KEGG   PATHWAY: cpha00010
Entry
cpha00010                   Pathway                                
Name
Glycolysis / Gluconeogenesis - Clavibacter phaseoli
Description
Glycolysis is the process of converting glucose into pyruvate and generating small amounts of ATP (energy) and NADH (reducing power). It is a central pathway that produces important precursor metabolites: six-carbon compounds of glucose-6P and fructose-6P and three-carbon compounds of glycerone-P, glyceraldehyde-3P, glycerate-3P, phosphoenolpyruvate, and pyruvate [MD:M00001]. Acetyl-CoA, another important precursor metabolite, is produced by oxidative decarboxylation of pyruvate [MD:M00307]. When the enzyme genes of this pathway are examined in completely sequenced genomes, the reaction steps of three-carbon compounds from glycerone-P to pyruvate form a conserved core module [MD:M00002], which is found in almost all organisms and which sometimes contains operon structures in bacterial genomes. Gluconeogenesis is a synthesis pathway of glucose from noncarbohydrate precursors. It is essentially a reversal of glycolysis with minor variations of alternative paths [MD:M00003].
Class
Metabolism; Carbohydrate metabolism
Pathway map
cpha00010  Glycolysis / Gluconeogenesis
cpha00010

Module
cpha_M00001  Glycolysis (Embden-Meyerhof pathway), glucose => pyruvate [PATH:cpha00010]
cpha_M00002  Glycolysis, core module involving three-carbon compounds [PATH:cpha00010]
cpha_M00003  Gluconeogenesis, oxaloacetate => fructose-6P [PATH:cpha00010]
cpha_M00307  Pyruvate oxidation, pyruvate => acetyl-CoA [PATH:cpha00010]
Other DBs
GO: 0006096 0006094
Organism
Clavibacter phaseoli [GN:cpha]
Gene
FGI33_02415  ROK family protein [KO:K00845] [EC:2.7.1.2]
FGI33_03735  ROK family glucokinase [KO:K25026] [EC:2.7.1.2]
FGI33_04465  glucose-6-phosphate isomerase [KO:K01810] [EC:5.3.1.9]
FGI33_10395  ATP-dependent 6-phosphofructokinase [KO:K21071] [EC:2.7.1.11 2.7.1.90]
FGI33_14400  glpX; class II fructose-bisphosphatase [KO:K02446] [EC:3.1.3.11]
FGI33_02015  fbaA; class II fructose-bisphosphate aldolase [KO:K01624] [EC:4.1.2.13]
FGI33_04435  triose-phosphate isomerase [KO:K01803] [EC:5.3.1.1]
FGI33_09425  triosephosphate isomerase [KO:K01803] [EC:5.3.1.1]
FGI33_04425  gap; type I glyceraldehyde-3-phosphate dehydrogenase [KO:K00134] [EC:1.2.1.12]
FGI33_04430  phosphoglycerate kinase [KO:K00927] [EC:2.7.2.3]
FGI33_00820  phosphoglyceromutase [KO:K01834] [EC:5.4.2.11]
FGI33_04590  histidine phosphatase family protein [KO:K15634] [EC:5.4.2.11]
FGI33_01835  phosphopyruvate hydratase [KO:K01689] [EC:4.2.1.11]
FGI33_04350  pyk; pyruvate kinase [KO:K00873] [EC:2.7.1.40]
FGI33_05055  aceE; pyruvate dehydrogenase (acetyl-transferring), homodimeric type [KO:K00163] [EC:1.2.4.1]
FGI33_04945  sucB; 2-oxoglutarate dehydrogenase, E2 component, dihydrolipoamide succinyltransferase [KO:K00627] [EC:2.3.1.12]
FGI33_04940  lpdA; dihydrolipoyl dehydrogenase [KO:K00382] [EC:1.8.1.4]
FGI33_06980  NAD(P)-dependent alcohol dehydrogenase [KO:K13953] [EC:1.1.1.1]
FGI33_02480  zinc-dependent alcohol dehydrogenase family protein [KO:K00001] [EC:1.1.1.1]
FGI33_01390  NAD(P)-dependent alcohol dehydrogenase [KO:K13979] [EC:1.1.1.2]
FGI33_10040  NAD(P)-dependent alcohol dehydrogenase [KO:K13979] [EC:1.1.1.2]
FGI33_12100  aldehyde dehydrogenase [KO:K00128] [EC:1.2.1.3]
FGI33_03450  AMP-binding protein [KO:K01895] [EC:6.2.1.1]
FGI33_04200  acs; acetate--CoA ligase [KO:K01895] [EC:6.2.1.1]
FGI33_08715  acs; acetate--CoA ligase [KO:K01895] [EC:6.2.1.1]
FGI33_00720  aldose epimerase [KO:K01785] [EC:5.1.3.3]
FGI33_10340  aldose epimerase [KO:K01785] [EC:5.1.3.3]
FGI33_07500  HAD-IA family hydrolase [KO:K20866] [EC:3.1.3.10]
FGI33_10820  alpha-D-glucose phosphate-specific phosphoglucomutase [KO:K01835] [EC:5.4.2.2]
FGI33_04995  ROK family protein [KO:K00886] [EC:2.7.1.63]
FGI33_13265  ROK family protein [KO:K00886] [EC:2.7.1.63]
FGI33_05855  phosphoenolpyruvate carboxykinase (GTP) [KO:K01596] [EC:4.1.1.32]
FGI33_11600  6-phospho-beta-glucosidase [KO:K01222] [EC:3.2.1.86]
Compound
C00022  Pyruvate
C00024  Acetyl-CoA
C00031  D-Glucose
C00033  Acetate
C00036  Oxaloacetate
C00068  Thiamin diphosphate
C00074  Phosphoenolpyruvate
C00084  Acetaldehyde
C00085  D-Fructose 6-phosphate
C00103  D-Glucose 1-phosphate
C00111  Glycerone phosphate
C00118  D-Glyceraldehyde 3-phosphate
C00186  (S)-Lactate
C00197  3-Phospho-D-glycerate
C00221  beta-D-Glucose
C00236  3-Phospho-D-glyceroyl phosphate
C00267  alpha-D-Glucose
C00354  D-Fructose 1,6-bisphosphate
C00469  Ethanol
C00631  2-Phospho-D-glycerate
C00668  alpha-D-Glucose 6-phosphate
C01159  2,3-Bisphospho-D-glycerate
C01172  beta-D-Glucose 6-phosphate
C01451  Salicin
C05125  2-(alpha-Hydroxyethyl)thiamine diphosphate
C06186  Arbutin
C06187  Arbutin 6-phosphate
C06188  Salicin 6-phosphate
C15972  Enzyme N6-(lipoyl)lysine
C15973  Enzyme N6-(dihydrolipoyl)lysine
C16255  [Dihydrolipoyllysine-residue acetyltransferase] S-acetyldihydrolipoyllysine
Reference
  Authors
Nishizuka Y (ed).
  Title
[Metabolic Maps] (In Japanese)
  Journal
Tokyo Kagaku Dojin (1980)
Reference
  Authors
Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).
  Title
[Cellular Functions and Metabolic Maps] (In Japanese)
  Journal
Tokyo Kagaku Dojin (1997)
Reference
  Authors
Michal G.
  Title
Biochemical Pathways
  Journal
Wiley (1999)
Related
pathway
cpha00020  Citrate cycle (TCA cycle)
cpha00030  Pentose phosphate pathway
cpha00500  Starch and sucrose metabolism
cpha00620  Pyruvate metabolism
cpha00640  Propanoate metabolism
cpha00710  Carbon fixation by Calvin cycle
KO pathway
ko00010   
LinkDB

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