KEGG   PATHWAY: cng03013
Entry
cng03013                    Pathway                                
Name
Nucleocytoplasmic transport - Cryptococcus neoformans var. grubii H99
Description
The exchange of molecules between the nucleus and cytoplasm is mediated through nuclear pore complexes (NPCs) embedded in the nuclear envelope. The NPC is composed of highly conserved, distinct structural modules: the inner pore ring, the cytoplasmic and nuclear rings as well as the cytoplasmic filaments and the nuclear basket. Nuclear transport receptors (e.g. importins and exportins) mediate translocation of cargos through the NPC. Cargo proteins harbouring a nuclear export signal (NES) bind to exportins and Ran-GTP to form an export complex in the nucleoplasm. Nuclear export of bulk mRNA is provided by the non-karyopherin transport proteins TAP-p15 in a Ran-GTP-independent manner. Several EJC factors are known to function in mRNA export.
Class
Genetic Information Processing; Translation
Pathway map
cng03013  Nucleocytoplasmic transport
cng03013

Other DBs
GO: 0050658
Organism
Cryptococcus neoformans var. grubii H99 [GN:cng]
Gene
CNAG_04745  hypothetical protein [KO:K18723]
CNAG_04362  ATP-dependent RNA helicase DBP5 [KO:K18655] [EC:5.6.2.7]
CNAG_06077  mRNA export factor [KO:K14298]
CNAG_07469  nuclear pore complex protein Nup98-Nup96 [KO:K14297]
CNAG_01197  ran GTPase-activating protein 1 [KO:K14319]
CNAG_04328  ubiquitin-conjugating enzyme E2 I [KO:K10577]
CNAG_01053  nuclear pore complex protein Nup160 [KO:K14303]
CNAG_03917  nuclear pore complex protein Nup85 [KO:K14304]
CNAG_04194  protein transporter SEC13 [KO:K14004]
CNAG_04149  nuclear pore complex protein Nup107 [KO:K14301]
CNAG_05353  nuclear pore complex protein Nup133 [KO:K14300]
CNAG_06772  nucleoporin SEH1 [KO:K14299]
CNAG_01199  nuclear pore complex protein Nup62 [KO:K14306]
CNAG_00411  nucleoporin p58/p45 [KO:K14307]
CNAG_04670  hypothetical protein [KO:K14308]
CNAG_02547  nuclear pore complex protein Nup205 [KO:K14310]
CNAG_05804  nuclear pore complex protein Nup188 [KO:K14311]
CNAG_01000  nuclear pore complex protein Nup155 [KO:K14312]
CNAG_02816  nuclear pore complex protein Nup93 [KO:K14309]
CNAG_01045  hypothetical protein [KO:K14315]
CNAG_01510  hypothetical protein [KO:K18725]
CNAG_02753  endoplasmic reticulum protein [KO:K20724]
CNAG_07925  nucleoprotein TPR [KO:K09291]
CNAG_07322  hypothetical protein [KO:K18722]
CNAG_00666  nucleoporin nsp1 [KO:K18721]
CNAG_01361  importin alpha subunit [KO:K15042]
CNAG_00988  importin subunit beta-1 [KO:K14293]
CNAG_02457  importin beta-2 subunit [KO:K18752]
CNAG_06279  transportin-3 [KO:K15436]
CNAG_05884  importin beta-4 subunit [KO:K20221]
CNAG_02203  karyopherin/importin that interacts with the nuclear pore complex, variant [KO:K20222]
CNAG_04973  hypothetical protein [KO:K20224]
CNAG_05486  hypothetical protein [KO:K25201]
CNAG_00439  hypothetical protein [KO:K25202]
CNAG_03418  exportin-1 [KO:K14290]
CNAG_07598  importin-alpha export receptor [KO:K18423]
CNAG_02265  exportin-T [KO:K14288]
CNAG_02257  GTP-binding nuclear protein spi1 [KO:K07936]
CNAG_06125  elongation factor 1-alpha [KO:K03231]
CNAG_06753  nuclear cap-binding protein subunit 1 [KO:K12882]
CNAG_05196  nuclear cap-binding protein subunit 2 [KO:K12883]
CNAG_02672  nonsense-mediated mRNA decay protein 3 [KO:K07562]
CNAG_02898  RNA-binding protein 8A [KO:K12876]
CNAG_00994  protein mago nashi [KO:K12877]
CNAG_01548  ATP-dependent RNA helicase FAL1 [KO:K13025] [EC:5.6.2.7]
CNAG_04679  histone deacetylase complex subunit [KO:K14324]
CNAG_02995  RNA-binding protein with serine-rich domain 1 [KO:K14325]
CNAG_03186  THO complex subunit 4 [KO:K12881]
CNAG_03249  THO complex subunit 4 [KO:K12881]
CNAG_01807  ATP-dependent helicase [KO:K14326] [EC:5.6.2.5 5.6.2.3]
CNAG_05829  hypothetical protein [KO:K14327]
CNAG_03276  hypothetical protein [KO:K14328]
CNAG_04211  nuclear RNA export factor 1/2 [KO:K14284]
CNAG_03020  hypothetical protein [KO:K14285]
CNAG_00741  ATP-dependent RNA helicase SUB2 [KO:K12812] [EC:5.6.2.7]
CNAG_06796  serine/arginine repetitive matrix protein 1 [KO:K13171]
CNAG_00577  hypothetical protein [KO:K14294]
CNAG_03235  THO complex subunit 1 [KO:K12878]
CNAG_03942  THO complex subunit 2 [KO:K12879]
CNAG_04234  hypothetical protein [KO:K13174]
Reference
PMID:16777596
  Authors
Tran EJ, Wente SR
  Title
Dynamic nuclear pore complexes: life on the edge.
  Journal
Cell 125:1041-53 (2006)
DOI:10.1016/j.cell.2006.05.027
Reference
PMID:15519698
  Authors
Rodriguez MS, Dargemont C, Stutz F
  Title
Nuclear export of RNA.
  Journal
Biol Cell 96:639-55 (2004)
DOI:10.1016/j.biolcel.2004.04.014
Reference
PMID:18313922
  Authors
Palancade B, Doye V
  Title
Sumoylating and desumoylating enzymes at nuclear pores: underpinning their unexpected duties?
  Journal
Trends Cell Biol 18:174-83 (2008)
DOI:10.1016/j.tcb.2008.02.001
Reference
PMID:15901496
  Authors
Reed R, Cheng H
  Title
TREX, SR proteins and export of mRNA.
  Journal
Curr Opin Cell Biol 17:269-73 (2005)
DOI:10.1016/j.ceb.2005.04.011
Reference
PMID:16314458
  Authors
Tange TO, Shibuya T, Jurica MS, Moore MJ
  Title
Biochemical analysis of the EJC reveals two new factors and a stable tetrameric protein core.
  Journal
RNA 11:1869-83 (2005)
DOI:10.1261/rna.2155905
Reference
PMID:28673770
  Authors
Beck M, Schirmacher P, Singer S
  Title
Alterations of the nuclear transport system in hepatocellular carcinoma - New basis for therapeutic strategies.
  Journal
J Hepatol 67:1051-1061 (2017)
DOI:10.1016/j.jhep.2017.06.021
Related
pathway
cng03015  mRNA surveillance pathway
KO pathway
ko03013   
LinkDB

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