KEGG   PATHWAY: cit00480
Entry
cit00480                    Pathway                                
Name
Glutathione metabolism - Citrus sinensis (Valencia orange)
Class
Metabolism; Metabolism of other amino acids
Pathway map
cit00480  Glutathione metabolism
cit00480

Module
cit_M00118  Glutathione biosynthesis, glutamate => glutathione [PATH:cit00480]
Other DBs
GO: 0006749
Organism
Citrus sinensis (Valencia orange) [GN:cit]
Gene
102607834  glutathione hydrolase 3-like [KO:K18592] [EC:2.3.2.2 3.4.19.13 3.4.19.14]
102619237  glutathione hydrolase 1-like isoform X1 [KO:K18592] [EC:2.3.2.2 3.4.19.13 3.4.19.14]
102608321  glutathione hydrolase 3 [KO:K18592] [EC:2.3.2.2 3.4.19.13 3.4.19.14]
102621501  gamma-glutamylcyclotransferase 2-1 [KO:K22596] [EC:4.3.2.9]
102624007  gamma-glutamylcyclotransferase 2-3 isoform X1 [KO:K22596] [EC:4.3.2.9]
102616108  5-oxoprolinase 1 [KO:K01469] [EC:3.5.2.9]
102610891  glutamate--cysteine ligase, chloroplastic [KO:K01919] [EC:6.3.2.2]
102626171  glutathione synthetase, chloroplastic [KO:K21456] [EC:6.3.2.3]
102608513  leucine aminopeptidase 1-like [KO:K01255] [EC:3.4.11.1]
102626303  puromycin-sensitive aminopeptidase [KO:K01256] [EC:3.4.11.2]
102625825  Glutathione S-transferase F12-like [KO:K00799] [EC:2.5.1.18]
102577965  GSTU1; glutathione S-transferase [KO:K00799] [EC:2.5.1.18]
102621042  probable glutathione S-transferase ParA [KO:K00799] [EC:2.5.1.18]
102619308  glutathione S-transferase U9-like [KO:K00799] [EC:2.5.1.18]
102624034  glutathione S-transferase F13 [KO:K00799] [EC:2.5.1.18]
102617095  probable glutathione S-transferase [KO:K00799] [EC:2.5.1.18]
102621583  glutathione S-transferase U17-like [KO:K00799] [EC:2.5.1.18]
102615141  glutathione S-transferase T1-like [KO:K00799] [EC:2.5.1.18]
102616012  glutathione S-transferase T1-like [KO:K00799] [EC:2.5.1.18]
102619592  glutathione S-transferase U10-like [KO:K00799] [EC:2.5.1.18]
102623140  probable glutathione S-transferase [KO:K00799] [EC:2.5.1.18]
102623713  probable glutathione S-transferase [KO:K00799] [EC:2.5.1.18]
102619233  glutathione S-transferase F9-like [KO:K00799] [EC:2.5.1.18]
102619530  glutathione S-transferase F9 [KO:K00799] [EC:2.5.1.18]
102610558  glutathione transferase GST 23-like [KO:K00799] [EC:2.5.1.18]
102614737  glutathione S-transferase F6 [KO:K00799] [EC:2.5.1.18]
102617304  probable glutathione S-transferase [KO:K00799] [EC:2.5.1.18]
102617590  probable glutathione S-transferase [KO:K00799] [EC:2.5.1.18]
102618160  glutathione transferase GST 23-like [KO:K00799] [EC:2.5.1.18]
102607762  glutathione S-transferase L3 [KO:K00799] [EC:2.5.1.18]
102631055  probable glutathione S-transferase [KO:K00799] [EC:2.5.1.18]
102624760  glutathione S-transferase-like [KO:K00799] [EC:2.5.1.18]
102622765  glutathione S-transferase U8-like [KO:K00799] [EC:2.5.1.18]
102623072  glutathione S-transferase U8-like [KO:K00799] [EC:2.5.1.18]
102624040  uncharacterized protein LOC102624040 isoform X2 [KO:K00799] [EC:2.5.1.18]
102621779  probable glutathione S-transferase [KO:K00799] [EC:2.5.1.18]
102611781  glutathione S-transferase L3-like [KO:K00799] [EC:2.5.1.18]
102612071  glutathione S-transferase L3-like isoform X2 [KO:K00799] [EC:2.5.1.18]
102612576  glutathione S-transferase L3-like [KO:K00799] [EC:2.5.1.18]
102617720  glutathione S-transferase U7-like [KO:K00799] [EC:2.5.1.18]
102618283  glutathione S-transferase U7-like [KO:K00799] [EC:2.5.1.18]
102607424  probable glutathione S-transferase [KO:K00799] [EC:2.5.1.18]
102626779  probable glutathione S-transferase [KO:K00799] [EC:2.5.1.18]
102627921  probable glutathione S-transferase [KO:K00799] [EC:2.5.1.18]
102631203  probable glutathione S-transferase [KO:K00799] [EC:2.5.1.18]
102606611  glutathione transferase GST 23-like [KO:K00799] [EC:2.5.1.18]
102606914  probable glutathione S-transferase [KO:K00799] [EC:2.5.1.18]
102607202  probable glutathione S-transferase [KO:K00799] [EC:2.5.1.18]
102628216  probable glutathione S-transferase isoform X1 [KO:K00799] [EC:2.5.1.18]
102606849  probable glutathione S-transferase [KO:K00799] [EC:2.5.1.18]
102630229  probable glutathione S-transferase ParC [KO:K00799] [EC:2.5.1.18]
102613773  probable glutathione S-transferase ParC [KO:K00799] [EC:2.5.1.18]
102616984  glutathione transferase GST 23-like [KO:K00799] [EC:2.5.1.18]
102626323  glutathione S-transferase F9-like [KO:K00799] [EC:2.5.1.18]
112496432  probable glutathione S-transferase [KO:K00799] [EC:2.5.1.18]
112496430  probable glutathione S-transferase [KO:K00799] [EC:2.5.1.18]
127898659  probable glutathione S-transferase [KO:K00799] [EC:2.5.1.18]
127899677  probable glutathione S-transferase isoform X1 [KO:K00799] [EC:2.5.1.18]
127899679  probable glutathione S-transferase [KO:K00799] [EC:2.5.1.18]
127901741  probable glutathione S-transferase [KO:K00799] [EC:2.5.1.18]
127901751  probable glutathione S-transferase [KO:K00799] [EC:2.5.1.18]
127901786  probable glutathione S-transferase ParC [KO:K00799] [EC:2.5.1.18]
102620936  glutathione S-transferase DHAR2-like [KO:K21888] [EC:1.8.5.1 2.5.1.18]
102629685  glutathione S-transferase DHAR3, chloroplastic [KO:K21888] [EC:1.8.5.1 2.5.1.18]
102611650  glutathione reductase, chloroplastic [KO:K00383] [EC:1.8.1.7]
102614323  glutathione reductase, cytosolic [KO:K00383] [EC:1.8.1.7]
102629733  isocitrate dehydrogenase [NADP], chloroplastic/mitochondrial [KO:K00031] [EC:1.1.1.42]
102609279  isocitrate dehydrogenase [NADP] isoform X1 [KO:K00031] [EC:1.1.1.42]
102618681  isocitrate dehydrogenase [NADP] [KO:K00031] [EC:1.1.1.42]
102610712  6-phosphogluconate dehydrogenase, decarboxylating 2 [KO:K00033] [EC:1.1.1.44 1.1.1.343]
102626400  6-phosphogluconate dehydrogenase, decarboxylating 1, chloroplastic isoform X2 [KO:K00033] [EC:1.1.1.44 1.1.1.343]
102611501  6-phosphogluconate dehydrogenase, decarboxylating 2-like [KO:K00033] [EC:1.1.1.44 1.1.1.343]
102624333  glucose-6-phosphate 1-dehydrogenase, chloroplastic isoform X1 [KO:K00036] [EC:1.1.1.49 1.1.1.363]
102620403  glucose-6-phosphate 1-dehydrogenase, chloroplastic-like [KO:K00036] [EC:1.1.1.49 1.1.1.363]
102608770  glucose-6-phosphate 1-dehydrogenase, cytoplasmic isoform [KO:K00036] [EC:1.1.1.49 1.1.1.363]
102627370  inactive glucose-6-phosphate 1-dehydrogenase 4, chloroplastic isoform X1 [KO:K00036] [EC:1.1.1.49 1.1.1.363]
102620737  probable phospholipid hydroperoxide glutathione peroxidase [KO:K00432] [EC:1.11.1.9]
102616580  probable phospholipid hydroperoxide glutathione peroxidase [KO:K00432] [EC:1.11.1.9]
102624686  probable glutathione peroxidase 8 [KO:K00432] [EC:1.11.1.9]
102620890  probable glutathione peroxidase 2 [KO:K00432] [EC:1.11.1.9]
102622715  LOW QUALITY PROTEIN: 1-Cys peroxiredoxin [KO:K11188] [EC:1.11.1.7 1.11.1.27 3.1.1.-]
102631326  ornithine decarboxylase 1B, chloroplastic-like [KO:K01581] [EC:4.1.1.17]
102619784  ornithine decarboxylase-like [KO:K01581] [EC:4.1.1.17]
102607262  spermidine synthase 1 [KO:K00797] [EC:2.5.1.16]
102621922  spermine synthase isoform X1 [KO:K00797] [EC:2.5.1.16]
102628833  spermidine synthase 1-like [KO:K00797] [EC:2.5.1.16]
102630188  L-ascorbate peroxidase 3 [KO:K00434] [EC:1.11.1.11]
102610460  probable L-ascorbate peroxidase 6, chloroplastic/mitochondrial isoform X1 [KO:K00434] [EC:1.11.1.11]
102623082  putative L-ascorbate peroxidase 6 [KO:K00434] [EC:1.11.1.11]
102607382  L-ascorbate peroxidase 3 [KO:K00434] [EC:1.11.1.11]
102629716  L-ascorbate peroxidase, cytosolic isoform X2 [KO:K00434] [EC:1.11.1.11]
102622372  L-ascorbate peroxidase 2, cytosolic [KO:K00434] [EC:1.11.1.11]
102611797  ribonucleoside-diphosphate reductase large subunit-like [KO:K10807] [EC:1.17.4.1]
102621651  ribonucleoside-diphosphate reductase large subunit-like isoform X1 [KO:K10807] [EC:1.17.4.1]
102612388  ribonucleoside-diphosphate reductase large subunit isoform X1 [KO:K10807] [EC:1.17.4.1]
102614082  ribonucleoside-diphosphate reductase small chain-like [KO:K10808] [EC:1.17.4.1]
102624257  ribonucleoside-diphosphate reductase small chain A [KO:K10808] [EC:1.17.4.1]
102625479  ribonucleoside-diphosphate reductase small chain [KO:K10808] [EC:1.17.4.1]
Compound
C00005  NADPH
C00006  NADP+
C00024  Acetyl-CoA
C00025  L-Glutamate
C00037  Glycine
C00051  Glutathione
C00072  Ascorbate
C00077  L-Ornithine
C00097  L-Cysteine
C00127  Glutathione disulfide
C00134  Putrescine
C00151  L-Amino acid
C00315  Spermidine
C00669  gamma-L-Glutamyl-L-cysteine
C00750  Spermine
C01322  RX
C01419  Cys-Gly
C01672  Cadaverine
C01879  5-Oxoproline
C02090  Trypanothione
C02320  R-S-Glutathione
C03170  Trypanothione disulfide
C03646  Bis-gamma-glutamylcystine
C03740  (5-L-Glutamyl)-L-amino acid
C05422  Dehydroascorbate
C05726  S-Substituted L-cysteine
C05727  S-Substituted N-acetyl-L-cysteine
C05729  R-S-Cysteinylglycine
C05730  Glutathionylspermidine
C16562  Glutathionylspermine
C16563  Bis(glutathionyl)spermine
C16564  Bis(glutathionyl)spermine disulfide
C16565  Aminopropylcadaverine
C16566  Glutathionylaminopropylcadaverine
C16567  Homotrypanothione
C16568  Homotrypanothione disulfide
C16663  Tryparedoxin
C16664  Tryparedoxin disulfide
Reference
  Authors
Josch C, Klotz LO, Sies H.
  Title
Identification of cytosolic leucyl aminopeptidase (EC 3.4.11.1) as the major cysteinylglycine-hydrolysing activity in rat liver.
  Journal
Biol Chem 384:213-8 (2003)
DOI:10.1515/BC.2003.023
Reference
  Authors
Chu L, Lai Y, Xu X, Eddy S, Yang S, Song L, Kolodrubetz D.
  Title
A 52-kDa leucyl aminopeptidase from treponema denticola is a cysteinylglycinase that mediates the second step of glutathione metabolism.
  Journal
J Biol Chem 283:19351-8 (2008)
DOI:10.1074/jbc.M801034200
Reference
  Authors
Cappiello M, Lazzarotti A, Buono F, Scaloni A, D'Ambrosio C, Amodeo P, Mendez BL, Pelosi P, Del Corso A, Mura U.
  Title
New role for leucyl aminopeptidase in glutathione turnover.
  Journal
Biochem J 378:35-44 (2004)
DOI:10.1042/BJ20031336
Reference
  Authors
Suzuki H, Kamatani S, Kim ES, Kumagai H.
  Title
Aminopeptidases A, B, and N and dipeptidase D are the four cysteinylglycinases of Escherichia coli K-12.
  Journal
J Bacteriol 183:1489-90 (2001)
DOI:10.1128/JB.183.4.1489-1490.2001
Reference
  Authors
Oza SL, Shaw MP, Wyllie S, Fairlamb AH.
  Title
Trypanothione biosynthesis in Leishmania major.
  Journal
Mol Biochem Parasitol 139:107-16 (2005)
DOI:10.1016/j.molbiopara.2004.10.004
Reference
  Authors
Oza SL, Ariyanayagam MR, Fairlamb AH.
  Title
Characterization of recombinant glutathionylspermidine synthetase/amidase from Crithidia fasciculata.
  Journal
Biochem J 364:679-86 (2002)
DOI:10.1042/BJ20011370
Reference
PMID:9677355
  Authors
Tetaud E, Manai F, Barrett MP, Nadeau K, Walsh CT, Fairlamb AH.
  Title
Cloning and characterization of the two enzymes responsible for trypanothione biosynthesis in Crithidia fasciculata.
  Journal
J Biol Chem 273:19383-90 (1998)
DOI:10.1074/jbc.273.31.19383
Reference
  Authors
Ariyanayagam MR, Oza SL, Mehlert A, Fairlamb AH.
  Title
Bis(glutathionyl)spermine and other novel trypanothione analogues in Trypanosoma cruzi.
  Journal
J Biol Chem 278:27612-9 (2003)
DOI:10.1074/jbc.M302750200
Reference
  Authors
Oza SL, Ariyanayagam MR, Aitcheson N, Fairlamb AH.
  Title
Properties of trypanothione synthetase from Trypanosoma brucei.
  Journal
Mol Biochem Parasitol 131:25-33 (2003)
DOI:10.1016/S0166-6851(03)00176-2
Reference
  Authors
Oza SL, Tetaud E, Ariyanayagam MR, Warnon SS, Fairlamb AH.
  Title
A single enzyme catalyses formation of Trypanothione from glutathione and spermidine in Trypanosoma cruzi.
  Journal
J Biol Chem 277:35853-61 (2002)
DOI:10.1074/jbc.M204403200
Reference
  Authors
Comini M, Menge U, Wissing J, Flohe L.
  Title
Trypanothione synthesis in crithidia revisited.
  Journal
J Biol Chem 280:6850-60 (2005)
DOI:10.1074/jbc.M404486200
Reference
PMID:7813456
  Authors
Hunter KJ, Le Quesne SA, Fairlamb AH.
  Title
Identification and biosynthesis of N1,N9-bis(glutathionyl)aminopropylcadaverine (homotrypanothione) in Trypanosoma cruzi.
  Journal
Eur J Biochem 226:1019-27 (1994)
DOI:10.1111/j.1432-1033.1994.t01-1-01019.x
Reference
  Authors
Krauth-Siegel RL, Meiering SK, Schmidt H.
  Title
The parasite-specific trypanothione metabolism of trypanosoma and leishmania.
  Journal
Biol Chem 384:539-49 (2003)
DOI:10.1515/BC.2003.062
Reference
  Authors
Krauth-Siegel RL, Comini MA.
  Title
Redox control in trypanosomatids, parasitic protozoa with trypanothione-based thiol metabolism.
  Journal
Biochim Biophys Acta 1780:1236-48 (2008)
DOI:10.1016/j.bbagen.2008.03.006
Reference
PMID:8892297
  Authors
Krauth-Siegel RL, Ludemann H.
  Title
Reduction of dehydroascorbate by trypanothione.
  Journal
Mol Biochem Parasitol 80:203-8 (1996)
DOI:10.1016/0166-6851(96)02689-8
Reference
  Authors
Dormeyer M, Reckenfelderbaumer N, Ludemann H, Krauth-Siegel RL.
  Title
Trypanothione-dependent synthesis of deoxyribonucleotides by Trypanosoma brucei ribonucleotide reductase.
  Journal
J Biol Chem 276:10602-6 (2001)
DOI:10.1074/jbc.M010352200
Reference
  Authors
Schmidt H, Krauth-Siegel RL.
  Title
Functional and physicochemical characterization of the thioredoxin system in Trypanosoma brucei.
  Journal
J Biol Chem 278:46329-36 (2003)
DOI:10.1074/jbc.M305338200
Reference
PMID:9851611
  Authors
Tetaud E, Fairlamb AH.
  Title
Cloning, expression and reconstitution of the trypanothione-dependent peroxidase system of Crithidia fasciculata.
  Journal
Mol Biochem Parasitol 96:111-23 (1998)
DOI:10.1016/S0166-6851(98)00120-0
Reference
  Authors
Castro H, Sousa C, Santos M, Cordeiro-da-Silva A, Flohe L, Tomas AM.
  Title
Complementary antioxidant defense by cytoplasmic and mitochondrial peroxiredoxins in Leishmania infantum.
  Journal
Free Radic Biol Med 33:1552-62 (2002)
DOI:10.1016/S0891-5849(02)01089-4
Reference
  Authors
Wilkinson SR, Temperton NJ, Mondragon A, Kelly JM.
  Title
Distinct mitochondrial and cytosolic enzymes mediate trypanothione-dependent peroxide metabolism in Trypanosoma cruzi.
  Journal
J Biol Chem 275:8220-5 (2000)
DOI:10.1074/jbc.275.11.8220
Reference
  Authors
Konig J, Fairlamb AH.
  Title
A comparative study of type I and type II tryparedoxin peroxidases in Leishmania major.
  Journal
FEBS J 274:5643-58 (2007)
DOI:10.1111/j.1742-4658.2007.06087.x
Reference
  Authors
Hillebrand H, Schmidt A, Krauth-Siegel RL.
  Title
A second class of peroxidases linked to the trypanothione metabolism.
  Journal
J Biol Chem 278:6809-15 (2003)
DOI:10.1074/jbc.M210392200
Reference
  Authors
Soksawatmaekhin W, Kuraishi A, Sakata K, Kashiwagi K, Igarashi K.
  Title
Excretion and uptake of cadaverine by CadB and its physiological functions in Escherichia coli.
  Journal
Mol Microbiol 51:1401-12 (2004)
DOI:10.1046/j.1365-2958.2003.03913.x
Reference
PMID:6798961
  Authors
Pegg AE, Shuttleworth K, Hibasami H.
  Title
Specificity of mammalian spermidine synthase and spermine synthase.
  Journal
Biochem J 197:315-20 (1981)
DOI:10.1042/bj1970315
Related
pathway
cit00220  Arginine biosynthesis
cit00250  Alanine, aspartate and glutamate metabolism
cit00270  Cysteine and methionine metabolism
cit00430  Taurine and hypotaurine metabolism
cit00460  Cyanoamino acid metabolism
KO pathway
ko00480   
LinkDB

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