KEGG   PATHWAY: gra00480
Entry
gra00480                    Pathway                                
Name
Glutathione metabolism - Gossypium raimondii
Class
Metabolism; Metabolism of other amino acids
Pathway map
gra00480  Glutathione metabolism
gra00480

Module
gra_M00118  Glutathione biosynthesis, glutamate => glutathione [PATH:gra00480]
Other DBs
GO: 0006749
Organism
Gossypium raimondii [GN:gra]
Gene
105787859  glutathione hydrolase 1 isoform X1 [KO:K18592] [EC:2.3.2.2 3.4.19.13 3.4.19.14]
105773435  glutathione hydrolase 3 isoform X1 [KO:K18592] [EC:2.3.2.2 3.4.19.13 3.4.19.14]
105802287  glutathione hydrolase 1 [KO:K18592] [EC:2.3.2.2 3.4.19.13 3.4.19.14]
128031898  glutathione hydrolase 1-like [KO:K18592] [EC:2.3.2.2 3.4.19.13 3.4.19.14]
105774461  gamma-glutamylcyclotransferase 2-1 isoform X2 [KO:K22596] [EC:4.3.2.9]
105773070  gamma-glutamylcyclotransferase 2-3 isoform X1 [KO:K22596] [EC:4.3.2.9]
105787418  gamma-glutamylcyclotransferase 2-1 [KO:K22596] [EC:4.3.2.9]
105794991  5-oxoprolinase 1 [KO:K01469] [EC:3.5.2.9]
105800237  glutamate--cysteine ligase, chloroplastic isoform X1 [KO:K01919] [EC:6.3.2.2]
105788073  glutathione synthetase, chloroplastic [KO:K21456] [EC:6.3.2.3]
105768012  leucine aminopeptidase 2, chloroplastic [KO:K01255] [EC:3.4.11.1]
105782212  leucine aminopeptidase 1 [KO:K01255] [EC:3.4.11.1]
105773246  leucine aminopeptidase 1 [KO:K01255] [EC:3.4.11.1]
105789112  puromycin-sensitive aminopeptidase [KO:K01256] [EC:3.4.11.2]
105792236  LOW QUALITY PROTEIN: puromycin-sensitive aminopeptidase [KO:K01256] [EC:3.4.11.2]
105788805  glutathione S-transferase F12 [KO:K00799] [EC:2.5.1.18]
105801212  uncharacterized protein LOC105801212 [KO:K00799] [EC:2.5.1.18]
105771408  probable glutathione S-transferase [KO:K00799] [EC:2.5.1.18]
105786454  glutathione S-transferase L3 [KO:K00799] [EC:2.5.1.18]
105787280  glutathione S-transferase U9 [KO:K00799] [EC:2.5.1.18]
105788767  glutathione S-transferase U7 [KO:K00799] [EC:2.5.1.18]
105791436  glutathione S-transferase F6 [KO:K00799] [EC:2.5.1.18]
105792211  glutathione S-transferase T1 [KO:K00799] [EC:2.5.1.18]
105790238  glutathione S-transferase U17 [KO:K00799] [EC:2.5.1.18]
105790239  glutathione S-transferase U17 [KO:K00799] [EC:2.5.1.18]
105790394  uncharacterized protein LOC105790394 isoform X2 [KO:K00799] [EC:2.5.1.18]
105795606  probable glutathione S-transferase isoform X1 [KO:K00799] [EC:2.5.1.18]
105796590  probable glutathione S-transferase [KO:K00799] [EC:2.5.1.18]
105796591  probable glutathione S-transferase [KO:K00799] [EC:2.5.1.18]
105796592  probable glutathione S-transferase [KO:K00799] [EC:2.5.1.18]
105796594  probable glutathione S-transferase isoform X2 [KO:K00799] [EC:2.5.1.18]
105796595  probable glutathione S-transferase [KO:K00799] [EC:2.5.1.18]
105796597  glutathione transferase GST 23 [KO:K00799] [EC:2.5.1.18]
105796600  probable glutathione S-transferase [KO:K00799] [EC:2.5.1.18]
105796604  probable glutathione S-transferase [KO:K00799] [EC:2.5.1.18]
105766256  probable glutathione S-transferase [KO:K00799] [EC:2.5.1.18]
105765214  glutathione S-transferase T1 [KO:K00799] [EC:2.5.1.18]
105774942  probable glutathione S-transferase [KO:K00799] [EC:2.5.1.18]
105779046  glutathione S-transferase U8 [KO:K00799] [EC:2.5.1.18]
105780232  glutathione S-transferase U16 [KO:K00799] [EC:2.5.1.18]
105780233  glutathione S-transferase U16 [KO:K00799] [EC:2.5.1.18]
105775553  glutathione S-transferase F9 [KO:K00799] [EC:2.5.1.18]
105783946  probable glutathione S-transferase [KO:K00799] [EC:2.5.1.18]
105783948  probable glutathione S-transferase isoform X2 [KO:K00799] [EC:2.5.1.18]
105782875  probable glutathione S-transferase parA [KO:K00799] [EC:2.5.1.18]
105781846  probable glutathione S-transferase [KO:K00799] [EC:2.5.1.18]
105780657  probable glutathione S-transferase [KO:K00799] [EC:2.5.1.18]
105780694  glutathione S-transferase U17 [KO:K00799] [EC:2.5.1.18]
105772381  glutathione transferase GST 23 [KO:K00799] [EC:2.5.1.18]
105779641  glutathione S-transferase U17 [KO:K00799] [EC:2.5.1.18]
105783254  glutathione S-transferase L3 [KO:K00799] [EC:2.5.1.18]
105782146  glutathione S-transferase U17 [KO:K00799] [EC:2.5.1.18]
105783265  probable glutathione S-transferase [KO:K00799] [EC:2.5.1.18]
105784493  probable glutathione S-transferase [KO:K00799] [EC:2.5.1.18]
105798609  probable glutathione S-transferase [KO:K00799] [EC:2.5.1.18]
105799890  glutathione S-transferase L3 [KO:K00799] [EC:2.5.1.18]
105799899  glutathione S-transferase U8 [KO:K00799] [EC:2.5.1.18]
105799900  glutathione S-transferase U8 [KO:K00799] [EC:2.5.1.18]
105801385  probable glutathione S-transferase [KO:K00799] [EC:2.5.1.18]
105800883  glutathione S-transferase T1 [KO:K00799] [EC:2.5.1.18]
105802397  glutathione S-transferase U17 [KO:K00799] [EC:2.5.1.18]
105801917  glutathione S-transferase T1 [KO:K00799] [EC:2.5.1.18]
105803509  glutathione S-transferase F9 [KO:K00799] [EC:2.5.1.18]
105804345  probable glutathione S-transferase [KO:K00799] [EC:2.5.1.18]
105804234  glutathione S-transferase [KO:K00799] [EC:2.5.1.18]
105803031  glutathione S-transferase F13 [KO:K00799] [EC:2.5.1.18]
105762664  glutathione S-transferase F6 [KO:K00799] [EC:2.5.1.18]
105789687  glutathione S-transferase U7 [KO:K00799] [EC:2.5.1.18]
105796603  probable glutathione S-transferase [KO:K00799] [EC:2.5.1.18]
105796605  probable glutathione S-transferase [KO:K00799] [EC:2.5.1.18]
105796606  probable glutathione S-transferase [KO:K00799] [EC:2.5.1.18]
105799901  LOW QUALITY PROTEIN: glutathione S-transferase U8-like [KO:K00799] [EC:2.5.1.18]
105804293  glutathione S-transferase U17-like [KO:K00799] [EC:2.5.1.18]
128031957  probable glutathione S-transferase [KO:K00799] [EC:2.5.1.18]
128034961  probable glutathione S-transferase [KO:K00799] [EC:2.5.1.18]
128039722  probable glutathione S-transferase [KO:K00799] [EC:2.5.1.18]
105785088  probable glutathione S-transferase [KO:K00799] [EC:2.5.1.18]
105776802  glutathione S-transferase DHAR2 [KO:K21888] [EC:1.8.5.1 2.5.1.18]
105780418  glutathione S-transferase DHAR2 [KO:K21888] [EC:1.8.5.1 2.5.1.18]
105789278  glutathione S-transferase DHAR3, chloroplastic [KO:K21888] [EC:1.8.5.1 2.5.1.18]
105794071  glutathione reductase, chloroplastic [KO:K00383] [EC:1.8.1.7]
105777495  glutathione reductase, chloroplastic [KO:K00383] [EC:1.8.1.7]
105803157  glutathione reductase, chloroplastic [KO:K00383] [EC:1.8.1.7]
105776446  isocitrate dehydrogenase [NADP] [KO:K00031] [EC:1.1.1.42]
105783266  isocitrate dehydrogenase [NADP] [KO:K00031] [EC:1.1.1.42]
105798339  isocitrate dehydrogenase [NADP], chloroplastic/mitochondrial [KO:K00031] [EC:1.1.1.42]
105803643  isocitrate dehydrogenase [NADP] [KO:K00031] [EC:1.1.1.42]
105801390  6-phosphogluconate dehydrogenase, decarboxylating 1 [KO:K00033] [EC:1.1.1.44 1.1.1.343]
105790552  6-phosphogluconate dehydrogenase, decarboxylating 2 [KO:K00033] [EC:1.1.1.44 1.1.1.343]
105765280  6-phosphogluconate dehydrogenase, decarboxylating 3, chloroplastic [KO:K00033] [EC:1.1.1.44 1.1.1.343]
105769373  glucose-6-phosphate 1-dehydrogenase, cytoplasmic isoform [KO:K00036] [EC:1.1.1.49 1.1.1.363]
105774486  glucose-6-phosphate 1-dehydrogenase, chloroplastic isoform X1 [KO:K00036] [EC:1.1.1.49 1.1.1.363]
105794780  glucose-6-phosphate 1-dehydrogenase, chloroplastic [KO:K00036] [EC:1.1.1.49 1.1.1.363]
105780574  glucose-6-phosphate 1-dehydrogenase, cytoplasmic isoform isoform X1 [KO:K00036] [EC:1.1.1.49 1.1.1.363]
105798412  glucose-6-phosphate 1-dehydrogenase, cytoplasmic isoform [KO:K00036] [EC:1.1.1.49 1.1.1.363]
105761136  inactive glucose-6-phosphate 1-dehydrogenase 4, chloroplastic [KO:K00036] [EC:1.1.1.49 1.1.1.363]
105803417  glucose-6-phosphate 1-dehydrogenase, chloroplastic [KO:K00036] [EC:1.1.1.49 1.1.1.363]
105775182  probable phospholipid hydroperoxide glutathione peroxidase isoform X1 [KO:K00432] [EC:1.11.1.9]
105792214  probable phospholipid hydroperoxide glutathione peroxidase [KO:K00432] [EC:1.11.1.9]
105792254  probable glutathione peroxidase 4 [KO:K00432] [EC:1.11.1.9]
105790752  probable glutathione peroxidase 4 [KO:K00432] [EC:1.11.1.9]
105790802  probable glutathione peroxidase 2 [KO:K00432] [EC:1.11.1.9]
105765215  probable phospholipid hydroperoxide glutathione peroxidase isoform X2 [KO:K00432] [EC:1.11.1.9]
105765222  probable glutathione peroxidase 8 [KO:K00432] [EC:1.11.1.9]
105799994  probable glutathione peroxidase 2 [KO:K00432] [EC:1.11.1.9]
105778178  1-Cys peroxiredoxin [KO:K11188] [EC:1.11.1.7 1.11.1.27 3.1.1.-]
105804704  ornithine decarboxylase 1B, chloroplastic [KO:K01581] [EC:4.1.1.17]
105804706  ornithine decarboxylase 1B, chloroplastic [KO:K01581] [EC:4.1.1.17]
105770463  spermidine synthase 2 isoform X1 [KO:K00797] [EC:2.5.1.16]
105791123  spermine synthase isoform X1 [KO:K00797] [EC:2.5.1.16]
105794668  spermidine synthase 1 [KO:K00797] [EC:2.5.1.16]
105765461  spermine synthase [KO:K00797] [EC:2.5.1.16]
105785908  L-ascorbate peroxidase 3 [KO:K00434] [EC:1.11.1.11]
105787462  probable L-ascorbate peroxidase 3 [KO:K00434] [EC:1.11.1.11]
105792368  L-ascorbate peroxidase, cytosolic [KO:K00434] [EC:1.11.1.11]
105792370  L-ascorbate peroxidase, cytosolic [KO:K00434] [EC:1.11.1.11]
105792371  L-ascorbate peroxidase, cytosolic [KO:K00434] [EC:1.11.1.11]
105795404  L-ascorbate peroxidase 3 [KO:K00434] [EC:1.11.1.11]
105772729  probable L-ascorbate peroxidase 6, chloroplastic/mitochondrial [KO:K00434] [EC:1.11.1.11]
105781150  L-ascorbate peroxidase, cytosolic [KO:K00434] [EC:1.11.1.11]
105773990  putative L-ascorbate peroxidase 6 isoform X1 [KO:K00434] [EC:1.11.1.11]
105767858  L-ascorbate peroxidase 2, cytosolic [KO:K00434] [EC:1.11.1.11]
105769825  probable L-ascorbate peroxidase 6, chloroplastic/mitochondrial [KO:K00434] [EC:1.11.1.11]
105769872  L-ascorbate peroxidase, cytosolic [KO:K00434] [EC:1.11.1.11]
105785380  ribonucleoside-diphosphate reductase large subunit [KO:K10807] [EC:1.17.4.1]
105787887  ribonucleoside-diphosphate reductase large subunit [KO:K10807] [EC:1.17.4.1]
105777778  ribonucleoside-diphosphate reductase small chain [KO:K10808] [EC:1.17.4.1]
105796620  ribonucleoside-diphosphate reductase small chain A [KO:K10808] [EC:1.17.4.1]
Compound
C00005  NADPH
C00006  NADP+
C00024  Acetyl-CoA
C00025  L-Glutamate
C00037  Glycine
C00051  Glutathione
C00072  Ascorbate
C00077  L-Ornithine
C00097  L-Cysteine
C00127  Glutathione disulfide
C00134  Putrescine
C00151  L-Amino acid
C00315  Spermidine
C00669  gamma-L-Glutamyl-L-cysteine
C00750  Spermine
C01322  RX
C01419  Cys-Gly
C01672  Cadaverine
C01879  5-Oxoproline
C02090  Trypanothione
C02320  R-S-Glutathione
C03170  Trypanothione disulfide
C03646  Bis-gamma-glutamylcystine
C03740  (5-L-Glutamyl)-L-amino acid
C05422  Dehydroascorbate
C05726  S-Substituted L-cysteine
C05727  S-Substituted N-acetyl-L-cysteine
C05729  R-S-Cysteinylglycine
C05730  Glutathionylspermidine
C16562  Glutathionylspermine
C16563  Bis(glutathionyl)spermine
C16564  Bis(glutathionyl)spermine disulfide
C16565  Aminopropylcadaverine
C16566  Glutathionylaminopropylcadaverine
C16567  Homotrypanothione
C16568  Homotrypanothione disulfide
C16663  Tryparedoxin
C16664  Tryparedoxin disulfide
Reference
  Authors
Josch C, Klotz LO, Sies H.
  Title
Identification of cytosolic leucyl aminopeptidase (EC 3.4.11.1) as the major cysteinylglycine-hydrolysing activity in rat liver.
  Journal
Biol Chem 384:213-8 (2003)
DOI:10.1515/BC.2003.023
Reference
  Authors
Chu L, Lai Y, Xu X, Eddy S, Yang S, Song L, Kolodrubetz D.
  Title
A 52-kDa leucyl aminopeptidase from treponema denticola is a cysteinylglycinase that mediates the second step of glutathione metabolism.
  Journal
J Biol Chem 283:19351-8 (2008)
DOI:10.1074/jbc.M801034200
Reference
  Authors
Cappiello M, Lazzarotti A, Buono F, Scaloni A, D'Ambrosio C, Amodeo P, Mendez BL, Pelosi P, Del Corso A, Mura U.
  Title
New role for leucyl aminopeptidase in glutathione turnover.
  Journal
Biochem J 378:35-44 (2004)
DOI:10.1042/BJ20031336
Reference
  Authors
Suzuki H, Kamatani S, Kim ES, Kumagai H.
  Title
Aminopeptidases A, B, and N and dipeptidase D are the four cysteinylglycinases of Escherichia coli K-12.
  Journal
J Bacteriol 183:1489-90 (2001)
DOI:10.1128/JB.183.4.1489-1490.2001
Reference
  Authors
Oza SL, Shaw MP, Wyllie S, Fairlamb AH.
  Title
Trypanothione biosynthesis in Leishmania major.
  Journal
Mol Biochem Parasitol 139:107-16 (2005)
DOI:10.1016/j.molbiopara.2004.10.004
Reference
  Authors
Oza SL, Ariyanayagam MR, Fairlamb AH.
  Title
Characterization of recombinant glutathionylspermidine synthetase/amidase from Crithidia fasciculata.
  Journal
Biochem J 364:679-86 (2002)
DOI:10.1042/BJ20011370
Reference
PMID:9677355
  Authors
Tetaud E, Manai F, Barrett MP, Nadeau K, Walsh CT, Fairlamb AH.
  Title
Cloning and characterization of the two enzymes responsible for trypanothione biosynthesis in Crithidia fasciculata.
  Journal
J Biol Chem 273:19383-90 (1998)
DOI:10.1074/jbc.273.31.19383
Reference
  Authors
Ariyanayagam MR, Oza SL, Mehlert A, Fairlamb AH.
  Title
Bis(glutathionyl)spermine and other novel trypanothione analogues in Trypanosoma cruzi.
  Journal
J Biol Chem 278:27612-9 (2003)
DOI:10.1074/jbc.M302750200
Reference
  Authors
Oza SL, Ariyanayagam MR, Aitcheson N, Fairlamb AH.
  Title
Properties of trypanothione synthetase from Trypanosoma brucei.
  Journal
Mol Biochem Parasitol 131:25-33 (2003)
DOI:10.1016/S0166-6851(03)00176-2
Reference
  Authors
Oza SL, Tetaud E, Ariyanayagam MR, Warnon SS, Fairlamb AH.
  Title
A single enzyme catalyses formation of Trypanothione from glutathione and spermidine in Trypanosoma cruzi.
  Journal
J Biol Chem 277:35853-61 (2002)
DOI:10.1074/jbc.M204403200
Reference
  Authors
Comini M, Menge U, Wissing J, Flohe L.
  Title
Trypanothione synthesis in crithidia revisited.
  Journal
J Biol Chem 280:6850-60 (2005)
DOI:10.1074/jbc.M404486200
Reference
PMID:7813456
  Authors
Hunter KJ, Le Quesne SA, Fairlamb AH.
  Title
Identification and biosynthesis of N1,N9-bis(glutathionyl)aminopropylcadaverine (homotrypanothione) in Trypanosoma cruzi.
  Journal
Eur J Biochem 226:1019-27 (1994)
DOI:10.1111/j.1432-1033.1994.t01-1-01019.x
Reference
  Authors
Krauth-Siegel RL, Meiering SK, Schmidt H.
  Title
The parasite-specific trypanothione metabolism of trypanosoma and leishmania.
  Journal
Biol Chem 384:539-49 (2003)
DOI:10.1515/BC.2003.062
Reference
  Authors
Krauth-Siegel RL, Comini MA.
  Title
Redox control in trypanosomatids, parasitic protozoa with trypanothione-based thiol metabolism.
  Journal
Biochim Biophys Acta 1780:1236-48 (2008)
DOI:10.1016/j.bbagen.2008.03.006
Reference
PMID:8892297
  Authors
Krauth-Siegel RL, Ludemann H.
  Title
Reduction of dehydroascorbate by trypanothione.
  Journal
Mol Biochem Parasitol 80:203-8 (1996)
DOI:10.1016/0166-6851(96)02689-8
Reference
  Authors
Dormeyer M, Reckenfelderbaumer N, Ludemann H, Krauth-Siegel RL.
  Title
Trypanothione-dependent synthesis of deoxyribonucleotides by Trypanosoma brucei ribonucleotide reductase.
  Journal
J Biol Chem 276:10602-6 (2001)
DOI:10.1074/jbc.M010352200
Reference
  Authors
Schmidt H, Krauth-Siegel RL.
  Title
Functional and physicochemical characterization of the thioredoxin system in Trypanosoma brucei.
  Journal
J Biol Chem 278:46329-36 (2003)
DOI:10.1074/jbc.M305338200
Reference
PMID:9851611
  Authors
Tetaud E, Fairlamb AH.
  Title
Cloning, expression and reconstitution of the trypanothione-dependent peroxidase system of Crithidia fasciculata.
  Journal
Mol Biochem Parasitol 96:111-23 (1998)
DOI:10.1016/S0166-6851(98)00120-0
Reference
  Authors
Castro H, Sousa C, Santos M, Cordeiro-da-Silva A, Flohe L, Tomas AM.
  Title
Complementary antioxidant defense by cytoplasmic and mitochondrial peroxiredoxins in Leishmania infantum.
  Journal
Free Radic Biol Med 33:1552-62 (2002)
DOI:10.1016/S0891-5849(02)01089-4
Reference
  Authors
Wilkinson SR, Temperton NJ, Mondragon A, Kelly JM.
  Title
Distinct mitochondrial and cytosolic enzymes mediate trypanothione-dependent peroxide metabolism in Trypanosoma cruzi.
  Journal
J Biol Chem 275:8220-5 (2000)
DOI:10.1074/jbc.275.11.8220
Reference
  Authors
Konig J, Fairlamb AH.
  Title
A comparative study of type I and type II tryparedoxin peroxidases in Leishmania major.
  Journal
FEBS J 274:5643-58 (2007)
DOI:10.1111/j.1742-4658.2007.06087.x
Reference
  Authors
Hillebrand H, Schmidt A, Krauth-Siegel RL.
  Title
A second class of peroxidases linked to the trypanothione metabolism.
  Journal
J Biol Chem 278:6809-15 (2003)
DOI:10.1074/jbc.M210392200
Reference
  Authors
Soksawatmaekhin W, Kuraishi A, Sakata K, Kashiwagi K, Igarashi K.
  Title
Excretion and uptake of cadaverine by CadB and its physiological functions in Escherichia coli.
  Journal
Mol Microbiol 51:1401-12 (2004)
DOI:10.1046/j.1365-2958.2003.03913.x
Reference
PMID:6798961
  Authors
Pegg AE, Shuttleworth K, Hibasami H.
  Title
Specificity of mammalian spermidine synthase and spermine synthase.
  Journal
Biochem J 197:315-20 (1981)
DOI:10.1042/bj1970315
Related
pathway
gra00220  Arginine biosynthesis
gra00250  Alanine, aspartate and glutamate metabolism
gra00270  Cysteine and methionine metabolism
gra00430  Taurine and hypotaurine metabolism
gra00460  Cyanoamino acid metabolism
KO pathway
ko00480   
LinkDB

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