KEGG   PATHWAY: dme04711
Entry
dme04711                    Pathway                                
Name
Circadian rhythm - fly - Drosophila melanogaster (fruit fly)
Description
Circadian rhythm is an internal biological clock, which enables to sustain an approximately 24-hour rhythm in the absence of environmental cues. In the fruit fly Drosophila melanogaster, seven genes that contribute to the central clock function are known: period (per), timeless (tim), Clock (Clk), cycle (cyc), vrille (vri), double-time (dbt), and shaggy (sgg). The core of the circadian clock consists of molecular feedback loops where per and tim gene products (PER and TIM proteins) eventually turn off their own transcription. The CLK/CYC heterodimer activates transcription of per and tim genes, while the PER and TIM repressor proteins accumulate in the cytoplasm. After nuclear entry of PER and TIM, transcription is inhibited by direct binding of the PER/TIM heterodimer to the CLK/CYC heterodimer. This shutoff lasts until the PER and TIM proteins are degraded allowing a new round of transcription to occur.
Class
Organismal Systems; Environmental adaptation
Pathway map
dme04711  Circadian rhythm - fly
dme04711

Other DBs
GO: 0007623
Organism
Drosophila melanogaster (fruit fly) [GN:dme]
Gene
Dmel_CG2048  dco; discs overgrown, isoform D [KO:K08960] [EC:2.7.11.1]
Dmel_CG2647  per; period, isoform B [KO:K02633]
Dmel_CG14164  Hez; hezron, isoform B [KO:K23643]
Dmel_CG15735  Lsm12a; LSM12 homolog a [KO:K23643]
Dmel_CG5166  Atx2; Ataxin-2, isoform B [KO:K23625]
Dmel_CG4857  tyf; twenty-four, isoform C [KO:K23644]
Dmel_CG3234  tim; timeless, isoform P [KO:K12074]
Dmel_CG7391  Clk; clock, isoform D [KO:K02223] [EC:2.3.1.48]
Dmel_CG8727  cyc; cycle [KO:K02296]
Dmel_CG14029  vri; vrille, isoform D [KO:K12114]
Dmel_CG17888  Pdp1; PAR-domain protein 1, isoform L [KO:K09057]
Dmel_CG2621  sgg; shaggy, isoform B [KO:K03083] [EC:2.7.11.26]
Dmel_CG31003  gskt; gasket [KO:K03083] [EC:2.7.11.26]
Reference
  Authors
Panda S, Hogenesch JB, Kay SA.
  Title
Circadian rhythms from flies to human.
  Journal
Nature 417:329-35 (2002)
DOI:10.1038/417329a
Reference
  Authors
Harmer SL, Panda S, Kay SA.
  Title
Molecular bases of circadian rhythms.
  Journal
Annu Rev Cell Dev Biol 17:215-53 (2001)
DOI:10.1146/annurev.cellbio.17.1.215
Reference
  Authors
Young MW, Kay SA.
  Title
Time zones: a comparative genetics of circadian clocks.
  Journal
Nat Rev Genet 2:702-15 (2001)
DOI:10.1038/35088576
Reference
  Authors
Cyran SA, Buchsbaum AM, Reddy KL, Lin MC, Glossop NR, Hardin PE, Young MW, Storti RV, Blau J.
  Title
vrille, Pdp1, and dClock form a second feedback loop in the Drosophila circadian clock.
  Journal
Cell 112:329-41 (2003)
DOI:10.1016/S0092-8674(03)00074-6
Reference
  Authors
Helfrich-Forster C
  Title
The circadian system of Drosophila melanogaster and its light input pathways.
  Journal
Zoology (Jena) 105:297-312 (2002)
DOI:10.1078/0944-2006-00074
Reference
  Authors
Stanewsky R
  Title
Genetic analysis of the circadian system in Drosophila melanogaster and mammals.
  Journal
J Neurobiol 54:111-47 (2003)
DOI:10.1002/neu.10164
Reference
  Authors
Lee J, Yoo E, Lee H, Park K, Hur JH, Lim C
  Title
LSM12 and ME31B/DDX6 Define Distinct Modes of Posttranscriptional Regulation by ATAXIN-2 Protein Complex in Drosophila Circadian Pacemaker Neurons.
  Journal
Mol Cell 66:129-140.e7 (2017)
DOI:10.1016/j.molcel.2017.03.004
KO pathway
ko04711   
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