminotransferase [KO:K00831] [EC:2.6.1.52]
IY72_06610  phosphoserine phosphatase [KO:K01079] [EC:3.1.3.3]
IY72_01425  5-aminolevulinate synthase [KO:K00643] [EC:2.3.1.37]
IY72_14600  glycine dehydrogenase [KO:K00281] [EC:1.4.4.2]
IY72_14610  glycine cleavage system protein T [KO:K00605] [EC:2.1.2.10]
IY72_05340  dihydrolipoamide dehydrogenase [KO:K00382] [EC:1.8.1.4]
IY72_09155  dihydrolipoamide dehydrogenase [KO:K00382] [EC:1.8.1.4]
IY72_13225  dihydrolipoamide dehydrogenase [KO:K00382] [EC:1.8.1.4]
IY72_14605  glycine cleavage system protein H [KO:K02437]
IY72_02000  CDP-diacylglycerol--serine O-phosphatidyltransferase [KO:K17103] [EC:2.7.8.8]
IY72_02555  choline dehydrogenase [KO:K00108] [EC:1.1.99.1]
IY72_02550  betaine-aldehyde dehydrogenase [KO:K00130] [EC:1.2.1.8]
IY72_06935  Rieske (2Fe-2S) protein [KO:K00479] [EC:1.14.13.251]
IY72_06940  NADH oxidase [KO:K21832] [EC:1.14.13.251]
IY72_00985  sarcosine oxidase subunit alpha [KO:K00302] [EC:1.5.3.24 1.5.3.1]
IY72_00975  sarcosine oxidase subunit beta [KO:K00303] [EC:1.5.3.24 1.5.3.1]
IY72_00990  sarcosine oxidase subunit gamma [KO:K00305] [EC:1.5.3.24 1.5.3.1]
IY72_00980  sarcosine oxidase subunit delta [KO:K00304] [EC:1.5.3.24 1.5.3.1]
IY72_05565  serine dehydratase [KO:K01752] [EC:4.3.1.17]
IY72_04955  threonine dehydratase [KO:K01754] [EC:4.3.1.19]
IY72_10365  trpA; tryptophan synthase subunit alpha [KO:K01695] [EC:4.2.1.20]
IY72_10375  tryptophan synthase subunit beta [KO:K01696] [EC:4.2.1.20]
Compound
C00011  CO2
C00014  Ammonia
C00022  Pyruvate
C00037  Glycine
C00048  Glyoxylate
C00049  L-Aspartate
C00065  L-Serine
C00078  L-Tryptophan
C00097  L-Cysteine
C00101  Tetrahydrofolate
C00109  2-Oxobutanoate
C00114  Choline
C00143  5,10-Methylenetetrahydrofolate
C00168  Hydroxypyruvate
C00188  L-Threonine
C00197  3-Phospho-D-glycerate
C00213  Sarcosine
C00258  D-Glycerate
C00263  L-Homoserine
C00300  Creatine
C00430  5-Aminolevulinate
C00441  L-Aspartate 4-semialdehyde
C00546  Methylglyoxal
C00576  Betaine aldehyde
C00581  Guanidinoacetate
C00631  2-Phospho-D-glycerate
C00719  Betaine
C00740  D-Serine
C00986  1,3-Diaminopropane
C01005  O-Phospho-L-serine
C01026  N,N-Dimethylglycine
C01102  O-Phospho-L-homoserine
C01242  [Protein]-S8-aminomethyldihydrolipoyllysine
C01888  Aminoacetone
C02051  Lipoylprotein
C02291  L-Cystathionine
C02737  Phosphatidylserine
C02972  Dihydrolipoylprotein
C03082  4-Phospho-L-aspartate
C03194  (R)-1-Aminopropan-2-ol
C03232  3-Phosphonooxypyruvate
C03283  L-2,4-Diaminobutanoate
C03508  L-2-Amino-3-oxobutanoic acid
C05519  L-Allothreonine
C06231  Ectoine
C06442  N(gamma)-Acetyldiaminobutyrate
C16432  5-Hydroxyectoine
C19929  N(alpha)-Acetyl-L-2,4-diaminobutyrate
Reference
  Authors
Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).
  Title
[Cellular Functions and Metabolic Maps] (In Japanese)
  Journal
Tokyo Kagaku Dojin (1997)
Reference
PMID:11823218
  Authors
Kuhlmann AU, Bremer E.
  Title
Osmotically regulated synthesis of the compatible solute ectoine in Bacillus pasteurii and related Bacillus spp.
  Journal
Appl Environ Microbiol 68:772-83 (2002)
DOI:10.1128/AEM.68.2.772-783.2002
Reference
PMID:10473374
  Authors
Canovas D, Borges N, Vargas C, Ventosa A, Nieto JJ, Santos H.
  Title
Role of Ngamma-acetyldiaminobutyrate as an enzyme stabilizer and an intermediate in the biosynthesis of hydroxyectoine.
  Journal
Appl Environ Microbiol 65:3774-9 (1999)
DOI:10.1128/AEM.65.9.3774-3779.1999
Reference
PMID:17636255
  Authors
Bursy J, Pierik AJ, Pica N, Bremer E.
  Title
Osmotically induced synthesis of the compatible solute hydroxyectoine is mediated by an evolutionarily conserved ectoine hydroxylase.
  Journal
J Biol Chem 282:31147-55 (2007)
DOI:10.1074/jbc.M704023200
Reference
PMID:16707670
  Authors
Garcia-Estepa R, Argandona M, Reina-Bueno M, Capote N, Iglesias-Guerra F, Nieto JJ, Vargas C.
  Title
The ectD gene, which is involved in the synthesis of the compatible solute hydroxyectoine, is essential for thermoprotection of the halophilic bacterium Chromohalobacter salexigens.
  Journal
J Bacteriol 188:3774-84 (2006)
DOI:10.1128/JB.00136-06
Reference
PMID:15470257
  Authors
Arevalo-Rodriguez M, Pan X, Boeke JD, Heitman J
  Title
FKBP12 controls aspartate pathway flux in Saccharomyces cerevisiae to prevent toxic intermediate accumulation.
  Journal
Eukaryot Cell 3:1287-96 (2004)
DOI:10.1128/EC.3.5.1287-1296.2004
Reference
PMID:7639721
  Authors
Rees WD, Hay SM
  Title
The biosynthesis of threonine by mammalian cells: expression of a complete bacterial biosynthetic pathway in an animal cell.
  Journal
Biochem J 309 ( Pt 3):999-1007 (1995)
DOI:10.1042/bj3090999
Reference
PMID:11341914
  Authors
Jacques SL, Nieman C, Bareich D, Broadhead G, Kinach R, Honek JF, Wright GD
  Title
Characterization of yeast homoserine dehydrogenase, an antifungal target: the invariant histidine 309 is important for enzyme integrity.
  Journal
Biochim Biophys Acta 1544:28-41 (2001)
DOI:10.1016/S0167-4838(00)00203-X
Reference
PMID:15520012
  Authors
Chen X, Jhee KH, Kruger WD
  Title
Production of the neuromodulator H2S by cystathionine beta-synthase via the condensation of cysteine and homocysteine.
  Journal
J Biol Chem 279:52082-6 (2004)
DOI:10.1074/jbc.C400481200
Related
pathway
bsg00010  Glycolysis / Gluconeogenesis
bsg00020  Citrate cycle (TCA cycle)
bsg00230  Purine metabolism
bsg00250  Alanine, aspartate and glutamate metabolism
bsg00270  Cysteine and methionine metabolism
bsg00290  Valine, leucine and isoleucine biosynthesis
bsg00300  Lysine biosynthesis
bsg00330  Arginine and proline metabolism
bsg00460  Cyanoamino acid metabolism
bsg00470  D-Amino acid metabolism
bsg00564  Glycerophospholipid metabolism
bsg00620  Pyruvate metabolism
bsg00630  Glyoxylate and dicarboxylate metabolism
bsg00640  Propanoate metabolism
bsg00680  Methane metabolism
bsg00860  Porphyrin metabolism
bsg00920  Sulfur metabolism
KO pathway
ko00260   
LinkDB

DBGET integrated database retrieval system