KEGG   PATHWAY: dosa00480
Entry
dosa00480                   Pathway                                
Name
Glutathione metabolism - Oryza sativa japonica (Japanese rice) (RAPDB)
Class
Metabolism; Metabolism of other amino acids
Pathway map
dosa00480  Glutathione metabolism
dosa00480

Module
dosa_M00118  Glutathione biosynthesis, glutamate => glutathione [PATH:dosa00480]
Other DBs
GO: 0006749
Organism
Oryza sativa japonica (Japanese rice) (RAPDB) [GN:dosa]
Gene
Os01t0151500-00  (RAP-DB) Os01g0151500; Similar to GGT4 (GAMMA-GLUTAMYL TRANSPEPTIDASE 4); gamma-glutamyltransferase/ glutathione gamma-glutamylcysteinyltransferase. [KO:K18592] [EC:2.3.2.2 3.4.19.13 3.4.19.14]
Os04t0457500-01  (RAP-DB) Os04g0457500; Similar to H0523F07.13 protein. [KO:K18592] [EC:2.3.2.2 3.4.19.13 3.4.19.14]
Os02t0465900-01  (RAP-DB) Os02g0465900; ChaC-like protein family protein. [KO:K22596] [EC:4.3.2.9]
Os04t0448600-01  (RAP-DB) Os04g0448600; ChaC-like protein family protein. [KO:K22596] [EC:4.3.2.9]
Os01t0966000-01  (RAP-DB) Os01g0966000; Similar to Plasma membrane H+-ATPase (EC 3.6.1.3). [KO:K01469] [EC:3.5.2.9]
Os05t0129000-01  (RAP-DB) Os05g0129000; Similar to Gamma-glutamylcysteine synthetase (Fragment). [KO:K01919] [EC:6.3.2.2]
Os11t0642800-01  (RAP-DB) Os11g0642800; Similar to Glutathione synthetase. [KO:K21456] [EC:6.3.2.3]
Os12t0263000-01  (RAP-DB) Os12g0263000; Similar to Glutathione synthase. [KO:K21456] [EC:6.3.2.3]
Os12t0434400-00  (RAP-DB) Os12g0434400; Similar to predicted protein. [KO:K01255] [EC:3.4.11.1]
Os02t0794700-01  (RAP-DB) Os02g0794700; Similar to Cytosol aminopeptidase (EC 3.4.11.1) (Leucine aminopeptidase) (LAP) (Leucyl aminopeptidase) (Proline aminopeptidase) (EC 3.4.11.5) (Prolyl aminopeptidase). [KO:K01255] [EC:3.4.11.1]
Os08t0562700-01  (RAP-DB) Os08g0562700; Similar to peptidase M1 family protein. [KO:K01256] [EC:3.4.11.2]
Os10t0530500-01  (RAP-DB) Os10g0530500; Similar to Glutathione-S-transferase Cla47. [KO:K00799] [EC:2.5.1.18]
Os01t0692000-01  (RAP-DB) Os01g0692000; Similar to Glutathione S-transferase GSTU6. [KO:K00799] [EC:2.5.1.18]
Os10t0529300-01  (RAP-DB) Os10g0529300; Similar to Tau class GST protein 3. [KO:K00799] [EC:2.5.1.18]
Os01t0370200-00  (RAP-DB) Os01g0370200; Similar to Glutathione-S-transferase 19E50. [KO:K00799] [EC:2.5.1.18]
Os09t0467200-01  (RAP-DB) Os09g0467200; Similar to Glutathione S-transferase GST 23 (EC 2.5.1.18) (Fragment). [KO:K00799] [EC:2.5.1.18]
Os07t0152700-00  (RAP-DB) Os07g0152700; Similar to Glutathione transferase. [KO:K00799] [EC:2.5.1.18]
Os07t0468100-01  (RAP-DB) Os07g0468100; Similar to Glutathione S-transferase GST 19 (EC 2.5.1.18). [KO:K00799] [EC:2.5.1.18]
Os05t0148900-01  (RAP-DB) Os05g0148900; Similar to Glutathione-S-transferase 19E50. [KO:K00799] [EC:2.5.1.18]
Os03t0134900-01  (RAP-DB) Os03g0134900; Similar to Glutathione S-transferase GSTF14 (Fragment). [KO:K00799] [EC:2.5.1.18]
Os03t0135100-01  (RAP-DB) Os03g0135100; Glutathione S-transferase GSTF15. [KO:K00799] [EC:2.5.1.18]
Os10t0525400-01  (RAP-DB) Os10g0525400; Similar to Glutathione S-transferase GSTU31 (Fragment). [KO:K00799] [EC:2.5.1.18]
Os10t0525500-01  (RAP-DB) Os10g0525500; Similar to glutathione transferase31. [KO:K00799] [EC:2.5.1.18]
Os10t0525800-00  (RAP-DB) Os10g0525800; Similar to Glutathione S-transferase GSTU31 (Fragment). [KO:K00799] [EC:2.5.1.18]
Os10t0527400-01  (RAP-DB) Os10g0527400; Similar to Tau class GST protein 3. [KO:K00799] [EC:2.5.1.18]
Os10t0527601-00  (RAP-DB) Os10g0527601; Glutathione S-transferase, C-terminal-like domain containing protein. [KO:K00799] [EC:2.5.1.18]
Os10t0527800-01  (RAP-DB) Os10g0527800; Similar to Tau class GST protein 3. [KO:K00799] [EC:2.5.1.18]
Os10t0528100-01  (RAP-DB) Os10g0528100; Similar to Glutathione S-transferase GST 42 (EC 2.5.1.18) (Fragment). [KO:K00799] [EC:2.5.1.18]
Os10t0528200-01  (RAP-DB) Os10g0528200; Similar to Glutathione S-transferase TSI-1 (EC 2.5.1.18) (Glutathione S- transferase 1). [KO:K00799] [EC:2.5.1.18]
Os10t0528300-01  (RAP-DB) Os10g0528300; Tau class GST protein 4. [KO:K00799] [EC:2.5.1.18]
Os10t0528400-01  (RAP-DB) Os10g0528400; Glutathione S-transferase, C-terminal-like domain containing protein. [KO:K00799] [EC:2.5.1.18]
Os10t0528900-01  (RAP-DB) Os10g0528900; Similar to Tau class GST protein 3. [KO:K00799] [EC:2.5.1.18]
Os10t0529400-01  (RAP-DB) Os10g0529400; Similar to Glutathione S-transferase GSTU6. [KO:K00799] [EC:2.5.1.18]
Os10t0529500-01  (RAP-DB) Os10g0529500; Similar to Glutathione-S-transferase 2. [KO:K00799] [EC:2.5.1.18]
Os10t0529700-01  (RAP-DB) Os10g0529700; Similar to glutathione transferase35. [KO:K00799] [EC:2.5.1.18]
Os03t0785900-01  (RAP-DB) Os03g0785900; Similar to Glutathione-S-transferase. [KO:K00799] [EC:2.5.1.18]
Os01t0949700-01  (RAP-DB) Os01g0949700; Glutathione S-transferase, C-terminal domain containing protein. [KO:K00799] [EC:2.5.1.18]
Os01t0949750-00  (RAP-DB) Os01g0949750; Similar to Glutathione S-transferase GST 28 (Fragment). [KO:K00799] [EC:2.5.1.18]
Os01t0949800-01  (RAP-DB) Os01g0949800; Similar to Glutathione S-transferase GST 28 (EC 2.5.1.18) (Fragment). [KO:K00799] [EC:2.5.1.18]
Os01t0950000-01  (RAP-DB) Os01g0950000; Similar to Glutathione S-transferase GST 28 (EC 2.5.1.18) (Fragment). [KO:K00799] [EC:2.5.1.18]
Os10t0529800-00  (RAP-DB) Os10g0529800; Similar to Tau class GST protein 4. [KO:K00799] [EC:2.5.1.18]
Os10t0530200-01  (RAP-DB) Os10g0530200; Similar to Glutathione S-transferase TSI-1 (EC 2.5.1.18) (Glutathione S- transferase 1). [KO:K00799] [EC:2.5.1.18]
Os10t0530600-01  (RAP-DB) Os10g0530600; Similar to Glutathione S-transferase GST 20 (EC 2.5.1.18). [KO:K00799] [EC:2.5.1.18]
Os10t0530900-01  (RAP-DB) Os10g0530900; Similar to Glutathione S-transferase GST 30 (EC 2.5.1.18). [KO:K00799] [EC:2.5.1.18]
Os10t0531400-01  (RAP-DB) Os10g0531400; Glutathione S-transferase GST 30 (EC 2.5.1.18). [KO:K00799] [EC:2.5.1.18]
Os10t0365200-00  (RAP-DB) Os10g0365200; Thioredoxin fold domain containing protein. [KO:K00799] [EC:2.5.1.18]
Os11t0588300-01  (RAP-DB) Os11g0588300; Similar to Glutathione transferase AtGST 10 (EC 2.5.1.18). [KO:K00799] [EC:2.5.1.18]
Os01t0369700-01  (RAP-DB) Os01g0369700; Similar to Glutathione S-transferase GST 8 (EC 2.5.1.18). [KO:K00799] [EC:2.5.1.18]
Os01t0370900-00  (RAP-DB) Os01g0370900; Similar to Glutathione transferase. [KO:K00799] [EC:2.5.1.18]
Os01t0371200-01  (RAP-DB) Os01g0371200; Similar to Glutathione-S-transferase 19E50. [KO:K00799] [EC:2.5.1.18]
Os01t0371400-00  (RAP-DB) Os01g0371400; Similar to Glutathione s-transferase gstf2. [KO:K00799] [EC:2.5.1.18]
Os01t0371500-01  (RAP-DB) Os01g0371500; Similar to Glutathione-S-transferase 19E50. [KO:K00799] [EC:2.5.1.18]
Os01t0372400-01  (RAP-DB) Os01g0372400; Glutathione S-transferase, C-terminal-like domain containing protein. [KO:K00799] [EC:2.5.1.18]
Os01t0374000-01  (RAP-DB) Os01g0374000; Similar to Glutathione S-transferase I (EC 2.5.1.18) (GST-I) (GST-29) (GST class- phi). [KO:K00799] [EC:2.5.1.18]
Os01t0933900-01  (RAP-DB) Os01g0933900; Similar to Glutathione transferase III(B) (EC 2.5.1.18). [KO:K00799] [EC:2.5.1.18]
Os09t0367700-01  (RAP-DB) Os09g0367700; Similar to GST6 protein (EC 2.5.1.18). [KO:K00799] [EC:2.5.1.18]
Os10t0543800-00  (RAP-DB) Os10g0543800; Similar to Glutathione S-transferase GST 11 (EC 2.5.1.18). [KO:K00799] [EC:2.5.1.18]
Os03t0135200-01  (RAP-DB) Os03g0135200; Similar to Glutathione S-transferase GST 9 (EC 2.5.1.18). [KO:K00799] [EC:2.5.1.18]
Os03t0135300-01  (RAP-DB) Os03g0135300; Similar to Glutathione S-transferase GST 10 (EC 2.5.1.18). [KO:K00799] [EC:2.5.1.18]
Os10t0481300-01  (RAP-DB) Os10g0481300; Similar to Glutathione S-transferase, N-terminal domain containing protein, expressed. [KO:K00799] [EC:2.5.1.18]
Os01t0558100-01  (RAP-DB) Os01g0558100; Similar to Glutathione S-transferase TSI-1 (EC 2.5.1.18) (Glutathione S- transferase 1). [KO:K00799] [EC:2.5.1.18]
Os03t0709000-01  (RAP-DB) Os03g0709000; Membrane-associated, eicosanoid and glutathione metabolism (MAPEG) domain containing protein. [KO:K00799] [EC:2.5.1.18]
Os10t0395400-00  (RAP-DB) Os10g0395400; Thioredoxin fold domain containing protein. [KO:K00799] [EC:2.5.1.18]
Os01t0692100-01  (RAP-DB) Os01g0692100; Glutathione S-transferase, C-terminal-like domain containing protein. [KO:K00799] [EC:2.5.1.18]
Os03t0283000-00  (RAP-DB) Os03g0283000; Similar to In2-1 protein. [KO:K00799] [EC:2.5.1.18]
Os03t0283100-01  (RAP-DB) Os03g0283100; Similar to In2-1 protein. [KO:K00799] [EC:2.5.1.18]
Os03t0283200-00  (RAP-DB) Os03g0283200; Similar to IN2-1 protein. [KO:K00799] [EC:2.5.1.18]
Os07t0168300-01  (RAP-DB) Os07g0168300; Similar to Glutathione S-transferase GSTU6. [KO:K00799] [EC:2.5.1.18]
Os05t0412800-01  (RAP-DB) Os05g0412800; Similar to Glutathione S-transferase GST 41 (EC 2.5.1.18). [KO:K00799] [EC:2.5.1.18]
Os12t0123200-01  (RAP-DB) Os12g0123200; Glutathione S-transferase GST 7 (EC 2.5.1.18). [KO:K00799] [EC:2.5.1.18]
Os01t0353400-00  (RAP-DB) Os01g0353400; Similar to Glutathione S-transferase GST 8 (EC 2.5.1.18). [KO:K00799] [EC:2.5.1.18]
Os10t0530400-01  (RAP-DB) Os10g0530400; Similar to Glutathione-S-transferase Cla47. [KO:K00799] [EC:2.5.1.18]
Os03t0643700-01  (RAP-DB) Os03g0643700; Similar to GST6 protein (EC 2.5.1.18). [KO:K00799] [EC:2.5.1.18]
Os01t0764000-01  (RAP-DB) Os01g0764000; Similar to Glutathione S-transferase I (EC 2.5.1.18) (GST-I) (GST-29) (GST class- phi). [KO:K00799] [EC:2.5.1.18]
Os03t0595600-00  (RAP-DB) Os03g0595600; Similar to Glutathione S-transferase, N-terminal domain containing protein, expressed. [KO:K00799] [EC:2.5.1.18]
Os05t0116100-01  (RAP-DB) Os05g0116100; Dehydroascorbate reductase. [KO:K21888] [EC:1.8.5.1 2.5.1.18]
Os06t0232600-01  (RAP-DB) Os06g0232600; Similar to Dehydroascorbate reductase. [KO:K21888] [EC:1.8.5.1 2.5.1.18]
Os03t0163300-01  (RAP-DB) Os03g0163300; Similar to Glutathione reductase (Fragment). [KO:K00383] [EC:1.8.1.7]
Os10t0415300-01  (RAP-DB) Os10g0415300; Similar to Chloroplastic glutathione reductase. [KO:K00383] [EC:1.8.1.7]
Os02t0813500-01  (RAP-DB) Os02g0813500; Glutathione reductase, cytosolic (EC 1.8.1.7) (GR) (GRase). [KO:K00383] [EC:1.8.1.7]
Os01t0654500-01  (RAP-DB) Os01g0654500; Similar to NADP-isocitrate dehydrogenase. [KO:K00031] [EC:1.1.1.42]
Os04t0508200-01  (RAP-DB) Os04g0508200; Isocitrate/isopropylmalate dehydrogenase domain containing protein. [KO:K00031] [EC:1.1.1.42]
Os05t0573200-00  (RAP-DB) Os05g0573200; Similar to Isocitrate dehydrogenase (Fragment). [KO:K00031] [EC:1.1.1.42]
Os01t0248400-01  (RAP-DB) Os01g0248400; Similar to Isocitrate dehydrogenase (Fragment). [KO:K00031] [EC:1.1.1.42]
Os06t0111500-01  (RAP-DB) Os06g0111500; Cytosolic 6-phosphogluconate dehydrogenase. [KO:K00033] [EC:1.1.1.44 1.1.1.343]
Os11t0484500-01  (RAP-DB) Os11g0484500; Similar to 6-phosphogluconate dehydrogenase. [KO:K00033] [EC:1.1.1.44 1.1.1.343]
Os04t0485300-01  (RAP-DB) Os04g0485300; Glucose-6-phosphate dehydrogenase. [KO:K00036] [EC:1.1.1.49 1.1.1.363]
Os07t0406300-01  (RAP-DB) Os07g0406300; Similar to Glucose-6-phosphate 1-dehydrogenase. [KO:K00036] [EC:1.1.1.49 1.1.1.363]
Os03t0318500-01  (RAP-DB) Os03g0318500; Similar to Glucose-6-phosphate 1-dehydrogenase, chloroplast precursor (EC 1.1.1.49) (G6PD). [KO:K00036] [EC:1.1.1.49 1.1.1.363]
Os02t0600400-01  (RAP-DB) Os02g0600400; Similar to Glucose-6-phosphate dehydrogenase. [KO:K00036] [EC:1.1.1.49 1.1.1.363]
Os03t0412800-01  (RAP-DB) Os03g0412800; Similar to Glucose-6-phosphate dehydrogenase precursor. [KO:K00036] [EC:1.1.1.49 1.1.1.363]
Os02t0664000-01  (RAP-DB) Os02g0664000; Similar to Phospholipid hydroperoxide glutathione peroxidase, chloroplast precursor (EC 1.11.1.12) (PHGPx). [KO:K00432] [EC:1.11.1.9]
Os04t0556300-01  (RAP-DB) Os04g0556300; Glutathione peroxidase. [KO:K00432] [EC:1.11.1.9]
Os06t0185900-01  (RAP-DB) Os06g0185900; Similar to Glutathione peroxidase. [KO:K00432] [EC:1.11.1.9]
Os11t0284900-01  (RAP-DB) Os11g0284900; Similar to Phospholipid hydroperoxide glutathione peroxidase (EC 1.11.1.9). [KO:K00432] [EC:1.11.1.9]
Os03t0358100-01  (RAP-DB) Os03g0358100; Similar to Glutathione peroxidase. [KO:K00432] [EC:1.11.1.9]
Os07t0638300-01  (RAP-DB) Os07g0638300; Similar to 1-Cys peroxiredoxin. [KO:K11188] [EC:1.11.1.7 1.11.1.27 3.1.1.-]
Os07t0638400-01  (RAP-DB) Os07g0638400; Similar to 1-Cys peroxiredoxin. [KO:K11188] [EC:1.11.1.7 1.11.1.27 3.1.1.-]
Os02t0482400-01  (RAP-DB) Os02g0482400; Similar to Ornithine decarboxylase (EC 4.1.1.17) (ODC). [KO:K01581] [EC:4.1.1.17]
Os09t0543400-00  (RAP-DB) Os09g0543400; Ornithine decarboxylase (EC 4.1.1.17). [KO:K01581] [EC:4.1.1.17]
Os06t0528600-01  (RAP-DB) Os06g0528600; Aminopropyl transferase. [KO:K00797] [EC:2.5.1.16]
Os07t0408700-02  (RAP-DB) Os07g0408700; Similar to Spermidine synthase 2 (EC 2.5.1.16) (Putrescine aminopropyltransferase 2) (SPDSY 2). [KO:K00797] [EC:2.5.1.16]
Os08t0522400-01  (RAP-DB) Os08g0522400; Similar to APX6; L-ascorbate peroxidase/ heme binding / peroxidase. [KO:K00434] [EC:1.11.1.11]
Os07t0694700-01  (RAP-DB) Os07g0694700; L-ascorbate peroxidase. [KO:K00434] [EC:1.11.1.11]
Os12t0178100-01  (RAP-DB) Os12g0178100; Haem peroxidase family protein. [KO:K00434] [EC:1.11.1.11]
Os12t0178200-01  (RAP-DB) Os12g0178200; Similar to Thylakoid-bound ascorbate peroxidase (EC 1.11.1.11) (Fragment). [KO:K00434] [EC:1.11.1.11]
Os02t0553200-01  (RAP-DB) Os02g0553200; Similar to thylakoid-bound ascorbate peroxidase APx8. [KO:K00434] [EC:1.11.1.11]
Os08t0549100-01  (RAP-DB) Os08g0549100; Similar to Peroxisome type ascorbate peroxidase. [KO:K00434] [EC:1.11.1.11]
Os04t0434800-01  (RAP-DB) Os04g0434800; Similar to Thylakoid-bound ascorbate peroxidase (EC 1.11.1.11) (Fragment). [KO:K00434] [EC:1.11.1.11]
Os04t0223300-00  (RAP-DB) Os04g0223300; Similar to Peroxisome type ascorbate peroxidase. [KO:K00434] [EC:1.11.1.11]
Os03t0285700-01  (RAP-DB) Os03g0285700; Similar to L-ascorbate peroxidase. [KO:K00434] [EC:1.11.1.11]
Os06t0168600-01  (RAP-DB) Os06g0168600; Ribonucleotide reductase, Chloroplast biogenesis [KO:K10807] [EC:1.17.4.1]
Os02t0804900-01  (RAP-DB) Os02g0804900; Ribonucleotide reductase, Chloroplast biogenesis [KO:K10807] [EC:1.17.4.1]
Os06t0127900-01  (RAP-DB) Os06g0127900; Ribonucleotide reductase, Chloroplast biogenesis [KO:K10808] [EC:1.17.4.1]
Os06t0257450-01  (RAP-DB) Os06g0257450; Ribonucleotide reductase, Chloroplast biogenesis [KO:K10808] [EC:1.17.4.1]
Compound
C00005  NADPH
C00006  NADP+
C00024  Acetyl-CoA
C00025  L-Glutamate
C00037  Glycine
C00051  Glutathione
C00072  Ascorbate
C00077  L-Ornithine
C00097  L-Cysteine
C00127  Glutathione disulfide
C00134  Putrescine
C00151  L-Amino acid
C00315  Spermidine
C00669  gamma-L-Glutamyl-L-cysteine
C00750  Spermine
C01322  RX
C01419  Cys-Gly
C01672  Cadaverine
C01879  5-Oxoproline
C02090  Trypanothione
C02320  R-S-Glutathione
C03170  Trypanothione disulfide
C03646  Bis-gamma-glutamylcystine
C03740  (5-L-Glutamyl)-L-amino acid
C05422  Dehydroascorbate
C05726  S-Substituted L-cysteine
C05727  S-Substituted N-acetyl-L-cysteine
C05729  R-S-Cysteinylglycine
C05730  Glutathionylspermidine
C16562  Glutathionylspermine
C16563  Bis(glutathionyl)spermine
C16564  Bis(glutathionyl)spermine disulfide
C16565  Aminopropylcadaverine
C16566  Glutathionylaminopropylcadaverine
C16567  Homotrypanothione
C16568  Homotrypanothione disulfide
C16663  Tryparedoxin
C16664  Tryparedoxin disulfide
Reference
PMID:12675513
  Authors
Josch C, Klotz LO, Sies H.
  Title
Identification of cytosolic leucyl aminopeptidase (EC 3.4.11.1) as the major cysteinylglycine-hydrolysing activity in rat liver.
  Journal
Biol Chem 384:213-8 (2003)
DOI:10.1515/BC.2003.023
Reference
PMID:18482986
  Authors
Chu L, Lai Y, Xu X, Eddy S, Yang S, Song L, Kolodrubetz D.
  Title
A 52-kDa leucyl aminopeptidase from treponema denticola is a cysteinylglycinase that mediates the second step of glutathione metabolism.
  Journal
J Biol Chem 283:19351-8 (2008)
DOI:10.1074/jbc.M801034200
Reference
PMID:14583094
  Authors
Cappiello M, Lazzarotti A, Buono F, Scaloni A, D'Ambrosio C, Amodeo P, Mendez BL, Pelosi P, Del Corso A, Mura U.
  Title
New role for leucyl aminopeptidase in glutathione turnover.
  Journal
Biochem J 378:35-44 (2004)
DOI:10.1042/BJ20031336
Reference
PMID:11157967
  Authors
Suzuki H, Kamatani S, Kim ES, Kumagai H.
  Title
Aminopeptidases A, B, and N and dipeptidase D are the four cysteinylglycinases of Escherichia coli K-12.
  Journal
J Bacteriol 183:1489-90 (2001)
DOI:10.1128/JB.183.4.1489-1490.2001
Reference
PMID:15610825
  Authors
Oza SL, Shaw MP, Wyllie S, Fairlamb AH.
  Title
Trypanothione biosynthesis in Leishmania major.
  Journal
Mol Biochem Parasitol 139:107-16 (2005)
DOI:10.1016/j.molbiopara.2004.10.004
Reference
PMID:12049631
  Authors
Oza SL, Ariyanayagam MR, Fairlamb AH.
  Title
Characterization of recombinant glutathionylspermidine synthetase/amidase from Crithidia fasciculata.
  Journal
Biochem J 364:679-86 (2002)
DOI:10.1042/BJ20011370
Reference
PMID:9677355
  Authors
Tetaud E, Manai F, Barrett MP, Nadeau K, Walsh CT, Fairlamb AH.
  Title
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pathway
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KO pathway
ko00480   
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