KEGG   PATHWAY: cave00480
Entry
cave00480                   Pathway                                
Name
Glutathione metabolism - Corylus avellana (European hazelnut)
Class
Metabolism; Metabolism of other amino acids
Pathway map
cave00480  Glutathione metabolism
cave00480

Module
cave_M00118  Glutathione biosynthesis, glutamate => glutathione [PATH:cave00480]
Other DBs
GO: 0006749
Organism
Corylus avellana (European hazelnut) [GN:cave]
Gene
132165567  glutathione hydrolase 3 [KO:K18592] [EC:2.3.2.2 3.4.19.13 3.4.19.14]
132165674  glutathione hydrolase 1-like [KO:K18592] [EC:2.3.2.2 3.4.19.13 3.4.19.14]
132171829  LOW QUALITY PROTEIN: glutathione hydrolase 1-like [KO:K18592] [EC:2.3.2.2 3.4.19.13 3.4.19.14]
132189659  gamma-glutamylcyclotransferase 2-1-like [KO:K22596] [EC:4.3.2.9]
132167035  gamma-glutamylcyclotransferase 2-3 [KO:K22596] [EC:4.3.2.9]
132177800  5-oxoprolinase 1 [KO:K01469] [EC:3.5.2.9]
132173368  glutamate--cysteine ligase, chloroplastic-like [KO:K01919] [EC:6.3.2.2]
132173370  glutamate--cysteine ligase, chloroplastic-like isoform X1 [KO:K01919] [EC:6.3.2.2]
132173873  glutamate--cysteine ligase, chloroplastic-like [KO:K01919] [EC:6.3.2.2]
132175280  LOW QUALITY PROTEIN: glutamate--cysteine ligase, chloroplastic-like [KO:K01919] [EC:6.3.2.2]
132171554  glutathione synthetase, chloroplastic isoform X1 [KO:K21456] [EC:6.3.2.3]
132183874  leucine aminopeptidase 1-like [KO:K01255] [EC:3.4.11.1]
132173593  puromycin-sensitive aminopeptidase [KO:K01256] [EC:3.4.11.2]
132163257  glutathione S-transferase U7-like [KO:K00799] [EC:2.5.1.18]
132187130  glutathione S-transferase F13-like [KO:K00799] [EC:2.5.1.18]
132187194  glutathione transferase GST 23-like [KO:K00799] [EC:2.5.1.18]
132187296  glutathione S-transferase F13-like [KO:K00799] [EC:2.5.1.18]
132187324  probable glutathione S-transferase [KO:K00799] [EC:2.5.1.18]
132187513  probable glutathione S-transferase [KO:K00799] [EC:2.5.1.18]
132176534  glutathione S-transferase T1 [KO:K00799] [EC:2.5.1.18]
132187681  glutathione transferase GST 23-like [KO:K00799] [EC:2.5.1.18]
132187850  probable glutathione S-transferase [KO:K00799] [EC:2.5.1.18]
132188421  glutathione S-transferase L3-like [KO:K00799] [EC:2.5.1.18]
132177543  glutathione transferase GST 23-like [KO:K00799] [EC:2.5.1.18]
132188422  glutathione S-transferase L3-like [KO:K00799] [EC:2.5.1.18]
132177574  glutathione transferase GST 23-like [KO:K00799] [EC:2.5.1.18]
132177746  glutathione S-transferase U17-like [KO:K00799] [EC:2.5.1.18]
132177747  glutathione S-transferase U17-like [KO:K00799] [EC:2.5.1.18]
132166058  probable glutathione S-transferase [KO:K00799] [EC:2.5.1.18]
132166288  glutathione transferase GST 23-like [KO:K00799] [EC:2.5.1.18]
132178781  probable glutathione S-transferase [KO:K00799] [EC:2.5.1.18]
132179022  probable glutathione S-transferase [KO:K00799] [EC:2.5.1.18]
132189998  glutathione S-transferase-like [KO:K00799] [EC:2.5.1.18]
132166450  probable glutathione S-transferase [KO:K00799] [EC:2.5.1.18]
132179080  glutathione S-transferase U8-like [KO:K00799] [EC:2.5.1.18]
132179336  glutathione S-transferase U8-like [KO:K00799] [EC:2.5.1.18]
132179610  probable glutathione S-transferase [KO:K00799] [EC:2.5.1.18]
132190646  probable glutathione S-transferase [KO:K00799] [EC:2.5.1.18]
132179854  glutathione S-transferase U9-like isoform X1 [KO:K00799] [EC:2.5.1.18]
132191502  glutathione S-transferase U8-like [KO:K00799] [EC:2.5.1.18]
132191772  glutathione S-transferase L3-like [KO:K00799] [EC:2.5.1.18]
132168742  probable glutathione S-transferase parC [KO:K00799] [EC:2.5.1.18]
132168743  probable glutathione S-transferase [KO:K00799] [EC:2.5.1.18]
132191993  glutathione S-transferase U8-like [KO:K00799] [EC:2.5.1.18]
132192013  probable glutathione S-transferase [KO:K00799] [EC:2.5.1.18]
132192048  probable glutathione S-transferase [KO:K00799] [EC:2.5.1.18]
132169881  probable glutathione S-transferase parC [KO:K00799] [EC:2.5.1.18]
132169885  glutathione S-transferase U24-like [KO:K00799] [EC:2.5.1.18]
132169886  probable glutathione S-transferase [KO:K00799] [EC:2.5.1.18]
132169892  probable glutathione S-transferase GSTU6 [KO:K00799] [EC:2.5.1.18]
132170261  glutathione S-transferase-like [KO:K00799] [EC:2.5.1.18]
132170263  glutathione S-transferase-like [KO:K00799] [EC:2.5.1.18]
132170296  probable glutathione S-transferase [KO:K00799] [EC:2.5.1.18]
132170297  probable glutathione S-transferase parC [KO:K00799] [EC:2.5.1.18]
132170457  probable glutathione S-transferase parC [KO:K00799] [EC:2.5.1.18]
132170458  probable glutathione S-transferase parC [KO:K00799] [EC:2.5.1.18]
132170706  probable glutathione S-transferase [KO:K00799] [EC:2.5.1.18]
132170707  probable glutathione S-transferase parC [KO:K00799] [EC:2.5.1.18]
132170717  probable glutathione S-transferase [KO:K00799] [EC:2.5.1.18]
132170718  glutathione S-transferase U19-like [KO:K00799] [EC:2.5.1.18]
132170719  probable glutathione S-transferase [KO:K00799] [EC:2.5.1.18]
132170722  probable glutathione S-transferase [KO:K00799] [EC:2.5.1.18]
132182389  uncharacterized protein LOC132182389 [KO:K00799] [EC:2.5.1.18]
132182658  glutathione S-transferase F11-like [KO:K00799] [EC:2.5.1.18]
132171407  probable glutathione S-transferase [KO:K00799] [EC:2.5.1.18]
132171408  probable glutathione S-transferase [KO:K00799] [EC:2.5.1.18]
132171409  probable glutathione S-transferase [KO:K00799] [EC:2.5.1.18]
132171410  probable glutathione S-transferase [KO:K00799] [EC:2.5.1.18]
132171411  probable glutathione S-transferase [KO:K00799] [EC:2.5.1.18]
132171412  probable glutathione S-transferase [KO:K00799] [EC:2.5.1.18]
132171413  probable glutathione S-transferase [KO:K00799] [EC:2.5.1.18]
132171737  glutathione S-transferase-like [KO:K00799] [EC:2.5.1.18]
132171784  probable glutathione S-transferase parC [KO:K00799] [EC:2.5.1.18]
132171785  glutathione S-transferase U22-like [KO:K00799] [EC:2.5.1.18]
132171786  probable glutathione S-transferase [KO:K00799] [EC:2.5.1.18]
132172115  probable glutathione S-transferase [KO:K00799] [EC:2.5.1.18]
132172377  glutathione S-transferase F13 [KO:K00799] [EC:2.5.1.18]
132172383  glutathione S-transferase U24-like [KO:K00799] [EC:2.5.1.18]
132172517  glutathione S-transferase-like [KO:K00799] [EC:2.5.1.18]
132172722  glutathione S-transferase-like [KO:K00799] [EC:2.5.1.18]
132172860  glutathione S-transferase-like [KO:K00799] [EC:2.5.1.18]
132184426  probable glutathione S-transferase [KO:K00799] [EC:2.5.1.18]
132184651  probable glutathione S-transferase [KO:K00799] [EC:2.5.1.18]
132161608  glutathione S-transferase U8-like [KO:K00799] [EC:2.5.1.18]
132161740  probable glutathione S-transferase [KO:K00799] [EC:2.5.1.18]
132161899  glutathione S-transferase U8-like [KO:K00799] [EC:2.5.1.18]
132162447  probable glutathione S-transferase [KO:K00799] [EC:2.5.1.18]
132186461  glutathione S-transferase L3-like [KO:K00799] [EC:2.5.1.18]
132186645  glutathione transferase GST 23-like [KO:K00799] [EC:2.5.1.18]
132186649  glutathione transferase GST 23-like [KO:K00799] [EC:2.5.1.18]
132186879  glutathione S-transferase DHAR2-like [KO:K21888] [EC:1.8.5.1 2.5.1.18]
132165551  glutathione reductase, chloroplastic [KO:K00383] [EC:1.8.1.7]
132178923  glutathione reductase, chloroplastic [KO:K00383] [EC:1.8.1.7]
132180433  isocitrate dehydrogenase [NADP] [KO:K00031] [EC:1.1.1.42]
132181361  isocitrate dehydrogenase [NADP], chloroplastic/mitochondrial-like [KO:K00031] [EC:1.1.1.42]
132173850  isocitrate dehydrogenase [NADP]-like [KO:K00031] [EC:1.1.1.42]
132175572  6-phosphogluconate dehydrogenase, decarboxylating 3, chloroplastic [KO:K00033] [EC:1.1.1.44 1.1.1.343]
132180380  6-phosphogluconate dehydrogenase, decarboxylating 2 [KO:K00033] [EC:1.1.1.44 1.1.1.343]
132179219  glucose-6-phosphate 1-dehydrogenase, chloroplastic [KO:K00036] [EC:1.1.1.49 1.1.1.363]
132179261  glucose-6-phosphate 1-dehydrogenase, chloroplastic-like [KO:K00036] [EC:1.1.1.49 1.1.1.363]
132180320  glucose-6-phosphate 1-dehydrogenase, chloroplastic-like isoform X1 [KO:K00036] [EC:1.1.1.49 1.1.1.363]
132180321  glucose-6-phosphate 1-dehydrogenase, chloroplastic-like isoform X1 [KO:K00036] [EC:1.1.1.49 1.1.1.363]
132180836  glucose-6-phosphate 1-dehydrogenase 6, cytoplasmic [KO:K00036] [EC:1.1.1.49 1.1.1.363]
132181260  glucose-6-phosphate 1-dehydrogenase, chloroplastic-like isoform X1 [KO:K00036] [EC:1.1.1.49 1.1.1.363]
132170498  inactive glucose-6-phosphate 1-dehydrogenase 4, chloroplastic [KO:K00036] [EC:1.1.1.49 1.1.1.363]
132176602  probable glutathione peroxidase 8 [KO:K00432] [EC:1.11.1.9]
132176603  probable glutathione peroxidase 8 [KO:K00432] [EC:1.11.1.9]
132189684  phospholipid hydroperoxide glutathione peroxidase 1, chloroplastic-like [KO:K00432] [EC:1.11.1.9]
132189906  phospholipid hydroperoxide glutathione peroxidase 1, chloroplastic-like [KO:K00432] [EC:1.11.1.9]
132171141  probable glutathione peroxidase 5 [KO:K00432] [EC:1.11.1.9]
132175076  LOW QUALITY PROTEIN: probable phospholipid hydroperoxide glutathione peroxidase [KO:K00432] [EC:1.11.1.9]
132186729  probable glutathione peroxidase 2 [KO:K00432] [EC:1.11.1.9]
132167365  1-Cys peroxiredoxin [KO:K11188] [EC:1.11.1.7 1.11.1.27 3.1.1.-]
132190333  ornithine decarboxylase-like [KO:K01581] [EC:4.1.1.17]
132186970  spermine synthase [KO:K00797] [EC:2.5.1.16]
132178835  spermidine synthase 1 [KO:K00797] [EC:2.5.1.16]
132173557  spermidine synthase 1-like [KO:K00797] [EC:2.5.1.16]
132163322  L-ascorbate peroxidase, cytosolic-like [KO:K00434] [EC:1.11.1.11]
132163374  L-ascorbate peroxidase, cytosolic-like [KO:K00434] [EC:1.11.1.11]
132187864  L-ascorbate peroxidase 3 [KO:K00434] [EC:1.11.1.11]
132188992  putative L-ascorbate peroxidase 6 isoform X1 [KO:K00434] [EC:1.11.1.11]
132191806  L-ascorbate peroxidase 2, cytosolic-like [KO:K00434] [EC:1.11.1.11]
132191918  L-ascorbate peroxidase 2, cytosolic [KO:K00434] [EC:1.11.1.11]
132171709  L-ascorbate peroxidase 3-like [KO:K00434] [EC:1.11.1.11]
132184096  probable L-ascorbate peroxidase 6, chloroplastic/mitochondrial isoform X1 [KO:K00434] [EC:1.11.1.11]
132162398  L-ascorbate peroxidase 2, cytosolic-like [KO:K00434] [EC:1.11.1.11]
132165788  ribonucleoside-diphosphate reductase large subunit [KO:K10807] [EC:1.17.4.1]
132184063  ribonucleoside-diphosphate reductase large subunit-like isoform X1 [KO:K10807] [EC:1.17.4.1]
132190994  ribonucleoside-diphosphate reductase small chain-like [KO:K10808] [EC:1.17.4.1]
132181638  ribonucleoside-diphosphate reductase small chain A isoform X1 [KO:K10808] [EC:1.17.4.1]
132183174  ribonucleoside-diphosphate reductase small chain [KO:K10808] [EC:1.17.4.1]
Compound
C00005  NADPH
C00006  NADP+
C00024  Acetyl-CoA
C00025  L-Glutamate
C00037  Glycine
C00051  Glutathione
C00072  Ascorbate
C00077  L-Ornithine
C00097  L-Cysteine
C00127  Glutathione disulfide
C00134  Putrescine
C00151  L-Amino acid
C00315  Spermidine
C00669  gamma-L-Glutamyl-L-cysteine
C00750  Spermine
C01322  RX
C01419  Cys-Gly
C01672  Cadaverine
C01879  5-Oxoproline
C02090  Trypanothione
C02320  R-S-Glutathione
C03170  Trypanothione disulfide
C03646  Bis-gamma-glutamylcystine
C03740  (5-L-Glutamyl)-L-amino acid
C05422  Dehydroascorbate
C05726  S-Substituted L-cysteine
C05727  S-Substituted N-acetyl-L-cysteine
C05729  R-S-Cysteinylglycine
C05730  Glutathionylspermidine
C16562  Glutathionylspermine
C16563  Bis(glutathionyl)spermine
C16564  Bis(glutathionyl)spermine disulfide
C16565  Aminopropylcadaverine
C16566  Glutathionylaminopropylcadaverine
C16567  Homotrypanothione
C16568  Homotrypanothione disulfide
C16663  Tryparedoxin
C16664  Tryparedoxin disulfide
Reference
  Authors
Josch C, Klotz LO, Sies H.
  Title
Identification of cytosolic leucyl aminopeptidase (EC 3.4.11.1) as the major cysteinylglycine-hydrolysing activity in rat liver.
  Journal
Biol Chem 384:213-8 (2003)
DOI:10.1515/BC.2003.023
Reference
  Authors
Chu L, Lai Y, Xu X, Eddy S, Yang S, Song L, Kolodrubetz D.
  Title
A 52-kDa leucyl aminopeptidase from treponema denticola is a cysteinylglycinase that mediates the second step of glutathione metabolism.
  Journal
J Biol Chem 283:19351-8 (2008)
DOI:10.1074/jbc.M801034200
Reference
  Authors
Cappiello M, Lazzarotti A, Buono F, Scaloni A, D'Ambrosio C, Amodeo P, Mendez BL, Pelosi P, Del Corso A, Mura U.
  Title
New role for leucyl aminopeptidase in glutathione turnover.
  Journal
Biochem J 378:35-44 (2004)
DOI:10.1042/BJ20031336
Reference
  Authors
Suzuki H, Kamatani S, Kim ES, Kumagai H.
  Title
Aminopeptidases A, B, and N and dipeptidase D are the four cysteinylglycinases of Escherichia coli K-12.
  Journal
J Bacteriol 183:1489-90 (2001)
DOI:10.1128/JB.183.4.1489-1490.2001
Reference
  Authors
Oza SL, Shaw MP, Wyllie S, Fairlamb AH.
  Title
Trypanothione biosynthesis in Leishmania major.
  Journal
Mol Biochem Parasitol 139:107-16 (2005)
DOI:10.1016/j.molbiopara.2004.10.004
Reference
  Authors
Oza SL, Ariyanayagam MR, Fairlamb AH.
  Title
Characterization of recombinant glutathionylspermidine synthetase/amidase from Crithidia fasciculata.
  Journal
Biochem J 364:679-86 (2002)
DOI:10.1042/BJ20011370
Reference
PMID:9677355
  Authors
Tetaud E, Manai F, Barrett MP, Nadeau K, Walsh CT, Fairlamb AH.
  Title
Cloning and characterization of the two enzymes responsible for trypanothione biosynthesis in Crithidia fasciculata.
  Journal
J Biol Chem 273:19383-90 (1998)
DOI:10.1074/jbc.273.31.19383
Reference
  Authors
Ariyanayagam MR, Oza SL, Mehlert A, Fairlamb AH.
  Title
Bis(glutathionyl)spermine and other novel trypanothione analogues in Trypanosoma cruzi.
  Journal
J Biol Chem 278:27612-9 (2003)
DOI:10.1074/jbc.M302750200
Reference
  Authors
Oza SL, Ariyanayagam MR, Aitcheson N, Fairlamb AH.
  Title
Properties of trypanothione synthetase from Trypanosoma brucei.
  Journal
Mol Biochem Parasitol 131:25-33 (2003)
DOI:10.1016/S0166-6851(03)00176-2
Reference
  Authors
Oza SL, Tetaud E, Ariyanayagam MR, Warnon SS, Fairlamb AH.
  Title
A single enzyme catalyses formation of Trypanothione from glutathione and spermidine in Trypanosoma cruzi.
  Journal
J Biol Chem 277:35853-61 (2002)
DOI:10.1074/jbc.M204403200
Reference
  Authors
Comini M, Menge U, Wissing J, Flohe L.
  Title
Trypanothione synthesis in crithidia revisited.
  Journal
J Biol Chem 280:6850-60 (2005)
DOI:10.1074/jbc.M404486200
Reference
PMID:7813456
  Authors
Hunter KJ, Le Quesne SA, Fairlamb AH.
  Title
Identification and biosynthesis of N1,N9-bis(glutathionyl)aminopropylcadaverine (homotrypanothione) in Trypanosoma cruzi.
  Journal
Eur J Biochem 226:1019-27 (1994)
DOI:10.1111/j.1432-1033.1994.t01-1-01019.x
Reference
  Authors
Krauth-Siegel RL, Meiering SK, Schmidt H.
  Title
The parasite-specific trypanothione metabolism of trypanosoma and leishmania.
  Journal
Biol Chem 384:539-49 (2003)
DOI:10.1515/BC.2003.062
Reference
  Authors
Krauth-Siegel RL, Comini MA.
  Title
Redox control in trypanosomatids, parasitic protozoa with trypanothione-based thiol metabolism.
  Journal
Biochim Biophys Acta 1780:1236-48 (2008)
DOI:10.1016/j.bbagen.2008.03.006
Reference
PMID:8892297
  Authors
Krauth-Siegel RL, Ludemann H.
  Title
Reduction of dehydroascorbate by trypanothione.
  Journal
Mol Biochem Parasitol 80:203-8 (1996)
DOI:10.1016/0166-6851(96)02689-8
Reference
  Authors
Dormeyer M, Reckenfelderbaumer N, Ludemann H, Krauth-Siegel RL.
  Title
Trypanothione-dependent synthesis of deoxyribonucleotides by Trypanosoma brucei ribonucleotide reductase.
  Journal
J Biol Chem 276:10602-6 (2001)
DOI:10.1074/jbc.M010352200
Reference
  Authors
Schmidt H, Krauth-Siegel RL.
  Title
Functional and physicochemical characterization of the thioredoxin system in Trypanosoma brucei.
  Journal
J Biol Chem 278:46329-36 (2003)
DOI:10.1074/jbc.M305338200
Reference
PMID:9851611
  Authors
Tetaud E, Fairlamb AH.
  Title
Cloning, expression and reconstitution of the trypanothione-dependent peroxidase system of Crithidia fasciculata.
  Journal
Mol Biochem Parasitol 96:111-23 (1998)
DOI:10.1016/S0166-6851(98)00120-0
Reference
  Authors
Castro H, Sousa C, Santos M, Cordeiro-da-Silva A, Flohe L, Tomas AM.
  Title
Complementary antioxidant defense by cytoplasmic and mitochondrial peroxiredoxins in Leishmania infantum.
  Journal
Free Radic Biol Med 33:1552-62 (2002)
DOI:10.1016/S0891-5849(02)01089-4
Reference
  Authors
Wilkinson SR, Temperton NJ, Mondragon A, Kelly JM.
  Title
Distinct mitochondrial and cytosolic enzymes mediate trypanothione-dependent peroxide metabolism in Trypanosoma cruzi.
  Journal
J Biol Chem 275:8220-5 (2000)
DOI:10.1074/jbc.275.11.8220
Reference
  Authors
Konig J, Fairlamb AH.
  Title
A comparative study of type I and type II tryparedoxin peroxidases in Leishmania major.
  Journal
FEBS J 274:5643-58 (2007)
DOI:10.1111/j.1742-4658.2007.06087.x
Reference
  Authors
Hillebrand H, Schmidt A, Krauth-Siegel RL.
  Title
A second class of peroxidases linked to the trypanothione metabolism.
  Journal
J Biol Chem 278:6809-15 (2003)
DOI:10.1074/jbc.M210392200
Reference
  Authors
Soksawatmaekhin W, Kuraishi A, Sakata K, Kashiwagi K, Igarashi K.
  Title
Excretion and uptake of cadaverine by CadB and its physiological functions in Escherichia coli.
  Journal
Mol Microbiol 51:1401-12 (2004)
DOI:10.1046/j.1365-2958.2003.03913.x
Reference
PMID:6798961
  Authors
Pegg AE, Shuttleworth K, Hibasami H.
  Title
Specificity of mammalian spermidine synthase and spermine synthase.
  Journal
Biochem J 197:315-20 (1981)
DOI:10.1042/bj1970315
Related
pathway
cave00220  Arginine biosynthesis
cave00250  Alanine, aspartate and glutamate metabolism
cave00270  Cysteine and methionine metabolism
cave00430  Taurine and hypotaurine metabolism
cave00460  Cyanoamino acid metabolism
KO pathway
ko00480   
LinkDB

DBGET integrated database retrieval system