KEGG   PATHWAY: clec04013
Entry
clec04013                   Pathway                                
Name
MAPK signaling pathway - fly - Cimex lectularius (bed bug)
Description
The mitogen-activated protein kinase (MAPK) signaling cascades that are highly conserved from yeast to mammals use protein phosphorylation to convey signals intracellularly, and play a crucial role in mitosis, apoptosis, motility and metabolism. In fruit fly, three major classes of MAPK pathways have been distinguished with little or no redundancy, including extracellular signal-regulated kinase (ERK) / Rolled, c-Jun N-terminal kinase (JNK) / Bsk, and p38 kinase. Signals from growth factors or mitogens are dominantly transduced by the ERK pathway, whereas the JNK and p38 pathways are activated mostly by environmental stresses. The MAPK signaling cascades are typically linked to regulation of gene expression, because transcription factors are often the targets of regulatory phosphorylation events.
Class
Environmental Information Processing; Signal transduction
Pathway map
clec04013  MAPK signaling pathway - fly
clec04013

Other DBs
GO: 0000165
Organism
Cimex lectularius (bed bug) [GN:clec]
Gene
106667157  torso-like protein isoform X1 [KO:K12377]
106665892  tyrosine-protein kinase receptor torso-like [KO:K12378] [EC:2.7.10.1]
106667712  protein giant-lens [KO:K02104]
106669170  protein vein isoform X1 [KO:K16690]
106670284  protein spitz-like isoform X1 [KO:K16691]
106668239  epidermal growth factor receptor isoform X1 [KO:K04361] [EC:2.7.10.1]
106667137  uncharacterized protein LOC106667137 isoform X2 [KO:K20230]
106672538  leucine-rich repeat-containing protein 4 [KO:K20230]
106668617  uncharacterized protein LOC106668617 isoform X1 [KO:K04623]
106666385  proto-oncogene tyrosine-protein kinase ROS [KO:K05088] [EC:2.7.10.1]
106670456  SHC-transforming protein 1 isoform X1 [KO:K06279]
106663478  protein enhancer of sevenless 2B [KO:K04364]
106674180  GRB2-associated-binding protein 1 [KO:K20231]
106671929  tyrosine-protein phosphatase corkscrew isoform X3 [KO:K07293] [EC:3.1.3.48]
106669246  protein son of sevenless isoform X1 [KO:K03099]
106674064  uncharacterized protein LOC106674064 [KO:K03099]
106670071  GTPase HRas [KO:K07827]
106672464  ras GTPase-activating protein 1 [KO:K04352]
106669731  GTPase-activating protein [KO:K12380]
106668148  raf homolog serine/threonine-protein kinase phl [KO:K04365] [EC:2.7.11.1]
106665013  14-3-3 protein zeta isoform X1 [KO:K16197]
106665085  serine/threonine-protein phosphatase PP2A [KO:K04382] [EC:3.1.3.16]
106664897  kinase suppressor of Ras 2 [KO:K18529] [EC:2.7.11.1]
106663880  dual specificity mitogen-activated protein kinase kinase dSOR1 [KO:K04368] [EC:2.7.12.2]
106669706  mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
106673848  importin-7 isoform X1 [KO:K20223]
106662748  putative transcription factor capicua isoform X3 [KO:K20225]
106664986  nuclear receptor subfamily 2 group E member 1 isoform X1 [KO:K08545]
106667336  nuclear receptor subfamily 2 group E member 1-like isoform X2 [KO:K08545]
106668411  protein groucho isoform X6 [KO:K04497]
106672153  transducin-like enhancer protein 4 isoform X1 [KO:K04497]
106665791  zinc finger protein 629-like [KO:K12379]
106668935  protein C-ets-1 isoform X1 [KO:K02678]
106663327  ets DNA-binding protein pokkuri isoform X1 [KO:K03211]
106661849  ets DNA-binding protein pokkuri [KO:K20232]
106667073  exportin-1 [KO:K14290]
106663689  protein tramtrack, beta isoform isoform X2 [KO:K09237]
106664754  E3 ubiquitin-protein ligase SIAH1B-like [KO:K04506] [EC:2.3.2.27]
106670878  E3 ubiquitin-protein ligase sina-like isoform X1 [KO:K04506] [EC:2.3.2.27]
106669719  F-box-like/WD repeat-containing protein TBL1XR1-B isoform X1 [KO:K04508]
106664017  ubiquitin-conjugating enzyme E2-17 kDa [KO:K06689] [EC:2.3.2.23]
106670230  protein lozenge [KO:K20214]
106672766  homeobox protein prospero isoform X3 [KO:K20211]
106670377  protein eiger [KO:K16678]
106670583  docking protein 2 isoform X1 [KO:K20234]
106670482  tyrosine-protein kinase Src42A [KO:K08892] [EC:2.7.10.2]
106663205  tyrosine-protein kinase Src64B [KO:K05704] [EC:2.7.10.2]
106669647  tyrosine-protein kinase shark [KO:K17512] [EC:2.7.10.2]
106669639  serine/threonine-protein kinase mig-15 isoform X1 [KO:K08840] [EC:2.7.11.1]
106671984  ras-related C3 botulinum toxin substrate 1 [KO:K04392]
106668273  ras-related protein Rac1 [KO:K04392]
106669404  ras-like GTP-binding protein RhoL [KO:K04392]
106670751  cdc42 homolog isoform X1 [KO:K04392]
106670044  TNF receptor-associated factor 6 isoform X1 [KO:K03175] [EC:2.3.2.27]
106670625  ubiquitin carboxyl-terminal hydrolase CYLD isoform X1 [KO:K08601] [EC:3.4.19.12]
106662728  mitogen-activated protein kinase kinase kinase 9 isoform X3 [KO:K04417] [EC:2.7.11.25]
106666550  mitogen-activated protein kinase kinase kinase 7-like [KO:K04427] [EC:2.7.11.25]
106664735  protein phosphatase 1B-like isoform X1 [KO:K04461] [EC:3.1.3.16]
112126108  protein phosphatase 1B-like [KO:K04461] [EC:3.1.3.16]
106668141  dual specificity mitogen-activated protein kinase kinase 7-like [KO:K04431] [EC:2.7.12.2]
106665045  dual specificity mitogen-activated protein kinase kinase 4-like isoform X1 [KO:K04430] [EC:2.7.12.2]
106665032  stress-activated protein kinase JNK isoform X1 [KO:K04440] [EC:2.7.11.24]
106667695  striatin-3 isoform X1 [KO:K17608]
106671812  transcription factor AP-1-like [KO:K04448]
106665033  transcription factor jun-D-like [KO:K04448]
106666911  transcription factor kayak-like isoform X1 [KO:K09031]
106662333  ras-responsive element-binding protein 1-like [KO:K20210]
106666357  uncharacterized protein LOC106666357 isoform X1 [KO:K20235]
106665529  protein decapentaplegic [KO:K04662]
106665658  profilin [KO:K05759]
106662822  dual specificity protein phosphatase 10 isoform X1 [KO:K20216] [EC:3.1.3.16 3.1.3.48]
106670988  bone morphogenetic protein receptor type-1B isoform X1 [KO:K13578] [EC:2.7.11.30]
106674197  mitogen-activated protein kinase kinase kinase 4 isoform X1 [KO:K04428] [EC:2.7.11.25]
106666144  dual specificity mitogen-activated protein kinase kinase 6 [KO:K04432] [EC:2.7.12.2]
106663306  mitogen-activated protein kinase 14A-like isoform X1 [KO:K04441] [EC:2.7.11.24]
106663685  cyclic AMP-dependent transcription factor ATF-2 isoform X1 [KO:K04450]
106669322  dual oxidase [KO:K13411] [EC:1.6.3.1 1.11.1.-]
106672846  optomotor-blind protein isoform X1 [KO:K10176]
106666867  myocyte-specific enhancer factor 2 [KO:K09260]
106673167  superoxide dismutase [Mn], mitochondrial-like [KO:K04564] [EC:1.15.1.1]
106672941  superoxide dismutase [Mn], mitochondrial-like isoform X1 [KO:K04564] [EC:1.15.1.1]
Reference
PMID:23732470
  Authors
Sopko R, Perrimon N
  Title
Receptor tyrosine kinases in Drosophila development.
  Journal
Cold Spring Harb Perspect Biol 5:a009050 (2013)
DOI:10.1101/cshperspect.a009050
Reference
PMID:15704136
  Authors
Li WX
  Title
Functions and mechanisms of receptor tyrosine kinase Torso signaling: lessons from Drosophila embryonic terminal development.
  Journal
Dev Dyn 232:656-72 (2005)
DOI:10.1002/dvdy.20295
Reference
PMID:12648473
  Authors
Shilo BZ
  Title
Signaling by the Drosophila epidermal growth factor receptor pathway during development.
  Journal
Exp Cell Res 284:140-9 (2003)
DOI:10.1016/S0014-4827(02)00094-0
Reference
PMID:10771085
  Authors
Raabe T
  Title
The sevenless signaling pathway: variations of a common theme.
  Journal
Biochim Biophys Acta 1496:151-63 (2000)
DOI:10.1016/S0167-4889(00)00020-3
Reference
PMID:23109363
  Authors
Rios-Barrera LD, Riesgo-Escovar JR
  Title
Regulating cell morphogenesis: the Drosophila Jun N-terminal kinase pathway.
  Journal
Genesis 51:147-62 (2013)
DOI:10.1002/dvg.22354
Reference
PMID:24981286
  Authors
Igaki T, Miura M
  Title
The Drosophila TNF ortholog Eiger: emerging physiological roles and evolution of the TNF system.
  Journal
Semin Immunol 26:267-74 (2014)
DOI:10.1016/j.smim.2014.05.003
Reference
PMID:16014325
  Authors
Zhuang ZH, Zhou Y, Yu MC, Silverman N, Ge BX
  Title
Regulation of Drosophila p38 activation by specific MAP2 kinase and MAP3 kinase in response to different stimuli.
  Journal
Cell Signal 18:441-8 (2006)
DOI:10.1016/j.cellsig.2005.05.013
Reference
PMID:10557109
  Authors
Stronach BE, Perrimon N
  Title
Stress signaling in Drosophila.
  Journal
Oncogene 18:6172-82 (1999)
DOI:10.1038/sj.onc.1203125
Related
pathway
clec04214  Apoptosis - fly
KO pathway
ko04013   
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