KEGG   PATHWAY: ghi00480
Entry
ghi00480                    Pathway                                
Name
Glutathione metabolism - Gossypium hirsutum (upland cotton)
Class
Metabolism; Metabolism of other amino acids
Pathway map
ghi00480  Glutathione metabolism
ghi00480

Module
ghi_M00118  Glutathione biosynthesis, glutamate => glutathione [PATH:ghi00480]
Other DBs
GO: 0006749
Organism
Gossypium hirsutum (upland cotton) [GN:ghi]
Gene
107899662  glutathione hydrolase 1 [KO:K18592] [EC:2.3.2.2 3.4.19.13 3.4.19.14]
107950889  glutathione hydrolase 1-like [KO:K18592] [EC:2.3.2.2 3.4.19.13 3.4.19.14]
107911647  glutathione hydrolase 1-like [KO:K18592] [EC:2.3.2.2 3.4.19.13 3.4.19.14]
107901150  glutathione hydrolase 3 [KO:K18592] [EC:2.3.2.2 3.4.19.13 3.4.19.14]
107941232  glutathione hydrolase 1 isoform X1 [KO:K18592] [EC:2.3.2.2 3.4.19.13 3.4.19.14]
107951667  glutathione hydrolase 1-like isoform X2 [KO:K18592] [EC:2.3.2.2 3.4.19.13 3.4.19.14]
107962699  glutathione hydrolase 3 isoform X1 [KO:K18592] [EC:2.3.2.2 3.4.19.13 3.4.19.14]
107893895  gamma-glutamylcyclotransferase 2-1 [KO:K22596] [EC:4.3.2.9]
107962505  gamma-glutamylcyclotransferase 2-3 isoform X1 [KO:K22596] [EC:4.3.2.9]
107901405  gamma-glutamylcyclotransferase 2-3 [KO:K22596] [EC:4.3.2.9]
107932947  gamma-glutamylcyclotransferase 2-1 [KO:K22596] [EC:4.3.2.9]
107959977  gamma-glutamylcyclotransferase 2-1-like [KO:K22596] [EC:4.3.2.9]
107930786  gamma-glutamylcyclotransferase 2-1-like [KO:K22596] [EC:4.3.2.9]
107886869  5-oxoprolinase [KO:K01469] [EC:3.5.2.9]
107909008  5-oxoprolinase [KO:K01469] [EC:3.5.2.9]
107896479  glutamate--cysteine ligase, chloroplastic [KO:K01919] [EC:6.3.2.2]
107890686  glutamate--cysteine ligase, chloroplastic isoform X1 [KO:K01919] [EC:6.3.2.2]
107913581  glutathione synthetase, chloroplastic [KO:K21456] [EC:6.3.2.3]
107935203  glutathione synthetase, chloroplastic [KO:K21456] [EC:6.3.2.3]
107893437  leucine aminopeptidase 1 [KO:K01255] [EC:3.4.11.1]
107961664  leucine aminopeptidase 1 [KO:K01255] [EC:3.4.11.1]
107888423  leucine aminopeptidase 1 [KO:K01255] [EC:3.4.11.1]
107920609  leucine aminopeptidase 2, chloroplastic isoform X1 [KO:K01255] [EC:3.4.11.1]
107901597  leucine aminopeptidase 1 [KO:K01255] [EC:3.4.11.1]
107929273  puromycin-sensitive aminopeptidase isoform X1 [KO:K01256] [EC:3.4.11.2]
107963795  puromycin-sensitive aminopeptidase isoform X2 [KO:K01256] [EC:3.4.11.2]
107887562  glutathione S-transferase U7-like [KO:K00799] [EC:2.5.1.18]
107926872  glutathione S-transferase F2-like [KO:K00799] [EC:2.5.1.18]
107891004  glutathione S-transferase U8-like isoform X1 [KO:K00799] [EC:2.5.1.18]
107899606  glutathione S-transferase U17 isoform X1 [KO:K00799] [EC:2.5.1.18]
107912678  glutathione S-transferase F9 [KO:K00799] [EC:2.5.1.18]
107923627  glutathione S-transferase F13 [KO:K00799] [EC:2.5.1.18]
107899632  glutathione S-transferase U16 [KO:K00799] [EC:2.5.1.18]
107899633  glutathione S-transferase U17 [KO:K00799] [EC:2.5.1.18]
107900989  glutathione S-transferase F9 [KO:K00799] [EC:2.5.1.18]
107903814  probable glutathione S-transferase [KO:K00799] [EC:2.5.1.18]
107891002  glutathione S-transferase U8 [KO:K00799] [EC:2.5.1.18]
107891011  glutathione S-transferase L3-like [KO:K00799] [EC:2.5.1.18]
107927800  probable glutathione S-transferase [KO:K00799] [EC:2.5.1.18]
107927802  probable glutathione S-transferase [KO:K00799] [EC:2.5.1.18]
107915000  probable glutathione S-transferase [KO:K00799] [EC:2.5.1.18]
107925898  glutathione transferase GST 23-like [KO:K00799] [EC:2.5.1.18]
107957970  glutathione S-transferase L3-like [KO:K00799] [EC:2.5.1.18]
107957971  glutathione S-transferase L3 [KO:K00799] [EC:2.5.1.18]
107901002  probable glutathione S-transferase [KO:K00799] [EC:2.5.1.18]
107905086  probable glutathione S-transferase [KO:K00799] [EC:2.5.1.18]
107953942  glutathione S-transferase F12 [KO:K00799] [EC:2.5.1.18]
107918871  probable glutathione S-transferase [KO:K00799] [EC:2.5.1.18]
107919244  glutathione S-transferase U16-like [KO:K00799] [EC:2.5.1.18]
107924089  probable glutathione S-transferase [KO:K00799] [EC:2.5.1.18]
107961142  probable glutathione S-transferase [KO:K00799] [EC:2.5.1.18]
107940808  glutathione S-transferase L3 [KO:K00799] [EC:2.5.1.18]
107919680  probable glutathione S-transferase [KO:K00799] [EC:2.5.1.18]
107924433  glutathione S-transferase F9-like [KO:K00799] [EC:2.5.1.18]
107887561  glutathione S-transferase U7-like [KO:K00799] [EC:2.5.1.18]
107903988  probable glutathione S-transferase [KO:K00799] [EC:2.5.1.18]
107948580  probable glutathione S-transferase [KO:K00799] [EC:2.5.1.18]
107954825  microsomal glutathione S-transferase 3 [KO:K00799] [EC:2.5.1.18]
107911737  glutathione S-transferase U17 [KO:K00799] [EC:2.5.1.18]
107948962  glutathione S-transferase U17 [KO:K00799] [EC:2.5.1.18]
107948964  glutathione S-transferase U16 [KO:K00799] [EC:2.5.1.18]
107950235  glutathione S-transferase U7-like [KO:K00799] [EC:2.5.1.18]
107950249  glutathione S-transferase U7-like [KO:K00799] [EC:2.5.1.18]
107952791  microsomal glutathione S-transferase 3 [KO:K00799] [EC:2.5.1.18]
107890435  probable glutathione S-transferase [KO:K00799] [EC:2.5.1.18]
107918950  probable glutathione S-transferase [KO:K00799] [EC:2.5.1.18]
107920527  glutathione S-transferase L3 [KO:K00799] [EC:2.5.1.18]
107904488  glutathione S-transferase T1-like [KO:K00799] [EC:2.5.1.18]
107904489  glutathione S-transferase T1-like isoform X1 [KO:K00799] [EC:2.5.1.18]
107905263  glutathione S-transferase L3 [KO:K00799] [EC:2.5.1.18]
107927622  probable glutathione S-transferase [KO:K00799] [EC:2.5.1.18]
107927628  probable glutathione S-transferase [KO:K00799] [EC:2.5.1.18]
107927630  glutathione transferase GST 23-like [KO:K00799] [EC:2.5.1.18]
107927631  probable glutathione S-transferase [KO:K00799] [EC:2.5.1.18]
107894096  glutathione S-transferase T1 isoform X1 [KO:K00799] [EC:2.5.1.18]
107900058  glutathione transferase GST 23-like [KO:K00799] [EC:2.5.1.18]
107962971  glutathione S-transferase T1 isoform X1 [KO:K00799] [EC:2.5.1.18]
107910155  glutathione S-transferase F6-like [KO:K00799] [EC:2.5.1.18]
107912931  probable glutathione S-transferase [KO:K00799] [EC:2.5.1.18]
107919009  probable glutathione S-transferase parA [KO:K00799] [EC:2.5.1.18]
107916899  microsomal glutathione S-transferase 3 [KO:K00799] [EC:2.5.1.18]
107963482  glutathione S-transferase U25-like [KO:K00799] [EC:2.5.1.18]
107898050  glutathione S-transferase F8, chloroplastic [KO:K00799] [EC:2.5.1.18]
107927646  probable glutathione S-transferase [KO:K00799] [EC:2.5.1.18]
107927652  probable glutathione S-transferase [KO:K00799] [EC:2.5.1.18]
107927661  probable glutathione S-transferase [KO:K00799] [EC:2.5.1.18]
107927662  probable glutathione S-transferase [KO:K00799] [EC:2.5.1.18]
107927671  glutathione S-transferase U7-like [KO:K00799] [EC:2.5.1.18]
107933287  glutathione S-transferase U17-like [KO:K00799] [EC:2.5.1.18]
107911335  probable glutathione S-transferase [KO:K00799] [EC:2.5.1.18]
107911340  probable glutathione S-transferase parA [KO:K00799] [EC:2.5.1.18]
107913663  glutathione S-transferase F8, chloroplastic-like [KO:K00799] [EC:2.5.1.18]
107924542  glutathione S-transferase T1 [KO:K00799] [EC:2.5.1.18]
107924543  glutathione S-transferase T1 [KO:K00799] [EC:2.5.1.18]
107890222  probable glutathione S-transferase [KO:K00799] [EC:2.5.1.18]
107899373  glutathione S-transferase F12-like [KO:K00799] [EC:2.5.1.18]
107899391  probable glutathione S-transferase [KO:K00799] [EC:2.5.1.18]
107936694  glutathione S-transferase T1 isoform X2 [KO:K00799] [EC:2.5.1.18]
107926873  glutathione S-transferase F6-like [KO:K00799] [EC:2.5.1.18]
107921598  glutathione S-transferase U9 [KO:K00799] [EC:2.5.1.18]
107913317  probable glutathione S-transferase [KO:K00799] [EC:2.5.1.18]
107947020  glutathione S-transferase T1 isoform X1 [KO:K00799] [EC:2.5.1.18]
107960472  probable glutathione S-transferase [KO:K00799] [EC:2.5.1.18]
107889730  glutathione S-transferase L3 [KO:K00799] [EC:2.5.1.18]
107889737  glutathione S-transferase U8 [KO:K00799] [EC:2.5.1.18]
107889738  glutathione S-transferase U8-like [KO:K00799] [EC:2.5.1.18]
107889739  glutathione S-transferase U8 [KO:K00799] [EC:2.5.1.18]
107926204  glutathione S-transferase U16-like [KO:K00799] [EC:2.5.1.18]
107920650  probable glutathione S-transferase [KO:K00799] [EC:2.5.1.18]
107927711  probable glutathione S-transferase [KO:K00799] [EC:2.5.1.18]
107929953  glutathione S-transferase F6 [KO:K00799] [EC:2.5.1.18]
107957058  probable glutathione S-transferase [KO:K00799] [EC:2.5.1.18]
107957060  glutathione transferase GST 23-like [KO:K00799] [EC:2.5.1.18]
107957061  probable glutathione S-transferase [KO:K00799] [EC:2.5.1.18]
107957062  glutathione S-transferase U7-like [KO:K00799] [EC:2.5.1.18]
107957063  probable glutathione S-transferase [KO:K00799] [EC:2.5.1.18]
107948407  glutathione S-transferase U17-like [KO:K00799] [EC:2.5.1.18]
107942084  probable glutathione S-transferase [KO:K00799] [EC:2.5.1.18]
107944272  microsomal glutathione S-transferase 3 [KO:K00799] [EC:2.5.1.18]
107962972  glutathione S-transferase T1 isoform X2 [KO:K00799] [EC:2.5.1.18]
107957354  uncharacterized protein LOC107957354 isoform X1 [KO:K00799] [EC:2.5.1.18]
121224610  glutathione S-transferase F6-like [KO:K00799] [EC:2.5.1.18]
107919470  glutathione S-transferase U17-like [KO:K00799] [EC:2.5.1.18]
107920349  glutathione S-transferase U23 isoform X3 [KO:K00799] [EC:2.5.1.18]
107956202  probable glutathione S-transferase [KO:K00799] [EC:2.5.1.18]
107957066  probable glutathione S-transferase [KO:K00799] [EC:2.5.1.18]
121209754  glutathione S-transferase F13-like [KO:K00799] [EC:2.5.1.18]
121209774  probable glutathione S-transferase [KO:K00799] [EC:2.5.1.18]
121210132  glutathione S-transferase U17-like [KO:K00799] [EC:2.5.1.18]
107925966  glutathione S-transferase DHAR2 [KO:K21888] [EC:1.8.5.1 2.5.1.18]
107930662  glutathione S-transferase DHAR2 [KO:K21888] [EC:1.8.5.1 2.5.1.18]
107953969  glutathione S-transferase DHAR3, chloroplastic [KO:K21888] [EC:1.8.5.1 2.5.1.18]
107897777  glutathione S-transferase DHAR2 [KO:K21888] [EC:1.8.5.1 2.5.1.18]
107887344  glutathione S-transferase DHAR3, chloroplastic [KO:K21888] [EC:1.8.5.1 2.5.1.18]
107959887  glutathione S-transferase DHAR2-like [KO:K21888] [EC:1.8.5.1 2.5.1.18]
107908477  glutathione reductase, chloroplastic [KO:K00383] [EC:1.8.1.7]
107924091  glutathione reductase, chloroplastic [KO:K00383] [EC:1.8.1.7]
107914842  glutathione reductase, chloroplastic [KO:K00383] [EC:1.8.1.7]
107887195  glutathione reductase, chloroplastic [KO:K00383] [EC:1.8.1.7]
107897752  glutathione reductase, chloroplastic [KO:K00383] [EC:1.8.1.7]
107923983  glutathione reductase, chloroplastic isoform X1 [KO:K00383] [EC:1.8.1.7]
107885926  cytosolic isocitrate dehydrogenase [NADP]-like [KO:K00031] [EC:1.1.1.42]
107914238  isocitrate dehydrogenase [NADP], chloroplastic/mitochondrial [KO:K00031] [EC:1.1.1.42]
107893548  isocitrate dehydrogenase [NADP] [KO:K00031] [EC:1.1.1.42]
107920416  isocitrate dehydrogenase [NADP] isoform X1 [KO:K00031] [EC:1.1.1.42]
107892269  isocitrate dehydrogenase [NADP], chloroplastic/mitochondrial [KO:K00031] [EC:1.1.1.42]
107897570  isocitrate dehydrogenase [NADP] [KO:K00031] [EC:1.1.1.42]
107912878  isocitrate dehydrogenase [NADP] [KO:K00031] [EC:1.1.1.42]
107888667  isocitrate dehydrogenase [NADP], chloroplastic/mitochondrial-like [KO:K00031] [EC:1.1.1.42]
107895258  isocitrate dehydrogenase [NADP]-like [KO:K00031] [EC:1.1.1.42]
107947100  6-phosphogluconate dehydrogenase, decarboxylating 3, chloroplastic [KO:K00033] [EC:1.1.1.44 1.1.1.343]
107954838  6-phosphogluconate dehydrogenase, decarboxylating 1 [KO:K00033] [EC:1.1.1.44 1.1.1.343]
107915537  6-phosphogluconate dehydrogenase, decarboxylating 2 [KO:K00033] [EC:1.1.1.44 1.1.1.343]
107950381  6-phosphogluconate dehydrogenase, decarboxylating 2 isoform X2 [KO:K00033] [EC:1.1.1.44 1.1.1.343]
107947079  6-phosphogluconate dehydrogenase, decarboxylating 3, chloroplastic [KO:K00033] [EC:1.1.1.44 1.1.1.343]
121219495  6-phosphogluconate dehydrogenase, decarboxylating 1 [KO:K00033] [EC:1.1.1.44 1.1.1.343]
107886719  glucose-6-phosphate 1-dehydrogenase, chloroplastic-like [KO:K00036] [EC:1.1.1.49 1.1.1.363]
107922783  glucose-6-phosphate 1-dehydrogenase, chloroplastic [KO:K00036] [EC:1.1.1.49 1.1.1.363]
107912598  glucose-6-phosphate 1-dehydrogenase, chloroplastic [KO:K00036] [EC:1.1.1.49 1.1.1.363]
107888699  glucose-6-phosphate 1-dehydrogenase, cytoplasmic isoform-like isoform X1 [KO:K00036] [EC:1.1.1.49 1.1.1.363]
107899693  glucose-6-phosphate 1-dehydrogenase, cytoplasmic isoform [KO:K00036] [EC:1.1.1.49 1.1.1.363]
107933096  glucose-6-phosphate 1-dehydrogenase, chloroplastic isoform X1 [KO:K00036] [EC:1.1.1.49 1.1.1.363]
107909547  glucose-6-phosphate 1-dehydrogenase, chloroplastic [KO:K00036] [EC:1.1.1.49 1.1.1.363]
107892194  glucose-6-phosphate 1-dehydrogenase, cytoplasmic isoform [KO:K00036] [EC:1.1.1.49 1.1.1.363]
107886427  inactive glucose-6-phosphate 1-dehydrogenase 4, chloroplastic-like [KO:K00036] [EC:1.1.1.49 1.1.1.363]
107927241  inactive glucose-6-phosphate 1-dehydrogenase 4, chloroplastic [KO:K00036] [EC:1.1.1.49 1.1.1.363]
107926487  glucose-6-phosphate 1-dehydrogenase, cytoplasmic isoform [KO:K00036] [EC:1.1.1.49 1.1.1.363]
107926532  glucose-6-phosphate 1-dehydrogenase, cytoplasmic isoform [KO:K00036] [EC:1.1.1.49 1.1.1.363]
107913385  probable glutathione peroxidase 2 [KO:K00432] [EC:1.11.1.9]
107952118  probable glutathione peroxidase 2 [KO:K00432] [EC:1.11.1.9]
107894097  probable phospholipid hydroperoxide glutathione peroxidase [KO:K00432] [EC:1.11.1.9]
107894104  probable glutathione peroxidase 8 isoform X1 [KO:K00432] [EC:1.11.1.9]
107953728  probable phospholipid hydroperoxide glutathione peroxidase isoform X1 [KO:K00432] [EC:1.11.1.9]
107962973  probable phospholipid hydroperoxide glutathione peroxidase [KO:K00432] [EC:1.11.1.9]
107934406  probable glutathione peroxidase 4 [KO:K00432] [EC:1.11.1.9]
107936710  probable phospholipid hydroperoxide glutathione peroxidase [KO:K00432] [EC:1.11.1.9]
107933606  probable glutathione peroxidase 2 [KO:K00432] [EC:1.11.1.9]
107947021  probable phospholipid hydroperoxide glutathione peroxidase isoform X2 [KO:K00432] [EC:1.11.1.9]
107947026  probable glutathione peroxidase 8 [KO:K00432] [EC:1.11.1.9]
121232000  probable phospholipid hydroperoxide glutathione peroxidase [KO:K00432] [EC:1.11.1.9]
107886161  probable glutathione peroxidase 4 [KO:K00432] [EC:1.11.1.9]
107916248  1-Cys peroxiredoxin [KO:K11188] [EC:1.11.1.7 1.11.1.27 3.1.1.-]
107896588  1-Cys peroxiredoxin-like [KO:K11188] [EC:1.11.1.7 1.11.1.27 3.1.1.-]
107926754  ornithine decarboxylase [KO:K01581] [EC:4.1.1.17]
107888839  ornithine decarboxylase [KO:K01581] [EC:4.1.1.17]
107888902  ornithine decarboxylase-like [KO:K01581] [EC:4.1.1.17]
107956533  spermidine synthase 2-like [KO:K00797] [EC:2.5.1.16]
107926644  spermidine synthase 2-like [KO:K00797] [EC:2.5.1.16]
107909636  spermidine synthase 1 [KO:K00797] [EC:2.5.1.16]
107947253  spermine synthase [KO:K00797] [EC:2.5.1.16]
107929559  spermine synthase-like [KO:K00797] [EC:2.5.1.16]
107886614  spermidine synthase 1 [KO:K00797] [EC:2.5.1.16]
107908990  spermine synthase isoform X1 [KO:K00797] [EC:2.5.1.16]
107910988  spermine synthase [KO:K00797] [EC:2.5.1.16]
107922467  L-ascorbate peroxidase 3 [KO:K00434] [EC:1.11.1.11]
107909465  probable L-ascorbate peroxidase 3 [KO:K00434] [EC:1.11.1.11]
107942909  L-ascorbate peroxidase, cytosolic-like [KO:K00434] [EC:1.11.1.11]
107959060  L-ascorbate peroxidase, cytosolic-like [KO:K00434] [EC:1.11.1.11]
107962799  L-ascorbate peroxidase, cytosolic [KO:K00434] [EC:1.11.1.11]
107962802  L-ascorbate peroxidase, cytosolic [KO:K00434] [EC:1.11.1.11]
107962803  L-ascorbate peroxidase, cytosolic [KO:K00434] [EC:1.11.1.11]
107906191  L-ascorbate peroxidase, cytosolic [KO:K00434] [EC:1.11.1.11]
107962527  probable L-ascorbate peroxidase 6, chloroplastic/mitochondrial [KO:K00434] [EC:1.11.1.11]
107908653  L-ascorbate peroxidase 3 [KO:K00434] [EC:1.11.1.11]
107936563  L-ascorbate peroxidase 3-like [KO:K00434] [EC:1.11.1.11]
107961677  putative L-ascorbate peroxidase 6 isoform X1 [KO:K00434] [EC:1.11.1.11]
107900057  putative L-ascorbate peroxidase 6 isoform X3 [KO:K00434] [EC:1.11.1.11]
107901425  probable L-ascorbate peroxidase 6, chloroplastic/mitochondrial [KO:K00434] [EC:1.11.1.11]
107938996  L-ascorbate peroxidase, cytosolic-like [KO:K00434] [EC:1.11.1.11]
107927982  L-ascorbate peroxidase 3, peroxisomal-like [KO:K00434] [EC:1.11.1.11]
107952958  L-ascorbate peroxidase 1, cytosolic-like [KO:K00434] [EC:1.11.1.11]
107916997  L-ascorbate peroxidase 3 isoform X1 [KO:K00434] [EC:1.11.1.11]
107924317  probable L-ascorbate peroxidase 6, chloroplastic [KO:K00434] [EC:1.11.1.11]
107898310  L-ascorbate peroxidase 2, cytosolic-like [KO:K00434] [EC:1.11.1.11]
121229506  probable L-ascorbate peroxidase 6, chloroplastic/mitochondrial isoform X1 [KO:K00434] [EC:1.11.1.11]
121212696  L-ascorbate peroxidase 2, cytosolic-like [KO:K00434] [EC:1.11.1.11]
107890889  ribonucleoside-diphosphate reductase large subunit [KO:K10807] [EC:1.17.4.1]
107925060  ribonucleoside-diphosphate reductase large subunit [KO:K10807] [EC:1.17.4.1]
107922452  ribonucleoside-diphosphate reductase large subunit [KO:K10807] [EC:1.17.4.1]
107950594  ribonucleoside-diphosphate reductase large subunit [KO:K10807] [EC:1.17.4.1]
107904823  ribonucleoside-diphosphate reductase small chain [KO:K10808] [EC:1.17.4.1]
107914143  ribonucleoside-diphosphate reductase small chain [KO:K10808] [EC:1.17.4.1]
107927807  ribonucleoside-diphosphate reductase small chain A [KO:K10808] [EC:1.17.4.1]
107943553  ribonucleoside-diphosphate reductase small chain A [KO:K10808] [EC:1.17.4.1]
107937090  ribonucleoside-diphosphate reductase small chain-like [KO:K10808] [EC:1.17.4.1]
107897287  ribonucleoside-diphosphate reductase small chain-like [KO:K10808] [EC:1.17.4.1]
Compound
C00005  NADPH
C00006  NADP+
C00024  Acetyl-CoA
C00025  L-Glutamate
C00037  Glycine
C00051  Glutathione
C00072  Ascorbate
C00077  L-Ornithine
C00097  L-Cysteine
C00127  Glutathione disulfide
C00134  Putrescine
C00151  L-Amino acid
C00315  Spermidine
C00669  gamma-L-Glutamyl-L-cysteine
C00750  Spermine
C01322  RX
C01419  Cys-Gly
C01672  Cadaverine
C01879  5-Oxoproline
C02090  Trypanothione
C02320  R-S-Glutathione
C03170  Trypanothione disulfide
C03646  Bis-gamma-glutamylcystine
C03740  (5-L-Glutamyl)-L-amino acid
C05422  Dehydroascorbate
C05726  S-Substituted L-cysteine
C05727  S-Substituted N-acetyl-L-cysteine
C05729  R-S-Cysteinylglycine
C05730  Glutathionylspermidine
C16562  Glutathionylspermine
C16563  Bis(glutathionyl)spermine
C16564  Bis(glutathionyl)spermine disulfide
C16565  Aminopropylcadaverine
C16566  Glutathionylaminopropylcadaverine
C16567  Homotrypanothione
C16568  Homotrypanothione disulfide
C16663  Tryparedoxin
C16664  Tryparedoxin disulfide
Reference
PMID:12675513
  Authors
Josch C, Klotz LO, Sies H.
  Title
Identification of cytosolic leucyl aminopeptidase (EC 3.4.11.1) as the major cysteinylglycine-hydrolysing activity in rat liver.
  Journal
Biol Chem 384:213-8 (2003)
DOI:10.1515/BC.2003.023
Reference
PMID:18482986
  Authors
Chu L, Lai Y, Xu X, Eddy S, Yang S, Song L, Kolodrubetz D.
  Title
A 52-kDa leucyl aminopeptidase from treponema denticola is a cysteinylglycinase that mediates the second step of glutathione metabolism.
  Journal
J Biol Chem 283:19351-8 (2008)
DOI:10.1074/jbc.M801034200
Reference
PMID:14583094
  Authors
Cappiello M, Lazzarotti A, Buono F, Scaloni A, D'Ambrosio C, Amodeo P, Mendez BL, Pelosi P, Del Corso A, Mura U.
  Title
New role for leucyl aminopeptidase in glutathione turnover.
  Journal
Biochem J 378:35-44 (2004)
DOI:10.1042/BJ20031336
Reference
PMID:11157967
  Authors
Suzuki H, Kamatani S, Kim ES, Kumagai H.
  Title
Aminopeptidases A, B, and N and dipeptidase D are the four cysteinylglycinases of Escherichia coli K-12.
  Journal
J Bacteriol 183:1489-90 (2001)
DOI:10.1128/JB.183.4.1489-1490.2001
Reference
PMID:15610825
  Authors
Oza SL, Shaw MP, Wyllie S, Fairlamb AH.
  Title
Trypanothione biosynthesis in Leishmania major.
  Journal
Mol Biochem Parasitol 139:107-16 (2005)
DOI:10.1016/j.molbiopara.2004.10.004
Reference
PMID:12049631
  Authors
Oza SL, Ariyanayagam MR, Fairlamb AH.
  Title
Characterization of recombinant glutathionylspermidine synthetase/amidase from Crithidia fasciculata.
  Journal
Biochem J 364:679-86 (2002)
DOI:10.1042/BJ20011370
Reference
PMID:9677355
  Authors
Tetaud E, Manai F, Barrett MP, Nadeau K, Walsh CT, Fairlamb AH.
  Title
Cloning and characterization of the two enzymes responsible for trypanothione biosynthesis in Crithidia fasciculata.
  Journal
J Biol Chem 273:19383-90 (1998)
DOI:10.1074/jbc.273.31.19383
Reference
PMID:12750367
  Authors
Ariyanayagam MR, Oza SL, Mehlert A, Fairlamb AH.
  Title
Bis(glutathionyl)spermine and other novel trypanothione analogues in Trypanosoma cruzi.
  Journal
J Biol Chem 278:27612-9 (2003)
DOI:10.1074/jbc.M302750200
Reference
PMID:12967709
  Authors
Oza SL, Ariyanayagam MR, Aitcheson N, Fairlamb AH.
  Title
Properties of trypanothione synthetase from Trypanosoma brucei.
  Journal
Mol Biochem Parasitol 131:25-33 (2003)
DOI:10.1016/S0166-6851(03)00176-2
Reference
PMID:12121990
  Authors
Oza SL, Tetaud E, Ariyanayagam MR, Warnon SS, Fairlamb AH.
  Title
A single enzyme catalyses formation of Trypanothione from glutathione and spermidine in Trypanosoma cruzi.
  Journal
J Biol Chem 277:35853-61 (2002)
DOI:10.1074/jbc.M204403200
Reference
PMID:15537651
  Authors
Comini M, Menge U, Wissing J, Flohe L.
  Title
Trypanothione synthesis in crithidia revisited.
  Journal
J Biol Chem 280:6850-60 (2005)
DOI:10.1074/jbc.M404486200
Reference
PMID:7813456
  Authors
Hunter KJ, Le Quesne SA, Fairlamb AH.
  Title
Identification and biosynthesis of N1,N9-bis(glutathionyl)aminopropylcadaverine (homotrypanothione) in Trypanosoma cruzi.
  Journal
Eur J Biochem 226:1019-27 (1994)
DOI:10.1111/j.1432-1033.1994.t01-1-01019.x
Reference
PMID:12751784
  Authors
Krauth-Siegel RL, Meiering SK, Schmidt H.
  Title
The parasite-specific trypanothione metabolism of trypanosoma and leishmania.
  Journal
Biol Chem 384:539-49 (2003)
DOI:10.1515/BC.2003.062
Reference
PMID:18395526
  Authors
Krauth-Siegel RL, Comini MA.
  Title
Redox control in trypanosomatids, parasitic protozoa with trypanothione-based thiol metabolism.
  Journal
Biochim Biophys Acta 1780:1236-48 (2008)
DOI:10.1016/j.bbagen.2008.03.006
Reference
PMID:8892297
  Authors
Krauth-Siegel RL, Ludemann H.
  Title
Reduction of dehydroascorbate by trypanothione.
  Journal
Mol Biochem Parasitol 80:203-8 (1996)
DOI:10.1016/0166-6851(96)02689-8
Reference
PMID:11150302
  Authors
Dormeyer M, Reckenfelderbaumer N, Ludemann H, Krauth-Siegel RL.
  Title
Trypanothione-dependent synthesis of deoxyribonucleotides by Trypanosoma brucei ribonucleotide reductase.
  Journal
J Biol Chem 276:10602-6 (2001)
DOI:10.1074/jbc.M010352200
Reference
PMID:12949079
  Authors
Schmidt H, Krauth-Siegel RL.
  Title
Functional and physicochemical characterization of the thioredoxin system in Trypanosoma brucei.
  Journal
J Biol Chem 278:46329-36 (2003)
DOI:10.1074/jbc.M305338200
Reference
PMID:9851611
  Authors
Tetaud E, Fairlamb AH.
  Title
Cloning, expression and reconstitution of the trypanothione-dependent peroxidase system of Crithidia fasciculata.
  Journal
Mol Biochem Parasitol 96:111-23 (1998)
DOI:10.1016/S0166-6851(98)00120-0
Reference
PMID:12446213
  Authors
Castro H, Sousa C, Santos M, Cordeiro-da-Silva A, Flohe L, Tomas AM.
  Title
Complementary antioxidant defense by cytoplasmic and mitochondrial peroxiredoxins in Leishmania infantum.
  Journal
Free Radic Biol Med 33:1552-62 (2002)
DOI:10.1016/S0891-5849(02)01089-4
Reference
PMID:10713147
  Authors
Wilkinson SR, Temperton NJ, Mondragon A, Kelly JM.
  Title
Distinct mitochondrial and cytosolic enzymes mediate trypanothione-dependent peroxide metabolism in Trypanosoma cruzi.
  Journal
J Biol Chem 275:8220-5 (2000)
DOI:10.1074/jbc.275.11.8220
Reference
PMID:17922848
  Authors
Konig J, Fairlamb AH.
  Title
A comparative study of type I and type II tryparedoxin peroxidases in Leishmania major.
  Journal
FEBS J 274:5643-58 (2007)
DOI:10.1111/j.1742-4658.2007.06087.x
Reference
PMID:12466271
  Authors
Hillebrand H, Schmidt A, Krauth-Siegel RL.
  Title
A second class of peroxidases linked to the trypanothione metabolism.
  Journal
J Biol Chem 278:6809-15 (2003)
DOI:10.1074/jbc.M210392200
Reference
PMID:14982633
  Authors
Soksawatmaekhin W, Kuraishi A, Sakata K, Kashiwagi K, Igarashi K.
  Title
Excretion and uptake of cadaverine by CadB and its physiological functions in Escherichia coli.
  Journal
Mol Microbiol 51:1401-12 (2004)
DOI:10.1046/j.1365-2958.2003.03913.x
Reference
PMID:6798961
  Authors
Pegg AE, Shuttleworth K, Hibasami H.
  Title
Specificity of mammalian spermidine synthase and spermine synthase.
  Journal
Biochem J 197:315-20 (1981)
DOI:10.1042/bj1970315
Related
pathway
ghi00220  Arginine biosynthesis
ghi00250  Alanine, aspartate and glutamate metabolism
ghi00270  Cysteine and methionine metabolism
ghi00430  Taurine and hypotaurine metabolism
ghi00460  Cyanoamino acid metabolism
KO pathway
ko00480   
LinkDB

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