KEGG   PATHWAY: cflu00020
Entry
cflu00020                   Pathway                                
Name
Citrate cycle (TCA cycle) - Chryseobacterium fluminis
Description
The citrate cycle (TCA cycle, Krebs cycle) is an important aerobic pathway for the final steps of the oxidation of carbohydrates and fatty acids. The cycle starts with acetyl-CoA, the activated form of acetate, derived from glycolysis and pyruvate oxidation for carbohydrates and from beta oxidation of fatty acids. The two-carbon acetyl group in acetyl-CoA is transferred to the four-carbon compound of oxaloacetate to form the six-carbon compound of citrate. In a series of reactions two carbons in citrate are oxidized to CO2 and the reaction pathway supplies NADH for use in the oxidative phosphorylation and other metabolic processes. The pathway also supplies important precursor metabolites including 2-oxoglutarate. At the end of the cycle the remaining four-carbon part is transformed back to oxaloacetate. According to the genome sequence data, many organisms seem to lack genes for the full cycle [MD:M00009], but contain genes for specific segments [MD:M00010 M00011].
Class
Metabolism; Carbohydrate metabolism
Pathway map
cflu00020  Citrate cycle (TCA cycle)
cflu00020

Module
cflu_M00003  Gluconeogenesis, oxaloacetate => fructose-6P [PATH:cflu00020]
cflu_M00009  Citrate cycle (TCA cycle, Krebs cycle) [PATH:cflu00020]
cflu_M00010  Citrate cycle, first carbon oxidation, oxaloacetate => 2-oxoglutarate [PATH:cflu00020]
cflu_M00011  Citrate cycle, second carbon oxidation, 2-oxoglutarate => oxaloacetate [PATH:cflu00020]
cflu_M00307  Pyruvate oxidation, pyruvate => acetyl-CoA [PATH:cflu00020]
Other DBs
GO: 0006099
Organism
Chryseobacterium fluminis [GN:cflu]
Gene
ODZ84_16460  citrate synthase [KO:K01647] [EC:2.3.3.1]
ODZ84_12785  aconitate hydratase [KO:K27802] [EC:4.2.1.3 4.2.1.99]
ODZ84_12780  bifunctional aconitate hydratase 2/2-methylisocitrate dehydratase [KO:K01682] [EC:4.2.1.3 4.2.1.99]
ODZ84_04470  NADP-dependent isocitrate dehydrogenase [KO:K00031] [EC:1.1.1.42]
ODZ84_03185  2-oxoglutarate dehydrogenase E1 component [KO:K00164] [EC:1.2.4.2]
ODZ84_03105  dihydrolipoamide acetyltransferase family protein [KO:K00658] [EC:2.3.1.61]
ODZ84_03180  odhB; 2-oxoglutarate dehydrogenase complex dihydrolipoyllysine-residue succinyltransferase [KO:K00658] [EC:2.3.1.61]
ODZ84_03480  lpdA; dihydrolipoyl dehydrogenase [KO:K00382] [EC:1.8.1.4]
ODZ84_06800  lpdA; dihydrolipoyl dehydrogenase [KO:K00382] [EC:1.8.1.4]
ODZ84_08920  sucD; succinate--CoA ligase subunit alpha [KO:K01902] [EC:6.2.1.5]
ODZ84_10425  sucC; ADP-forming succinate--CoA ligase subunit beta [KO:K01903] [EC:6.2.1.5]
ODZ84_08590  fumarate reductase/succinate dehydrogenase flavoprotein subunit [KO:K00239] [EC:1.3.5.1]
ODZ84_11675  fumarate reductase/succinate dehydrogenase flavoprotein subunit [KO:K00239] [EC:1.3.5.1]
ODZ84_08595  succinate dehydrogenase/fumarate reductase iron-sulfur subunit [KO:K00240] [EC:1.3.5.1]
ODZ84_11665  succinate dehydrogenase/fumarate reductase iron-sulfur subunit [KO:K00240] [EC:1.3.5.1]
ODZ84_08585  succinate dehydrogenase cytochrome b subunit [KO:K00241]
ODZ84_11680  succinate dehydrogenase cytochrome b subunit [KO:K00241]
ODZ84_13170  fumC; class II fumarate hydratase [KO:K01679] [EC:4.2.1.2]
ODZ84_08555  malate dehydrogenase [KO:K00024] [EC:1.1.1.37]
ODZ84_18645  mqo; malate dehydrogenase (quinone) [KO:K00116] [EC:1.1.5.4]
ODZ84_15845  pckA; phosphoenolpyruvate carboxykinase (ATP) [KO:K01610] [EC:4.1.1.49]
ODZ84_01275  pdhA; pyruvate dehydrogenase (acetyl-transferring) E1 component subunit alpha [KO:K00161] [EC:1.2.4.1]
ODZ84_09500  pyruvate dehydrogenase complex E1 component subunit beta [KO:K00162] [EC:1.2.4.1]
ODZ84_01280  2-oxo acid dehydrogenase subunit E2 [KO:K00627] [EC:2.3.1.12]
Compound
C00022  Pyruvate
C00024  Acetyl-CoA
C00026  2-Oxoglutarate
C00036  Oxaloacetate
C00042  Succinate
C00068  Thiamin diphosphate
C00074  Phosphoenolpyruvate
C00091  Succinyl-CoA
C00122  Fumarate
C00149  (S)-Malate
C00158  Citrate
C00311  Isocitrate
C00417  cis-Aconitate
C05125  2-(alpha-Hydroxyethyl)thiamine diphosphate
C05379  Oxalosuccinate
C05381  3-Carboxy-1-hydroxypropyl-ThPP
C15972  Enzyme N6-(lipoyl)lysine
C15973  Enzyme N6-(dihydrolipoyl)lysine
C16254  [Dihydrolipoyllysine-residue succinyltransferase] S-succinyldihydrolipoyllysine
C16255  [Dihydrolipoyllysine-residue acetyltransferase] S-acetyldihydrolipoyllysine
Reference
  Authors
Nishizuka Y (ed).
  Title
[Metabolic Maps] (In Japanese)
  Journal
Tokyo Kagaku Dojin (1980)
Reference
  Authors
Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).
  Title
[Cellular Functions and Metabolic Maps] (In Japanese)
  Journal
Tokyo Kagaku Dojin (1997)
Reference
  Authors
Michal G.
  Title
Biochemical Pathways
  Journal
Wiley (1999)
Related
pathway
cflu00010  Glycolysis / Gluconeogenesis
cflu00053  Ascorbate and aldarate metabolism
cflu00061  Fatty acid biosynthesis
cflu00071  Fatty acid degradation
cflu00190  Oxidative phosphorylation
cflu00220  Arginine biosynthesis
cflu00250  Alanine, aspartate and glutamate metabolism
cflu00280  Valine, leucine and isoleucine degradation
cflu00350  Tyrosine metabolism
cflu00470  D-Amino acid metabolism
cflu00630  Glyoxylate and dicarboxylate metabolism
KO pathway
ko00020   
LinkDB

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