KEGG   PATHWAY: ccaj00480
Entry
ccaj00480                   Pathway                                
Name
Glutathione metabolism - Cajanus cajan (pigeon pea)
Class
Metabolism; Metabolism of other amino acids
Pathway map
ccaj00480  Glutathione metabolism
ccaj00480

Module
ccaj_M00118  Glutathione biosynthesis, glutamate => glutathione [PATH:ccaj00480]
Other DBs
GO: 0006749
Organism
Cajanus cajan (pigeon pea) [GN:ccaj]
Gene
109804318  glutathione hydrolase 3 [KO:K18592] [EC:2.3.2.2 3.4.19.13 3.4.19.14]
109796046  glutathione hydrolase 1 [KO:K18592] [EC:2.3.2.2 3.4.19.13 3.4.19.14]
109798174  gamma-glutamylcyclotransferase 2-1 [KO:K22596] [EC:4.3.2.9]
109796148  gamma-glutamylcyclotransferase 2-3 [KO:K22596] [EC:4.3.2.9]
109796453  gamma-glutamylcyclotransferase 2-3-like [KO:K22596] [EC:4.3.2.9]
109805176  5-oxoprolinase isoform X1 [KO:K01469] [EC:3.5.2.9]
109801602  glutamate--cysteine ligase, chloroplastic [KO:K01919] [EC:6.3.2.2]
109800112  glutamate--cysteine ligase, chloroplastic [KO:K01919] [EC:6.3.2.2]
109789082  glutamate--cysteine ligase, chloroplastic [KO:K01919] [EC:6.3.2.2]
109816165  glutathione synthetase, chloroplastic isoform X1 [KO:K21456] [EC:6.3.2.3]
109796437  glutathione synthetase, chloroplastic [KO:K21456] [EC:6.3.2.3]
109797327  glutathione synthetase, chloroplastic [KO:K21456] [EC:6.3.2.3]
109797450  glutathione synthetase, chloroplastic [KO:K21456] [EC:6.3.2.3]
109810255  leucine aminopeptidase 1 [KO:K01255] [EC:3.4.11.1]
109814964  leucine aminopeptidase 1 [KO:K01255] [EC:3.4.11.1]
109800122  puromycin-sensitive aminopeptidase isoform X3 [KO:K01256] [EC:3.4.11.2]
109808248  probable glutathione S-transferase [KO:K00799] [EC:2.5.1.18]
109818120  glutathione transferase GST 23 [KO:K00799] [EC:2.5.1.18]
109798114  glutathione S-transferase F13 [KO:K00799] [EC:2.5.1.18]
109805318  probable glutathione S-transferase [KO:K00799] [EC:2.5.1.18]
109805327  probable glutathione S-transferase [KO:K00799] [EC:2.5.1.18]
109804992  glutathione S-transferase U7 [KO:K00799] [EC:2.5.1.18]
109804993  probable glutathione S-transferase [KO:K00799] [EC:2.5.1.18]
109814156  glutathione S-transferase U25 [KO:K00799] [EC:2.5.1.18]
109801710  probable glutathione S-transferase [KO:K00799] [EC:2.5.1.18]
109818665  glutathione S-transferase U9 [KO:K00799] [EC:2.5.1.18]
109805264  probable glutathione S-transferase [KO:K00799] [EC:2.5.1.18]
109805984  probable glutathione S-transferase [KO:K00799] [EC:2.5.1.18]
109808069  probable glutathione S-transferase [KO:K00799] [EC:2.5.1.18]
109808070  probable glutathione S-transferase [KO:K00799] [EC:2.5.1.18]
109801088  glutathione S-transferase T1 [KO:K00799] [EC:2.5.1.18]
109795264  probable glutathione S-transferase [KO:K00799] [EC:2.5.1.18]
109808739  probable glutathione S-transferase [KO:K00799] [EC:2.5.1.18]
109818966  glutathione S-transferase F10 [KO:K00799] [EC:2.5.1.18]
109818967  glutathione S-transferase F9 [KO:K00799] [EC:2.5.1.18]
109818968  glutathione S-transferase F9 [KO:K00799] [EC:2.5.1.18]
109790845  probable glutathione S-transferase [KO:K00799] [EC:2.5.1.18]
109790846  probable glutathione S-transferase [KO:K00799] [EC:2.5.1.18]
109790848  glutathione transferase GST 23 [KO:K00799] [EC:2.5.1.18]
109800817  probable glutathione S-transferase parA [KO:K00799] [EC:2.5.1.18]
109789953  glutathione S-transferase L3 [KO:K00799] [EC:2.5.1.18]
109789954  glutathione S-transferase L3 [KO:K00799] [EC:2.5.1.18]
109789955  glutathione S-transferase L3 [KO:K00799] [EC:2.5.1.18]
109791471  probable glutathione S-transferase [KO:K00799] [EC:2.5.1.18]
109791473  probable glutathione S-transferase [KO:K00799] [EC:2.5.1.18]
109791474  probable glutathione S-transferase [KO:K00799] [EC:2.5.1.18]
109796060  glutathione S-transferase F11 [KO:K00799] [EC:2.5.1.18]
109796656  glutathione S-transferase L3 [KO:K00799] [EC:2.5.1.18]
109799928  glutathione S-transferase U17 [KO:K00799] [EC:2.5.1.18]
109800973  glutathione S-transferase T1 [KO:K00799] [EC:2.5.1.18]
109788127  probable glutathione S-transferase [KO:K00799] [EC:2.5.1.18]
109803077  glutathione transferase GST 23 [KO:K00799] [EC:2.5.1.18]
109797096  glutathione S-transferase L3 [KO:K00799] [EC:2.5.1.18]
109818005  glutathione S-transferase U17 [KO:K00799] [EC:2.5.1.18]
109818006  glutathione S-transferase U17 [KO:K00799] [EC:2.5.1.18]
109818009  glutathione S-transferase U17 [KO:K00799] [EC:2.5.1.18]
109791726  glutathione S-transferase F9 [KO:K00799] [EC:2.5.1.18]
109794089  probable glutathione S-transferase parC [KO:K00799] [EC:2.5.1.18]
109801893  glutathione S-transferase 3 [KO:K00799] [EC:2.5.1.18]
109801894  glutathione S-transferase 3-like [KO:K00799] [EC:2.5.1.18]
109801919  probable glutathione S-transferase [KO:K00799] [EC:2.5.1.18]
109801920  glutathione S-transferase 3 [KO:K00799] [EC:2.5.1.18]
109801921  probable glutathione S-transferase [KO:K00799] [EC:2.5.1.18]
109801922  glutathione S-transferase 3 [KO:K00799] [EC:2.5.1.18]
109801923  probable glutathione S-transferase [KO:K00799] [EC:2.5.1.18]
109788649  glutathione S-transferase F6 [KO:K00799] [EC:2.5.1.18]
109788653  probable glutathione S-transferase [KO:K00799] [EC:2.5.1.18]
109797855  glutathione S-transferase L3 [KO:K00799] [EC:2.5.1.18]
109794641  probable glutathione S-transferase [KO:K00799] [EC:2.5.1.18]
109802815  probable glutathione S-transferase [KO:K00799] [EC:2.5.1.18]
109802844  glutathione S-transferase U25-like [KO:K00799] [EC:2.5.1.18]
109816691  glutathione S-transferase isoform X2 [KO:K00799] [EC:2.5.1.18]
109810985  glutathione transferase GST 23 [KO:K00799] [EC:2.5.1.18]
109789892  probable glutathione S-transferase parC [KO:K00799] [EC:2.5.1.18]
109789893  probable glutathione S-transferase parC [KO:K00799] [EC:2.5.1.18]
109806165  probable glutathione S-transferase [KO:K00799] [EC:2.5.1.18]
109806919  glutathione S-transferase DHAR3, chloroplastic [KO:K21888] [EC:1.8.5.1 2.5.1.18]
109792184  glutathione S-transferase DHAR2 [KO:K21888] [EC:1.8.5.1 2.5.1.18]
109812336  glutathione reductase, cytosolic [KO:K00383] [EC:1.8.1.7]
109813535  glutathione reductase, chloroplastic [KO:K00383] [EC:1.8.1.7]
109814168  isocitrate dehydrogenase [NADP] [KO:K00031] [EC:1.1.1.42]
109792495  isocitrate dehydrogenase [NADP] [KO:K00031] [EC:1.1.1.42]
109807897  isocitrate dehydrogenase [NADP], chloroplastic/mitochondrial [KO:K00031] [EC:1.1.1.42]
109817236  6-phosphogluconate dehydrogenase, decarboxylating 2 [KO:K00033] [EC:1.1.1.44 1.1.1.343]
109806574  6-phosphogluconate dehydrogenase, decarboxylating 1, chloroplastic [KO:K00033] [EC:1.1.1.44 1.1.1.343]
109810066  glucose-6-phosphate 1-dehydrogenase, cytoplasmic isoform [KO:K00036] [EC:1.1.1.49 1.1.1.363]
109812423  glucose-6-phosphate 1-dehydrogenase, chloroplastic [KO:K00036] [EC:1.1.1.49 1.1.1.363]
109797097  inactive glucose-6-phosphate 1-dehydrogenase 4, chloroplastic [KO:K00036] [EC:1.1.1.49 1.1.1.363]
109789343  glucose-6-phosphate 1-dehydrogenase, cytoplasmic isoform [KO:K00036] [EC:1.1.1.49 1.1.1.363]
109808904  glucose-6-phosphate 1-dehydrogenase, chloroplastic isoform X1 [KO:K00036] [EC:1.1.1.49 1.1.1.363]
109800633  probable glutathione peroxidase 8 [KO:K00432] [EC:1.11.1.9]
109798011  probable glutathione peroxidase 4 [KO:K00432] [EC:1.11.1.9]
109804450  probable glutathione peroxidase 2 [KO:K00432] [EC:1.11.1.9]
109800972  probable glutathione peroxidase 8 [KO:K00432] [EC:1.11.1.9]
109793003  phospholipid hydroperoxide glutathione peroxidase, chloroplastic isoform X3 [KO:K00432] [EC:1.11.1.9]
109800947  probable phospholipid hydroperoxide glutathione peroxidase [KO:K00432] [EC:1.11.1.9]
109812815  1-Cys peroxiredoxin [KO:K11188] [EC:1.11.1.7 1.11.1.27 3.1.1.-]
109801723  ornithine decarboxylase [KO:K01581] [EC:4.1.1.17]
109808954  spermidine synthase 2 [KO:K00797] [EC:2.5.1.16]
109800281  spermidine synthase 1 [KO:K00797] [EC:2.5.1.16]
109819327  spermidine synthase 2 isoform X2 [KO:K00797] [EC:2.5.1.16]
109809064  spermidine synthase 2 [KO:K00797] [EC:2.5.1.16]
109797457  spermine synthase [KO:K00797] [EC:2.5.1.16]
109800264  L-ascorbate peroxidase 5, peroxisomal-like [KO:K00434] [EC:1.11.1.11]
109800265  L-ascorbate peroxidase 3 [KO:K00434] [EC:1.11.1.11]
109800266  L-ascorbate peroxidase 3-like [KO:K00434] [EC:1.11.1.11]
109808156  probable L-ascorbate peroxidase 6, chloroplastic/mitochondrial isoform X1 [KO:K00434] [EC:1.11.1.11]
109800688  L-ascorbate peroxidase 3 [KO:K00434] [EC:1.11.1.11]
109798454  L-ascorbate peroxidase 3 [KO:K00434] [EC:1.11.1.11]
109817680  putative L-ascorbate peroxidase 6 [KO:K00434] [EC:1.11.1.11]
109798834  L-ascorbate peroxidase, cytosolic [KO:K00434] [EC:1.11.1.11]
109797689  ribonucleoside-diphosphate reductase large subunit [KO:K10807] [EC:1.17.4.1]
109799467  ribonucleoside-diphosphate reductase large subunit [KO:K10807] [EC:1.17.4.1]
109819173  ribonucleoside-diphosphate reductase small chain [KO:K10808] [EC:1.17.4.1]
109808687  ribonucleoside-diphosphate reductase small chain A [KO:K10808] [EC:1.17.4.1]
Compound
C00005  NADPH
C00006  NADP+
C00024  Acetyl-CoA
C00025  L-Glutamate
C00037  Glycine
C00051  Glutathione
C00072  Ascorbate
C00077  L-Ornithine
C00097  L-Cysteine
C00127  Glutathione disulfide
C00134  Putrescine
C00151  L-Amino acid
C00315  Spermidine
C00669  gamma-L-Glutamyl-L-cysteine
C00750  Spermine
C01322  RX
C01419  Cys-Gly
C01672  Cadaverine
C01879  5-Oxoproline
C02090  Trypanothione
C02320  R-S-Glutathione
C03170  Trypanothione disulfide
C03646  Bis-gamma-glutamylcystine
C03740  (5-L-Glutamyl)-L-amino acid
C05422  Dehydroascorbate
C05726  S-Substituted L-cysteine
C05727  S-Substituted N-acetyl-L-cysteine
C05729  R-S-Cysteinylglycine
C05730  Glutathionylspermidine
C16562  Glutathionylspermine
C16563  Bis(glutathionyl)spermine
C16564  Bis(glutathionyl)spermine disulfide
C16565  Aminopropylcadaverine
C16566  Glutathionylaminopropylcadaverine
C16567  Homotrypanothione
C16568  Homotrypanothione disulfide
C16663  Tryparedoxin
C16664  Tryparedoxin disulfide
Reference
  Authors
Josch C, Klotz LO, Sies H.
  Title
Identification of cytosolic leucyl aminopeptidase (EC 3.4.11.1) as the major cysteinylglycine-hydrolysing activity in rat liver.
  Journal
Biol Chem 384:213-8 (2003)
DOI:10.1515/BC.2003.023
Reference
  Authors
Chu L, Lai Y, Xu X, Eddy S, Yang S, Song L, Kolodrubetz D.
  Title
A 52-kDa leucyl aminopeptidase from treponema denticola is a cysteinylglycinase that mediates the second step of glutathione metabolism.
  Journal
J Biol Chem 283:19351-8 (2008)
DOI:10.1074/jbc.M801034200
Reference
  Authors
Cappiello M, Lazzarotti A, Buono F, Scaloni A, D'Ambrosio C, Amodeo P, Mendez BL, Pelosi P, Del Corso A, Mura U.
  Title
New role for leucyl aminopeptidase in glutathione turnover.
  Journal
Biochem J 378:35-44 (2004)
DOI:10.1042/BJ20031336
Reference
  Authors
Suzuki H, Kamatani S, Kim ES, Kumagai H.
  Title
Aminopeptidases A, B, and N and dipeptidase D are the four cysteinylglycinases of Escherichia coli K-12.
  Journal
J Bacteriol 183:1489-90 (2001)
DOI:10.1128/JB.183.4.1489-1490.2001
Reference
  Authors
Oza SL, Shaw MP, Wyllie S, Fairlamb AH.
  Title
Trypanothione biosynthesis in Leishmania major.
  Journal
Mol Biochem Parasitol 139:107-16 (2005)
DOI:10.1016/j.molbiopara.2004.10.004
Reference
  Authors
Oza SL, Ariyanayagam MR, Fairlamb AH.
  Title
Characterization of recombinant glutathionylspermidine synthetase/amidase from Crithidia fasciculata.
  Journal
Biochem J 364:679-86 (2002)
DOI:10.1042/BJ20011370
Reference
PMID:9677355
  Authors
Tetaud E, Manai F, Barrett MP, Nadeau K, Walsh CT, Fairlamb AH.
  Title
Cloning and characterization of the two enzymes responsible for trypanothione biosynthesis in Crithidia fasciculata.
  Journal
J Biol Chem 273:19383-90 (1998)
DOI:10.1074/jbc.273.31.19383
Reference
  Authors
Ariyanayagam MR, Oza SL, Mehlert A, Fairlamb AH.
  Title
Bis(glutathionyl)spermine and other novel trypanothione analogues in Trypanosoma cruzi.
  Journal
J Biol Chem 278:27612-9 (2003)
DOI:10.1074/jbc.M302750200
Reference
  Authors
Oza SL, Ariyanayagam MR, Aitcheson N, Fairlamb AH.
  Title
Properties of trypanothione synthetase from Trypanosoma brucei.
  Journal
Mol Biochem Parasitol 131:25-33 (2003)
DOI:10.1016/S0166-6851(03)00176-2
Reference
  Authors
Oza SL, Tetaud E, Ariyanayagam MR, Warnon SS, Fairlamb AH.
  Title
A single enzyme catalyses formation of Trypanothione from glutathione and spermidine in Trypanosoma cruzi.
  Journal
J Biol Chem 277:35853-61 (2002)
DOI:10.1074/jbc.M204403200
Reference
  Authors
Comini M, Menge U, Wissing J, Flohe L.
  Title
Trypanothione synthesis in crithidia revisited.
  Journal
J Biol Chem 280:6850-60 (2005)
DOI:10.1074/jbc.M404486200
Reference
PMID:7813456
  Authors
Hunter KJ, Le Quesne SA, Fairlamb AH.
  Title
Identification and biosynthesis of N1,N9-bis(glutathionyl)aminopropylcadaverine (homotrypanothione) in Trypanosoma cruzi.
  Journal
Eur J Biochem 226:1019-27 (1994)
DOI:10.1111/j.1432-1033.1994.t01-1-01019.x
Reference
  Authors
Krauth-Siegel RL, Meiering SK, Schmidt H.
  Title
The parasite-specific trypanothione metabolism of trypanosoma and leishmania.
  Journal
Biol Chem 384:539-49 (2003)
DOI:10.1515/BC.2003.062
Reference
  Authors
Krauth-Siegel RL, Comini MA.
  Title
Redox control in trypanosomatids, parasitic protozoa with trypanothione-based thiol metabolism.
  Journal
Biochim Biophys Acta 1780:1236-48 (2008)
DOI:10.1016/j.bbagen.2008.03.006
Reference
PMID:8892297
  Authors
Krauth-Siegel RL, Ludemann H.
  Title
Reduction of dehydroascorbate by trypanothione.
  Journal
Mol Biochem Parasitol 80:203-8 (1996)
DOI:10.1016/0166-6851(96)02689-8
Reference
  Authors
Dormeyer M, Reckenfelderbaumer N, Ludemann H, Krauth-Siegel RL.
  Title
Trypanothione-dependent synthesis of deoxyribonucleotides by Trypanosoma brucei ribonucleotide reductase.
  Journal
J Biol Chem 276:10602-6 (2001)
DOI:10.1074/jbc.M010352200
Reference
  Authors
Schmidt H, Krauth-Siegel RL.
  Title
Functional and physicochemical characterization of the thioredoxin system in Trypanosoma brucei.
  Journal
J Biol Chem 278:46329-36 (2003)
DOI:10.1074/jbc.M305338200
Reference
PMID:9851611
  Authors
Tetaud E, Fairlamb AH.
  Title
Cloning, expression and reconstitution of the trypanothione-dependent peroxidase system of Crithidia fasciculata.
  Journal
Mol Biochem Parasitol 96:111-23 (1998)
DOI:10.1016/S0166-6851(98)00120-0
Reference
  Authors
Castro H, Sousa C, Santos M, Cordeiro-da-Silva A, Flohe L, Tomas AM.
  Title
Complementary antioxidant defense by cytoplasmic and mitochondrial peroxiredoxins in Leishmania infantum.
  Journal
Free Radic Biol Med 33:1552-62 (2002)
DOI:10.1016/S0891-5849(02)01089-4
Reference
  Authors
Wilkinson SR, Temperton NJ, Mondragon A, Kelly JM.
  Title
Distinct mitochondrial and cytosolic enzymes mediate trypanothione-dependent peroxide metabolism in Trypanosoma cruzi.
  Journal
J Biol Chem 275:8220-5 (2000)
DOI:10.1074/jbc.275.11.8220
Reference
  Authors
Konig J, Fairlamb AH.
  Title
A comparative study of type I and type II tryparedoxin peroxidases in Leishmania major.
  Journal
FEBS J 274:5643-58 (2007)
DOI:10.1111/j.1742-4658.2007.06087.x
Reference
  Authors
Hillebrand H, Schmidt A, Krauth-Siegel RL.
  Title
A second class of peroxidases linked to the trypanothione metabolism.
  Journal
J Biol Chem 278:6809-15 (2003)
DOI:10.1074/jbc.M210392200
Reference
  Authors
Soksawatmaekhin W, Kuraishi A, Sakata K, Kashiwagi K, Igarashi K.
  Title
Excretion and uptake of cadaverine by CadB and its physiological functions in Escherichia coli.
  Journal
Mol Microbiol 51:1401-12 (2004)
DOI:10.1046/j.1365-2958.2003.03913.x
Reference
PMID:6798961
  Authors
Pegg AE, Shuttleworth K, Hibasami H.
  Title
Specificity of mammalian spermidine synthase and spermine synthase.
  Journal
Biochem J 197:315-20 (1981)
DOI:10.1042/bj1970315
Related
pathway
ccaj00220  Arginine biosynthesis
ccaj00250  Alanine, aspartate and glutamate metabolism
ccaj00270  Cysteine and methionine metabolism
ccaj00430  Taurine and hypotaurine metabolism
ccaj00460  Cyanoamino acid metabolism
KO pathway
ko00480   
LinkDB

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