KEGG   PATHWAY: dpe00480
Entry
dpe00480                    Pathway                                
Name
Glutathione metabolism - Drosophila persimilis
Class
Metabolism; Metabolism of other amino acids
Pathway map
dpe00480  Glutathione metabolism
dpe00480

Module
dpe_M00118  Glutathione biosynthesis, glutamate => glutathione [PATH:dpe00480]
Other DBs
GO: 0006749
Organism
Drosophila persimilis [GN:dpe]
Gene
6601773  glutathione hydrolase 1 proenzyme [KO:K18592] [EC:2.3.2.2 3.4.19.13 3.4.19.14]
6597690  glutathione hydrolase 1 proenzyme [KO:K18592] [EC:2.3.2.2 3.4.19.13 3.4.19.14]
113566212  glutathione hydrolase 1 proenzyme-like [KO:K18592] [EC:2.3.2.2 3.4.19.13 3.4.19.14]
6599418  glutathione hydrolase 1 proenzyme [KO:K18592] [EC:2.3.2.2 3.4.19.13 3.4.19.14]
6600095  glutathione hydrolase 1 proenzyme [KO:K18592] [EC:2.3.2.2 3.4.19.13 3.4.19.14]
6599030  gamma-glutamylcyclotransferase [KO:K00682] [EC:4.3.2.9]
6599031  gamma-glutamylcyclotransferase [KO:K00682] [EC:4.3.2.9]
6603236  putative glutathione-specific gamma-glutamylcyclotransferase 2 [KO:K07232] [EC:4.3.2.7]
6595088  glutathione-specific gamma-glutamylcyclotransferase 1 [KO:K07232] [EC:4.3.2.7]
6592401  5-oxoprolinase [KO:K01469] [EC:3.5.2.9]
6598248  glutamate--cysteine ligase [KO:K11204] [EC:6.3.2.2]
113565375  glutamate--cysteine ligase regulatory subunit [KO:K11205]
6597778  glutathione synthetase isoform X1 [KO:K21456] [EC:6.3.2.3]
113566955  cytosol aminopeptidase-like [KO:K11142] [EC:3.4.11.1 3.4.11.5]
113566956  cytosol aminopeptidase-like [KO:K11142] [EC:3.4.11.1 3.4.11.5]
113566957  cytosol aminopeptidase-like [KO:K11142] [EC:3.4.11.1 3.4.11.5]
113567004  cytosol aminopeptidase-like [KO:K11142] [EC:3.4.11.1 3.4.11.5]
113567005  cytosol aminopeptidase-like [KO:K11142] [EC:3.4.11.1 3.4.11.5]
113567006  cytosol aminopeptidase-like [KO:K11142] [EC:3.4.11.1 3.4.11.5]
113567007  cytosol aminopeptidase-like [KO:K11142] [EC:3.4.11.1 3.4.11.5]
113567008  cytosol aminopeptidase-like [KO:K11142] [EC:3.4.11.1 3.4.11.5]
6604081  cytosol aminopeptidase [KO:K11142] [EC:3.4.11.1 3.4.11.5]
113567089  cytosol aminopeptidase-like [KO:K11142] [EC:3.4.11.1 3.4.11.5]
6604048  cytosol aminopeptidase [KO:K11142] [EC:3.4.11.1 3.4.11.5]
6592377  cytosol aminopeptidase [KO:K11142] [EC:3.4.11.1 3.4.11.5]
113567150  cytosol aminopeptidase-like [KO:K11142] [EC:3.4.11.1 3.4.11.5]
113567217  cytosol aminopeptidase-like [KO:K11142] [EC:3.4.11.1 3.4.11.5]
6602488  cytosol aminopeptidase [KO:K11142] [EC:3.4.11.1 3.4.11.5]
6603644  cytosol aminopeptidase [KO:K11142] [EC:3.4.11.1 3.4.11.5]
6604045  cytosol aminopeptidase [KO:K11142] [EC:3.4.11.1 3.4.11.5]
6604133  cytosol aminopeptidase [KO:K11142] [EC:3.4.11.1 3.4.11.5]
6589933  cytosol aminopeptidase [KO:K11142] [EC:3.4.11.1 3.4.11.5]
6592655  cytosol aminopeptidase [KO:K11142] [EC:3.4.11.1 3.4.11.5]
6587876  putative aminopeptidase W07G4.4 [KO:K01255] [EC:3.4.11.1]
113566814  cytosol aminopeptidase-like [KO:K01255] [EC:3.4.11.1]
113567305  cytosol aminopeptidase-like [KO:K01255] [EC:3.4.11.1]
6587958  aminopeptidase N [KO:K11140] [EC:3.4.11.2]
6587907  aminopeptidase N [KO:K11140] [EC:3.4.11.2]
6590311  aminopeptidase N [KO:K11140] [EC:3.4.11.2]
6595233  aminopeptidase N isoform X1 [KO:K11140] [EC:3.4.11.2]
6595234  aminopeptidase N [KO:K11140] [EC:3.4.11.2]
6597989  aminopeptidase Ey [KO:K11140] [EC:3.4.11.2]
6587443  aminopeptidase N [KO:K11140] [EC:3.4.11.2]
6598653  aminopeptidase N isoform X1 [KO:K11140] [EC:3.4.11.2]
6598612  glutathione S-transferase 1-1 [KO:K00799] [EC:2.5.1.18]
6598611  glutathione S-transferase 1-1 isoform X2 [KO:K00799] [EC:2.5.1.18]
6592320  glutathione S-transferase 1 [KO:K00799] [EC:2.5.1.18]
6601432  pyrimidodiazepine synthase isoform X1 [KO:K00799] [EC:2.5.1.18]
6592353  glutathione S-transferase 1 [KO:K00799] [EC:2.5.1.18]
6592904  glutathione S-transferase 1 [KO:K00799] [EC:2.5.1.18]
6593094  glutathione S-transferase theta-3 isoform X1 [KO:K00799] [EC:2.5.1.18]
6592322  glutathione S-transferase 1 [KO:K00799] [EC:2.5.1.18]
6594397  uncharacterized protein LOC6594397 isoform X1 [KO:K00799] [EC:2.5.1.18]
6601765  glutathione S-transferase theta-3 [KO:K00799] [EC:2.5.1.18]
6597893  microsomal glutathione S-transferase 1 isoform X1 [KO:K00799] [EC:2.5.1.18]
6592850  glutathione S-transferase 1 [KO:K00799] [EC:2.5.1.18]
6592319  glutathione S-transferase 1 [KO:K00799] [EC:2.5.1.18]
6592321  glutathione S-transferase 1 [KO:K00799] [EC:2.5.1.18]
6592323  glutathione S-transferase 1 [KO:K00799] [EC:2.5.1.18]
6592324  glutathione S-transferase 1 [KO:K00799] [EC:2.5.1.18]
6592884  glutathione S-transferase 1 [KO:K00799] [EC:2.5.1.18]
6592318  glutathione S-transferase 1 [KO:K00799] [EC:2.5.1.18]
6599375  glutathione S-transferase theta-1 [KO:K00799] [EC:2.5.1.18]
6598610  glutathione S-transferase 1-1 [KO:K00799] [EC:2.5.1.18]
6598613  glutathione S-transferase D7 [KO:K00799] [EC:2.5.1.18]
6598615  glutathione S-transferase D4 [KO:K00799] [EC:2.5.1.18]
6598616  glutathione S-transferase 1-1 [KO:K00799] [EC:2.5.1.18]
6598618  glutathione S-transferase D7 [KO:K00799] [EC:2.5.1.18]
6600403  microsomal glutathione S-transferase 1 [KO:K00799] [EC:2.5.1.18]
6600404  microsomal glutathione S-transferase 1 [KO:K00799] [EC:2.5.1.18]
6590380  glutathione S-transferase E14 [KO:K00799] [EC:2.5.1.18]
6592395  glutathione S-transferase S1 [KO:K04097] [EC:5.3.99.2 2.5.1.18]
6601212  isocitrate dehydrogenase [NADP] cytoplasmic isoform X3 [KO:K00031] [EC:1.1.1.42]
6596889  6-phosphogluconate dehydrogenase, decarboxylating [KO:K00033] [EC:1.1.1.44 1.1.1.343]
6600741  glucose-6-phosphate 1-dehydrogenase isoform X1 [KO:K00036] [EC:1.1.1.49 1.1.1.363]
6602186  glucose-6-phosphate 1-dehydrogenase [KO:K00036] [EC:1.1.1.49 1.1.1.363]
6590333  probable phospholipid hydroperoxide glutathione peroxidase [KO:K00432] [EC:1.11.1.9]
6601068  probable phospholipid hydroperoxide glutathione peroxidase isoform X1 [KO:K00432] [EC:1.11.1.9]
6596421  peroxiredoxin-6 [KO:K11188] [EC:1.11.1.7 1.11.1.27 3.1.1.-]
6601435  pyrimidodiazepine synthase [KO:K00310] [EC:1.5.4.1]
6601434  pyrimidodiazepine synthase isoform X2 [KO:K00310] [EC:1.5.4.1]
6601436  pyrimidodiazepine synthase [KO:K00310] [EC:1.5.4.1]
6590129  ornithine decarboxylase 1 [KO:K01581] [EC:4.1.1.17]
6591819  spermidine synthase [KO:K00797] [EC:2.5.1.16]
6596081  spermine synthase isoform X2 [KO:K00802] [EC:2.5.1.22]
6588723  ribonucleoside-diphosphate reductase large subunit [KO:K10807] [EC:1.17.4.1]
6602081  ribonucleoside-diphosphate reductase subunit M2 [KO:K10808] [EC:1.17.4.1]
Compound
C00005  NADPH
C00006  NADP+
C00024  Acetyl-CoA
C00025  L-Glutamate
C00037  Glycine
C00051  Glutathione
C00072  Ascorbate
C00077  L-Ornithine
C00097  L-Cysteine
C00127  Glutathione disulfide
C00134  Putrescine
C00151  L-Amino acid
C00315  Spermidine
C00669  gamma-L-Glutamyl-L-cysteine
C00750  Spermine
C01322  RX
C01419  Cys-Gly
C01672  Cadaverine
C01879  5-Oxoproline
C02090  Trypanothione
C02320  R-S-Glutathione
C03170  Trypanothione disulfide
C03646  Bis-gamma-glutamylcystine
C03740  (5-L-Glutamyl)-L-amino acid
C05422  Dehydroascorbate
C05726  S-Substituted L-cysteine
C05727  S-Substituted N-acetyl-L-cysteine
C05729  R-S-Cysteinylglycine
C05730  Glutathionylspermidine
C16562  Glutathionylspermine
C16563  Bis(glutathionyl)spermine
C16564  Bis(glutathionyl)spermine disulfide
C16565  Aminopropylcadaverine
C16566  Glutathionylaminopropylcadaverine
C16567  Homotrypanothione
C16568  Homotrypanothione disulfide
C16663  Tryparedoxin
C16664  Tryparedoxin disulfide
Reference
  Authors
Josch C, Klotz LO, Sies H.
  Title
Identification of cytosolic leucyl aminopeptidase (EC 3.4.11.1) as the major cysteinylglycine-hydrolysing activity in rat liver.
  Journal
Biol Chem 384:213-8 (2003)
DOI:10.1515/BC.2003.023
Reference
  Authors
Chu L, Lai Y, Xu X, Eddy S, Yang S, Song L, Kolodrubetz D.
  Title
A 52-kDa leucyl aminopeptidase from treponema denticola is a cysteinylglycinase that mediates the second step of glutathione metabolism.
  Journal
J Biol Chem 283:19351-8 (2008)
DOI:10.1074/jbc.M801034200
Reference
  Authors
Cappiello M, Lazzarotti A, Buono F, Scaloni A, D'Ambrosio C, Amodeo P, Mendez BL, Pelosi P, Del Corso A, Mura U.
  Title
New role for leucyl aminopeptidase in glutathione turnover.
  Journal
Biochem J 378:35-44 (2004)
DOI:10.1042/BJ20031336
Reference
  Authors
Suzuki H, Kamatani S, Kim ES, Kumagai H.
  Title
Aminopeptidases A, B, and N and dipeptidase D are the four cysteinylglycinases of Escherichia coli K-12.
  Journal
J Bacteriol 183:1489-90 (2001)
DOI:10.1128/JB.183.4.1489-1490.2001
Reference
  Authors
Oza SL, Shaw MP, Wyllie S, Fairlamb AH.
  Title
Trypanothione biosynthesis in Leishmania major.
  Journal
Mol Biochem Parasitol 139:107-16 (2005)
DOI:10.1016/j.molbiopara.2004.10.004
Reference
  Authors
Oza SL, Ariyanayagam MR, Fairlamb AH.
  Title
Characterization of recombinant glutathionylspermidine synthetase/amidase from Crithidia fasciculata.
  Journal
Biochem J 364:679-86 (2002)
DOI:10.1042/BJ20011370
Reference
PMID:9677355
  Authors
Tetaud E, Manai F, Barrett MP, Nadeau K, Walsh CT, Fairlamb AH.
  Title
Cloning and characterization of the two enzymes responsible for trypanothione biosynthesis in Crithidia fasciculata.
  Journal
J Biol Chem 273:19383-90 (1998)
DOI:10.1074/jbc.273.31.19383
Reference
  Authors
Ariyanayagam MR, Oza SL, Mehlert A, Fairlamb AH.
  Title
Bis(glutathionyl)spermine and other novel trypanothione analogues in Trypanosoma cruzi.
  Journal
J Biol Chem 278:27612-9 (2003)
DOI:10.1074/jbc.M302750200
Reference
  Authors
Oza SL, Ariyanayagam MR, Aitcheson N, Fairlamb AH.
  Title
Properties of trypanothione synthetase from Trypanosoma brucei.
  Journal
Mol Biochem Parasitol 131:25-33 (2003)
DOI:10.1016/S0166-6851(03)00176-2
Reference
  Authors
Oza SL, Tetaud E, Ariyanayagam MR, Warnon SS, Fairlamb AH.
  Title
A single enzyme catalyses formation of Trypanothione from glutathione and spermidine in Trypanosoma cruzi.
  Journal
J Biol Chem 277:35853-61 (2002)
DOI:10.1074/jbc.M204403200
Reference
  Authors
Comini M, Menge U, Wissing J, Flohe L.
  Title
Trypanothione synthesis in crithidia revisited.
  Journal
J Biol Chem 280:6850-60 (2005)
DOI:10.1074/jbc.M404486200
Reference
PMID:7813456
  Authors
Hunter KJ, Le Quesne SA, Fairlamb AH.
  Title
Identification and biosynthesis of N1,N9-bis(glutathionyl)aminopropylcadaverine (homotrypanothione) in Trypanosoma cruzi.
  Journal
Eur J Biochem 226:1019-27 (1994)
DOI:10.1111/j.1432-1033.1994.t01-1-01019.x
Reference
  Authors
Krauth-Siegel RL, Meiering SK, Schmidt H.
  Title
The parasite-specific trypanothione metabolism of trypanosoma and leishmania.
  Journal
Biol Chem 384:539-49 (2003)
DOI:10.1515/BC.2003.062
Reference
  Authors
Krauth-Siegel RL, Comini MA.
  Title
Redox control in trypanosomatids, parasitic protozoa with trypanothione-based thiol metabolism.
  Journal
Biochim Biophys Acta 1780:1236-48 (2008)
DOI:10.1016/j.bbagen.2008.03.006
Reference
PMID:8892297
  Authors
Krauth-Siegel RL, Ludemann H.
  Title
Reduction of dehydroascorbate by trypanothione.
  Journal
Mol Biochem Parasitol 80:203-8 (1996)
DOI:10.1016/0166-6851(96)02689-8
Reference
  Authors
Dormeyer M, Reckenfelderbaumer N, Ludemann H, Krauth-Siegel RL.
  Title
Trypanothione-dependent synthesis of deoxyribonucleotides by Trypanosoma brucei ribonucleotide reductase.
  Journal
J Biol Chem 276:10602-6 (2001)
DOI:10.1074/jbc.M010352200
Reference
  Authors
Schmidt H, Krauth-Siegel RL.
  Title
Functional and physicochemical characterization of the thioredoxin system in Trypanosoma brucei.
  Journal
J Biol Chem 278:46329-36 (2003)
DOI:10.1074/jbc.M305338200
Reference
PMID:9851611
  Authors
Tetaud E, Fairlamb AH.
  Title
Cloning, expression and reconstitution of the trypanothione-dependent peroxidase system of Crithidia fasciculata.
  Journal
Mol Biochem Parasitol 96:111-23 (1998)
DOI:10.1016/S0166-6851(98)00120-0
Reference
  Authors
Castro H, Sousa C, Santos M, Cordeiro-da-Silva A, Flohe L, Tomas AM.
  Title
Complementary antioxidant defense by cytoplasmic and mitochondrial peroxiredoxins in Leishmania infantum.
  Journal
Free Radic Biol Med 33:1552-62 (2002)
DOI:10.1016/S0891-5849(02)01089-4
Reference
  Authors
Wilkinson SR, Temperton NJ, Mondragon A, Kelly JM.
  Title
Distinct mitochondrial and cytosolic enzymes mediate trypanothione-dependent peroxide metabolism in Trypanosoma cruzi.
  Journal
J Biol Chem 275:8220-5 (2000)
DOI:10.1074/jbc.275.11.8220
Reference
  Authors
Konig J, Fairlamb AH.
  Title
A comparative study of type I and type II tryparedoxin peroxidases in Leishmania major.
  Journal
FEBS J 274:5643-58 (2007)
DOI:10.1111/j.1742-4658.2007.06087.x
Reference
  Authors
Hillebrand H, Schmidt A, Krauth-Siegel RL.
  Title
A second class of peroxidases linked to the trypanothione metabolism.
  Journal
J Biol Chem 278:6809-15 (2003)
DOI:10.1074/jbc.M210392200
Reference
  Authors
Soksawatmaekhin W, Kuraishi A, Sakata K, Kashiwagi K, Igarashi K.
  Title
Excretion and uptake of cadaverine by CadB and its physiological functions in Escherichia coli.
  Journal
Mol Microbiol 51:1401-12 (2004)
DOI:10.1046/j.1365-2958.2003.03913.x
Reference
PMID:6798961
  Authors
Pegg AE, Shuttleworth K, Hibasami H.
  Title
Specificity of mammalian spermidine synthase and spermine synthase.
  Journal
Biochem J 197:315-20 (1981)
DOI:10.1042/bj1970315
Related
pathway
dpe00220  Arginine biosynthesis
dpe00250  Alanine, aspartate and glutamate metabolism
dpe00270  Cysteine and methionine metabolism
dpe00430  Taurine and hypotaurine metabolism
KO pathway
ko00480   
LinkDB

DBGET integrated database retrieval system