KEGG   PATHWAY: ccan04136
Entry
ccan04136                   Pathway                                
Name
Autophagy - other - Castor canadensis (American beaver)
Description
Autophagy is a degradative pathway for the removal of cytoplasmic materials in eukaryotic cells, and is characterized by the formation of a double-membrane structure called the autophagosome, either in a housekeeping capacity or during stress and senescence. The process of autophagy could be divided into several stages: induction, vesicle nucleation, elongation and closure, and fusion and digestion. Most essential autophagic machineries are conserved throughout eukaryotes (see map04140 for animals and map04138 for fungi). This map is for other eukaryotes including plants and protists, where autophagy related genes (ATGs) play similar roles in the life cycle. However, autophagy has been relatively less studied in lower eukaryotes.
Class
Cellular Processes; Transport and catabolism
Pathway map
ccan04136  Autophagy - other
ccan04136

Other DBs
GO: 0006914
Organism
Castor canadensis (American beaver) [GN:ccan]
Gene
109689889  Rptor; regulatory-associated protein of mTOR isoform X1 [KO:K07204]
109689656  Mtor; serine/threonine-protein kinase mTOR [KO:K07203] [EC:2.7.11.1]
109690158  Mlst8; target of rapamycin complex subunit LST8 isoform X1 [KO:K08266]
109687740  Ulk2; serine/threonine-protein kinase ULK2 isoform X1 [KO:K08269] [EC:2.7.11.1]
109696258  Atg13; autophagy-related protein 13 isoform X1 [KO:K08331]
109701402  Atg101; autophagy-related protein 101 isoform X1 [KO:K19730]
109682900  Igbp1; immunoglobulin-binding protein 1 [KO:K17606]
109682902  immunoglobulin-binding protein 1-like isoform X1 [KO:K17606]
109692163  Ppp2cb; serine/threonine-protein phosphatase 2A catalytic subunit beta isoform [KO:K04382] [EC:3.1.3.16]
109689490  Ppp2ca; serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform [KO:K04382] [EC:3.1.3.16]
109691072  Atg9a; autophagy-related protein 9A [KO:K17907]
109694436  Atg9b; LOW QUALITY PROTEIN: autophagy-related protein 9B [KO:K17907]
109687168  Atg2a; autophagy-related protein 2 homolog A isoform X1 [KO:K17906]
109697559  Atg2b; autophagy-related protein 2 homolog B isoform X1 [KO:K17906]
109687467  WD repeat domain phosphoinositide-interacting protein 1 [KO:K17908]
109687468  WD repeat domain phosphoinositide-interacting protein 1-like [KO:K17908]
109694858  Wipi2; WD repeat domain phosphoinositide-interacting protein 2 isoform X1 [KO:K17908]
109681398  LOW QUALITY PROTEIN: WD repeat domain phosphoinositide-interacting protein 2-like [KO:K17908]
109687340  Becn1; beclin-1 isoform X1 [KO:K08334]
109693432  Becn2; beclin-2 [KO:K08334]
109701401  Pik3c3; phosphatidylinositol 3-kinase catalytic subunit type 3 [KO:K00914] [EC:2.7.1.137]
109678218  phosphoinositide 3-kinase regulatory subunit 4 [KO:K08333] [EC:2.7.11.1]
109691512  Atg12; ubiquitin-like protein ATG12 isoform X1 [KO:K08336]
109701355  Atg5; autophagy protein 5 isoform X1 [KO:K08339]
109695961  Atg16l1; autophagy-related protein 16-1 isoform X1 [KO:K17890]
109694948  Atg7; ubiquitin-like modifier-activating enzyme ATG7 isoform X1 [KO:K08337]
109695467  Atg10; ubiquitin-like-conjugating enzyme ATG10 isoform X1 [KO:K17888]
109683338  Atg3; ubiquitin-like-conjugating enzyme ATG3 [KO:K08343]
109674552  Gabarap; gamma-aminobutyric acid receptor-associated protein [KO:K08341]
109684019  Gabarapl2; gamma-aminobutyric acid receptor-associated protein-like 2 [KO:K08341]
109689711  Gabarapl1; gamma-aminobutyric acid receptor-associated protein-like 1 [KO:K08341]
109682471  Atg4b; cysteine protease ATG4B [KO:K08342] [EC:3.4.22.-]
109686142  Atg4c; cysteine protease ATG4C isoform X1 [KO:K08342] [EC:3.4.22.-]
109696110  Atg4d; cysteine protease ATG4D isoform X1 [KO:K08342] [EC:3.4.22.-]
109685429  cysteine protease ATG4A isoform X1 [KO:K08342] [EC:3.4.22.-]
Compound
C00350  Phosphatidylethanolamine
C01194  1-Phosphatidyl-D-myo-inositol
C04549  1-Phosphatidyl-1D-myo-inositol 3-phosphate
Reference
  Authors
Duszenko M, Ginger ML, Brennand A, Gualdron-Lopez M, Colombo MI, Coombs GH, Coppens I, Jayabalasingham B, Langsley G, de Castro SL, Menna-Barreto R, Mottram JC, Navarro M, Rigden DJ, Romano PS, Stoka V, Turk B, Michels PA
  Title
Autophagy in protists.
  Journal
Autophagy 7:127-58 (2011)
DOI:10.4161/auto.7.2.13310
Reference
  Authors
Avin-Wittenberg T, Honig A, Galili G
  Title
Variations on a theme: plant autophagy in comparison to yeast and mammals.
  Journal
Protoplasma 249:285-99 (2012)
DOI:10.1007/s00709-011-0296-z
Reference
  Authors
Liu Y, Bassham DC
  Title
Autophagy: pathways for self-eating in plant cells.
  Journal
Annu Rev Plant Biol 63:215-37 (2012)
DOI:10.1146/annurev-arplant-042811-105441
Reference
  Authors
Yoshimoto K
  Title
Beginning to understand autophagy, an intracellular self-degradation system in plants.
  Journal
Plant Cell Physiol 53:1355-65 (2012)
DOI:10.1093/pcp/pcs099
Reference
  Authors
Li F, Chung T, Vierstra RD
  Title
AUTOPHAGY-RELATED11 plays a critical role in general autophagy- and senescence-induced mitophagy in Arabidopsis.
  Journal
Plant Cell 26:788-807 (2014)
DOI:10.1105/tpc.113.120014
Reference
  Authors
Michaeli S, Galili G, Genschik P, Fernie AR, Avin-Wittenberg T
  Title
Autophagy in Plants--What's New on the Menu?
  Journal
Trends Plant Sci 21:134-44 (2016)
DOI:10.1016/j.tplants.2015.10.008
Reference
  Authors
Yang X, Bassham DC
  Title
New Insight into the Mechanism and Function of Autophagy in Plant Cells.
  Journal
Int Rev Cell Mol Biol 320:1-40 (2015)
DOI:10.1016/bs.ircmb.2015.07.005
KO pathway
ko04136   
LinkDB

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