Entry
Name
ABC transporters - Chelonoidis abingdonii (Abingdon island giant tortoise)
Description
The ATP-binding cassette (ABC) transporters form one of the largest known protein families, and are widespread in bacteria, archaea, and eukaryotes. They couple ATP hydrolysis to active transport of a wide variety of substrates such as ions, sugars, lipids, sterols, peptides, proteins, and drugs. The structure of a prokaryotic ABC transporter usually consists of three components; typically two integral membrane proteins each having six transmembrane segments, two peripheral proteins that bind and hydrolyze ATP, and a periplasmic (or lipoprotein) substrate-binding protein. Many of the genes for the three components form operons as in fact observed in many bacterial and archaeal genomes. On the other hand, in a typical eukaryotic ABC transporter, the membrane spanning protein and the ATP-binding protein are fused, forming a multi-domain protein with the membrane-spanning domain (MSD) and the nucleotide-binding domain (NBD).
Class
Environmental Information Processing; Membrane transport
BRITE hierarchy
Pathway map
Ortholog table
Other DBs
Organism
Chelonoidis abingdonii (Abingdon island giant tortoise) [GN:
cabi ]
Gene
116820644 ABCA1; phospholipid-transporting ATPase ABCA1 isoform X1 [KO:K05641 ]
116828036 ABCA7; LOW QUALITY PROTEIN: phospholipid-transporting ATPase ABCA7 [KO:K05641 ]
116824674 ABCA2; ATP-binding cassette sub-family A member 2 isoform X1 [KO:K05642 ]
116823379 ABCA4; retinal-specific phospholipid-transporting ATPase ABCA4 [KO:K05644 ]
116832038 ABCA13; LOW QUALITY PROTEIN: ATP-binding cassette sub-family A member 13 [KO:K05647 ]
116834877 ATP-binding cassette sub-family A member 9-like isoform X1 [KO:K05651 ]
116834204 ABCB8; mitochondrial potassium channel ATP-binding subunit [KO:K05655 ]
116836795 ABCB9; ATP-binding cassette sub-family B member 9 isoform X1 [KO:K05656 ]
116826832 ABCB10; ATP-binding cassette sub-family B member 10, mitochondrial isoform X1 [KO:K05657 ]
116816795 LOW QUALITY PROTEIN: ATP-dependent translocase ABCB1-like [KO:K05660 ]
116816801 LOW QUALITY PROTEIN: ATP-dependent translocase ABCB1-like [KO:K05660 ]
116831551 ABCB6; LOW QUALITY PROTEIN: ATP-binding cassette sub-family B member 6, mitochondrial [KO:K05661 ]
116828889 ABCB7; ATP-binding cassette sub-family B member 7, mitochondrial isoform X1 [KO:K05662 ]
116817639 ABCC2; canalicular multispecific organic anion transporter 1 isoform X1 [KO:K05666 ]
116827531 ABCC3; canalicular multispecific organic anion transporter 2 isoform X1 [KO:K05667 ]
116838540 ABCC5; multidrug resistance-associated protein 5 isoform X1 [KO:K05668 ]
116830837 ABCC6; multidrug resistance-associated protein 6 isoform X1 [KO:K05669 ]
116819045 ABCC10; multidrug resistance-associated protein 7 isoform X1 [KO:K05674 ]
116828569 multidrug resistance-associated protein 1-like isoform X1 [KO:K05670 ]
116835930 ABCC8; ATP-binding cassette sub-family C member 8 isoform X1 [KO:K05032 ]
116835474 ABCC9; ATP-binding cassette sub-family C member 9 isoform X1 [KO:K05033 ]
116823584 broad substrate specificity ATP-binding cassette transporter ABCG2-like [KO:K05681 ]
116833591 broad substrate specificity ATP-binding cassette transporter ABCG2-like [KO:K05681 ]
116836542 broad substrate specificity ATP-binding cassette transporter ABCG2-like [KO:K05681 ]
116836543 broad substrate specificity ATP-binding cassette transporter ABCG2-like isoform X1 [KO:K05681 ]
116821658 ABCG5; LOW QUALITY PROTEIN: ATP-binding cassette sub-family G member 5 [KO:K05683 ]
116821559 ABCG8; LOW QUALITY PROTEIN: ATP-binding cassette sub-family G member 8 [KO:K05684 ]
Compound
C00093 sn-Glycerol 3-phosphate
C01153 Orthophosphoric monoester
C01181 4-Trimethylammoniobutanoate
C01279 4-Amino-5-hydroxymethyl-2-methylpyrimidine
C03557 2-Aminoethylphosphonate
C03611 Galactose oligosaccharide
C03619 Methyl beta-D-galactoside
C04114 (E)-4-(Trimethylammonio)but-2-enoate
C06705 Capsular polysaccharide
C19872 N-Formyl-4-amino-5-aminomethyl-2-methylpyrimidine
C20570 alpha-1,5-L-Arabinobiose
C20571 alpha-1,5-L-Arabinotriose
C20572 alpha-1,5-L-Arabinotetraose
Reference
Authors
Tomii K, Kanehisa M.
Title
A comparative analysis of ABC transporters in complete microbial genomes.
Journal
Reference
Authors
Sperandeo P, Lau FK, Carpentieri A, De Castro C, Molinaro A, Deho G, Silhavy TJ, Polissi A
Title
Functional analysis of the protein machinery required for transport of lipopolysaccharide to the outer membrane of Escherichia coli.
Journal
Reference
Authors
Ruiz N, Gronenberg LS, Kahne D, Silhavy TJ
Title
Identification of two inner-membrane proteins required for the transport of lipopolysaccharide to the outer membrane of Escherichia coli.
Journal
Reference
Authors
Omata T, Price GD, Badger MR, Okamura M, Gohta S, Ogawa T
Title
Identification of an ATP-binding cassette transporter involved in bicarbonate uptake in the cyanobacterium Synechococcus sp. strain PCC 7942.
Journal
Reference
Authors
Quintero MJ, Montesinos ML, Herrero A, Flores E
Title
Identification of genes encoding amino acid permeases by inactivation of selected ORFs from the Synechocystis genomic sequence.
Journal
Reference
Authors
Picossi S, Montesinos ML, Pernil R, Lichtle C, Herrero A, Flores E
Title
ABC-type neutral amino acid permease N-I is required for optimal diazotrophic growth and is repressed in the heterocysts of Anabaena sp. strain PCC 7120.
Journal
Reference
Authors
Valladares A, Montesinos ML, Herrero A, Flores E.
Title
An ABC-type, high-affinity urea permease identified in cyanobacteria.
Journal
Reference
Authors
Richard-Fogal CL, Frawley ER, Kranz RG
Title
Topology and function of CcmD in cytochrome c maturation.
Journal
Reference
Authors
Suzuki H, Koyanagi T, Izuka S, Onishi A, Kumagai H
Title
The yliA, -B, -C, and -D genes of Escherichia coli K-12 encode a novel glutathione importer with an ATP-binding cassette.
Journal
Reference
Authors
Novikova M, Metlitskaya A, Datsenko K, Kazakov T, Kazakov A, Wanner B, Severinov K
Title
The Escherichia coli Yej transporter is required for the uptake of translation inhibitor microcin C.
Journal
Reference
Authors
Tikhonova EB, Devroy VK, Lau SY, Zgurskaya HI
Title
Reconstitution of the Escherichia coli macrolide transporter: the periplasmic membrane fusion protein MacA stimulates the ATPase activity of MacB.
Journal
Reference
Authors
Yamanaka H, Kobayashi H, Takahashi E, Okamoto K
Title
MacAB is involved in the secretion of Escherichia coli heat-stable enterotoxin II.
Journal
KO pathway
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