KEGG   PATHWAY: ecs00230
Entry
ecs00230                    Pathway                                
Name
Purine metabolism - Escherichia coli O157:H7 Sakai (EHEC)
Class
Metabolism; Nucleotide metabolism
Pathway map
ecs00230  Purine metabolism
ecs00230

Module
ecs_M00005  PRPP biosynthesis, ribose-5P => PRPP [PATH:ecs00230]
ecs_M00048  De novo purine biosynthesis, PRPP + glutamine => IMP [PATH:ecs00230]
ecs_M00049  Adenine ribonucleotide biosynthesis, IMP => ADP,ATP [PATH:ecs00230]
ecs_M00050  Guanine ribonucleotide biosynthesis, IMP => GDP,GTP [PATH:ecs00230]
ecs_M00053  Deoxyribonucleotide biosynthesis, ADP/GDP/CDP/UDP => dATP/dGTP/dCTP/dUTP [PATH:ecs00230]
ecs_M00958  Adenine ribonucleotide degradation, AMP => Urate [PATH:ecs00230]
ecs_M00959  Guanine ribonucleotide degradation, GMP => Urate [PATH:ecs00230]
Other DBs
GO: 0006163 0042278
Organism
Escherichia coli O157:H7 Sakai (EHEC) [GN:ecs]
Gene
ECs_0054  apaH; diadenosine tetraphosphatase [KO:K01525] [EC:3.6.1.41]
ECs_0108  guaC; GMP reductase [KO:K00364] [EC:1.7.1.7]
ECs_0129  hpt; hypoxanthine phosphoribosyltransferase [KO:K00760] [EC:2.4.2.8]
ECs_0164  dgt; deoxyguanosine triphosphate triphosphohydrolase [KO:K01129] [EC:3.1.5.1]
ECs_0265  gpt; xanthine phosphoribosyltransferase [KO:K00769] [EC:2.4.2.22]
ECs_0314  paoC; moco-containing subunit of PaoABC aldehyde oxidoreductase [KO:K11177] [EC:1.17.1.4]
ECs_0315  paoB; FAD-containing subunit of PaoABC aldehyde oxidoreductase [KO:K11178] [EC:1.17.1.4]
ECs_0316  yagT; xanthine dehydrogenase [KO:K13483]
ECs_0372  yahI; carbamate kinase [KO:K00926] [EC:2.7.2.2]
ECs_0441  yaiE; hypothetical protein [KO:K09913] [EC:2.4.2.1 2.4.2.2]
ECs_0522  apt; adenine phosphoribosyltransferase [KO:K00759] [EC:2.4.2.7]
ECs_0527  adk; adenylate kinase [KO:K00939] [EC:2.7.4.3]
ECs_0530  gsk; inosine/guanosine kinase [KO:K00892] [EC:2.7.1.73]
ECs_0533  ushA; UDP-sugar hydrolase [KO:K11751] [EC:3.1.3.5 3.6.1.45]
ECs_0566  allA; ureidoglycolate hydrolase [KO:K01483] [EC:4.3.2.3]
ECs_0577  ylbA; hypothetical protein [KO:K14977] [EC:3.5.3.26]
ECs_0578  allC; allantoate amidohydrolase [KO:K02083] [EC:3.5.3.9]
ECs_0579  allD; ureidoglycolate dehydrogenase [KO:K00073] [EC:1.1.1.350]
ECs_0583  ybcF; carbonate kinase [KO:K00926] [EC:2.7.2.2]
ECs_0584  purK; N5-carboxyaminoimidazole ribonucleotide synthase [KO:K01589] [EC:6.3.4.18]
ECs_0585  purE; N5-carboxyaminoimidazole ribonucleotide mutase [KO:K01588] [EC:5.4.99.18]
ECs_0705  umpH; UMP phosphatase [KO:K02566] [EC:3.1.3.5]
ECs_0719  pgm; phosphoglucomutase [KO:K01835] [EC:5.4.2.2]
ECs_1322  ureA; urease subunit gamma [KO:K01430] [EC:3.5.1.5]
ECs_1323  ureB; urease subunit beta [KO:K01429] [EC:3.5.1.5]
ECs_1324  ureC; urease subunit alpha [KO:K01428] [EC:3.5.1.5]
ECs_1603  purB; adenylosuccinate lyase [KO:K01756] [EC:4.3.2.2]
ECs_1712  prs; phosphoribosylpyrophosphate synthase [KO:K00948] [EC:2.7.6.1]
ECs_2331  add; adenosine deaminase [KO:K01488] [EC:3.5.4.4]
ECs_2559  purT; phosphoribosylglycinamide formyltransferase 2 [KO:K08289] [EC:6.3.1.21]
ECs_2708  hiuH; hydroxyisourate hydrolase [KO:K07127] [EC:3.5.2.17]
ECs_2779  amn; AMP nucleosidase [KO:K01241] [EC:3.2.2.4]
ECs_3117  nrdA; ribonucleoside-diphosphate reductase 1 alpha subunit [KO:K00525] [EC:1.17.4.1]
ECs_3118  nrdB; ribonucleoside-diphosphate reductase 1 beta subunit ferritin-like protein [KO:K00526] [EC:1.17.4.1]
ECs_3175  yfbR; 5'-nucleotidase [KO:K08722] [EC:3.1.3.89]
ECs_3196  purF; amidophosphoribosyltransferase [KO:K00764] [EC:2.4.2.14]
ECs_3338  purC; phosphoribosylaminoimidazole-succinocarboxamide synthetase [KO:K01923] [EC:6.3.2.6]
ECs_3361  purM; phosphoribosylaminoimidazole synthetase [KO:K01933] [EC:6.3.3.1]
ECs_3362  purN; phosphoribosylglycinamide formyltransferase 1 [KO:K11175] [EC:2.1.2.2]
ECs_3364  ppx; exopolyphosphatase [KO:K01524] [EC:3.6.1.11 3.6.1.40]
ECs_3369  guaA; glutamine aminotransferase [KO:K01951] [EC:6.3.5.2]
ECs_3370  guaB; IMP dehydrogenase [KO:K00088] [EC:1.1.1.205]
ECs_3380  ndk; multifunctional nucleoside diphosphate kinase and apyrimidinic endonuclease and 3'-phosphodiesterase [KO:K00940] [EC:2.7.4.6]
ECs_3423  purL; phosphoribosylformyl-glycineamide synthetase [KO:K01952] [EC:6.3.5.3]
ECs_3456  yfiH; hypothetical protein [KO:K05810] [EC:2.4.2.1 2.4.2.28 3.5.4.4]
ECs_3538  nrdE; ribonucleoside-diphosphate reductase 2 alpha subunit [KO:K00525] [EC:1.17.4.1]
ECs_3539  nrdF; ribonucleoside-diphosphate reductase 2 beta subunit [KO:K00526] [EC:1.17.4.1]
ECs_3598  umpG; broad specificity 5'(3')-nucleotidase and polyphosphatase [KO:K03787] [EC:3.1.3.5 3.1.3.6]
ECs_3604  cysC; adenosine 5'-phosphosulfate kinase [KO:K00860] [EC:2.7.1.25]
ECs_3605  cysN; sulfate adenylyltransferase subunit 1 [KO:K00956] [EC:2.7.7.4]
ECs_3606  cysD; sulfate adenylyltransferase subunit 2 [KO:K00957] [EC:2.7.7.4]
ECs_3641  mazG; nucleoside triphosphate pyrophosphohydrolase [KO:K04765] [EC:3.6.1.9]
ECs_3644  relA; (p)ppGpp synthetase RelA [KO:K00951] [EC:2.7.6.5]
ECs_3655  ygdH; hypothetical protein [KO:K06966] [EC:3.2.2.10 3.2.2.-]
ECs_3739  xdhA; xanthine dehydrogenase molybdenum binding subunit [KO:K00087] [EC:1.17.1.4]
ECs_3740  xdhB; xanthine dehydrogenase FAD-binding subunit [KO:K13479] [EC:1.17.1.4]
ECs_3741  xdhC; xanthine dehydrogenase Fe-S binding subunit [KO:K13480]
ECs_3747  yqeA; amino acid kinase [KO:K00926] [EC:2.7.2.2]
ECs_3756  guaD; guanine deaminase [KO:K01487] [EC:3.5.4.3]
ECs_3830  rdgB; dITP/XTP pyrophosphatase [KO:K01519] [EC:3.6.1.66]
ECs_3920  cpdA; 3',5' cAMP phosphodiesterase [KO:K03651] [EC:3.1.4.53]
ECs_3922  nudF; ADP-ribose pyrophosphatase [KO:K01515] [EC:3.6.1.13 3.6.1.-]
ECs_4239  nudE; adenosine nucleotide hydrolase [KO:K08312] [EC:3.6.1.-]
ECs_4241  yrfG; GMP/IMP nucleotidase [KO:K20881] [EC:3.1.3.-]
ECs_4523  gmk; guanylate kinase [KO:K00942] [EC:2.7.4.8]
ECs_4525  spoT; bifunctional (p)ppGpp synthase/hydrolase SpoT [KO:K01139] [EC:2.7.6.5 3.1.7.2]
ECs_4602  adeD; cryptic adenine deaminase [KO:K01486] [EC:3.5.4.2]
ECs_4712  gpp; guanosine pentaphosphatase/exopolyphosphatase [KO:K01524] [EC:3.6.1.11 3.6.1.40]
ECs_4736  cyaA; adenylate cyclase [KO:K05851] [EC:4.6.1.1]
ECs_4928  purD; phosphoribosylglycinamide synthetase phosphoribosylamine-glycine ligase [KO:K01945] [EC:6.3.4.13]
ECs_4929  purH; IMP cyclohydrolase and phosphoribosylaminoimidazolecarboxamide formyltransferase [KO:K00602] [EC:2.1.2.3 3.5.4.10]
ECs_5153  purA; adenylosuccinate synthetase [KO:K01939] [EC:6.3.4.4]
ECs_5191  cpdB; 2':3'-cyclic-nucleotide 2'-phosphodiesterase [KO:K01119] [EC:3.1.4.16 3.1.3.6]
ECs_5215  nrdD; anaerobic ribonucleoside-triphosphate reductase [KO:K21636] [EC:1.1.98.6]
ECs_5342  deoB; phosphopentomutase [KO:K01839] [EC:5.4.2.7]
ECs_5343  deoD; purine nucleoside phosphorylase [KO:K03784] [EC:2.4.2.1]
ECs_5352  yjjX; non-canonical purine NTP phosphatase [KO:K01529]
Compound
C00002  ATP
C00008  ADP
C00011  CO2
C00014  Ammonia
C00020  AMP
C00035  GDP
C00037  Glycine
C00039  DNA
C00044  GTP
C00046  RNA
C00048  Glyoxylate
C00053  3'-Phosphoadenylyl sulfate
C00054  Adenosine 3',5'-bisphosphate
C00059  Sulfate
C00064  L-Glutamine
C00081  ITP
C00086  Urea
C00104  IDP
C00117  D-Ribose 5-phosphate
C00119  5-Phospho-alpha-D-ribose 1-diphosphate
C00130  IMP
C00131  dATP
C00144  GMP
C00147  Adenine
C00169  Carbamoyl phosphate
C00206  dADP
C00209  Oxalate
C00212  Adenosine
C00224  Adenylyl sulfate
C00242  Guanine
C00262  Hypoxanthine
C00286  dGTP
C00288  HCO3-
C00294  Inosine
C00301  ADP-ribose
C00330  Deoxyguanosine
C00360  dAMP
C00361  dGDP
C00362  dGMP
C00366  Urate
C00385  Xanthine
C00387  Guanosine
C00499  Allantoate
C00559  Deoxyadenosine
C00575  3',5'-Cyclic AMP
C00603  (S)-Ureidoglycolate
C00620  alpha-D-Ribose 1-phosphate
C00655  Xanthosine 5'-phosphate
C00700  XTP
C00802  Oxalureate
C00942  3',5'-Cyclic GMP
C01228  Guanosine 3',5'-bis(diphosphate)
C01260  P1,P4-Bis(5'-adenosyl)tetraphosphate
C01261  P1,P4-Bis(5'-guanosyl) tetraphosphate
C01344  dIDP
C01345  dITP
C01367  3'-AMP
C01444  Oxamate
C01762  Xanthosine
C02091  (S)-Ureidoglycine
C02348  (R)(-)-Allantoin
C02350  (S)-Allantoin
C02353  2',3'-Cyclic AMP
C02718  N-Formiminoglycine
C03090  5-Phosphoribosylamine
C03373  Aminoimidazole ribotide
C03483  Adenosine tetraphosphate
C03614  Inosine 5'-tetraphosphate
C03794  N6-(1,2-Dicarboxyethyl)-AMP
C03838  5'-Phosphoribosylglycinamide
C04051  5-Amino-4-imidazolecarboxyamide
C04376  5'-Phosphoribosyl-N-formylglycinamide
C04392  P1,P4-Bis(5'-xanthosyl) tetraphosphate
C04494  Guanosine 3'-diphosphate 5'-triphosphate
C04640  2-(Formamido)-N1-(5'-phosphoribosyl)acetamidine
C04677  1-(5'-Phosphoribosyl)-5-amino-4-imidazolecarboxamide
C04734  1-(5'-Phosphoribosyl)-5-formamido-4-imidazolecarboxamide
C04751  1-(5-Phospho-D-ribosyl)-5-amino-4-imidazolecarboxylate
C04823  1-(5'-Phosphoribosyl)-5-amino-4-(N-succinocarboxamide)-imidazole
C05239  5-Aminoimidazole
C05512  Deoxyinosine
C05513  Urate-3-ribonucleoside
C05515  5-Ureido-4-imidazole carboxylate
C05516  5-Amino-4-imidazole carboxylate
C05993  Acetyl adenylate
C06193  Guanosine 3'-phosphate
C06194  2',3'-Cyclic GMP
C06195  Imidazolone
C06196  2'-Deoxyinosine 5'-phosphate
C06197  P1,P3-Bis(5'-adenosyl) triphosphate
C06433  5'-Benzoylphosphoadenosine
C06435  5'-Butyrylphosphoinosine
C11821  5-Hydroxyisourate
C12248  5-Hydroxy-2-oxo-4-ureido-2,5-dihydro-1H-imidazole-5-carboxylate
C15667  5-Carboxyamino-1-(5-phospho-D-ribosyl)imidazole
C22395  N6-Succino-2-amino-2'-deoxyadenylate
C22441  dZMP
C22442  dZDP
C22443  dZTP
C22499  8-Hydroxyadenine
C22500  2,8-Dihydroxyadenine
Reference
PMID:10601204
  Authors
Cusa E, Obradors N, Baldoma L, Badia J, Aguilar J.
  Title
Genetic analysis of a chromosomal region containing genes required for assimilation of allantoin nitrogen and linked glyoxylate metabolism in Escherichia coli.
  Journal
J Bacteriol 181:7479-84 (1999)
DOI:10.1128/JB.181.24.7479-7484.1999
Reference
PMID:10986234
  Authors
Xi H, Schneider BL, Reitzer L.
  Title
Purine catabolism in Escherichia coli and function of xanthine dehydrogenase in purine salvage.
  Journal
J Bacteriol 182:5332-41 (2000)
DOI:10.1128/JB.182.19.5332-5341.2000
Related
pathway
ecs00030  Pentose phosphate pathway
ecs00220  Arginine biosynthesis
ecs00250  Alanine, aspartate and glutamate metabolism
ecs00260  Glycine, serine and threonine metabolism
ecs00340  Histidine metabolism
ecs00630  Glyoxylate and dicarboxylate metabolism
ecs00730  Thiamine metabolism
ecs00740  Riboflavin metabolism
ecs00790  Folate biosynthesis
KO pathway
ko00230   

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