KEGG   PATHWAY: csin00020
Entry
csin00020                   Pathway                                
Name
Citrate cycle (TCA cycle) - Camellia sinensis (tea plant)
Description
The citrate cycle (TCA cycle, Krebs cycle) is an important aerobic pathway for the final steps of the oxidation of carbohydrates and fatty acids. The cycle starts with acetyl-CoA, the activated form of acetate, derived from glycolysis and pyruvate oxidation for carbohydrates and from beta oxidation of fatty acids. The two-carbon acetyl group in acetyl-CoA is transferred to the four-carbon compound of oxaloacetate to form the six-carbon compound of citrate. In a series of reactions two carbons in citrate are oxidized to CO2 and the reaction pathway supplies NADH for use in the oxidative phosphorylation and other metabolic processes. The pathway also supplies important precursor metabolites including 2-oxoglutarate. At the end of the cycle the remaining four-carbon part is transformed back to oxaloacetate. According to the genome sequence data, many organisms seem to lack genes for the full cycle [MD:M00009], but contain genes for specific segments [MD:M00010 M00011].
Class
Metabolism; Carbohydrate metabolism
Pathway map
csin00020  Citrate cycle (TCA cycle)
csin00020

Module
csin_M00003  Gluconeogenesis, oxaloacetate => fructose-6P [PATH:csin00020]
csin_M00010  Citrate cycle, first carbon oxidation, oxaloacetate => 2-oxoglutarate [PATH:csin00020]
csin_M00307  Pyruvate oxidation, pyruvate => acetyl-CoA [PATH:csin00020]
Other DBs
GO: 0006099
Organism
Camellia sinensis (tea plant) [GN:csin]
Gene
114310501  citrate synthase, mitochondrial [KO:K01647] [EC:2.3.3.1]
114304692  citrate synthase, mitochondrial-like [KO:K01647] [EC:2.3.3.1]
114272994  citrate synthase, mitochondrial-like [KO:K01647] [EC:2.3.3.1]
114294490  citrate synthase, mitochondrial-like [KO:K01647] [EC:2.3.3.1]
114255790  citrate synthase, glyoxysomal [KO:K01647] [EC:2.3.3.1]
114310671  ATP-citrate synthase alpha chain protein 3 isoform X1 [KO:K01648] [EC:2.3.3.8]
114313640  ATP-citrate synthase alpha chain protein 1 [KO:K01648] [EC:2.3.3.8]
114281561  ATP-citrate synthase beta chain protein 2 [KO:K01648] [EC:2.3.3.8]
114261649  ATP-citrate synthase beta chain protein 2-like [KO:K01648] [EC:2.3.3.8]
114264465  ATP-citrate synthase beta chain protein 2-like [KO:K01648] [EC:2.3.3.8]
114270651  ATP-citrate synthase alpha chain protein 2-like [KO:K01648] [EC:2.3.3.8]
114260938  aconitate hydratase, cytoplasmic-like [KO:K01681] [EC:4.2.1.3]
114263909  aconitate hydratase, cytoplasmic isoform X1 [KO:K01681] [EC:4.2.1.3]
114316295  isocitrate dehydrogenase [NADP] [KO:K00031] [EC:1.1.1.42]
114318511  isocitrate dehydrogenase [NADP]-like [KO:K00031] [EC:1.1.1.42]
114294895  isocitrate dehydrogenase [NADP] [KO:K00031] [EC:1.1.1.42]
114308067  3-isopropylmalate dehydrogenase, chloroplastic-like [KO:K00030] [EC:1.1.1.41]
114308280  isocitrate dehydrogenase [NAD] regulatory subunit 1, mitochondrial [KO:K00030] [EC:1.1.1.41]
114302050  isocitrate dehydrogenase [NAD] regulatory subunit 1, mitochondrial-like isoform X1 [KO:K00030] [EC:1.1.1.41]
114269232  3-isopropylmalate dehydrogenase, chloroplastic-like isoform X1 [KO:K00030] [EC:1.1.1.41]
114277614  isocitrate dehydrogenase [NAD] regulatory subunit 1, mitochondrial-like isoform X1 [KO:K00030] [EC:1.1.1.41]
114323437  2-oxoglutarate dehydrogenase, mitochondrial [KO:K00164] [EC:1.2.4.2]
114308596  dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex 2, mitochondrial-like isoform X1 [KO:K00658] [EC:2.3.1.61]
114261644  dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex 1, mitochondrial-like isoform X1 [KO:K00658] [EC:2.3.1.61]
114294075  dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex 1, mitochondrial-like isoform X1 [KO:K00658] [EC:2.3.1.61]
114278062  dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex 1, mitochondrial-like [KO:K00658] [EC:2.3.1.61]
114291759  dihydrolipoyl dehydrogenase, mitochondrial [KO:K00382] [EC:1.8.1.4]
114277661  dihydrolipoyl dehydrogenase 2, chloroplastic-like isoform X1 [KO:K00382] [EC:1.8.1.4]
114258636  dihydrolipoyl dehydrogenase 2, chloroplastic-like isoform X1 [KO:K00382] [EC:1.8.1.4]
114268312  succinate--CoA ligase [ADP-forming] subunit alpha-1, mitochondrial [KO:K01899] [EC:6.2.1.4 6.2.1.5]
114294799  succinate--CoA ligase [ADP-forming] subunit beta, mitochondrial-like [KO:K01900] [EC:6.2.1.4 6.2.1.5]
114256362  succinate--CoA ligase [ADP-forming] subunit beta, mitochondrial [KO:K01900] [EC:6.2.1.4 6.2.1.5]
114315156  succinate dehydrogenase [ubiquinone] flavoprotein subunit 1, mitochondrial-like [KO:K00234] [EC:1.3.5.1]
114274958  succinate dehydrogenase [ubiquinone] flavoprotein subunit 1, mitochondrial isoform X1 [KO:K00234] [EC:1.3.5.1]
114320040  succinate dehydrogenase [ubiquinone] iron-sulfur subunit 2, mitochondrial-like [KO:K00235] [EC:1.3.5.1]
114274279  succinate dehydrogenase [ubiquinone] iron-sulfur subunit 2, mitochondrial-like [KO:K00235] [EC:1.3.5.1]
40867564  sdh3; succinate dehydrogenase subunit 3 [KO:K00236]
114286572  fumarate hydratase 1, mitochondrial-like [KO:K01679] [EC:4.2.1.2]
114269090  fumarate hydratase 1, mitochondrial isoform X1 [KO:K01679] [EC:4.2.1.2]
114318188  malate dehydrogenase [KO:K00025] [EC:1.1.1.37]
114264061  malate dehydrogenase-like [KO:K00025] [EC:1.1.1.37]
114274248  malate dehydrogenase-like [KO:K00025] [EC:1.1.1.37]
114297464  LOW QUALITY PROTEIN: malate dehydrogenase 2, cytoplasmic-like [KO:K00025] [EC:1.1.1.37]
114279597  malate dehydrogenase 2, cytoplasmic-like [KO:K00025] [EC:1.1.1.37]
114279625  malate dehydrogenase 2, cytoplasmic-like isoform X1 [KO:K00025] [EC:1.1.1.37]
114323322  malate dehydrogenase, glyoxysomal [KO:K00026] [EC:1.1.1.37]
114319347  malate dehydrogenase, chloroplastic-like isoform X1 [KO:K00026] [EC:1.1.1.37]
114319369  malate dehydrogenase, chloroplastic-like [KO:K00026] [EC:1.1.1.37]
114289779  malate dehydrogenase, glyoxysomal-like [KO:K00026] [EC:1.1.1.37]
114291262  malate dehydrogenase, chloroplastic-like isoform X1 [KO:K00026] [EC:1.1.1.37]
114294559  malate dehydrogenase, mitochondrial-like [KO:K00026] [EC:1.1.1.37]
114298316  malate dehydrogenase, chloroplastic-like [KO:K00026] [EC:1.1.1.37]
114279255  malate dehydrogenase, mitochondrial [KO:K00026] [EC:1.1.1.37]
114323464  phosphoenolpyruvate carboxykinase (ATP)-like isoform X1 [KO:K01610] [EC:4.1.1.49]
114277188  phosphoenolpyruvate carboxykinase (ATP)-like [KO:K01610] [EC:4.1.1.49]
114280504  pyruvate dehydrogenase E1 component subunit alpha, mitochondrial-like [KO:K00161] [EC:1.2.4.1]
114283582  pyruvate dehydrogenase E1 component subunit alpha-3, chloroplastic-like [KO:K00161] [EC:1.2.4.1]
114267165  pyruvate dehydrogenase E1 component subunit alpha-3, chloroplastic-like [KO:K00161] [EC:1.2.4.1]
114314334  pyruvate dehydrogenase E1 component subunit beta-3, chloroplastic [KO:K00162] [EC:1.2.4.1]
114317106  pyruvate dehydrogenase E1 component subunit beta-1, mitochondrial-like isoform X1 [KO:K00162] [EC:1.2.4.1]
114266618  pyruvate dehydrogenase E1 component subunit beta-1, mitochondrial isoform X1 [KO:K00162] [EC:1.2.4.1]
114288195  pyruvate dehydrogenase E1 component subunit beta-1, mitochondrial-like isoform X1 [KO:K00162] [EC:1.2.4.1]
114291723  pyruvate dehydrogenase E1 component subunit beta-1, mitochondrial-like [KO:K00162] [EC:1.2.4.1]
114296146  pyruvate dehydrogenase E1 component subunit beta-3, chloroplastic-like [KO:K00162] [EC:1.2.4.1]
114286033  dihydrolipoyllysine-residue acetyltransferase component 4 of pyruvate dehydrogenase complex, chloroplastic [KO:K00627] [EC:2.3.1.12]
114270115  dihydrolipoyllysine-residue acetyltransferase component 5 of pyruvate dehydrogenase complex, chloroplastic-like [KO:K00627] [EC:2.3.1.12]
114291067  dihydrolipoyllysine-residue acetyltransferase component 1 of pyruvate dehydrogenase complex, mitochondrial isoform X1 [KO:K00627] [EC:2.3.1.12]
114275545  dihydrolipoyllysine-residue acetyltransferase component 2 of pyruvate dehydrogenase complex, mitochondrial-like [KO:K00627] [EC:2.3.1.12]
Compound
C00022  Pyruvate
C00024  Acetyl-CoA
C00026  2-Oxoglutarate
C00036  Oxaloacetate
C00042  Succinate
C00068  Thiamin diphosphate
C00074  Phosphoenolpyruvate
C00091  Succinyl-CoA
C00122  Fumarate
C00149  (S)-Malate
C00158  Citrate
C00311  Isocitrate
C00417  cis-Aconitate
C05125  2-(alpha-Hydroxyethyl)thiamine diphosphate
C05379  Oxalosuccinate
C05381  3-Carboxy-1-hydroxypropyl-ThPP
C15972  Enzyme N6-(lipoyl)lysine
C15973  Enzyme N6-(dihydrolipoyl)lysine
C16254  [Dihydrolipoyllysine-residue succinyltransferase] S-succinyldihydrolipoyllysine
C16255  [Dihydrolipoyllysine-residue acetyltransferase] S-acetyldihydrolipoyllysine
Reference
  Authors
Nishizuka Y (ed).
  Title
[Metabolic Maps] (In Japanese)
  Journal
Tokyo Kagaku Dojin (1980)
Reference
  Authors
Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).
  Title
[Cellular Functions and Metabolic Maps] (In Japanese)
  Journal
Tokyo Kagaku Dojin (1997)
Reference
  Authors
Michal G.
  Title
Biochemical Pathways
  Journal
Wiley (1999)
Related
pathway
csin00010  Glycolysis / Gluconeogenesis
csin00053  Ascorbate and aldarate metabolism
csin00061  Fatty acid biosynthesis
csin00062  Fatty acid elongation
csin00071  Fatty acid degradation
csin00190  Oxidative phosphorylation
csin00220  Arginine biosynthesis
csin00250  Alanine, aspartate and glutamate metabolism
csin00280  Valine, leucine and isoleucine degradation
csin00350  Tyrosine metabolism
csin00470  D-Amino acid metabolism
csin00630  Glyoxylate and dicarboxylate metabolism
KO pathway
ko00020   
LinkDB

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