KEGG   PATHWAY: cfa00450
Entry
cfa00450                    Pathway                                
Name
Selenocompound metabolism - Canis lupus familiaris (dog)
Class
Metabolism; Metabolism of other amino acids
Pathway map
cfa00450  Selenocompound metabolism
cfa00450

Organism
Canis lupus familiaris (dog) [GN:cfa]
Gene
479959  KYAT3; kynurenine--oxoglutarate transaminase 3 isoform X2 [KO:K00816] [EC:2.6.1.7 4.4.1.13 2.6.1.64]
491310  KYAT1; kynurenine--oxoglutarate transaminase 1 isoform X2 [KO:K00816] [EC:2.6.1.7 4.4.1.13 2.6.1.64]
479190  MTR; methionine synthase isoform X2 [KO:K00548] [EC:2.1.1.13]
479991  CTH; cystathionine gamma-lyase [KO:K01758] [EC:4.4.1.1]
477422  SCLY; selenocysteine lyase isoform X1 [KO:K01763] [EC:4.4.1.16]
474536  TXNRD1; thioredoxin reductase 1, cytoplasmic [KO:K22182] [EC:1.8.1.9]
484619  TXNRD3; thioredoxin reductase 3 [KO:K22182] [EC:1.8.1.9]
608155  TXNRD2; thioredoxin reductase 2, mitochondrial isoform X4 [KO:K22182] [EC:1.8.1.9]
486463  PAPSS2; bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 2 isoform X1 [KO:K13811] [EC:2.7.7.4 2.7.1.25]
478504  PAPSS1; bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 1 isoform X2 [KO:K13811] [EC:2.7.7.4 2.7.1.25]
489904  SEPHS2; selenide, water dikinase 2 [KO:K01008] [EC:2.7.9.3]
477999  SEPHS1; selenide, water dikinase 1 [KO:K01008] [EC:2.7.9.3]
100684412  LOW QUALITY PROTEIN: selenide, water dikinase 1-like [KO:K01008] [EC:2.7.9.3]
477855  PSTK; L-seryl-tRNA(Sec) kinase isoform X1 [KO:K10837] [EC:2.7.1.164]
488852  SEPSECS; O-phosphoseryl-tRNA(Sec) selenium transferase isoform X1 [KO:K03341] [EC:2.9.1.2]
474414  MARS1; methionine--tRNA ligase, cytoplasmic isoform X2 [KO:K01874] [EC:6.1.1.10]
106557464  MARS2; methionine--tRNA ligase, mitochondrial [KO:K01874] [EC:6.1.1.10]
Compound
C00017  Protein
C00041  L-Alanine
C01528  Hydrogen selenide
C02535  Dimethyl selenide
C05172  Selenophosphoric acid
C05335  L-Selenomethionine
C05336  Selenomethionyl-tRNA(Met)
C05684  Selenite
C05686  Adenylylselenate
C05688  L-Selenocysteine
C05689  Se-Methyl-L-selenocysteine
C05690  Se-Methylselenomethionine
C05695  gamma-Glutamyl-Se-methylselenocysteine
C05697  Selenate
C05698  Selenohomocysteine
C05699  L-Selenocystathionine
C05703  Methaneselenol
C06481  L-Seryl-tRNA(Sec)
C06482  L-Selenocysteinyl-tRNA(Sec)
C16638  O-Phosphoseryl-tRNA(Sec)
C18870  Selenodiglutathione
C18871  Glutathioselenol
C18872  Trimethylselenonium
C18893  1-Methylseleno-N-acetyl-D-galactosamine
C18902  Methylselenic acid
C18904  Methylselenopyruvate
C18905  Methylselenocysteine Se-oxide
Reference
  Authors
Hoefig CS, Renko K, Kohrle J, Birringer M, Schomburg L
  Title
Comparison of different selenocompounds with respect to nutritional value vs. toxicity using liver cells in culture.
  Journal
J Nutr Biochem 22:945-55 (2011)
DOI:10.1016/j.jnutbio.2010.08.006
Reference
  Authors
McKenzie MJ, Hunter DA, Pathirana R, Watson LM, Joyce NI, Matich AJ, Rowan DD, Brummell DA
  Title
Accumulation of an organic anticancer selenium compound in a transgenic Solanaceous species shows wider applicability of the selenocysteine methyltransferase transgene from selenium hyperaccumulators.
  Journal
Transgenic Res 18:407-24 (2009)
DOI:10.1007/s11248-008-9233-0
Reference
  Authors
Pinto JT, Lee JI, Sinha R, MacEwan ME, Cooper AJ
  Title
Chemopreventive mechanisms of alpha-keto acid metabolites of naturally occurring organoselenium compounds.
  Journal
Amino Acids 41:29-41 (2011)
DOI:10.1007/s00726-010-0578-3
Reference
  Authors
Suzuki KT, Kurasaki K, Suzuki N
  Title
Selenocysteine beta-lyase and methylselenol demethylase in the metabolism of Se-methylated selenocompounds into selenide.
  Journal
Biochim Biophys Acta 1770:1053-61 (2007)
DOI:10.1016/j.bbagen.2007.03.007
Reference
  Authors
Gromer S, Gross JH
  Title
Methylseleninate is a substrate rather than an inhibitor of mammalian thioredoxin reductase. Implications for the antitumor effects of selenium.
  Journal
J Biol Chem 277:9701-6 (2002)
DOI:10.1074/jbc.M109234200
KO pathway
ko00450   
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