KEGG   PATHWAY: cill00480
Entry
cill00480                   Pathway                                
Name
Glutathione metabolism - Carya illinoinensis (pecan)
Class
Metabolism; Metabolism of other amino acids
Pathway map
cill00480  Glutathione metabolism
cill00480

Module
cill_M00118  Glutathione biosynthesis, glutamate => glutathione [PATH:cill00480]
Other DBs
GO: 0006749
Organism
Carya illinoinensis (pecan) [GN:cill]
Gene
122304410  glutathione hydrolase 3-like [KO:K18592] [EC:2.3.2.2 3.4.19.13 3.4.19.14]
122308105  glutathione hydrolase 3 [KO:K18592] [EC:2.3.2.2 3.4.19.13 3.4.19.14]
122308222  glutathione hydrolase 1-like [KO:K18592] [EC:2.3.2.2 3.4.19.13 3.4.19.14]
122313440  gamma-glutamylcyclotransferase 2-3 [KO:K22596] [EC:4.3.2.9]
122317099  gamma-glutamylcyclotransferase 2-1-like [KO:K22596] [EC:4.3.2.9]
122279185  5-oxoprolinase [KO:K01469] [EC:3.5.2.9]
122280360  glutamate--cysteine ligase, chloroplastic-like isoform X1 [KO:K01919] [EC:6.3.2.2]
122289893  glutamate--cysteine ligase, chloroplastic-like [KO:K01919] [EC:6.3.2.2]
122317921  glutathione synthetase, chloroplastic [KO:K21456] [EC:6.3.2.3]
122296271  leucine aminopeptidase 2, chloroplastic-like [KO:K01255] [EC:3.4.11.1]
122299454  leucine aminopeptidase 1-like [KO:K01255] [EC:3.4.11.1]
122281124  puromycin-sensitive aminopeptidase isoform X1 [KO:K01256] [EC:3.4.11.2]
122276138  glutathione S-transferase U8-like [KO:K00799] [EC:2.5.1.18]
122276983  glutathione transferase GST 23-like [KO:K00799] [EC:2.5.1.18]
122277327  glutathione S-transferase U8-like [KO:K00799] [EC:2.5.1.18]
122277542  probable glutathione S-transferase [KO:K00799] [EC:2.5.1.18]
122277732  glutathione S-transferase U8-like [KO:K00799] [EC:2.5.1.18]
122310662  glutathione S-transferase U17-like [KO:K00799] [EC:2.5.1.18]
122278310  probable glutathione S-transferase [KO:K00799] [EC:2.5.1.18]
122278311  probable glutathione S-transferase isoform X1 [KO:K00799] [EC:2.5.1.18]
122278340  glutathione S-transferase U8-like [KO:K00799] [EC:2.5.1.18]
122296891  glutathione S-transferase U7-like [KO:K00799] [EC:2.5.1.18]
122279102  probable glutathione S-transferase parC [KO:K00799] [EC:2.5.1.18]
122279103  probable glutathione S-transferase [KO:K00799] [EC:2.5.1.18]
122279104  probable glutathione S-transferase [KO:K00799] [EC:2.5.1.18]
122279381  glutathione S-transferase L3-like [KO:K00799] [EC:2.5.1.18]
122279382  glutathione S-transferase L3-like [KO:K00799] [EC:2.5.1.18]
122298366  glutathione transferase GST 23-like [KO:K00799] [EC:2.5.1.18]
122298367  glutathione transferase GST 23-like [KO:K00799] [EC:2.5.1.18]
122298729  probable glutathione S-transferase [KO:K00799] [EC:2.5.1.18]
122298744  probable glutathione S-transferase [KO:K00799] [EC:2.5.1.18]
122312528  glutathione S-transferase U17-like [KO:K00799] [EC:2.5.1.18]
122313413  glutathione S-transferase U17-like [KO:K00799] [EC:2.5.1.18]
122313414  glutathione S-transferase U17-like [KO:K00799] [EC:2.5.1.18]
122313415  glutathione S-transferase U17-like [KO:K00799] [EC:2.5.1.18]
122279780  glutathione S-transferase U8-like [KO:K00799] [EC:2.5.1.18]
122280415  glutathione S-transferase U9 [KO:K00799] [EC:2.5.1.18]
122300610  probable glutathione S-transferase [KO:K00799] [EC:2.5.1.18]
122300611  probable glutathione S-transferase [KO:K00799] [EC:2.5.1.18]
122300612  probable glutathione S-transferase [KO:K00799] [EC:2.5.1.18]
122314112  glutathione S-transferase U10-like [KO:K00799] [EC:2.5.1.18]
122315090  glutathione S-transferase-like [KO:K00799] [EC:2.5.1.18]
122315298  glutathione S-transferase-like [KO:K00799] [EC:2.5.1.18]
122281374  glutathione S-transferase T1-like [KO:K00799] [EC:2.5.1.18]
122316058  glutathione S-transferase-like [KO:K00799] [EC:2.5.1.18]
122282182  glutathione S-transferase U9-like [KO:K00799] [EC:2.5.1.18]
122302982  microsomal glutathione S-transferase 3-like [KO:K00799] [EC:2.5.1.18]
122316678  glutathione S-transferase-like [KO:K00799] [EC:2.5.1.18]
122316684  glutathione S-transferase-like [KO:K00799] [EC:2.5.1.18]
122317176  glutathione S-transferase F13 [KO:K00799] [EC:2.5.1.18]
122317296  glutathione S-transferase-like [KO:K00799] [EC:2.5.1.18]
122289827  glutathione S-transferase T1-like [KO:K00799] [EC:2.5.1.18]
122318163  glutathione S-transferase PARB-like [KO:K00799] [EC:2.5.1.18]
122318423  glutathione S-transferase U9-like [KO:K00799] [EC:2.5.1.18]
122289965  protein IN2-1 homolog B-like [KO:K00799] [EC:2.5.1.18]
122318605  glutathione S-transferase-like [KO:K00799] [EC:2.5.1.18]
122307322  microsomal glutathione S-transferase 3-like [KO:K00799] [EC:2.5.1.18]
122307812  glutathione S-transferase F11-like [KO:K00799] [EC:2.5.1.18]
122307863  probable glutathione S-transferase [KO:K00799] [EC:2.5.1.18]
122275318  probable glutathione S-transferase [KO:K00799] [EC:2.5.1.18]
122275319  glutathione S-transferase U8-like [KO:K00799] [EC:2.5.1.18]
122275832  probable glutathione S-transferase isoform X1 [KO:K00799] [EC:2.5.1.18]
122275833  probable glutathione S-transferase [KO:K00799] [EC:2.5.1.18]
122275834  probable glutathione S-transferase [KO:K00799] [EC:2.5.1.18]
122275835  probable glutathione S-transferase [KO:K00799] [EC:2.5.1.18]
122275836  probable glutathione S-transferase [KO:K00799] [EC:2.5.1.18]
122275837  probable glutathione S-transferase [KO:K00799] [EC:2.5.1.18]
122275838  probable glutathione S-transferase [KO:K00799] [EC:2.5.1.18]
122276066  glutathione S-transferase L3-like isoform X1 [KO:K00799] [EC:2.5.1.18]
122276067  glutathione S-transferase L3-like [KO:K00799] [EC:2.5.1.18]
122276069  glutathione S-transferase L3-like isoform X1 [KO:K00799] [EC:2.5.1.18]
122276070  glutathione S-transferase L3-like [KO:K00799] [EC:2.5.1.18]
122309070  glutathione S-transferase U17-like [KO:K00799] [EC:2.5.1.18]
122301238  glutathione S-transferase DHAR2-like [KO:K21888] [EC:1.8.5.1 2.5.1.18]
122302890  glutathione S-transferase DHAR3, chloroplastic-like [KO:K21888] [EC:1.8.5.1 2.5.1.18]
122290216  glutathione S-transferase DHAR2-like [KO:K21888] [EC:1.8.5.1 2.5.1.18]
122308076  glutathione S-transferase DHAR3, chloroplastic-like [KO:K21888] [EC:1.8.5.1 2.5.1.18]
122300287  glutathione reductase, cytosolic-like [KO:K00383] [EC:1.8.1.7]
122316235  glutathione reductase, cytosolic-like [KO:K00383] [EC:1.8.1.7]
122305277  glutathione reductase, chloroplastic-like [KO:K00383] [EC:1.8.1.7]
122296347  isocitrate dehydrogenase [NADP]-like [KO:K00031] [EC:1.1.1.42]
122302610  isocitrate dehydrogenase [NADP]-like [KO:K00031] [EC:1.1.1.42]
122302956  isocitrate dehydrogenase [NADP] [KO:K00031] [EC:1.1.1.42]
122307148  isocitrate dehydrogenase [NADP]-like [KO:K00031] [EC:1.1.1.42]
122310621  6-phosphogluconate dehydrogenase, decarboxylating 1-like [KO:K00033] [EC:1.1.1.44 1.1.1.343]
122281609  6-phosphogluconate dehydrogenase, decarboxylating 3, chloroplastic-like [KO:K00033] [EC:1.1.1.44 1.1.1.343]
122282295  6-phosphogluconate dehydrogenase, decarboxylating 3, chloroplastic-like [KO:K00033] [EC:1.1.1.44 1.1.1.343]
122302960  6-phosphogluconate dehydrogenase, decarboxylating 2-like [KO:K00033] [EC:1.1.1.44 1.1.1.343]
122302985  6-phosphogluconate dehydrogenase, decarboxylating 2 [KO:K00033] [EC:1.1.1.44 1.1.1.343]
122289905  6-phosphogluconate dehydrogenase, decarboxylating 3, chloroplastic [KO:K00033] [EC:1.1.1.44 1.1.1.343]
122311056  glucose-6-phosphate 1-dehydrogenase, chloroplastic-like isoform X1 [KO:K00036] [EC:1.1.1.49 1.1.1.363]
122313648  glucose-6-phosphate 1-dehydrogenase, chloroplastic-like isoform X1 [KO:K00036] [EC:1.1.1.49 1.1.1.363]
122302703  glucose-6-phosphate 1-dehydrogenase, cytoplasmic isoform-like [KO:K00036] [EC:1.1.1.49 1.1.1.363]
122316738  inactive glucose-6-phosphate 1-dehydrogenase 4, chloroplastic isoform X1 [KO:K00036] [EC:1.1.1.49 1.1.1.363]
122305489  glucose-6-phosphate 1-dehydrogenase, chloroplastic isoform X1 [KO:K00036] [EC:1.1.1.49 1.1.1.363]
122306162  glucose-6-phosphate 1-dehydrogenase, chloroplastic-like [KO:K00036] [EC:1.1.1.49 1.1.1.363]
122307532  glucose-6-phosphate 1-dehydrogenase 6, cytoplasmic [KO:K00036] [EC:1.1.1.49 1.1.1.363]
122314379  probable glutathione peroxidase 2 [KO:K00432] [EC:1.11.1.9]
122280859  probable glutathione peroxidase 8 [KO:K00432] [EC:1.11.1.9]
122280860  probable phospholipid hydroperoxide glutathione peroxidase [KO:K00432] [EC:1.11.1.9]
122316559  probable glutathione peroxidase 5 [KO:K00432] [EC:1.11.1.9]
122317490  probable phospholipid hydroperoxide glutathione peroxidase [KO:K00432] [EC:1.11.1.9]
122289543  probable phospholipid hydroperoxide glutathione peroxidase [KO:K00432] [EC:1.11.1.9]
122317763  phospholipid hydroperoxide glutathione peroxidase 1, chloroplastic-like [KO:K00432] [EC:1.11.1.9]
122315915  ornithine decarboxylase-like [KO:K01581] [EC:4.1.1.17]
122309808  spermine synthase-like isoform X1 [KO:K00797] [EC:2.5.1.16]
122311531  spermidine synthase 1-like [KO:K00797] [EC:2.5.1.16]
122313530  spermine synthase-like [KO:K00797] [EC:2.5.1.16]
122313684  spermidine synthase 1 [KO:K00797] [EC:2.5.1.16]
122280891  spermidine synthase 1-like [KO:K00797] [EC:2.5.1.16]
122290203  spermidine synthase 2-like [KO:K00797] [EC:2.5.1.16]
122296386  probable L-ascorbate peroxidase 6, chloroplastic/mitochondrial isoform X1 [KO:K00434] [EC:1.11.1.11]
122277817  L-ascorbate peroxidase 2, cytosolic [KO:K00434] [EC:1.11.1.11]
122313335  L-ascorbate peroxidase 3-like isoform X1 [KO:K00434] [EC:1.11.1.11]
122317412  putative L-ascorbate peroxidase 6 isoform X1 [KO:K00434] [EC:1.11.1.11]
122318915  L-ascorbate peroxidase 3-like [KO:K00434] [EC:1.11.1.11]
122292426  L-ascorbate peroxidase, cytosolic [KO:K00434] [EC:1.11.1.11]
122295574  ribonucleoside-diphosphate reductase large subunit-like isoform X1 [KO:K10807] [EC:1.17.4.1]
122303494  ribonucleoside-diphosphate reductase large subunit-like [KO:K10807] [EC:1.17.4.1]
122307173  ribonucleoside-diphosphate reductase large subunit [KO:K10807] [EC:1.17.4.1]
122300498  ribonucleoside-diphosphate reductase small chain A isoform X1 [KO:K10808] [EC:1.17.4.1]
122302752  ribonucleoside-diphosphate reductase small chain [KO:K10808] [EC:1.17.4.1]
122308532  ribonucleoside-diphosphate reductase small chain-like [KO:K10808] [EC:1.17.4.1]
Compound
C00005  NADPH
C00006  NADP+
C00024  Acetyl-CoA
C00025  L-Glutamate
C00037  Glycine
C00051  Glutathione
C00072  Ascorbate
C00077  L-Ornithine
C00097  L-Cysteine
C00127  Glutathione disulfide
C00134  Putrescine
C00151  L-Amino acid
C00315  Spermidine
C00669  gamma-L-Glutamyl-L-cysteine
C00750  Spermine
C01322  RX
C01419  Cys-Gly
C01672  Cadaverine
C01879  5-Oxoproline
C02090  Trypanothione
C02320  R-S-Glutathione
C03170  Trypanothione disulfide
C03646  Bis-gamma-glutamylcystine
C03740  (5-L-Glutamyl)-L-amino acid
C05422  Dehydroascorbate
C05726  S-Substituted L-cysteine
C05727  S-Substituted N-acetyl-L-cysteine
C05729  R-S-Cysteinylglycine
C05730  Glutathionylspermidine
C16562  Glutathionylspermine
C16563  Bis(glutathionyl)spermine
C16564  Bis(glutathionyl)spermine disulfide
C16565  Aminopropylcadaverine
C16566  Glutathionylaminopropylcadaverine
C16567  Homotrypanothione
C16568  Homotrypanothione disulfide
C16663  Tryparedoxin
C16664  Tryparedoxin disulfide
Reference
  Authors
Josch C, Klotz LO, Sies H.
  Title
Identification of cytosolic leucyl aminopeptidase (EC 3.4.11.1) as the major cysteinylglycine-hydrolysing activity in rat liver.
  Journal
Biol Chem 384:213-8 (2003)
DOI:10.1515/BC.2003.023
Reference
  Authors
Chu L, Lai Y, Xu X, Eddy S, Yang S, Song L, Kolodrubetz D.
  Title
A 52-kDa leucyl aminopeptidase from treponema denticola is a cysteinylglycinase that mediates the second step of glutathione metabolism.
  Journal
J Biol Chem 283:19351-8 (2008)
DOI:10.1074/jbc.M801034200
Reference
  Authors
Cappiello M, Lazzarotti A, Buono F, Scaloni A, D'Ambrosio C, Amodeo P, Mendez BL, Pelosi P, Del Corso A, Mura U.
  Title
New role for leucyl aminopeptidase in glutathione turnover.
  Journal
Biochem J 378:35-44 (2004)
DOI:10.1042/BJ20031336
Reference
  Authors
Suzuki H, Kamatani S, Kim ES, Kumagai H.
  Title
Aminopeptidases A, B, and N and dipeptidase D are the four cysteinylglycinases of Escherichia coli K-12.
  Journal
J Bacteriol 183:1489-90 (2001)
DOI:10.1128/JB.183.4.1489-1490.2001
Reference
  Authors
Oza SL, Shaw MP, Wyllie S, Fairlamb AH.
  Title
Trypanothione biosynthesis in Leishmania major.
  Journal
Mol Biochem Parasitol 139:107-16 (2005)
DOI:10.1016/j.molbiopara.2004.10.004
Reference
  Authors
Oza SL, Ariyanayagam MR, Fairlamb AH.
  Title
Characterization of recombinant glutathionylspermidine synthetase/amidase from Crithidia fasciculata.
  Journal
Biochem J 364:679-86 (2002)
DOI:10.1042/BJ20011370
Reference
PMID:9677355
  Authors
Tetaud E, Manai F, Barrett MP, Nadeau K, Walsh CT, Fairlamb AH.
  Title
Cloning and characterization of the two enzymes responsible for trypanothione biosynthesis in Crithidia fasciculata.
  Journal
J Biol Chem 273:19383-90 (1998)
DOI:10.1074/jbc.273.31.19383
Reference
  Authors
Ariyanayagam MR, Oza SL, Mehlert A, Fairlamb AH.
  Title
Bis(glutathionyl)spermine and other novel trypanothione analogues in Trypanosoma cruzi.
  Journal
J Biol Chem 278:27612-9 (2003)
DOI:10.1074/jbc.M302750200
Reference
  Authors
Oza SL, Ariyanayagam MR, Aitcheson N, Fairlamb AH.
  Title
Properties of trypanothione synthetase from Trypanosoma brucei.
  Journal
Mol Biochem Parasitol 131:25-33 (2003)
DOI:10.1016/S0166-6851(03)00176-2
Reference
  Authors
Oza SL, Tetaud E, Ariyanayagam MR, Warnon SS, Fairlamb AH.
  Title
A single enzyme catalyses formation of Trypanothione from glutathione and spermidine in Trypanosoma cruzi.
  Journal
J Biol Chem 277:35853-61 (2002)
DOI:10.1074/jbc.M204403200
Reference
  Authors
Comini M, Menge U, Wissing J, Flohe L.
  Title
Trypanothione synthesis in crithidia revisited.
  Journal
J Biol Chem 280:6850-60 (2005)
DOI:10.1074/jbc.M404486200
Reference
PMID:7813456
  Authors
Hunter KJ, Le Quesne SA, Fairlamb AH.
  Title
Identification and biosynthesis of N1,N9-bis(glutathionyl)aminopropylcadaverine (homotrypanothione) in Trypanosoma cruzi.
  Journal
Eur J Biochem 226:1019-27 (1994)
DOI:10.1111/j.1432-1033.1994.t01-1-01019.x
Reference
  Authors
Krauth-Siegel RL, Meiering SK, Schmidt H.
  Title
The parasite-specific trypanothione metabolism of trypanosoma and leishmania.
  Journal
Biol Chem 384:539-49 (2003)
DOI:10.1515/BC.2003.062
Reference
  Authors
Krauth-Siegel RL, Comini MA.
  Title
Redox control in trypanosomatids, parasitic protozoa with trypanothione-based thiol metabolism.
  Journal
Biochim Biophys Acta 1780:1236-48 (2008)
DOI:10.1016/j.bbagen.2008.03.006
Reference
PMID:8892297
  Authors
Krauth-Siegel RL, Ludemann H.
  Title
Reduction of dehydroascorbate by trypanothione.
  Journal
Mol Biochem Parasitol 80:203-8 (1996)
DOI:10.1016/0166-6851(96)02689-8
Reference
  Authors
Dormeyer M, Reckenfelderbaumer N, Ludemann H, Krauth-Siegel RL.
  Title
Trypanothione-dependent synthesis of deoxyribonucleotides by Trypanosoma brucei ribonucleotide reductase.
  Journal
J Biol Chem 276:10602-6 (2001)
DOI:10.1074/jbc.M010352200
Reference
  Authors
Schmidt H, Krauth-Siegel RL.
  Title
Functional and physicochemical characterization of the thioredoxin system in Trypanosoma brucei.
  Journal
J Biol Chem 278:46329-36 (2003)
DOI:10.1074/jbc.M305338200
Reference
PMID:9851611
  Authors
Tetaud E, Fairlamb AH.
  Title
Cloning, expression and reconstitution of the trypanothione-dependent peroxidase system of Crithidia fasciculata.
  Journal
Mol Biochem Parasitol 96:111-23 (1998)
DOI:10.1016/S0166-6851(98)00120-0
Reference
  Authors
Castro H, Sousa C, Santos M, Cordeiro-da-Silva A, Flohe L, Tomas AM.
  Title
Complementary antioxidant defense by cytoplasmic and mitochondrial peroxiredoxins in Leishmania infantum.
  Journal
Free Radic Biol Med 33:1552-62 (2002)
DOI:10.1016/S0891-5849(02)01089-4
Reference
  Authors
Wilkinson SR, Temperton NJ, Mondragon A, Kelly JM.
  Title
Distinct mitochondrial and cytosolic enzymes mediate trypanothione-dependent peroxide metabolism in Trypanosoma cruzi.
  Journal
J Biol Chem 275:8220-5 (2000)
DOI:10.1074/jbc.275.11.8220
Reference
  Authors
Konig J, Fairlamb AH.
  Title
A comparative study of type I and type II tryparedoxin peroxidases in Leishmania major.
  Journal
FEBS J 274:5643-58 (2007)
DOI:10.1111/j.1742-4658.2007.06087.x
Reference
  Authors
Hillebrand H, Schmidt A, Krauth-Siegel RL.
  Title
A second class of peroxidases linked to the trypanothione metabolism.
  Journal
J Biol Chem 278:6809-15 (2003)
DOI:10.1074/jbc.M210392200
Reference
  Authors
Soksawatmaekhin W, Kuraishi A, Sakata K, Kashiwagi K, Igarashi K.
  Title
Excretion and uptake of cadaverine by CadB and its physiological functions in Escherichia coli.
  Journal
Mol Microbiol 51:1401-12 (2004)
DOI:10.1046/j.1365-2958.2003.03913.x
Reference
PMID:6798961
  Authors
Pegg AE, Shuttleworth K, Hibasami H.
  Title
Specificity of mammalian spermidine synthase and spermine synthase.
  Journal
Biochem J 197:315-20 (1981)
DOI:10.1042/bj1970315
Related
pathway
cill00220  Arginine biosynthesis
cill00250  Alanine, aspartate and glutamate metabolism
cill00270  Cysteine and methionine metabolism
cill00430  Taurine and hypotaurine metabolism
cill00460  Cyanoamino acid metabolism
KO pathway
ko00480   
LinkDB

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