KEGG   PATHWAY: ecg00630
Entry
ecg00630                    Pathway                                
Name
Glyoxylate and dicarboxylate metabolism - Escherichia coli O127:H6 E2348/69 (EPEC)
Class
Metabolism; Carbohydrate metabolism
Pathway map
ecg00630  Glyoxylate and dicarboxylate metabolism
ecg00630

Module
ecg_M00012  Glyoxylate cycle [PATH:ecg00630]
ecg_M00621  Glycine cleavage system [PATH:ecg00630]
Other DBs
GO: 0046487 0043648
Organism
Escherichia coli O127:H6 E2348/69 (EPEC) [GN:ecg]
Gene
E2348C_4318  aceA; isocitrate lyase [KO:K01637] [EC:4.1.3.1]
E2348C_4392  acs; acetyl-CoA synthetase [KO:K01895] [EC:6.2.1.1]
E2348C_4317  aceB; malate synthase A [KO:K01638] [EC:2.3.3.9]
E2348C_3255  glcB; malate synthase G [KO:K01638] [EC:2.3.3.9]
E2348C_3507  mdh; malate dehydrogenase, NAD(P)-binding [KO:K00024] [EC:1.1.1.37]
E2348C_0600  gltA; citrate synthase [KO:K01647] [EC:2.3.3.1]
E2348C_0648  ybhJ; predicted hydratase [KO:K01681] [EC:4.2.1.3]
E2348C_1468  acnA; aconitate hydratase 1 [KO:K01681] [EC:4.2.1.3]
E2348C_0121  acnB; bifunctional aconitate hydratase 2/2-methylisocitrate dehydratase [KO:K01682] [EC:4.2.1.3 4.2.1.99]
E2348C_3115  yqeF; predicted acyltransferase [KO:K00626] [EC:2.3.1.9]
E2348C_2369  atoB; acetyl-CoA acetyltransferase [KO:K00626] [EC:2.3.1.9]
E2348C_0612  predicted glutamate mutase S [KO:K01846] [EC:5.4.99.1]
E2348C_3259  glcD; glycolate oxidase subunit, FAD-linked [KO:K00104] [EC:1.1.99.14]
E2348C_3258  glcE; glycolate oxidase FAD binding subunit [KO:K11472] [EC:1.1.99.14]
E2348C_3257  glcF; glycolate oxidase iron-sulfur subunit [KO:K11473] [EC:1.1.99.14]
E2348C_1860  katE; hydroperoxidase HPII (III) (catalase) [KO:K03781] [EC:1.11.1.6]
E2348C_1123  ghrA; 2-ketoacid reductase [KO:K12972] [EC:1.1.1.79 1.1.1.81]
E2348C_3805  ghrB; 2-keto-D-gluconate reductase (glyoxalatereductase) (2-ketoaldonate reductase) [KO:K00090] [EC:1.1.1.79 1.1.1.81 1.1.1.215]
E2348C_3629  gph; phosphoglycolate phosphatase [KO:K01091] [EC:3.1.3.18]
E2348C_4176  glnA; glutamine synthetase [KO:K01915] [EC:6.3.1.2]
E2348C_2828  glyA; serine hydroxymethyltransferase [KO:K00600] [EC:2.1.2.1]
E2348C_3155  gcvP; glycine decarboxylase, PLP-dependent, subunit (protein P) of glycine cleavage complex [KO:K00281] [EC:1.4.4.2]
E2348C_3157  gcvT; aminomethyltransferase, tetrahydrofolate-dependent, subunit (T protein) of glycine cleavage complex [KO:K00605] [EC:2.1.2.10]
E2348C_4372  predicted dihydrolipoamide dehydrogenase [KO:K00382] [EC:1.8.1.4]
E2348C_0119  lpd; lipoamide dehydrogenase, E3 component is part of three enzyme complexes [KO:K00382] [EC:1.8.1.4]
E2348C_3156  gcvH; glycine cleavage complex lipoylprotein [KO:K02437]
E2348C_0441  gcl; glyoxylate carboligase [KO:K01608] [EC:4.1.1.47]
E2348C_0442  hyi; hydroxypyruvate isomerase [KO:K01816] [EC:5.3.1.22]
E2348C_0443  glxR; tartronate semialdehyde reductase, NADH-dependent [KO:K00042] [EC:1.1.1.60]
E2348C_3411  garR; tartronate semialdehyde reductase [KO:K00042] [EC:1.1.1.60]
E2348C_3410  garK; glycerate kinase I [KO:K00865] [EC:2.7.1.165]
E2348C_0447  glxK; glycerate kinase II [KO:K00865] [EC:2.7.1.165]
E2348C_1553  aldA; aldehyde dehydrogenase A, NAD-linked [KO:K07248] [EC:1.2.1.22 1.2.1.21]
E2348C_3066  fucO; L-1,2-propanediol oxidoreductase [KO:K00048] [EC:1.1.1.77]
E2348C_3354  ttdA; L-tartrate dehydratase, alpha subunit [KO:K03779] [EC:4.2.1.32]
E2348C_3355  ttdB; L-tartrate dehydratase, beta subunit [KO:K03780] [EC:4.2.1.32]
E2348C_1975  eda; multifunctional 2-keto-3-deoxygluconate 6-phosphate aldolase and 2-keto-4-hydroxyglutarate aldolase and oxaloacetate decarboxylase [KO:K01625] [EC:4.1.2.14 4.1.3.42]
E2348C_4197  fdoG; formate dehydrogenase-O, large subunit [KO:K00123] [EC:1.17.1.9]
E2348C_4196  fdoH; formate dehydrogenase-O, Fe-S subunit FdoH [KO:K00124]
E2348C_4195  fdoI; formate dehydrogenase-O, cytochrome b556 subunit FdoI [KO:K00127]
E2348C_1359  purU; formyltetrahydrofolate hydrolase [KO:K01433] [EC:3.5.1.10]
E2348C_2566  oxc; predicted oxalyl-CoA decarboxylase [KO:K01577] [EC:4.1.1.8]
E2348C_2567  frc; formyl-CoA transferase, NAD(P)-binding [KO:K07749] [EC:2.8.3.16]
Compound
C00007  Oxygen
C00011  CO2
C00014  Ammonia
C00022  Pyruvate
C00024  Acetyl-CoA
C00025  L-Glutamate
C00026  2-Oxoglutarate
C00027  Hydrogen peroxide
C00033  Acetate
C00036  Oxaloacetate
C00037  Glycine
C00042  Succinate
C00048  Glyoxylate
C00058  Formate
C00064  L-Glutamine
C00065  L-Serine
C00091  Succinyl-CoA
C00100  Propanoyl-CoA
C00111  Glycerone phosphate
C00136  Butanoyl-CoA
C00149  (S)-Malate
C00158  Citrate
C00160  Glycolate
C00168  Hydroxypyruvate
C00197  3-Phospho-D-glycerate
C00209  Oxalate
C00258  D-Glycerate
C00266  Glycolaldehyde
C00311  Isocitrate
C00313  Oxalyl-CoA
C00332  Acetoacetyl-CoA
C00417  cis-Aconitate
C00552  meso-Tartaric acid
C00631  2-Phospho-D-glycerate
C00683  (S)-Methylmalonyl-CoA
C00798  Formyl-CoA
C00877  Crotonoyl-CoA
C00888  Pentanoyl-CoA
C00898  (R,R)-Tartaric acid
C00975  Dihydroxyfumarate
C00988  2-Phosphoglycolate
C01127  4-Hydroxy-2-oxoglutarate
C01146  2-Hydroxy-3-oxopropanoate
C01182  D-Ribulose 1,5-bisphosphate
C01213  (R)-Methylmalonyl-CoA
C01380  Ethylene glycol
C01732  Mesaconate
C01989  3-Ethylmalate
C01990  3-Oxalomalate
C02123  3-Propylmalate
C02405  Formyl phosphate
C03217  2-Hydroxy-3-oxoadipate
C03459  2-Hydroxy-3-oxosuccinate
C03548  trans-2,3-Epoxysuccinate
C03561  (R)-3-Hydroxybutanoyl-CoA
C03618  L-threo-3-Methylaspartate
C04348  L-Malyl-CoA
C06027  L-erythro-3-Methylmalyl-CoA
C06028  2-Methylfumaryl-CoA
C06049  N-Formylderivatives
C18026  (2S)-Ethylmalonyl-CoA
C18324  (2S)-Methylsuccinyl-CoA
C20238  (2R)-Ethylmalonyl-CoA
C22337  D-Ribulose 1-phosphate
Reference
PMID:10978349
  Authors
Njau RK, Herndon CA, Hawes JW.
  Title
Novel beta-hydroxyacid dehydrogenases in Escherichia coli and Haemophilus influenzae.
  Journal
J Biol Chem 275:38780-6 (2000)
DOI:10.1074/jbc.M007432200
Reference
PMID:18065535
  Authors
Zarzycki J, Schlichting A, Strychalsky N, Muller M, Alber BE, Fuchs G
  Title
Mesaconyl-coenzyme A hydratase, a new enzyme of two central carbon metabolic pathways in bacteria.
  Journal
J Bacteriol 190:1366-74 (2008)
DOI:10.1128/JB.01621-07
Reference
PMID:18819910
  Authors
Erb TJ, Retey J, Fuchs G, Alber BE
  Title
Ethylmalonyl-CoA mutase from Rhodobacter sphaeroides defines a new subclade of coenzyme B12-dependent acyl-CoA mutases.
  Journal
J Biol Chem 283:32283-93 (2008)
DOI:10.1074/jbc.M805527200
Reference
PMID:9596633
  Authors
Coschigano KT, Melo-Oliveira R, Lim J, Coruzzi GM
  Title
Arabidopsis gls mutants and distinct Fd-GOGAT genes. Implications for photorespiration and primary nitrogen assimilation.
  Journal
Plant Cell 10:741-52 (1998)
DOI:10.1105/tpc.10.5.741
Reference
PMID:16407450
  Authors
Masclaux-Daubresse C, Reisdorf-Cren M, Pageau K, Lelandais M, Grandjean O, Kronenberger J, Valadier MH, Feraud M, Jouglet T, Suzuki A
  Title
Glutamine synthetase-glutamate synthase pathway and glutamate dehydrogenase play distinct roles in the sink-source nitrogen cycle in tobacco.
  Journal
Plant Physiol 140:444-56 (2006)
DOI:10.1104/pp.105.071910
Reference
PMID:21252347
  Authors
Khomyakova M, Bukmez O, Thomas LK, Erb TJ, Berg IA
  Title
A methylaspartate cycle in haloarchaea.
  Journal
Science 331:334-7 (2011)
DOI:10.1126/science.1196544
Reference
PMID:11513957
  Authors
Serrano JA, Bonete MJ
  Title
Sequencing, phylogenetic and transcriptional analysis of the glyoxylate bypass operon (ace) in the halophilic archaeon Haloferax volcanii.
  Journal
Biochim Biophys Acta 1520:154-62 (2001)
DOI:10.1016/S0167-4781(01)00263-9
Related
pathway
ecg00010  Glycolysis / Gluconeogenesis
ecg00020  Citrate cycle (TCA cycle)
ecg00030  Pentose phosphate pathway
ecg00053  Ascorbate and aldarate metabolism
ecg00071  Fatty acid degradation
ecg00230  Purine metabolism
ecg00250  Alanine, aspartate and glutamate metabolism
ecg00260  Glycine, serine and threonine metabolism
ecg00620  Pyruvate metabolism
ecg00710  Carbon fixation by Calvin cycle
ecg00750  Vitamin B6 metabolism
ecg00910  Nitrogen metabolism
KO pathway
ko00630   
LinkDB

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