KEGG   PATHWAY: eus00480
Entry
eus00480                    Pathway                                
Name
Glutathione metabolism - Eutrema salsugineum (saltwater cress)
Class
Metabolism; Metabolism of other amino acids
Pathway map
eus00480  Glutathione metabolism
eus00480

Module
eus_M00118  Glutathione biosynthesis, glutamate => glutathione [PATH:eus00480]
Other DBs
GO: 0006749
Organism
Eutrema salsugineum (saltwater cress) [GN:eus]
Gene
EUTSA_v10024658mg  hypothetical protein [KO:K18592] [EC:2.3.2.2 3.4.19.13 3.4.19.14]
EUTSA_v10024966mg  hypothetical protein [KO:K18592] [EC:2.3.2.2 3.4.19.13 3.4.19.14]
EUTSA_v10024781mg  hypothetical protein [KO:K18592] [EC:2.3.2.2 3.4.19.13 3.4.19.14]
EUTSA_v10027365mg  hypothetical protein [KO:K18592] [EC:2.3.2.2 3.4.19.13 3.4.19.14]
EUTSA_v10019745mg  hypothetical protein [KO:K18592] [EC:2.3.2.2 3.4.19.13 3.4.19.14]
EUTSA_v10019543mg  hypothetical protein [KO:K18592] [EC:2.3.2.2 3.4.19.13 3.4.19.14]
EUTSA_v10004888mg  hypothetical protein [KO:K22596] [EC:4.3.2.9]
EUTSA_v10026164mg  hypothetical protein [KO:K22596] [EC:4.3.2.9]
EUTSA_v10011803mg  hypothetical protein [KO:K22596] [EC:4.3.2.9]
EUTSA_v10027622mg  hypothetical protein [KO:K01469] [EC:3.5.2.9]
EUTSA_v10024916mg  hypothetical protein [KO:K01919] [EC:6.3.2.2]
EUTSA_v10003956mg  hypothetical protein [KO:K21456] [EC:6.3.2.3]
EUTSA_v10000127mg  hypothetical protein [KO:K01255] [EC:3.4.11.1]
EUTSA_v10024754mg  hypothetical protein [KO:K01255] [EC:3.4.11.1]
EUTSA_v10023233mg  hypothetical protein [KO:K01256] [EC:3.4.11.2]
EUTSA_v10019483mg  hypothetical protein [KO:K00799] [EC:2.5.1.18]
EUTSA_v10019490mg  hypothetical protein [KO:K00799] [EC:2.5.1.18]
EUTSA_v10010587mg  hypothetical protein [KO:K00799] [EC:2.5.1.18]
EUTSA_v10017228mg  hypothetical protein [KO:K00799] [EC:2.5.1.18]
EUTSA_v10011759mg  hypothetical protein [KO:K00799] [EC:2.5.1.18]
EUTSA_v10014654mg  hypothetical protein [KO:K00799] [EC:2.5.1.18]
EUTSA_v10006426mg  hypothetical protein [KO:K00799] [EC:2.5.1.18]
EUTSA_v10017840mg  hypothetical protein [KO:K00799] [EC:2.5.1.18]
EUTSA_v10017257mg  hypothetical protein [KO:K00799] [EC:2.5.1.18]
EUTSA_v10017193mg  hypothetical protein [KO:K00799] [EC:2.5.1.18]
EUTSA_v10017660mg  hypothetical protein [KO:K00799] [EC:2.5.1.18]
EUTSA_v10017227mg  hypothetical protein [KO:K00799] [EC:2.5.1.18]
EUTSA_v10027981mg  hypothetical protein [KO:K00799] [EC:2.5.1.18]
EUTSA_v10021507mg  hypothetical protein [KO:K00799] [EC:2.5.1.18]
EUTSA_v10023672mg  hypothetical protein [KO:K00799] [EC:2.5.1.18]
EUTSA_v10023665mg  hypothetical protein [KO:K00799] [EC:2.5.1.18]
EUTSA_v10019031mg  hypothetical protein [KO:K00799] [EC:2.5.1.18]
EUTSA_v10019743mg  hypothetical protein [KO:K00799] [EC:2.5.1.18]
EUTSA_v10019120mg  hypothetical protein [KO:K00799] [EC:2.5.1.18]
EUTSA_v10019479mg  hypothetical protein [KO:K00799] [EC:2.5.1.18]
EUTSA_v10019480mg  hypothetical protein [KO:K00799] [EC:2.5.1.18]
EUTSA_v10019118mg  hypothetical protein [KO:K00799] [EC:2.5.1.18]
EUTSA_v10023667mg  hypothetical protein [KO:K00799] [EC:2.5.1.18]
EUTSA_v10021472mg  hypothetical protein [KO:K00799] [EC:2.5.1.18]
EUTSA_v10028957mg  hypothetical protein [KO:K00799] [EC:2.5.1.18]
EUTSA_v10001585mg  hypothetical protein [KO:K00799] [EC:2.5.1.18]
EUTSA_v10019114mg  hypothetical protein [KO:K00799] [EC:2.5.1.18]
EUTSA_v10012273mg  hypothetical protein [KO:K00799] [EC:2.5.1.18]
EUTSA_v10011727mg  hypothetical protein [KO:K00799] [EC:2.5.1.18]
EUTSA_v10023666mg  hypothetical protein [KO:K00799] [EC:2.5.1.18]
EUTSA_v10023760mg  hypothetical protein [KO:K00799] [EC:2.5.1.18]
EUTSA_v10027900mg  hypothetical protein [KO:K00799] [EC:2.5.1.18]
EUTSA_v10017210mg  hypothetical protein [KO:K00799] [EC:2.5.1.18]
EUTSA_v10017212mg  hypothetical protein [KO:K00799] [EC:2.5.1.18]
EUTSA_v10008691mg  hypothetical protein [KO:K00799] [EC:2.5.1.18]
EUTSA_v10008734mg  hypothetical protein [KO:K00799] [EC:2.5.1.18]
EUTSA_v10008735mg  hypothetical protein [KO:K00799] [EC:2.5.1.18]
EUTSA_v10017209mg  hypothetical protein [KO:K00799] [EC:2.5.1.18]
EUTSA_v10008682mg  hypothetical protein [KO:K00799] [EC:2.5.1.18]
EUTSA_v10009674mg  hypothetical protein [KO:K00799] [EC:2.5.1.18]
EUTSA_v10008570mg  hypothetical protein [KO:K00799] [EC:2.5.1.18]
EUTSA_v10008776mg  hypothetical protein [KO:K00799] [EC:2.5.1.18]
EUTSA_v10008761mg  hypothetical protein [KO:K21888] [EC:1.8.5.1 2.5.1.18]
EUTSA_v10014453mg  hypothetical protein [KO:K21888] [EC:1.8.5.1 2.5.1.18]
EUTSA_v10019864mg  hypothetical protein [KO:K21888] [EC:1.8.5.1 2.5.1.18]
EUTSA_v10002792mg  hypothetical protein [KO:K00383] [EC:1.8.1.7]
EUTSA_v10010250mg  hypothetical protein [KO:K00383] [EC:1.8.1.7]
EUTSA_v10012325mg  hypothetical protein [KO:K00031] [EC:1.1.1.42]
EUTSA_v10018635mg  hypothetical protein [KO:K00031] [EC:1.1.1.42]
EUTSA_v10013384mg  hypothetical protein [KO:K00031] [EC:1.1.1.42]
EUTSA_v10023427mg  hypothetical protein [KO:K00033] [EC:1.1.1.44 1.1.1.343]
EUTSA_v10023511mg  hypothetical protein [KO:K00033] [EC:1.1.1.44 1.1.1.343]
EUTSA_v10020604mg  hypothetical protein [KO:K00033] [EC:1.1.1.44 1.1.1.343]
EUTSA_v10003851mg  hypothetical protein [KO:K00036] [EC:1.1.1.49 1.1.1.363]
EUTSA_v10004014mg  hypothetical protein [KO:K00036] [EC:1.1.1.49 1.1.1.363]
EUTSA_v10013032mg  hypothetical protein [KO:K00036] [EC:1.1.1.49 1.1.1.363]
EUTSA_v10027727mg  hypothetical protein [KO:K00036] [EC:1.1.1.49 1.1.1.363]
EUTSA_v10007147mg  hypothetical protein [KO:K00036] [EC:1.1.1.49 1.1.1.363]
EUTSA_v10007053mg  hypothetical protein [KO:K00036] [EC:1.1.1.49 1.1.1.363]
EUTSA_v10028932mg  hypothetical protein [KO:K00432] [EC:1.11.1.9]
EUTSA_v10017319mg  hypothetical protein [KO:K00432] [EC:1.11.1.9]
EUTSA_v10001660mg  hypothetical protein [KO:K00432] [EC:1.11.1.9]
EUTSA_v10001645mg  hypothetical protein [KO:K00432] [EC:1.11.1.9]
EUTSA_v10023725mg  hypothetical protein [KO:K00432] [EC:1.11.1.9]
EUTSA_v10006247mg  hypothetical protein [KO:K00432] [EC:1.11.1.9]
EUTSA_v10000311mg  hypothetical protein [KO:K00432] [EC:1.11.1.9]
EUTSA_v10026852mg  hypothetical protein [KO:K00432] [EC:1.11.1.9]
EUTSA_v10012121mg  hypothetical protein [KO:K11188] [EC:1.11.1.7 1.11.1.27 3.1.1.-]
EUTSA_v10013929mg  hypothetical protein [KO:K00797] [EC:2.5.1.16]
EUTSA_v10007822mg  hypothetical protein [KO:K00797] [EC:2.5.1.16]
EUTSA_v10025942mg  hypothetical protein [KO:K00434] [EC:1.11.1.11]
EUTSA_v10025911mg  hypothetical protein [KO:K00434] [EC:1.11.1.11]
EUTSA_v10028759mg  hypothetical protein [KO:K00434] [EC:1.11.1.11]
EUTSA_v10023023mg  hypothetical protein [KO:K00434] [EC:1.11.1.11]
EUTSA_v10022797mg  hypothetical protein [KO:K00434] [EC:1.11.1.11]
EUTSA_v10018581mg  hypothetical protein [KO:K00434] [EC:1.11.1.11]
EUTSA_v10021381mg  hypothetical protein [KO:K00434] [EC:1.11.1.11]
EUTSA_v10025686mg  hypothetical protein [KO:K00434] [EC:1.11.1.11]
EUTSA_v10008402mg  hypothetical protein [KO:K00434] [EC:1.11.1.11]
EUTSA_v10027643mg  hypothetical protein [KO:K10807] [EC:1.17.4.1]
EUTSA_v10024430mg  hypothetical protein [KO:K10807] [EC:1.17.4.1]
EUTSA_v10000480mg  hypothetical protein [KO:K10807] [EC:1.17.4.1]
EUTSA_v10004569mg  hypothetical protein [KO:K10808] [EC:1.17.4.1]
EUTSA_v10021074mg  hypothetical protein [KO:K10808] [EC:1.17.4.1]
Compound
C00005  NADPH
C00006  NADP+
C00024  Acetyl-CoA
C00025  L-Glutamate
C00037  Glycine
C00051  Glutathione
C00072  Ascorbate
C00077  L-Ornithine
C00097  L-Cysteine
C00127  Glutathione disulfide
C00134  Putrescine
C00151  L-Amino acid
C00315  Spermidine
C00669  gamma-L-Glutamyl-L-cysteine
C00750  Spermine
C01322  RX
C01419  Cys-Gly
C01672  Cadaverine
C01879  5-Oxoproline
C02090  Trypanothione
C02320  R-S-Glutathione
C03170  Trypanothione disulfide
C03646  Bis-gamma-glutamylcystine
C03740  (5-L-Glutamyl)-L-amino acid
C05422  Dehydroascorbate
C05726  S-Substituted L-cysteine
C05727  S-Substituted N-acetyl-L-cysteine
C05729  R-S-Cysteinylglycine
C05730  Glutathionylspermidine
C16562  Glutathionylspermine
C16563  Bis(glutathionyl)spermine
C16564  Bis(glutathionyl)spermine disulfide
C16565  Aminopropylcadaverine
C16566  Glutathionylaminopropylcadaverine
C16567  Homotrypanothione
C16568  Homotrypanothione disulfide
C16663  Tryparedoxin
C16664  Tryparedoxin disulfide
Reference
  Authors
Josch C, Klotz LO, Sies H.
  Title
Identification of cytosolic leucyl aminopeptidase (EC 3.4.11.1) as the major cysteinylglycine-hydrolysing activity in rat liver.
  Journal
Biol Chem 384:213-8 (2003)
DOI:10.1515/BC.2003.023
Reference
  Authors
Chu L, Lai Y, Xu X, Eddy S, Yang S, Song L, Kolodrubetz D.
  Title
A 52-kDa leucyl aminopeptidase from treponema denticola is a cysteinylglycinase that mediates the second step of glutathione metabolism.
  Journal
J Biol Chem 283:19351-8 (2008)
DOI:10.1074/jbc.M801034200
Reference
  Authors
Cappiello M, Lazzarotti A, Buono F, Scaloni A, D'Ambrosio C, Amodeo P, Mendez BL, Pelosi P, Del Corso A, Mura U.
  Title
New role for leucyl aminopeptidase in glutathione turnover.
  Journal
Biochem J 378:35-44 (2004)
DOI:10.1042/BJ20031336
Reference
  Authors
Suzuki H, Kamatani S, Kim ES, Kumagai H.
  Title
Aminopeptidases A, B, and N and dipeptidase D are the four cysteinylglycinases of Escherichia coli K-12.
  Journal
J Bacteriol 183:1489-90 (2001)
DOI:10.1128/JB.183.4.1489-1490.2001
Reference
  Authors
Oza SL, Shaw MP, Wyllie S, Fairlamb AH.
  Title
Trypanothione biosynthesis in Leishmania major.
  Journal
Mol Biochem Parasitol 139:107-16 (2005)
DOI:10.1016/j.molbiopara.2004.10.004
Reference
  Authors
Oza SL, Ariyanayagam MR, Fairlamb AH.
  Title
Characterization of recombinant glutathionylspermidine synthetase/amidase from Crithidia fasciculata.
  Journal
Biochem J 364:679-86 (2002)
DOI:10.1042/BJ20011370
Reference
PMID:9677355
  Authors
Tetaud E, Manai F, Barrett MP, Nadeau K, Walsh CT, Fairlamb AH.
  Title
Cloning and characterization of the two enzymes responsible for trypanothione biosynthesis in Crithidia fasciculata.
  Journal
J Biol Chem 273:19383-90 (1998)
DOI:10.1074/jbc.273.31.19383
Reference
  Authors
Ariyanayagam MR, Oza SL, Mehlert A, Fairlamb AH.
  Title
Bis(glutathionyl)spermine and other novel trypanothione analogues in Trypanosoma cruzi.
  Journal
J Biol Chem 278:27612-9 (2003)
DOI:10.1074/jbc.M302750200
Reference
  Authors
Oza SL, Ariyanayagam MR, Aitcheson N, Fairlamb AH.
  Title
Properties of trypanothione synthetase from Trypanosoma brucei.
  Journal
Mol Biochem Parasitol 131:25-33 (2003)
DOI:10.1016/S0166-6851(03)00176-2
Reference
  Authors
Oza SL, Tetaud E, Ariyanayagam MR, Warnon SS, Fairlamb AH.
  Title
A single enzyme catalyses formation of Trypanothione from glutathione and spermidine in Trypanosoma cruzi.
  Journal
J Biol Chem 277:35853-61 (2002)
DOI:10.1074/jbc.M204403200
Reference
  Authors
Comini M, Menge U, Wissing J, Flohe L.
  Title
Trypanothione synthesis in crithidia revisited.
  Journal
J Biol Chem 280:6850-60 (2005)
DOI:10.1074/jbc.M404486200
Reference
PMID:7813456
  Authors
Hunter KJ, Le Quesne SA, Fairlamb AH.
  Title
Identification and biosynthesis of N1,N9-bis(glutathionyl)aminopropylcadaverine (homotrypanothione) in Trypanosoma cruzi.
  Journal
Eur J Biochem 226:1019-27 (1994)
DOI:10.1111/j.1432-1033.1994.t01-1-01019.x
Reference
  Authors
Krauth-Siegel RL, Meiering SK, Schmidt H.
  Title
The parasite-specific trypanothione metabolism of trypanosoma and leishmania.
  Journal
Biol Chem 384:539-49 (2003)
DOI:10.1515/BC.2003.062
Reference
  Authors
Krauth-Siegel RL, Comini MA.
  Title
Redox control in trypanosomatids, parasitic protozoa with trypanothione-based thiol metabolism.
  Journal
Biochim Biophys Acta 1780:1236-48 (2008)
DOI:10.1016/j.bbagen.2008.03.006
Reference
PMID:8892297
  Authors
Krauth-Siegel RL, Ludemann H.
  Title
Reduction of dehydroascorbate by trypanothione.
  Journal
Mol Biochem Parasitol 80:203-8 (1996)
DOI:10.1016/0166-6851(96)02689-8
Reference
  Authors
Dormeyer M, Reckenfelderbaumer N, Ludemann H, Krauth-Siegel RL.
  Title
Trypanothione-dependent synthesis of deoxyribonucleotides by Trypanosoma brucei ribonucleotide reductase.
  Journal
J Biol Chem 276:10602-6 (2001)
DOI:10.1074/jbc.M010352200
Reference
  Authors
Schmidt H, Krauth-Siegel RL.
  Title
Functional and physicochemical characterization of the thioredoxin system in Trypanosoma brucei.
  Journal
J Biol Chem 278:46329-36 (2003)
DOI:10.1074/jbc.M305338200
Reference
PMID:9851611
  Authors
Tetaud E, Fairlamb AH.
  Title
Cloning, expression and reconstitution of the trypanothione-dependent peroxidase system of Crithidia fasciculata.
  Journal
Mol Biochem Parasitol 96:111-23 (1998)
DOI:10.1016/S0166-6851(98)00120-0
Reference
  Authors
Castro H, Sousa C, Santos M, Cordeiro-da-Silva A, Flohe L, Tomas AM.
  Title
Complementary antioxidant defense by cytoplasmic and mitochondrial peroxiredoxins in Leishmania infantum.
  Journal
Free Radic Biol Med 33:1552-62 (2002)
DOI:10.1016/S0891-5849(02)01089-4
Reference
  Authors
Wilkinson SR, Temperton NJ, Mondragon A, Kelly JM.
  Title
Distinct mitochondrial and cytosolic enzymes mediate trypanothione-dependent peroxide metabolism in Trypanosoma cruzi.
  Journal
J Biol Chem 275:8220-5 (2000)
DOI:10.1074/jbc.275.11.8220
Reference
  Authors
Konig J, Fairlamb AH.
  Title
A comparative study of type I and type II tryparedoxin peroxidases in Leishmania major.
  Journal
FEBS J 274:5643-58 (2007)
DOI:10.1111/j.1742-4658.2007.06087.x
Reference
  Authors
Hillebrand H, Schmidt A, Krauth-Siegel RL.
  Title
A second class of peroxidases linked to the trypanothione metabolism.
  Journal
J Biol Chem 278:6809-15 (2003)
DOI:10.1074/jbc.M210392200
Reference
  Authors
Soksawatmaekhin W, Kuraishi A, Sakata K, Kashiwagi K, Igarashi K.
  Title
Excretion and uptake of cadaverine by CadB and its physiological functions in Escherichia coli.
  Journal
Mol Microbiol 51:1401-12 (2004)
DOI:10.1046/j.1365-2958.2003.03913.x
Reference
PMID:6798961
  Authors
Pegg AE, Shuttleworth K, Hibasami H.
  Title
Specificity of mammalian spermidine synthase and spermine synthase.
  Journal
Biochem J 197:315-20 (1981)
DOI:10.1042/bj1970315
Related
pathway
eus00220  Arginine biosynthesis
eus00250  Alanine, aspartate and glutamate metabolism
eus00270  Cysteine and methionine metabolism
eus00430  Taurine and hypotaurine metabolism
eus00460  Cyanoamino acid metabolism
KO pathway
ko00480   
LinkDB

DBGET integrated database retrieval system