KEGG   PATHWAY: cot00260
Entry
cot00260                    Pathway                                
Name
Glycine, serine and threonine metabolism - Candida orthopsilosis
Description
Serine is derived from 3-phospho-D-glycerate, an intermediate of glycolysis [MD:M00020], and glycine is derived from serine. Threonine is an essential amino acid, which animals cannot synthesize. In bacteria and plants, threonine is derived from aspartate [MD:M00018].
Class
Metabolism; Amino acid metabolism
Pathway map
cot00260  Glycine, serine and threonine metabolism
cot00260

Module
cot_M00018  Threonine biosynthesis, aspartate => homoserine => threonine [PATH:cot00260]
cot_M00020  Serine biosynthesis, glycerate-3P => serine [PATH:cot00260]
cot_M00338  Cysteine biosynthesis, homocysteine + serine => cysteine [PATH:cot00260]
cot_M00621  Glycine cleavage system [PATH:cot00260]
Other DBs
GO: 0006544 0006563 0070178 0006566
Organism
Candida orthopsilosis [GN:cot]
Gene
CORT_0B00680  Hom3 L-aspartate 4-P-transferase [KO:K00928] [EC:2.7.2.4]
CORT_0A10210  Hom2 aspartate-semialdehyde dehydrogenase [KO:K00133] [EC:1.2.1.11]
CORT_0B07880  Hom6 homoserine dehydrogenase [KO:K00003] [EC:1.1.1.3]
CORT_0E05890  Thr1 homoserine kinase [KO:K00872] [EC:2.7.1.39]
CORT_0E06550  Thr4 threonine synthase [KO:K01733] [EC:4.2.3.1]
CORT_0A04290  Gly1 L-threonine aldolase [KO:K01620] [EC:4.1.2.48]
CORT_0D04070  hydroxytrimethyllysine aldolase [KO:K01620] [EC:4.1.2.48]
CORT_0G03790  Shm1 mitochondrial serine hydroxymethyltransferase [KO:K00600] [EC:2.1.2.1]
CORT_0H02330  Shm2 cytoplasmic serine hydroxymethyltransferase [KO:K00600] [EC:2.1.2.1]
CORT_0H02390  Hbr2 alanine glyoxylate aminotransferase [KO:K00830] [EC:2.6.1.44 2.6.1.45 2.6.1.51]
CORT_0B08190  Gpm2 phosphoglycerate mutase [KO:K01834] [EC:5.4.2.11]
CORT_0A11150  Gpm1 phosphoglycerate mutase [KO:K01834] [EC:5.4.2.11]
CORT_0D01130  Ygr205w protein [KO:K15918] [EC:2.7.1.31]
CORT_0A05120  Ser33 protein [KO:K00058] [EC:1.1.1.95 1.1.1.399]
CORT_0B05990  Ser1 3-phosphoserine aminotransferase [KO:K00831] [EC:2.6.1.52]
CORT_0A11650  Ser2 protein [KO:K01079] [EC:3.1.3.3]
CORT_0E01030  Ymr226c protein [KO:K16066] [EC:1.1.1.381 1.1.1.-]
CORT_0A01140  Hem1 5-aminolevulinate synthase [KO:K00643] [EC:2.3.1.37]
CORT_0B05660  Amo2 protein [KO:K00276] [EC:1.4.3.21]
CORT_0A10990  Amo1 peroxisomal copper amine oxidase [KO:K00276] [EC:1.4.3.21]
CORT_0A06430  Gcv2 glycine decarboxylase subunit P [KO:K00281] [EC:1.4.4.2]
CORT_0F02900  hypothetical protein [KO:K00605] [EC:2.1.2.10]
CORT_0D06080  Lpd1 dihydrolipoamide dehydrogenase [KO:K00382] [EC:1.8.1.4]
CORT_0D01600  Gcv3 glycine decarboxylase subunit H [KO:K02437]
CORT_0B10010  Dao1 D-amino acid oxidase [KO:K00273] [EC:1.4.3.3]
CORT_0E04630  hypothetical protein [KO:K00273] [EC:1.4.3.3]
CORT_0E03480  Dao2 D-amino acid oxidase [KO:K00273] [EC:1.4.3.3]
CORT_0E06250  Ifg3 D-amino acid oxidase [KO:K00273] [EC:1.4.3.3]
CORT_0A08330  Cho1 phosphatidylserine synthase [KO:K17103] [EC:2.7.8.8]
CORT_0B07990  Cys4 cystathionine beta-synthase [KO:K01697] [EC:4.2.1.22]
CORT_0G02290  Cys3 cystathionine gamma-lyase [KO:K01758] [EC:4.4.1.1]
CORT_0B06010  Ilv1 threonine dehydratase [KO:K01754] [EC:4.3.1.19]
CORT_0A13260  Cha1 protein [KO:K17989] [EC:4.3.1.17 4.3.1.19]
CORT_0E00490  Cha1 protein [KO:K17989] [EC:4.3.1.17 4.3.1.19]
CORT_0B01530  Trp5 predicted tryptophan synthase [KO:K01694] [EC:4.2.1.20]
Compound
C00011  CO2
C00014  Ammonia
C00022  Pyruvate
C00037  Glycine
C00048  Glyoxylate
C00049  L-Aspartate
C00065  L-Serine
C00078  L-Tryptophan
C00097  L-Cysteine
C00101  Tetrahydrofolate
C00109  2-Oxobutanoate
C00114  Choline
C00143  5,10-Methylenetetrahydrofolate
C00168  Hydroxypyruvate
C00188  L-Threonine
C00197  3-Phospho-D-glycerate
C00213  Sarcosine
C00258  D-Glycerate
C00263  L-Homoserine
C00300  Creatine
C00430  5-Aminolevulinate
C00441  L-Aspartate 4-semialdehyde
C00546  Methylglyoxal
C00576  Betaine aldehyde
C00581  Guanidinoacetate
C00631  2-Phospho-D-glycerate
C00719  Betaine
C00740  D-Serine
C00986  1,3-Diaminopropane
C01005  O-Phospho-L-serine
C01026  N,N-Dimethylglycine
C01102  O-Phospho-L-homoserine
C01242  [Protein]-S8-aminomethyldihydrolipoyllysine
C01888  Aminoacetone
C02051  Lipoylprotein
C02291  L-Cystathionine
C02737  Phosphatidylserine
C02972  Dihydrolipoylprotein
C03082  4-Phospho-L-aspartate
C03194  (R)-1-Aminopropan-2-ol
C03232  3-Phosphonooxypyruvate
C03283  L-2,4-Diaminobutanoate
C03508  L-2-Amino-3-oxobutanoic acid
C05519  L-Allothreonine
C06231  Ectoine
C06442  N(gamma)-Acetyldiaminobutyrate
C16432  5-Hydroxyectoine
C19929  N(alpha)-Acetyl-L-2,4-diaminobutyrate
Reference
  Authors
Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).
  Title
[Cellular Functions and Metabolic Maps] (In Japanese)
  Journal
Tokyo Kagaku Dojin (1997)
Reference
PMID:11823218
  Authors
Kuhlmann AU, Bremer E.
  Title
Osmotically regulated synthesis of the compatible solute ectoine in Bacillus pasteurii and related Bacillus spp.
  Journal
Appl Environ Microbiol 68:772-83 (2002)
DOI:10.1128/AEM.68.2.772-783.2002
Reference
PMID:10473374
  Authors
Canovas D, Borges N, Vargas C, Ventosa A, Nieto JJ, Santos H.
  Title
Role of Ngamma-acetyldiaminobutyrate as an enzyme stabilizer and an intermediate in the biosynthesis of hydroxyectoine.
  Journal
Appl Environ Microbiol 65:3774-9 (1999)
DOI:10.1128/AEM.65.9.3774-3779.1999
Reference
PMID:17636255
  Authors
Bursy J, Pierik AJ, Pica N, Bremer E.
  Title
Osmotically induced synthesis of the compatible solute hydroxyectoine is mediated by an evolutionarily conserved ectoine hydroxylase.
  Journal
J Biol Chem 282:31147-55 (2007)
DOI:10.1074/jbc.M704023200
Reference
PMID:16707670
  Authors
Garcia-Estepa R, Argandona M, Reina-Bueno M, Capote N, Iglesias-Guerra F, Nieto JJ, Vargas C.
  Title
The ectD gene, which is involved in the synthesis of the compatible solute hydroxyectoine, is essential for thermoprotection of the halophilic bacterium Chromohalobacter salexigens.
  Journal
J Bacteriol 188:3774-84 (2006)
DOI:10.1128/JB.00136-06
Reference
PMID:15470257
  Authors
Arevalo-Rodriguez M, Pan X, Boeke JD, Heitman J
  Title
FKBP12 controls aspartate pathway flux in Saccharomyces cerevisiae to prevent toxic intermediate accumulation.
  Journal
Eukaryot Cell 3:1287-96 (2004)
DOI:10.1128/EC.3.5.1287-1296.2004
Reference
PMID:7639721
  Authors
Rees WD, Hay SM
  Title
The biosynthesis of threonine by mammalian cells: expression of a complete bacterial biosynthetic pathway in an animal cell.
  Journal
Biochem J 309 ( Pt 3):999-1007 (1995)
DOI:10.1042/bj3090999
Reference
PMID:11341914
  Authors
Jacques SL, Nieman C, Bareich D, Broadhead G, Kinach R, Honek JF, Wright GD
  Title
Characterization of yeast homoserine dehydrogenase, an antifungal target: the invariant histidine 309 is important for enzyme integrity.
  Journal
Biochim Biophys Acta 1544:28-41 (2001)
DOI:10.1016/S0167-4838(00)00203-X
Reference
PMID:15520012
  Authors
Chen X, Jhee KH, Kruger WD
  Title
Production of the neuromodulator H2S by cystathionine beta-synthase via the condensation of cysteine and homocysteine.
  Journal
J Biol Chem 279:52082-6 (2004)
DOI:10.1074/jbc.C400481200
Related
pathway
cot00010  Glycolysis / Gluconeogenesis
cot00020  Citrate cycle (TCA cycle)
cot00230  Purine metabolism
cot00250  Alanine, aspartate and glutamate metabolism
cot00270  Cysteine and methionine metabolism
cot00290  Valine, leucine and isoleucine biosynthesis
cot00300  Lysine biosynthesis
cot00330  Arginine and proline metabolism
cot00460  Cyanoamino acid metabolism
cot00470  D-Amino acid metabolism
cot00564  Glycerophospholipid metabolism
cot00600  Sphingolipid metabolism
cot00620  Pyruvate metabolism
cot00630  Glyoxylate and dicarboxylate metabolism
cot00640  Propanoate metabolism
cot00680  Methane metabolism
cot00860  Porphyrin metabolism
cot00920  Sulfur metabolism
KO pathway
ko00260   
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