KEGG   PATHWAY: ecs00790
Entry
ecs00790                    Pathway                                
Name
Folate biosynthesis - Escherichia coli O157:H7 Sakai (EHEC)
Class
Metabolism; Metabolism of cofactors and vitamins
Pathway map
ecs00790  Folate biosynthesis
ecs00790

Module
ecs_M00126  Tetrahydrofolate biosynthesis, GTP => THF [PATH:ecs00790]
ecs_M00880  Molybdenum cofactor biosynthesis, GTP => molybdenum cofactor [PATH:ecs00790]
Other DBs
GO: 0046656
Organism
Escherichia coli O157:H7 Sakai (EHEC) [GN:ecs]
Gene
ECs_3045  folE; GTP cyclohydrolase I [KO:K01495] [EC:3.5.4.16]
ECs_0433  phoA; bacterial alkaline phosphatase [KO:K01077] [EC:3.1.3.1]
ECs_2575  nudB; dihydroneopterin triphosphate pyrophosphatase [KO:K08310] [EC:3.6.1.67]
ECs_3941  folB; dihydroneopterin aldolase [KO:K01633] [EC:4.1.2.25 5.1.99.8 1.13.11.81]
ECs_0146  folK; 2-amino-4-hydroxy-6-hydroxymethyldihyropteridine pyrophosphokinase [KO:K00950] [EC:2.7.6.3]
ECs_4056  folP; 7,8-dihydropteroate synthase [KO:K00796] [EC:2.5.1.15]
ECs_0051  folA; dihydrofolate reductase [KO:K00287] [EC:1.5.1.3]
ECs_3199  folC; bifunctional folylpolyglutamate synthase/dihydrofolate synthase [KO:K11754] [EC:6.3.2.12 6.3.2.17]
ECs_1850  ribA; GTP cyclohydrolase II [KO:K01497] [EC:3.5.4.25]
ECs_4211  pabA; aminodeoxychorismate synthase subunit II [KO:K01664] [EC:2.6.1.85]
ECs_2521  pabB; aminodeoxychorismate synthase subunit I [KO:K01665] [EC:2.6.1.85]
ECs_1474  pabC; 4-amino-4-deoxychorismate lyase component of para-aminobenzoate synthase multienzyme complex [KO:K02619] [EC:4.1.3.38]
ECs_3187  folX; D-erythro-7,8-dihydroneopterin triphosphate 2'-epimerase and dihydroneopterin aldolase [KO:K07589] [EC:5.1.99.7]
ECs_2312  folM; dihydromonapterin reductase [KO:K13938] [EC:1.5.1.50 1.5.1.3]
ECs_3620  queD; 6-pyruvoyl tetrahydrobiopterin synthase [KO:K01737] [EC:4.2.3.12 4.1.2.50]
ECs_3633  queE; 7-carboxy-7-deazaguanine synthase [KO:K10026] [EC:4.3.99.3]
ECs_0498  queC; 7-cyano-7-deazaguanine synthase [KO:K06920] [EC:6.3.4.20]
ECs_3654  queF; 7-cyano-7-deazaguanine reductase [KO:K06879] [EC:1.7.1.13]
ECs_0859  moaA; molybdopterin biosynthesis protein A [KO:K03639] [EC:4.1.99.22]
ECs_0861  moaC; molybdopterin biosynthesis protein C [KO:K03637] [EC:4.6.1.17]
ECs_0863  moaE; molybdopterin synthase large subunit [KO:K03635] [EC:2.8.1.12]
ECs_0009  mog; molybdochelatase incorporating molybdenum into molybdopterin [KO:K03831] [EC:2.7.7.75]
ECs_0860  moaB; inactive molybdopterin adenylyltransferase [KO:K03638] [EC:2.7.7.75]
ECs_0905  moeA; molybdopterin molybdenumtransferase [KO:K03750] [EC:2.10.1.1]
ECs_3750  mocA; molybdenum cofactor cytidylyltransferase [KO:K07141] [EC:2.7.7.76]
ECs_4780  mobA; molybdopterin-guanine dinucleotide synthase [KO:K03752] [EC:2.7.7.77]
Compound
C00044  GTP
C00101  Tetrahydrofolate
C00119  5-Phospho-alpha-D-ribose 1-diphosphate
C00156  4-Hydroxybenzoate
C00251  Chorismate
C00266  Glycolaldehyde
C00268  Dihydrobiopterin
C00272  Tetrahydrobiopterin
C00415  Dihydrofolate
C00504  Folate
C00568  4-Aminobenzoate
C00835  Sepiapterin
C00921  Dihydropteroate
C01217  5,6,7,8-Tetrahydromethanopterin
C01300  6-(Hydroxymethyl)-7,8-dihydropterin
C01304  2,5-Diamino-6-(5-phospho-D-ribosylamino)pyrimidin-4(3H)-one
C02587  Pyrimidodiazepine
C02953  7,8-Dihydrobiopterin
C03541  THF-polyglutamate
C03684  6-Pyruvoyltetrahydropterin
C04244  6-Lactoyl-5,6,7,8-tetrahydropterin
C04807  6-Hydroxymethyl-7,8-dihydropterin diphosphate
C04874  7,8-Dihydroneopterin
C04895  7,8-Dihydroneopterin 3'-triphosphate
C05922  Formamidopyrimidine nucleoside triphosphate
C05923  2,5-Diaminopyrimidine nucleoside triphosphate
C05924  Molybdopterin
C05925  Dihydroneopterin phosphate
C05926  Neopterin
C05927  7,8-Dihydromethanopterin
C06148  2,5-Diamino-6-(5'-triphosphoryl-3',4'-trihydroxy-2'-oxopentyl)-amino-4-oxopyrimidine
C06313  Biopterin
C09332  THF-L-glutamate
C11355  4-Amino-4-deoxychorismate
C15522  4a-Hydroxytetrahydrobiopterin
C15996  7-Cyano-7-carbaguanine
C16675  7-Aminomethyl-7-carbaguanine
C18237  Molybdoenzyme molybdenum cofactor
C18239  Precursor Z
C18802  Tetrahydrosarcinapterin
C19848  Adenylated molybdopterin
C19871  Guanylyl molybdenum cofactor
C20239  6-Carboxy-5,6,7,8-tetrahydropterin
C20248  7-Carboxy-7-carbaguanine
C20264  L-threo-Tetrahydrobiopterin
C20559  4-(beta-D-Ribofuranosyl)aniline 5'-phosphate
C20562  N-[(7,8-Dihydropterin-6-yl)methyl]-4-(beta-D-ribofuranosyl)aniline 5'-phosphate
C20566  7,8-Dihydroneopterin 2'-phosphate
C20567  7,8-Dihydroneopterin 2',3'-cyclic phosphate
C21007  5,6,7,8-Tetrahydromonapterin
C21008  7,8-Dihydromonapterin
C21065  7,8-Dihydroxanthopterin
C21094  7,8-Dihydromonapterin 3'-triphosphate
C21107  4-(beta-D-Ribofuranosyl)phenol 5'-phosphate
C21310  (8S)-3',8-Cyclo-7,8-dihydroguanosine 5'-triphosphate
C21485  Cytidylyl molybdenum cofactor
C21486  Thio-molybdenum cofactor
C21640  6-(1'-Hydroxy-2'-oxopropyl)-tetrahydropterin
Reference
  Authors
Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).
  Title
[Cellular Functions and Metabolic Maps] (In Japanese)
  Journal
Tokyo Kagaku Dojin (1997)
Reference
PMID:19675644
  Authors
Schwarz G, Mendel RR, Ribbe MW
  Title
Molybdenum cofactors, enzymes and pathways.
  Journal
Nature 460:839-47 (2009)
DOI:10.1038/nature08302
Reference
PMID:16632608
  Authors
Hanzelmann P, Schindelin H
  Title
Binding of 5'-GTP to the C-terminal FeS cluster of the radical S-adenosylmethionine enzyme MoaA provides insights into its mechanism.
  Journal
Proc Natl Acad Sci U S A 103:6829-34 (2006)
DOI:10.1073/pnas.0510711103
Reference
PMID:18092812
  Authors
Daniels JN, Wuebbens MM, Rajagopalan KV, Schindelin H
  Title
Crystal structure of a molybdopterin synthase-precursor Z complex: insight into its sulfur transfer mechanism and its role in molybdenum cofactor deficiency.
  Journal
Biochemistry 47:615-26 (2008)
DOI:10.1021/bi701734g
Reference
PMID:12571226
  Authors
Wuebbens MM, Rajagopalan KV
  Title
Mechanistic and mutational studies of Escherichia coli molybdopterin synthase clarify the final step of molybdopterin biosynthesis.
  Journal
J Biol Chem 278:14523-32 (2003)
DOI:10.1074/jbc.M300453200
Reference
PMID:21867484
  Authors
Werner ER, Blau N, Thony B
  Title
Tetrahydrobiopterin: biochemistry and pathophysiology.
  Journal
Biochem J 438:397-414 (2011)
DOI:10.1042/BJ20110293
Reference
PMID:12893295
  Authors
Iino T, Tabata M, Takikawa S, Sawada H, Shintaku H, Ishikura S, Hara A
  Title
Tetrahydrobiopterin is synthesized from 6-pyruvoyl-tetrahydropterin by the human aldo-keto reductase AKR1 family members.
  Journal
Arch Biochem Biophys 416:180-7 (2003)
DOI:10.1016/S0003-9861(03)00295-9
Reference
PMID:1902669
  Authors
Park YS, Heizmann CW, Wermuth B, Levine RA, Steinerstauch P, Guzman J, Blau N
  Title
Human carbonyl and aldose reductases: new catalytic functions in tetrahydrobiopterin biosynthesis.
  Journal
Biochem Biophys Res Commun 175:738-44 (1991)
DOI:10.1016/0006-291X(91)91628-P
Related
pathway
ecs00230  Purine metabolism
ecs00362  Benzoate degradation
ecs00400  Phenylalanine, tyrosine and tryptophan biosynthesis
ecs00670  One carbon pool by folate
ecs00680  Methane metabolism
KO pathway
ko00790   
LinkDB

DBGET integrated database retrieval system