KEGG PATHWAY: csol04142

KEGG

PATHWAY: csol04142

Entry

csol04142                   Pathway

Name

Lysosome - Ceratosolen solmsi marchali (fig wasp)

Description

Lysosomes are membrane-delimited organelles in animal cells serving as the cell's main digestive compartment to which all sorts of macromolecules are delivered for degradation. They contain more than 40 hydrolases in an acidic environment (pH of about 5). After synthesis in the ER, lysosomal enzymes are decorated with mannose-6-phosphate residues, which are recognized by mannose-6-phosphate receptors in the trans-Golgi network. They are packaged into clathrin-coated vesicles and are transported to late endosomes. Substances for digestion are acquired by the lysosomes via a series of processes including endocytosis, phagocytosis, and autophagy.

Class

Cellular Processes; Transport and catabolism

Pathway map

Lysosome

Other DBs

GO:

Organism

Ceratosolen solmsi marchali (fig wasp) [GN:csol]

Gene

V-type proton ATPase 116 kDa subunit a isoform 1 isoform X1 [KO:K02154]

V-type proton ATPase 116 kDa subunit a isoform 1 isoform X1 [KO:K02154]

V-type proton ATPase subunit d [KO:K02146]

V-type proton ATPase subunit H [KO:K02144]

uncharacterized protein LOC105368498 [KO:K03662]

V-type proton ATPase 16 kDa proteolipid subunit [KO:K02155]

V-type proton ATPase 21 kDa proteolipid subunit-like [KO:K03661]

dmX-like protein 2 [KO:K24155]

WD repeat-containing protein 7 [KO:K24738]

oxidation resistance protein 1 [KO:K25442]

lysosomal aspartic protease [KO:K01379] [EC:3.4.23.5]

uncharacterized protein LOC105360904 [KO:K01373] [EC:3.4.22.41]

cathepsin L [KO:K01365] [EC:3.4.22.15]

cathepsin O-like isoform X1 [KO:K01374] [EC:3.4.22.42]

beta-galactosidase-like [KO:K12309] [EC:3.2.1.23]

beta-galactosidase-like [KO:K12309] [EC:3.2.1.23]

beta-galactosidase-like [KO:K12309] [EC:3.2.1.23]

lysosomal alpha-glucosidase-like [KO:K12316] [EC:3.2.1.20]

glucosylceramidase-like [KO:K01201] [EC:3.2.1.45]

alpha-N-acetylgalactosaminidase [KO:K01204] [EC:3.2.1.49]

alpha-N-acetylglucosaminidase [KO:K01205] [EC:3.2.1.50]

beta-glucuronidase-like [KO:K01195] [EC:3.2.1.31]

beta-glucuronidase-like [KO:K01195] [EC:3.2.1.31]

beta-glucuronidase-like [KO:K01195] [EC:3.2.1.31]

alpha-L-fucosidase-like [KO:K01206] [EC:3.2.1.51]

alpha-L-fucosidase-like [KO:K01206] [EC:3.2.1.51]

chitooligosaccharidolytic beta-N-acetylglucosaminidase [KO:K12373] [EC:3.2.1.52]

beta-hexosaminidase subunit beta-like [KO:K12373] [EC:3.2.1.52]

LOW QUALITY PROTEIN: chitooligosaccharidolytic beta-N-acetylglucosaminidase [KO:K12373] [EC:3.2.1.52]

beta-mannosidase [KO:K01192] [EC:3.2.1.25]

lysosomal alpha-mannosidase [KO:K12311] [EC:3.2.1.24]

LOW QUALITY PROTEIN: hyaluronidase-like [KO:K01197] [EC:3.2.1.35]

arylsulfatase B-like [KO:K01135] [EC:3.1.6.12]

arylsulfatase I [KO:K01135] [EC:3.1.6.12]

arylsulfatase B-like [KO:K01135] [EC:3.1.6.12]

arylsulfatase B-like [KO:K01135] [EC:3.1.6.12]

N-acetylglucosamine-6-sulfatase-like [KO:K01137] [EC:3.1.6.14]

iduronate 2-sulfatase isoform X1 [KO:K01136] [EC:3.1.6.13]

N-sulphoglucosamine sulphohydrolase [KO:K01565] [EC:3.10.1.1]

lipase 3-like [KO:K01052] [EC:3.1.1.13]

lipase 3-like [KO:K01052] [EC:3.1.1.13]

lipase 3-like [KO:K01052] [EC:3.1.1.13]

lipase 3-like [KO:K01052] [EC:3.1.1.13]

lipase 3-like [KO:K01052] [EC:3.1.1.13]

lipase 1-like isoform X1 [KO:K01052] [EC:3.1.1.13]

lipase 3-like [KO:K01052] [EC:3.1.1.13]

lipase 3-like [KO:K01052] [EC:3.1.1.13]

LOW QUALITY PROTEIN: lysosomal acid lipase/cholesteryl ester hydrolase-like [KO:K01052] [EC:3.1.1.13]

lipase 3-like [KO:K01052] [EC:3.1.1.13]

group XV phospholipase A2-like [KO:K06129] [EC:3.1.1.5]

plancitoxin-1 [KO:K01158] [EC:3.1.22.1]

uncharacterized protein LOC105364387 [KO:K14410] [EC:3.1.3.2]

lysosomal acid phosphatase-like [KO:K14410] [EC:3.1.3.2]

prostatic acid phosphatase-like isoform X1 [KO:K14410] [EC:3.1.3.2]

sphingomyelin phosphodiesterase-like [KO:K12350] [EC:3.1.4.12]

sphingomyelin phosphodiesterase-like [KO:K12350] [EC:3.1.4.12]

N(4)-(Beta-N-acetylglucosaminyl)-L-asparaginase- like [KO:K01444] [EC:3.5.1.26]

N(4)-(Beta-N-acetylglucosaminyl)-L-asparaginase- like [KO:K01444] [EC:3.5.1.26]

uncharacterized protein LOC105364885 [KO:K12382]

palmitoyl-protein thioesterase 1 [KO:K01074] [EC:3.1.2.22]

lysosomal thioesterase PPT2 homolog [KO:K01074] [EC:3.1.2.22]

lysosome-associated membrane glycoprotein 1 [KO:K06528]

CD63 antigen-like [KO:K06497]

CD63 antigen [KO:K06497]

CD63 antigen-like [KO:K06497]

CD63 antigen [KO:K06497]

sensory neuron membrane protein 2-like [KO:K12384]

sensory neuron membrane protein 1 [KO:K12384]

LOW QUALITY PROTEIN: Niemann-Pick C1 protein-like [KO:K12385]

Niemann-Pick C1 protein-like [KO:K12385]

patched domain-containing protein 3-like [KO:K12385]

MD-2-related lipid-recognition protein-like [KO:K13443]

protein NPC2 homolog [KO:K13443]

protein NPC2 homolog [KO:K13443]

cystinosin homolog isoform X1 [KO:K12386]

uncharacterized protein LOC105360309 [KO:K12386]

sialin-like isoform X1 [KO:K12301]

sialin-like [KO:K12301]

putative inorganic phosphate cotransporter [KO:K12301]

putative inorganic phosphate cotransporter isoform X1 [KO:K12301]

protein Malvolio [KO:K21398]

integumentary mucin C.1-like [KO:K06546]

battenin [KO:K12389]

major facilitator superfamily domain-containing protein 8 [KO:K12307]

heparan-alpha-glucosaminide N-acetyltransferase-like [KO:K10532] [EC:2.3.1.78]

heparan-alpha-glucosaminide N-acetyltransferase-like [KO:K10532] [EC:2.3.1.78]

sulfatase-modifying factor 1 [KO:K13444] [EC:1.8.3.7]

N-acetylglucosamine-1-phosphotransferase subunits alpha/beta [KO:K08239] [EC:2.7.8.17]

clathrin light chain isoform X1 [KO:K04645]

clathrin heavy chain [KO:K04646]

AP-1 complex subunit gamma-1 isoform X1 [KO:K12391]

AP-1 complex subunit beta-1 isoform X1 [KO:K12392]

AP-1 complex subunit mu-1 [KO:K12393]

AP-1 complex subunit sigma-2 isoform X1 [KO:K12394]

AP-3 complex subunit delta-1 [KO:K12396]

AP-3 complex subunit beta-1 [KO:K12397]

AP-3 complex subunit mu-1 isoform X1 [KO:K12398]

AP-3 complex subunit sigma-2 [KO:K12399]

uncharacterized protein LOC105367861 [KO:K19363]

lipopolysaccharide-induced tumor necrosis factor-alpha factor homolog [KO:K19363]

Compound

ATP

ADP

D-Mannose

D-Mannose 6-phosphate

Reference

Authors

Eskelinen EL, Tanaka Y, Saftig P

Title

At the acidic edge: emerging functions for lysosomal membrane proteins.

Journal

Trends Cell Biol 13:137-45 (2003)
DOI:10.1016/S0962-8924(03)00005-9

Reference

Authors

Neufeld EF

Title

Lysosomal storage diseases.

Journal

Annu Rev Biochem 60:257-80 (1991)
DOI:10.1146/annurev.bi.60.070191.001353

Reference

Authors

von Figura K, Hasilik A

Title

Lysosomal enzymes and their receptors.

Journal

Annu Rev Biochem 55:167-93 (1986)
DOI:10.1146/annurev.bi.55.070186.001123

Reference

Authors

Janvier K, Bonifacino JS

Title

Role of the endocytic machinery in the sorting of lysosome-associated membrane proteins.

Journal

Mol Biol Cell 16:4231-42 (2005)
DOI:10.1091/mbc.E05-03-0213

Reference

Authors

Vergarajauregui S, Puertollano R

Title

Mucolipidosis type IV: the importance of functional lysosomes for efficient autophagy.

Journal

Autophagy 4:832-4 (2008)
DOI:10.4161/auto.6567

Reference

Authors

Jaskolka MC, Winkley SR, Kane PM

Title

RAVE and Rabconnectin-3 Complexes as Signal Dependent Regulators of Organelle Acidification.

Journal

Front Cell Dev Biol 9:698190 (2021)
DOI:10.3389/fcell.2021.698190

Reference

Authors

Majdoul S, Compton AA

Title

Lessons in self-defence: inhibition of virus entry by intrinsic immunity.

Journal

Nat Rev Immunol 10.1038/s41577-021-00626-8 (2021)
DOI:10.1038/s41577-021-00626-8

Related
pathway

Other glycan degradation

Glycosaminoglycan degradation

SNARE interactions in vesicular transport

Autophagy - animal

Endocytosis

KO pathway

LinkDB

DBGET integrated database retrieval system