KEGG   PATHWAY: cam04148
Entry
cam04148                    Pathway                                
Name
Efferocytosis - Cicer arietinum (chickpea)
Class
Cellular Processes; Transport and catabolism
Pathway map
cam04148  Efferocytosis
cam04148

Organism
Cicer arietinum (chickpea) [GN:cam]
Gene
101499291  sphingosine kinase 1 [KO:K04718] [EC:2.7.1.91]
101496681  mitogen-activated protein kinase homolog NTF6 [KO:K04371] [EC:2.7.11.24]
101494029  mitogen-activated protein kinase kinase 6 [KO:K04368] [EC:2.7.12.2]
101500730  uncharacterized LOC101500730 [KO:K17398] [EC:2.1.1.37]
101497959  calcium-transporting ATPase 3, endoplasmic reticulum-type [KO:K05853] [EC:7.2.2.10]
101507352  protein-tyrosine-phosphatase IBR5 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
101513003  phospholipid-transporting ATPase 3-like [KO:K14802] [EC:7.6.2.1]
101513493  phospholipid-transporting ATPase 1-like [KO:K14802] [EC:7.6.2.1]
101506046  phospholipid-transporting ATPase 3-like [KO:K14802] [EC:7.6.2.1]
101489367  phospholipid-transporting ATPase 1-like [KO:K14802] [EC:7.6.2.1]
101500614  phospholipid-transporting ATPase 1-like [KO:K14802] [EC:7.6.2.1]
101493035  putative ALA-interacting subunit 2 [KO:K26935]
101506567  ALA-interacting subunit 3-like [KO:K26935]
101504967  ALA-interacting subunit 3-like [KO:K26935]
101488345  ALA-interacting subunit 1-like [KO:K26935]
101489166  ALA-interacting subunit 3-like [KO:K26935]
101509014  rac-like GTP-binding protein RAC2 [KO:K04392]
101509334  rac-like GTP-binding protein RAC2 [KO:K04392]
101504276  rac-like GTP-binding protein ARAC8 [KO:K04392]
101502829  rac-like GTP-binding protein ARAC7 [KO:K04392]
101500273  rac-like GTP-binding protein RHO1 [KO:K04392]
101498092  rac-like GTP-binding protein RAC13 [KO:K04392]
101507428  rac-like GTP-binding protein RAC1-like [KO:K04392]
101508512  rac-like GTP-binding protein RHO1 [KO:K04392]
101514432  calreticulin-3-like [KO:K08057]
101511865  calreticulin [KO:K08057]
101501628  calreticulin-3 [KO:K08057]
101506556  ras-related protein RHN1-like [KO:K07889]
101489102  ras-related protein RHN1 [KO:K07889]
101512595  ras-related protein RHN1-like [KO:K07889]
101489880  transforming growth factor-beta receptor-associated protein 1 [KO:K20177]
101515093  vacuolar protein sorting-associated protein 8 homolog [KO:K20178]
101504486  vacuolar protein-sorting-associated protein 11 homolog [KO:K20179]
101498618  protein VACUOLELESS1 [KO:K20180]
101506892  vacuolar protein sorting-associated protein 18 homolog [KO:K20181]
101504257  vacuolar protein-sorting-associated protein 33 homolog [KO:K20182]
101501247  vam6/Vps39-like protein [KO:K20183]
101514515  vam6/Vps39-like protein [KO:K20183]
101492342  vacuolar protein sorting-associated protein 41 homolog [KO:K20184]
101509216  ras-related protein Rab7-like [KO:K07897]
101498677  ras-related protein Rab7 [KO:K07897]
101504052  ras-related protein Rab7-like [KO:K07897]
101496247  ras-related protein Rab7 [KO:K07897]
101514161  ras-related protein Rab7-like [KO:K07897]
101510738  ras-related protein Rab7-like [KO:K07897]
101513957  ras-related protein Rab7-like [KO:K07897]
101513545  uncharacterized LOC101513545 [KO:K23678]
101492625  uncharacterized LOC101492625 [KO:K23678]
101515728  seven transmembrane protein 1 [KO:K23678]
101497220  arginase 1, mitochondrial [KO:K01476] [EC:3.5.3.1]
101494284  ornithine decarboxylase-like [KO:K01581] [EC:4.1.1.17]
101511521  cytochrome b-c1 complex subunit Rieske-4, mitochondrial-like [KO:K00411] [EC:7.1.1.8]
101509247  triacylglycerol lipase 2-like [KO:K01052] [EC:3.1.1.13]
101507810  triacylglycerol lipase 1 [KO:K01052] [EC:3.1.1.13]
Compound
C00002  ATP
C00003  NAD+
C00019  S-Adenosyl-L-methionine
C00031  D-Glucose
C00062  L-Arginine
C00073  L-Methionine
C00075  UTP
C00077  L-Ornithine
C00134  Putrescine
C00162  Fatty acid
C00186  (S)-Lactate
C00187  Cholesterol
C00584  Prostaglandin E2
C02530  Cholesterol ester
C02737  Phosphatidylserine
C04230  1-Acyl-sn-glycero-3-phosphocholine
C06124  Sphingosine 1-phosphate
C06314  Lipoxin A4
C15519  25-Hydroxycholesterol
C15610  Cholest-5-ene-3beta,26-diol
C18178  Resolvin D1
Reference
PMID:31822793
  Authors
Doran AC, Yurdagul A Jr, Tabas I
  Title
Efferocytosis in health and disease.
  Journal
Nat Rev Immunol 20:254-267 (2020)
DOI:10.1038/s41577-019-0240-6
Reference
PMID:36028471
  Authors
Zhang J, Ding W, Zhao M, Liu J, Xu Y, Wan J, Wang M
  Title
Mechanisms of efferocytosis in determining inflammation resolution: Therapeutic potential and the association with cardiovascular disease.
  Journal
Br J Pharmacol 179:5151-5171 (2022)
DOI:10.1111/bph.15939
Reference
PMID:30165442
  Authors
Kawano M, Nagata S
  Title
Efferocytosis and autoimmune disease.
  Journal
Int Immunol 30:551-558 (2018)
DOI:10.1093/intimm/dxy055
Reference
PMID:35650427
  Authors
Mehrotra P, Ravichandran KS
  Title
Drugging the efferocytosis process: concepts and opportunities.
  Journal
Nat Rev Drug Discov 21:601-620 (2022)
DOI:10.1038/s41573-022-00470-y
Reference
PMID:28496201
  Authors
Park SY, Kim IS
  Title
Engulfment signals and the phagocytic machinery for apoptotic cell clearance.
  Journal
Exp Mol Med 49:e331 (2017)
DOI:10.1038/emm.2017.52
Reference
PMID:28137963
  Authors
Kojima Y, Weissman IL, Leeper NJ
  Title
The Role of Efferocytosis in Atherosclerosis.
  Journal
Circulation 135:476-489 (2017)
DOI:10.1161/CIRCULATIONAHA.116.025684
Related
pathway
cam00010  Glycolysis / Gluconeogenesis
cam04145  Phagosome
KO pathway
ko04148   
LinkDB

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