KEGG   PATHWAY: cqi00020
Entry
cqi00020                    Pathway                                
Name
Citrate cycle (TCA cycle) - Chenopodium quinoa (quinoa)
Description
The citrate cycle (TCA cycle, Krebs cycle) is an important aerobic pathway for the final steps of the oxidation of carbohydrates and fatty acids. The cycle starts with acetyl-CoA, the activated form of acetate, derived from glycolysis and pyruvate oxidation for carbohydrates and from beta oxidation of fatty acids. The two-carbon acetyl group in acetyl-CoA is transferred to the four-carbon compound of oxaloacetate to form the six-carbon compound of citrate. In a series of reactions two carbons in citrate are oxidized to CO2 and the reaction pathway supplies NADH for use in the oxidative phosphorylation and other metabolic processes. The pathway also supplies important precursor metabolites including 2-oxoglutarate. At the end of the cycle the remaining four-carbon part is transformed back to oxaloacetate. According to the genome sequence data, many organisms seem to lack genes for the full cycle [MD:M00009], but contain genes for specific segments [MD:M00010 M00011].
Class
Metabolism; Carbohydrate metabolism
Pathway map
cqi00020  Citrate cycle (TCA cycle)
cqi00020

Module
cqi_M00003  Gluconeogenesis, oxaloacetate => fructose-6P [PATH:cqi00020]
cqi_M00010  Citrate cycle, first carbon oxidation, oxaloacetate => 2-oxoglutarate [PATH:cqi00020]
cqi_M00307  Pyruvate oxidation, pyruvate => acetyl-CoA [PATH:cqi00020]
Other DBs
GO: 0006099
Organism
Chenopodium quinoa (quinoa) [GN:cqi]
Gene
110735417  citrate synthase, glyoxysomal-like [KO:K01647] [EC:2.3.3.1]
110698677  citrate synthase, mitochondrial-like [KO:K01647] [EC:2.3.3.1]
110736282  citrate synthase, mitochondrial-like [KO:K01647] [EC:2.3.3.1]
110699667  citrate synthase, glyoxysomal-like [KO:K01647] [EC:2.3.3.1]
110703266  citrate synthase, mitochondrial [KO:K01647] [EC:2.3.3.1]
110717188  citrate synthase, mitochondrial-like [KO:K01647] [EC:2.3.3.1]
110717432  ATP-citrate synthase alpha chain protein 2-like [KO:K01648] [EC:2.3.3.8]
110738229  ATP-citrate synthase beta chain protein 1 [KO:K01648] [EC:2.3.3.8]
110722057  ATP-citrate synthase alpha chain protein 2 [KO:K01648] [EC:2.3.3.8]
110694192  ATP-citrate synthase alpha chain protein 1 [KO:K01648] [EC:2.3.3.8]
110709049  ATP-citrate synthase alpha chain protein 1-like [KO:K01648] [EC:2.3.3.8]
110697282  ATP-citrate synthase beta chain protein 1-like [KO:K01648] [EC:2.3.3.8]
110735841  putative aconitate hydratase, cytoplasmic [KO:K01681] [EC:4.2.1.3]
110738477  putative aconitate hydratase, cytoplasmic [KO:K01681] [EC:4.2.1.3]
110738479  putative aconitate hydratase, cytoplasmic [KO:K01681] [EC:4.2.1.3]
110697002  putative aconitate hydratase, cytoplasmic [KO:K01681] [EC:4.2.1.3]
110735157  isocitrate dehydrogenase [NADP]-like [KO:K00031] [EC:1.1.1.42]
110738987  isocitrate dehydrogenase [NADP] [KO:K00031] [EC:1.1.1.42]
110709946  isocitrate dehydrogenase [NADP]-like [KO:K00031] [EC:1.1.1.42]
110724429  isocitrate dehydrogenase [NADP]-like [KO:K00031] [EC:1.1.1.42]
110689308  isocitrate dehydrogenase [NADP]-like [KO:K00031] [EC:1.1.1.42]
110718165  isocitrate dehydrogenase [NADP]-like [KO:K00031] [EC:1.1.1.42]
110740099  isocitrate dehydrogenase [NAD] regulatory subunit 1, mitochondrial-like [KO:K00030] [EC:1.1.1.41]
110738453  isocitrate dehydrogenase [NAD] regulatory subunit 1, mitochondrial-like [KO:K00030] [EC:1.1.1.41]
110724961  isocitrate dehydrogenase [NAD] catalytic subunit 5, mitochondrial-like [KO:K00030] [EC:1.1.1.41]
110690841  probable isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial [KO:K00030] [EC:1.1.1.41]
110697688  isocitrate dehydrogenase [NAD] catalytic subunit 5, mitochondrial-like [KO:K00030] [EC:1.1.1.41]
110721213  isocitrate dehydrogenase [NAD] regulatory subunit 1, mitochondrial-like [KO:K00030] [EC:1.1.1.41]
110727239  isocitrate dehydrogenase [NAD] regulatory subunit 1, mitochondrial-like isoform X1 [KO:K00030] [EC:1.1.1.41]
110735398  2-oxoglutarate dehydrogenase, mitochondrial-like [KO:K00164] [EC:1.2.4.2]
110698479  2-oxoglutarate dehydrogenase, mitochondrial-like [KO:K00164] [EC:1.2.4.2]
110705070  2-oxoglutarate dehydrogenase, mitochondrial-like [KO:K00164] [EC:1.2.4.2]
110694712  2-oxoglutarate dehydrogenase, mitochondrial-like [KO:K00164] [EC:1.2.4.2]
110724691  2-oxoglutarate dehydrogenase, mitochondrial-like [KO:K00164] [EC:1.2.4.2]
110687388  dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex 1, mitochondrial-like [KO:K00658] [EC:2.3.1.61]
110731316  dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex 1, mitochondrial-like [KO:K00658] [EC:2.3.1.61]
110738060  dihydrolipoyl dehydrogenase 2, chloroplastic-like [KO:K00382] [EC:1.8.1.4]
110722076  dihydrolipoyl dehydrogenase, mitochondrial-like [KO:K00382] [EC:1.8.1.4]
110697208  dihydrolipoyl dehydrogenase 2, chloroplastic-like [KO:K00382] [EC:1.8.1.4]
110718206  dihydrolipoyl dehydrogenase, mitochondrial [KO:K00382] [EC:1.8.1.4]
110702094  succinate--CoA ligase [ADP-forming] subunit alpha-2, mitochondrial-like [KO:K01899] [EC:6.2.1.4 6.2.1.5]
110716262  succinate--CoA ligase [ADP-forming] subunit alpha-2, mitochondrial-like [KO:K01899] [EC:6.2.1.4 6.2.1.5]
110695123  succinate--CoA ligase [ADP-forming] subunit beta, mitochondrial [KO:K01900] [EC:6.2.1.4 6.2.1.5]
110681960  succinate--CoA ligase [ADP-forming] subunit beta, mitochondrial [KO:K01900] [EC:6.2.1.4 6.2.1.5]
110736916  succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial-like [KO:K00234] [EC:1.3.5.1]
110708623  succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial [KO:K00234] [EC:1.3.5.1]
110682479  succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial-like [KO:K00234] [EC:1.3.5.1]
110685786  succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial-like [KO:K00234] [EC:1.3.5.1]
110681710  succinate dehydrogenase [ubiquinone] iron-sulfur subunit 3, mitochondrial-like [KO:K00235] [EC:1.3.5.1]
110717784  succinate dehydrogenase [ubiquinone] iron-sulfur subunit 3, mitochondrial-like [KO:K00235] [EC:1.3.5.1]
110740304  succinate dehydrogenase [ubiquinone] iron-sulfur subunit 2, mitochondrial-like [KO:K00235] [EC:1.3.5.1]
110711834  succinate dehydrogenase [ubiquinone] iron-sulfur subunit 2, mitochondrial-like [KO:K00235] [EC:1.3.5.1]
110702017  succinate dehydrogenase [ubiquinone] cytochrome b subunit, mitochondrial-like [KO:K00236]
110687516  succinate dehydrogenase [ubiquinone] cytochrome b subunit, mitochondrial-like [KO:K00236]
110727946  fumarate hydratase 1, mitochondrial [KO:K01679] [EC:4.2.1.2]
110689783  fumarate hydratase 1, mitochondrial-like [KO:K01679] [EC:4.2.1.2]
110721337  malate dehydrogenase, cytoplasmic-like [KO:K00025] [EC:1.1.1.37]
110703738  malate dehydrogenase, cytoplasmic-like isoform X1 [KO:K00025] [EC:1.1.1.37]
110718311  malate dehydrogenase, cytoplasmic [KO:K00025] [EC:1.1.1.37]
110714132  malate dehydrogenase, cytoplasmic-like [KO:K00025] [EC:1.1.1.37]
110689431  malate dehydrogenase, cytoplasmic [KO:K00025] [EC:1.1.1.37]
110686158  malate dehydrogenase, glyoxysomal [KO:K00026] [EC:1.1.1.37]
110737759  malate dehydrogenase, mitochondrial-like [KO:K00026] [EC:1.1.1.37]
110700602  malate dehydrogenase, chloroplastic-like [KO:K00026] [EC:1.1.1.37]
110722334  malate dehydrogenase, glyoxysomal-like [KO:K00026] [EC:1.1.1.37]
110726448  malate dehydrogenase, chloroplastic-like [KO:K00026] [EC:1.1.1.37]
110686902  malate dehydrogenase, mitochondrial-like [KO:K00026] [EC:1.1.1.37]
110689818  malate dehydrogenase, chloroplastic-like [KO:K00026] [EC:1.1.1.37]
110728589  malate dehydrogenase, chloroplastic-like [KO:K00026] [EC:1.1.1.37]
110706401  phosphoenolpyruvate carboxykinase (ATP)-like [KO:K01610] [EC:4.1.1.49]
110713391  phosphoenolpyruvate carboxykinase (ATP)-like [KO:K01610] [EC:4.1.1.49]
110735092  pyruvate dehydrogenase E1 component subunit alpha-3, chloroplastic-like [KO:K00161] [EC:1.2.4.1]
110697506  pyruvate dehydrogenase E1 component subunit alpha-3, chloroplastic-like [KO:K00161] [EC:1.2.4.1]
110705204  pyruvate dehydrogenase E1 component subunit alpha-3, chloroplastic-like [KO:K00161] [EC:1.2.4.1]
110698093  pyruvate dehydrogenase E1 component subunit alpha-1, mitochondrial-like [KO:K00161] [EC:1.2.4.1]
110713867  pyruvate dehydrogenase E1 component subunit alpha-1, mitochondrial-like [KO:K00161] [EC:1.2.4.1]
110739657  pyruvate dehydrogenase E1 component subunit beta-1, mitochondrial-like [KO:K00162] [EC:1.2.4.1]
110703927  pyruvate dehydrogenase E1 component subunit beta-1, mitochondrial isoform X1 [KO:K00162] [EC:1.2.4.1]
110728546  pyruvate dehydrogenase E1 component subunit beta-3, chloroplastic-like [KO:K00162] [EC:1.2.4.1]
110696550  pyruvate dehydrogenase E1 component subunit beta-3, chloroplastic-like [KO:K00162] [EC:1.2.4.1]
110690489  pyruvate dehydrogenase E1 component subunit beta-1, mitochondrial-like [KO:K00162] [EC:1.2.4.1]
110708889  pyruvate dehydrogenase E1 component subunit beta-like [KO:K00162] [EC:1.2.4.1]
110711593  pyruvate dehydrogenase E1 component subunit beta-1, mitochondrial-like [KO:K00162] [EC:1.2.4.1]
110708957  pyruvate dehydrogenase E1 component subunit beta-2, chloroplastic-like [KO:K00162] [EC:1.2.4.1]
110709042  pyruvate dehydrogenase E1 component subunit beta-like [KO:K00162] [EC:1.2.4.1]
110739002  dihydrolipoyllysine-residue acetyltransferase component 1 of pyruvate dehydrogenase complex, mitochondrial-like [KO:K00627] [EC:2.3.1.12]
110713887  dihydrolipoyllysine-residue acetyltransferase component 2 of pyruvate dehydrogenase complex, mitochondrial-like [KO:K00627] [EC:2.3.1.12]
110719476  dihydrolipoyllysine-residue acetyltransferase component 4 of pyruvate dehydrogenase complex, chloroplastic-like [KO:K00627] [EC:2.3.1.12]
110720264  dihydrolipoyllysine-residue acetyltransferase component 1 of pyruvate dehydrogenase complex, mitochondrial-like [KO:K00627] [EC:2.3.1.12]
110721396  dihydrolipoyllysine-residue acetyltransferase component 2 of pyruvate dehydrogenase complex, mitochondrial-like isoform X1 [KO:K00627] [EC:2.3.1.12]
110725269  dihydrolipoyllysine-residue acetyltransferase component 5 of pyruvate dehydrogenase complex, chloroplastic-like [KO:K00627] [EC:2.3.1.12]
110714576  dihydrolipoyllysine-residue acetyltransferase component 5 of pyruvate dehydrogenase complex, chloroplastic-like [KO:K00627] [EC:2.3.1.12]
110691230  dihydrolipoyllysine-residue acetyltransferase component 4 of pyruvate dehydrogenase complex, chloroplastic [KO:K00627] [EC:2.3.1.12]
Compound
C00022  Pyruvate
C00024  Acetyl-CoA
C00026  2-Oxoglutarate
C00036  Oxaloacetate
C00042  Succinate
C00068  Thiamin diphosphate
C00074  Phosphoenolpyruvate
C00091  Succinyl-CoA
C00122  Fumarate
C00149  (S)-Malate
C00158  Citrate
C00311  Isocitrate
C00417  cis-Aconitate
C05125  2-(alpha-Hydroxyethyl)thiamine diphosphate
C05379  Oxalosuccinate
C05381  3-Carboxy-1-hydroxypropyl-ThPP
C15972  Enzyme N6-(lipoyl)lysine
C15973  Enzyme N6-(dihydrolipoyl)lysine
C16254  [Dihydrolipoyllysine-residue succinyltransferase] S-succinyldihydrolipoyllysine
C16255  [Dihydrolipoyllysine-residue acetyltransferase] S-acetyldihydrolipoyllysine
Reference
  Authors
Nishizuka Y (ed).
  Title
[Metabolic Maps] (In Japanese)
  Journal
Tokyo Kagaku Dojin (1980)
Reference
  Authors
Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).
  Title
[Cellular Functions and Metabolic Maps] (In Japanese)
  Journal
Tokyo Kagaku Dojin (1997)
Reference
  Authors
Michal G.
  Title
Biochemical Pathways
  Journal
Wiley (1999)
Related
pathway
cqi00010  Glycolysis / Gluconeogenesis
cqi00053  Ascorbate and aldarate metabolism
cqi00061  Fatty acid biosynthesis
cqi00062  Fatty acid elongation
cqi00071  Fatty acid degradation
cqi00190  Oxidative phosphorylation
cqi00220  Arginine biosynthesis
cqi00250  Alanine, aspartate and glutamate metabolism
cqi00280  Valine, leucine and isoleucine degradation
cqi00350  Tyrosine metabolism
cqi00470  D-Amino acid metabolism
cqi00630  Glyoxylate and dicarboxylate metabolism
KO pathway
ko00020   
LinkDB

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