KEGG   PATHWAY: cal00260
Entry
cal00260                    Pathway                                
Name
Glycine, serine and threonine metabolism - Candida albicans
Description
Serine is derived from 3-phospho-D-glycerate, an intermediate of glycolysis [MD:M00020], and glycine is derived from serine. Threonine is an essential amino acid, which animals cannot synthesize. In bacteria and plants, threonine is derived from aspartate [MD:M00018].
Class
Metabolism; Amino acid metabolism
Pathway map
cal00260  Glycine, serine and threonine metabolism
cal00260

Module
cal_M00018  Threonine biosynthesis, aspartate => homoserine => threonine [PATH:cal00260]
cal_M00020  Serine biosynthesis, glycerate-3P => serine [PATH:cal00260]
cal_M00338  Cysteine biosynthesis, homocysteine + serine => cysteine [PATH:cal00260]
cal_M00621  Glycine cleavage system [PATH:cal00260]
Other DBs
GO: 0006544 0006563 0070178 0006566
Organism
Candida albicans [GN:cal]
Gene
CAALFM_C405540WA  HOM3; aspartate kinase [KO:K00928] [EC:2.7.2.4]
CAALFM_C202370CA  HOM2; aspartate-semialdehyde dehydrogenase [KO:K00133] [EC:1.2.1.11]
CAALFM_C102620CA  HOM6; homoserine dehydrogenase [KO:K00003] [EC:1.1.1.3]
CAALFM_C500650CA  THR1; homoserine kinase [KO:K00872] [EC:2.7.1.39]
CAALFM_C502270WA  THR4; threonine synthase [KO:K01733] [EC:4.2.3.1]
CAALFM_C110450WA  GLY1; Gly1p [KO:K01620] [EC:4.1.2.48]
CAALFM_CR04880WA  CaO19.6305; threonine aldolase [KO:K01620] [EC:4.1.2.48]
CAALFM_C603760CA  SHM2; glycine hydroxymethyltransferase [KO:K00600] [EC:2.1.2.1]
CAALFM_C703330CA  SHM1; glycine hydroxymethyltransferase [KO:K00600] [EC:2.1.2.1]
CAALFM_C104320WA  GPM2; Gpm2p [KO:K01834] [EC:5.4.2.11]
CAALFM_C203270WA  GPM1; phosphoglycerate mutase [KO:K01834] [EC:5.4.2.11]
CAALFM_CR09500CA  CaO19.7345; putative ATP-dependent kinase [KO:K15918] [EC:2.7.1.31]
CAALFM_C112030WA  SER33; phosphoglycerate dehydrogenase [KO:K00058] [EC:1.1.1.95 1.1.1.399]
CAALFM_C206210CA  SER1; O-phospho-L-serine:2-oxoglutarate transaminase [KO:K00831] [EC:2.6.1.52]
CAALFM_C202690WA  SER2; phosphoserine phosphatase [KO:K01079] [EC:3.1.3.3]
CAALFM_C401510WA  CaO19.4633; oxidoreductase [KO:K16066] [EC:1.1.1.381 1.1.1.-]
CAALFM_CR02000CA  HEM1; 5-aminolevulinate synthase [KO:K00643] [EC:2.3.1.37]
CAALFM_C206700WA  AMO2; Amo2p [KO:K00276] [EC:1.4.3.21]
CAALFM_C203120WA  AMO1; Amo1p [KO:K00276] [EC:1.4.3.21]
CAALFM_C108400CA  GCV2; glycine decarboxylase subunit P [KO:K00281] [EC:1.4.4.2]
CAALFM_C602500CA  GCV1; glycine decarboxylase subunit T [KO:K00605] [EC:2.1.2.10]
CAALFM_CR07400CA  LPD1; dihydrolipoyl dehydrogenase [KO:K00382] [EC:1.8.1.4]
CAALFM_C113680CA  GCV3; glycine decarboxylase subunit H [KO:K02437]
CAALFM_C103670CA  DAO1; Dao1p [KO:K00273] [EC:1.4.3.3]
CAALFM_C500450CA  IFG3; Ifg3p [KO:K00273] [EC:1.4.3.3]
CAALFM_C403380CA  DAO2; Dao2p [KO:K00273] [EC:1.4.3.3]
CAALFM_C111240CA  CHO1; CDP-diacylglycerol-serine O-phosphatidyltransferase [KO:K17103] [EC:2.7.8.8]
CAALFM_C101870CA  CYS4; cystathionine beta-synthase [KO:K01697] [EC:4.2.1.22]
CAALFM_CR08340WA  CYS3; cystathionine gamma-lyase [KO:K01758] [EC:4.4.1.1]
CAALFM_C206190WA  ILV1; threonine ammonia-lyase [KO:K01754] [EC:4.3.1.19]
CAALFM_C306280WA  CaO19.7404; L-serine/L-threonine ammonia-lyase [KO:K17989] [EC:4.3.1.17 4.3.1.19]
CAALFM_C201270WA  CHA1; Cha1p [KO:K17989] [EC:4.3.1.17 4.3.1.19]
CAALFM_C406110CA  TRP5; tryptophan synthase [KO:K01694] [EC:4.2.1.20]
Compound
C00011  CO2
C00014  Ammonia
C00022  Pyruvate
C00037  Glycine
C00048  Glyoxylate
C00049  L-Aspartate
C00065  L-Serine
C00078  L-Tryptophan
C00097  L-Cysteine
C00101  Tetrahydrofolate
C00109  2-Oxobutanoate
C00114  Choline
C00143  5,10-Methylenetetrahydrofolate
C00168  Hydroxypyruvate
C00188  L-Threonine
C00197  3-Phospho-D-glycerate
C00213  Sarcosine
C00258  D-Glycerate
C00263  L-Homoserine
C00300  Creatine
C00430  5-Aminolevulinate
C00441  L-Aspartate 4-semialdehyde
C00546  Methylglyoxal
C00576  Betaine aldehyde
C00581  Guanidinoacetate
C00631  2-Phospho-D-glycerate
C00719  Betaine
C00740  D-Serine
C00986  1,3-Diaminopropane
C01005  O-Phospho-L-serine
C01026  N,N-Dimethylglycine
C01102  O-Phospho-L-homoserine
C01242  [Protein]-S8-aminomethyldihydrolipoyllysine
C01888  Aminoacetone
C02051  Lipoylprotein
C02291  L-Cystathionine
C02737  Phosphatidylserine
C02972  Dihydrolipoylprotein
C03082  4-Phospho-L-aspartate
C03194  (R)-1-Aminopropan-2-ol
C03232  3-Phosphonooxypyruvate
C03283  L-2,4-Diaminobutanoate
C03508  L-2-Amino-3-oxobutanoic acid
C05519  L-Allothreonine
C06231  Ectoine
C06442  N(gamma)-Acetyldiaminobutyrate
C16432  5-Hydroxyectoine
C19929  N(alpha)-Acetyl-L-2,4-diaminobutyrate
Reference
  Authors
Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).
  Title
[Cellular Functions and Metabolic Maps] (In Japanese)
  Journal
Tokyo Kagaku Dojin (1997)
Reference
PMID:11823218
  Authors
Kuhlmann AU, Bremer E.
  Title
Osmotically regulated synthesis of the compatible solute ectoine in Bacillus pasteurii and related Bacillus spp.
  Journal
Appl Environ Microbiol 68:772-83 (2002)
DOI:10.1128/AEM.68.2.772-783.2002
Reference
PMID:10473374
  Authors
Canovas D, Borges N, Vargas C, Ventosa A, Nieto JJ, Santos H.
  Title
Role of Ngamma-acetyldiaminobutyrate as an enzyme stabilizer and an intermediate in the biosynthesis of hydroxyectoine.
  Journal
Appl Environ Microbiol 65:3774-9 (1999)
DOI:10.1128/AEM.65.9.3774-3779.1999
Reference
PMID:17636255
  Authors
Bursy J, Pierik AJ, Pica N, Bremer E.
  Title
Osmotically induced synthesis of the compatible solute hydroxyectoine is mediated by an evolutionarily conserved ectoine hydroxylase.
  Journal
J Biol Chem 282:31147-55 (2007)
DOI:10.1074/jbc.M704023200
Reference
PMID:16707670
  Authors
Garcia-Estepa R, Argandona M, Reina-Bueno M, Capote N, Iglesias-Guerra F, Nieto JJ, Vargas C.
  Title
The ectD gene, which is involved in the synthesis of the compatible solute hydroxyectoine, is essential for thermoprotection of the halophilic bacterium Chromohalobacter salexigens.
  Journal
J Bacteriol 188:3774-84 (2006)
DOI:10.1128/JB.00136-06
Reference
PMID:15470257
  Authors
Arevalo-Rodriguez M, Pan X, Boeke JD, Heitman J
  Title
FKBP12 controls aspartate pathway flux in Saccharomyces cerevisiae to prevent toxic intermediate accumulation.
  Journal
Eukaryot Cell 3:1287-96 (2004)
DOI:10.1128/EC.3.5.1287-1296.2004
Reference
PMID:7639721
  Authors
Rees WD, Hay SM
  Title
The biosynthesis of threonine by mammalian cells: expression of a complete bacterial biosynthetic pathway in an animal cell.
  Journal
Biochem J 309 ( Pt 3):999-1007 (1995)
DOI:10.1042/bj3090999
Reference
PMID:11341914
  Authors
Jacques SL, Nieman C, Bareich D, Broadhead G, Kinach R, Honek JF, Wright GD
  Title
Characterization of yeast homoserine dehydrogenase, an antifungal target: the invariant histidine 309 is important for enzyme integrity.
  Journal
Biochim Biophys Acta 1544:28-41 (2001)
DOI:10.1016/S0167-4838(00)00203-X
Reference
PMID:15520012
  Authors
Chen X, Jhee KH, Kruger WD
  Title
Production of the neuromodulator H2S by cystathionine beta-synthase via the condensation of cysteine and homocysteine.
  Journal
J Biol Chem 279:52082-6 (2004)
DOI:10.1074/jbc.C400481200
Related
pathway
cal00010  Glycolysis / Gluconeogenesis
cal00020  Citrate cycle (TCA cycle)
cal00230  Purine metabolism
cal00250  Alanine, aspartate and glutamate metabolism
cal00270  Cysteine and methionine metabolism
cal00290  Valine, leucine and isoleucine biosynthesis
cal00300  Lysine biosynthesis
cal00330  Arginine and proline metabolism
cal00460  Cyanoamino acid metabolism
cal00470  D-Amino acid metabolism
cal00564  Glycerophospholipid metabolism
cal00600  Sphingolipid metabolism
cal00620  Pyruvate metabolism
cal00630  Glyoxylate and dicarboxylate metabolism
cal00640  Propanoate metabolism
cal00680  Methane metabolism
cal00860  Porphyrin metabolism
cal00920  Sulfur metabolism
KO pathway
ko00260   
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