KEGG   PATHWAY: ccat04142
Entry
ccat04142                   Pathway                                
Name
Lysosome - Ceratitis capitata (Mediterranean fruit fly)
Description
Lysosomes are membrane-delimited organelles in animal cells serving as the cell's main digestive compartment to which all sorts of macromolecules are delivered for degradation. They contain more than 40 hydrolases in an acidic environment (pH of about 5). After synthesis in the ER, lysosomal enzymes are decorated with mannose-6-phosphate residues, which are recognized by mannose-6-phosphate receptors in the trans-Golgi network. They are packaged into clathrin-coated vesicles and are transported to late endosomes. Substances for digestion are acquired by the lysosomes via a series of processes including endocytosis, phagocytosis, and autophagy.
Class
Cellular Processes; Transport and catabolism
Pathway map
ccat04142  Lysosome
ccat04142

Other DBs
GO: 0005764
Organism
Ceratitis capitata (Mediterranean fruit fly) [GN:ccat]
Gene
101448466  V-type proton ATPase 116 kDa subunit a isoform X1 [KO:K02154]
101450921  V-type proton ATPase 116 kDa subunit a [KO:K02154]
101451100  V-type proton ATPase 116 kDa subunit a [KO:K02154]
101454260  V-type proton ATPase 116 kDa subunit a [KO:K02154]
101451542  V-type proton ATPase 116 kDa subunit a [KO:K02154]
101457521  V-type proton ATPase 116 kDa subunit a [KO:K02154]
101460592  V-type proton ATPase subunit d 1 [KO:K02146]
101455192  V-type proton ATPase subunit H isoform X1 [KO:K02144]
101449616  uncharacterized protein LOC101449616 [KO:K03662]
101451190  uncharacterized protein LOC101451190 [KO:K03662]
101449125  V-type proton ATPase 16 kDa proteolipid subunit [KO:K02155]
101450938  V-type proton ATPase 21 kDa proteolipid subunit [KO:K03661]
101460163  dmX-like protein 2 isoform X1 [KO:K24155]
101451750  WD repeat-containing protein 7 [KO:K24738]
101456148  nuclear receptor coactivator 7 isoform X1 [KO:K25442]
101454096  cathepsin B [KO:K01363] [EC:3.4.22.1]
101455855  lysosomal aspartic protease [KO:K01379] [EC:3.4.23.5]
101461751  lysosomal aspartic protease [KO:K01379] [EC:3.4.23.5]
101461927  aspartic proteinase oryzasin-1 [KO:K01379] [EC:3.4.23.5]
101455167  lysosomal aspartic protease-like [KO:K01379] [EC:3.4.23.5]
101455507  lysosomal aspartic protease-like [KO:K01379] [EC:3.4.23.5]
101455674  lysosomal aspartic protease-like [KO:K01379] [EC:3.4.23.5]
101455851  lysosomal aspartic protease-like [KO:K01379] [EC:3.4.23.5]
101461571  lysosomal aspartic protease-like [KO:K01379] [EC:3.4.23.5]
110118532  lysosomal aspartic protease-like [KO:K01379] [EC:3.4.23.5]
101455337  lysosomal aspartic protease-like [KO:K01379] [EC:3.4.23.5]
101459695  putative cysteine proteinase CG12163 [KO:K01373] [EC:3.4.22.41]
101463270  cathepsin L1 [KO:K01371] [EC:3.4.22.38]
101448435  cathepsin L1 [KO:K01371] [EC:3.4.22.38]
101460387  cathepsin L [KO:K01365] [EC:3.4.22.15]
101450944  cathepsin L1-like [KO:K01365] [EC:3.4.22.15]
101454532  beta-galactosidase [KO:K12309] [EC:3.2.1.23]
101462256  beta-galactosidase [KO:K12309] [EC:3.2.1.23]
105664599  glucosylceramidase [KO:K01201] [EC:3.2.1.45]
101460008  glucosylceramidase [KO:K01201] [EC:3.2.1.45]
101458143  glucosylceramidase [KO:K01201] [EC:3.2.1.45]
101461980  alpha-L-iduronidase [KO:K01217] [EC:3.2.1.76]
101452734  alpha-N-acetylgalactosaminidase [KO:K01204] [EC:3.2.1.49]
101453099  alpha-N-acetylglucosaminidase [KO:K01205] [EC:3.2.1.50]
101450292  beta-glucuronidase isoform X1 [KO:K01195] [EC:3.2.1.31]
101451305  beta-glucuronidase [KO:K01195] [EC:3.2.1.31]
101450644  putative alpha-L-fucosidase [KO:K01206] [EC:3.2.1.51]
101451962  chitooligosaccharidolytic beta-N-acetylglucosaminidase [KO:K12373] [EC:3.2.1.52]
101451373  chitooligosaccharidolytic beta-N-acetylglucosaminidase [KO:K12373] [EC:3.2.1.52]
101453932  beta-hexosaminidase subunit beta [KO:K12373] [EC:3.2.1.52]
101448391  chitooligosaccharidolytic beta-N-acetylglucosaminidase [KO:K12373] [EC:3.2.1.52]
101452226  beta-mannosidase isoform X1 [KO:K01192] [EC:3.2.1.25]
101453976  beta-mannosidase [KO:K01192] [EC:3.2.1.25]
101452410  beta-mannosidase [KO:K01192] [EC:3.2.1.25]
101453540  lysosomal alpha-mannosidase [KO:K12311] [EC:3.2.1.24]
101453721  lysosomal alpha-mannosidase isoform X1 [KO:K12311] [EC:3.2.1.24]
101460904  arylsulfatase B [KO:K01135] [EC:3.1.6.12]
101455257  arylsulfatase J [KO:K01135] [EC:3.1.6.12]
101449590  N-acetylglucosamine-6-sulfatase [KO:K01137] [EC:3.1.6.14]
101450281  iduronate 2-sulfatase [KO:K01136] [EC:3.1.6.13]
101455311  N-sulphoglucosamine sulphohydrolase [KO:K01565] [EC:3.10.1.1]
101448390  lipase 1 [KO:K01052] [EC:3.1.1.13]
101448463  lipase 3 isoform X1 [KO:K01052] [EC:3.1.1.13]
101461453  LOW QUALITY PROTEIN: lipase 3 [KO:K01052] [EC:3.1.1.13]
101455229  group XV phospholipase A2 [KO:K06129] [EC:3.1.1.5]
101453982  deoxyribonuclease-2-alpha [KO:K01158] [EC:3.1.22.1]
101457213  prostatic acid phosphatase isoform X1 [KO:K14410] [EC:3.1.3.2]
101461530  venom acid phosphatase Acph-1 [KO:K14410] [EC:3.1.3.2]
101456345  sphingomyelin phosphodiesterase isoform X1 [KO:K12350] [EC:3.1.4.12]
101460282  putative N(4)-(beta-N-acetylglucosaminyl)-L-asparaginase GD10667 [KO:K01444] [EC:3.5.1.26]
101456930  uncharacterized protein LOC101456930 [KO:K12382]
101451476  palmitoyl-protein thioesterase 1 [KO:K01074] [EC:3.1.2.22]
101460358  lysosomal thioesterase PPT2 homolog [KO:K01074] [EC:3.1.2.22]
101449369  lysosome-associated membrane glycoprotein 1 [KO:K06528]
101463520  CD63 antigen [KO:K06497]
101462835  23 kDa integral membrane protein [KO:K06497]
101463133  23 kDa integral membrane protein [KO:K06497]
101463312  23 kDa integral membrane protein [KO:K06497]
101448577  23 kDa integral membrane protein [KO:K06497]
101460397  23 kDa integral membrane protein [KO:K06497]
101452939  CD63 antigen [KO:K06497]
101458443  Niemann-Pick C1 protein isoform X1 [KO:K12385]
101452471  Niemann-Pick type protein homolog 1B [KO:K12385]
101448531  ecdysteroid-regulated 16 kDa protein [KO:K13443]
101458485  protein NPC2 homolog [KO:K13443]
101456188  epididymal secretory protein E1 [KO:K13443]
101462556  MD-2-related lipid-recognition protein [KO:K13443]
101454473  cystinosin homolog isoform X1 [KO:K12386]
101450771  sialin [KO:K12301]
101460533  putative inorganic phosphate cotransporter isoform X1 [KO:K12301]
101458130  putative inorganic phosphate cotransporter isoform X1 [KO:K12301]
101449204  protein Malvolio isoform X1 [KO:K21398]
101449260  lysosomal-associated transmembrane protein 4A [KO:K12387]
101463056  LOW QUALITY PROTEIN: integumentary mucin C.1 [KO:K06546]
101451312  battenin [KO:K12389]
101460541  battenin [KO:K12389]
101455091  major facilitator superfamily domain-containing protein 8 isoform X1 [KO:K12307]
101452968  heparan-alpha-glucosaminide N-acetyltransferase isoform X1 [KO:K10532] [EC:2.3.1.78]
101452948  sulfatase-modifying factor 1 [KO:K13444] [EC:1.8.3.7]
101451009  N-acetylglucosamine-1-phosphotransferase subunits alpha/beta [KO:K08239] [EC:2.7.8.17]
101449754  clathrin heavy chain [KO:K04646]
101457144  AP-1 complex subunit gamma-1 isoform X2 [KO:K12391]
101462431  AP-1 complex subunit beta-1 [KO:K12392]
101462016  AP-1 complex subunit mu-1 [KO:K12393]
101461466  AP-1 complex subunit sigma-2 isoform X2 [KO:K12394]
101452279  AP-3 complex subunit delta [KO:K12396]
101448367  AP-3 complex subunit beta-2 [KO:K12397]
101454034  AP-3 complex subunit mu-2 [KO:K12398]
101453448  AP-3 complex subunit sigma-1 [KO:K12399]
101448541  ADP-ribosylation factor-binding protein GGA1 isoform X1 [KO:K12404]
101453833  lipopolysaccharide-induced tumor necrosis factor-alpha factor homolog [KO:K19363]
101454013  uncharacterized protein LOC101454013 [KO:K19363]
101454178  lipopolysaccharide-induced tumor necrosis factor-alpha factor homolog isoform X2 [KO:K19363]
101454353  lipopolysaccharide-induced tumor necrosis factor-alpha factor homolog isoform X1 [KO:K19363]
101462663  lipopolysaccharide-induced tumor necrosis factor-alpha factor homolog [KO:K19363]
101448479  lipopolysaccharide-induced tumor necrosis factor-alpha factor [KO:K19363]
101462838  LOW QUALITY PROTEIN: lipopolysaccharide-induced tumor necrosis factor-alpha factor homolog [KO:K19363]
Compound
C00002  ATP
C00008  ADP
C00159  D-Mannose
C00275  D-Mannose 6-phosphate
Reference
PMID:12628346
  Authors
Eskelinen EL, Tanaka Y, Saftig P
  Title
At the acidic edge: emerging functions for lysosomal membrane proteins.
  Journal
Trends Cell Biol 13:137-45 (2003)
DOI:10.1016/S0962-8924(03)00005-9
Reference
PMID:1883197
  Authors
Neufeld EF
  Title
Lysosomal storage diseases.
  Journal
Annu Rev Biochem 60:257-80 (1991)
DOI:10.1146/annurev.bi.60.070191.001353
Reference
PMID:2943218
  Authors
von Figura K, Hasilik A
  Title
Lysosomal enzymes and their receptors.
  Journal
Annu Rev Biochem 55:167-93 (1986)
DOI:10.1146/annurev.bi.55.070186.001123
Reference
PMID:15987739
  Authors
Janvier K, Bonifacino JS
  Title
Role of the endocytic machinery in the sorting of lysosome-associated membrane proteins.
  Journal
Mol Biol Cell 16:4231-42 (2005)
DOI:10.1091/mbc.E05-03-0213
Reference
PMID:18635948
  Authors
Vergarajauregui S, Puertollano R
  Title
Mucolipidosis type IV: the importance of functional lysosomes for efficient autophagy.
  Journal
Autophagy 4:832-4 (2008)
DOI:10.4161/auto.6567
Reference
PMID:34249946
  Authors
Jaskolka MC, Winkley SR, Kane PM
  Title
RAVE and Rabconnectin-3 Complexes as Signal Dependent Regulators of Organelle Acidification.
  Journal
Front Cell Dev Biol 9:698190 (2021)
DOI:10.3389/fcell.2021.698190
Reference
PMID:34646033
  Authors
Majdoul S, Compton AA
  Title
Lessons in self-defence: inhibition of virus entry by intrinsic immunity.
  Journal
Nat Rev Immunol 10.1038/s41577-021-00626-8 (2021)
DOI:10.1038/s41577-021-00626-8
Related
pathway
ccat00511  Other glycan degradation
ccat00531  Glycosaminoglycan degradation
ccat04130  SNARE interactions in vesicular transport
ccat04140  Autophagy - animal
ccat04144  Endocytosis
KO pathway
ko04142   
LinkDB

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