KEGG   PATHWAY: hai04740
Entry
hai04740                    Pathway                                
Name
Olfactory transduction - Hipposideros armiger (great roundleaf bat)
Description
Within the compact cilia of the olfactory receptor neurons (ORNs) a cascade of enzymatic activity transduces the binding of an odorant molecule to a receptor into an electrical signal that can be transmitted to the brain. Odorant molecules bind to a receptor protein (R) coupled to an olfactory specific Gs-protein (G) and activate a type III adenylyl cyclase (AC), increasing intracellular cAMP levels. cAMP targets an olfactory-specific cyclic-nucleotide gated ion channel (CNG), allowing cations, particularly Na and Ca, to flow down their electrochemical gradients into the cell, depolarizing the ORN. Furthermore, the Ca entering the cell is able to activate a Ca-activated Cl channel, which would allow Cl to flow out of the cell, thus further increasing the depolarization. Elevated intracellular Ca causes adaptation by at least two different molecular steps: inhibition of the activity of adenylyl cyclase via CAMKII-dependent phosphorylation and down-regulation of the affinity of the CNG channel to cAMP.
Class
Organismal Systems; Sensory system
Pathway map
hai04740  Olfactory transduction
hai04740

Other DBs
GO: 0007608
Organism
Hipposideros armiger (great roundleaf bat) [GN:hai]
Gene
109382391  olfactory receptor 1N1-like [KO:K04257]
109379759  olfactory receptor 4D1 [KO:K04257]
109382409  olfactory receptor 10H1 [KO:K04257]
109382392  olfactory receptor 2Z1-like [KO:K04257]
109379044  olfactory receptor 1F12-like [KO:K04257]
109379302  olfactory receptor 2K2 [KO:K04257]
109378517  olfactory receptor 1J4-like [KO:K04257]
109378518  olfactory receptor 1J1-like [KO:K04257]
109378520  olfactory receptor 1J2 [KO:K04257]
109378560  olfactory receptor 1020-like [KO:K04257]
109378561  olfactory receptor 5L1-like [KO:K04257]
109378597  olfactory receptor 18-like [KO:K04257]
109378616  olfactory receptor 1J4-like [KO:K04257]
109371568  olfactory receptor 11A1-like [KO:K04257]
109371598  LOW QUALITY PROTEIN: olfactory receptor-like protein COR8 [KO:K04257]
109371602  putative olfactory receptor 5AK3 [KO:K04257]
109371603  putative olfactory receptor 5AK3 [KO:K04257]
109371606  olfactory receptor 1013-like [KO:K04257]
109371607  olfactory receptor 9G4 [KO:K04257]
109371608  olfactory receptor 1013-like [KO:K04257]
109371609  olfactory receptor 10A7-like [KO:K04257]
109371610  olfactory receptor 1030 [KO:K04257]
109371611  olfactory receptor 1030-like [KO:K04257]
109371612  olfactory receptor 5M9 [KO:K04257]
109371613  olfactory receptor 5AL1-like [KO:K04257]
109371614  olfactory receptor 8U9-like [KO:K04257]
109371615  olfactory receptor 8J1-like [KO:K04257]
109371616  olfactory receptor 5J2 [KO:K04257]
109371617  olfactory receptor 8K3-like [KO:K04257]
109371621  olfactory receptor 8K1 [KO:K04257]
109371622  olfactory receptor 9Q2 [KO:K04257]
109371623  olfactory receptor 9Q1-like [KO:K04257]
109371624  olfactory receptor 9I1-like [KO:K04257]
109371625  olfactory receptor 1038 [KO:K04257]
109371626  olfactory receptor 5M8 [KO:K04257]
109374258  olfactory receptor 10G2-like [KO:K04257]
109374275  olfactory receptor 10G2 [KO:K04257]
109374276  olfactory receptor 4E2 [KO:K04257]
109374277  olfactory receptor 10G2-like [KO:K04257]
109374278  olfactory receptor 10G3 [KO:K04257]
109374280  olfactory receptor 4E1 [KO:K04257]
109374281  olfactory receptor 5AU1 [KO:K04257]
109374330  olfactory receptor 5 [KO:K04257]
109377107  olfactory receptor 10T2-like [KO:K04257]
109378639  olfactory receptor 11H4-like [KO:K04257]
109378646  olfactory receptor 51Q1-like [KO:K04257]
109378653  olfactory receptor 7A10-like [KO:K04257]
109378661  LOW QUALITY PROTEIN: olfactory receptor 11H6-like [KO:K04257]
109378662  olfactory receptor 11H7-like [KO:K04257]
109378663  olfactory receptor 11H4 [KO:K04257]
109378668  olfactory receptor 4N5-like [KO:K04257]
109378674  olfactory receptor 5K1 [KO:K04257]
109378676  olfactory receptor 4K2 [KO:K04257]
109378678  olfactory receptor 8A1-like [KO:K04257]
109378693  olfactory receptor 7A10-like [KO:K04257]
109386867  olfactory receptor 1D2 [KO:K04257]
109386869  olfactory receptor 1A1-like [KO:K04257]
109371627  olfactory receptor 8K5-like [KO:K04257]
109371629  olfactory receptor 8K3-like [KO:K04257]
109371630  olfactory receptor 5M11 [KO:K04257]
109371631  olfactory receptor 5M10 [KO:K04257]
109371632  olfactory receptor 1030-like isoform X1 [KO:K04257]
109371633  olfactory receptor 8U9 [KO:K04257]
109371634  olfactory receptor 5AP2 [KO:K04257]
109371635  olfactory receptor 5AL1-like [KO:K04257]
109371637  olfactory receptor 1019 [KO:K04257]
109371640  olfactory receptor 6Q1 [KO:K04257]
109371642  olfactory receptor 1009-like [KO:K04257]
109374332  olfactory receptor 13H1-like [KO:K04257]
109378721  olfactory receptor 7A5-like [KO:K04257]
109378726  olfactory receptor 1J4-like [KO:K04257]
109378727  olfactory receptor 1J2-like [KO:K04257]
109378728  olfactory receptor 1J1-like [KO:K04257]
109378774  olfactory receptor 5W2-like [KO:K04257]
109393620  olfactory receptor 49-like [KO:K04257]
109374474  olfactory receptor 2A5-like [KO:K04257]
109374475  olfactory receptor 2A2-like [KO:K04257]
109374476  olfactory receptor-like protein OLF3 [KO:K04257]
109374477  olfactory receptor-like protein OLF3 [KO:K04257]
109374482  olfactory receptor 10AC1-like [KO:K04257]
109374483  olfactory receptor-like protein OLF3 [KO:K04257]
109374484  olfactory receptor 6B1 [KO:K04257]
109374485  olfactory receptor 2A5 [KO:K04257]
109374486  olfactory receptor 2A14-like [KO:K04257]
109374487  olfactory receptor 2A25-like [KO:K04257]
109377306  olfactory receptor 2T6-like [KO:K04257]
109377307  LOW QUALITY PROTEIN: olfactory receptor 2AJ1-like [KO:K04257]
109377308  LOW QUALITY PROTEIN: olfactory receptor 2T33-like [KO:K04257]
109377311  olfactory receptor 11L1 [KO:K04257]
109377312  olfactory receptor 2W3-like [KO:K04257]
109378832  olfactory receptor 1J4-like [KO:K04257]
109378847  olfactory receptor 8B12-like [KO:K04257]
109378867  olfactory receptor 8B12-like [KO:K04257]
109393206  LOW QUALITY PROTEIN: olfactory receptor 8S1 [KO:K04257]
109371268  olfactory receptor 13F1-like [KO:K04257]
109371270  olfactory receptor 13D1-like [KO:K04257]
109371271  LOW QUALITY PROTEIN: olfactory receptor 13C4-like [KO:K04257]
109371274  olfactory receptor 13C8-like [KO:K04257]
109371275  olfactory receptor 13C2 [KO:K04257]
109373945  olfactory receptor 5AC1 [KO:K04257]
109373949  olfactory receptor 5H2-like [KO:K04257]
109373951  olfactory receptor 5AC1-like [KO:K04257]
109383376  putative olfactory receptor 2B3 [KO:K04257]
109383380  olfactory receptor 2G3-like [KO:K04257]
109394237  olfactory receptor 7A17-like [KO:K04257]
109394238  olfactory receptor 7A17-like [KO:K04257]
109394248  olfactory receptor 7A10-like [KO:K04257]
109396836  olfactory receptor 6C2 [KO:K04257]
109396837  olfactory receptor 6C2-like [KO:K04257]
109396841  olfactory receptor 6C2-like [KO:K04257]
109396842  LOW QUALITY PROTEIN: olfactory receptor 9 [KO:K04257]
109396850  olfactory receptor 6C2-like [KO:K04257]
109396851  olfactory receptor 6C2-like [KO:K04257]
109396852  olfactory receptor 6C68-like [KO:K04257]
109396853  olfactory receptor 6C2-like [KO:K04257]
109396854  olfactory receptor 6C2-like [KO:K04257]
109396855  olfactory receptor 2AP1 [KO:K04257]
109396856  olfactory receptor 6C2-like [KO:K04257]
109396858  olfactory receptor 6C4-like [KO:K04257]
109396859  olfactory receptor 6C2-like [KO:K04257]
109396860  olfactory receptor 6C2-like [KO:K04257]
109396861  olfactory receptor 6C70-like [KO:K04257]
109396862  olfactory receptor 6C2-like [KO:K04257]
109373695  olfactory receptor 1052-like [KO:K04257]
109378155  olfactory receptor 18-like [KO:K04257]
109378181  olfactory receptor 1571-like [KO:K04257]
109378182  olfactory receptor 7A17-like [KO:K04257]
109378185  olfactory receptor 7A17-like [KO:K04257]
109378187  olfactory receptor 7A10-like [KO:K04257]
109378192  olfactory receptor 56 [KO:K04257]
109378216  olfactory receptor 56-like [KO:K04257]
109378217  olfactory receptor 2V2-like [KO:K04257]
109378221  olfactory receptor 14J1 [KO:K04257]
109378273  olfactory receptor-like protein DTMT [KO:K04257]
109378274  olfactory receptor-like protein DTMT [KO:K04257]
109378275  olfactory receptor 139 [KO:K04257]
109390008  olfactory receptor 4D6 [KO:K04257]
109390009  olfactory receptor 4D10 [KO:K04257]
109390010  olfactory receptor 5B3-like [KO:K04257]
109390011  olfactory receptor 5B2-like [KO:K04257]
109390012  olfactory receptor 5B2-like [KO:K04257]
109390013  olfactory receptor 5A1 [KO:K04257]
109390017  olfactory receptor 10W1 [KO:K04257]
109390018  olfactory receptor 10V1 [KO:K04257]
109391336  olfactory receptor 5C1 [KO:K04257]
109376443  olfactory receptor 6S1 [KO:K04257]
109376472  olfactory receptor 18-like [KO:K04257]
109376476  LOW QUALITY PROTEIN: olfactory receptor 7G2-like [KO:K04257]
109376477  LOW QUALITY PROTEIN: olfactory receptor 7G2-like [KO:K04257]
109376483  olfactory receptor 7D4-like [KO:K04257]
109376484  LOW QUALITY PROTEIN: olfactory receptor 7D4-like [KO:K04257]
109376485  olfactory receptor 7D2 [KO:K04257]
109376486  olfactory receptor 7G3-like [KO:K04257]
109377849  olfactory receptor 4S2-like [KO:K04257]
109377851  olfactory receptor 4L1-like [KO:K04257]
109377853  olfactory receptor 4N5 [KO:K04257]
109377854  olfactory receptor 4M1 [KO:K04257]
109377856  olfactory receptor 4Q3 [KO:K04257]
109377900  LOW QUALITY PROTEIN: olfactory receptor 2H2 [KO:K04257]
109377943  olfactory receptor 7A17-like [KO:K04257]
109377944  olfactory receptor-like protein OLF4 [KO:K04257]
109377952  LOW QUALITY PROTEIN: olfactory receptor 51A7-like [KO:K04257]
109377955  olfactory receptor 51H1-like [KO:K04257]
109377957  olfactory receptor 51A7 [KO:K04257]
109377958  olfactory receptor 51A4 [KO:K04257]
109377959  olfactory receptor 51G1 [KO:K04257]
109377960  olfactory receptor 51A7-like [KO:K04257]
109373431  olfactory receptor 4F6-like [KO:K04257]
109373433  olfactory receptor 4F3/4F16/4F29-like [KO:K04257]
109373434  olfactory receptor 4F15-like [KO:K04257]
109389753  olfactory receptor 1361-like [KO:K04257]
109393749  olfactory receptor 13C7-like [KO:K04257]
109393750  olfactory receptor 13C7 [KO:K04257]
109377611  olfactory receptor 10AG1-like [KO:K04257]
109377612  olfactory receptor 10AG1-like [KO:K04257]
109377613  olfactory receptor 10AG1-like [KO:K04257]
109377614  olfactory receptor 5AS1 [KO:K04257]
109377615  olfactory receptor 1052-like [KO:K04257]
109377616  olfactory receptor 5F1-like [KO:K04257]
109377617  olfactory receptor 5T2-like [KO:K04257]
109377618  olfactory receptor 10AG1-like [KO:K04257]
109377619  olfactory receptor 10AG1-like [KO:K04257]
109377620  olfactory receptor 10AG1-like [KO:K04257]
109377621  olfactory receptor 10AG1-like [KO:K04257]
109377622  olfactory receptor 10AG1-like [KO:K04257]
109377623  olfactory receptor 10AG1-like [KO:K04257]
109377625  olfactory receptor 5W2-like [KO:K04257]
109377626  olfactory receptor 5F1-like [KO:K04257]
109373200  LOW QUALITY PROTEIN: olfactory receptor 8B3-like [KO:K04257]
109373204  olfactory receptor 145 [KO:K04257]
109373205  olfactory receptor 8B4 [KO:K04257]
109373206  olfactory receptor 8B3 [KO:K04257]
109373207  olfactory receptor 8B12-like [KO:K04257]
109374564  olfactory receptor 10A3 [KO:K04257]
109377364  olfactory receptor 52M1-like [KO:K04257]
109377365  olfactory receptor 51F2-like [KO:K04257]
109377368  olfactory receptor 51F2-like [KO:K04257]
109377369  olfactory receptor 51E1 [KO:K04257]
109377370  olfactory receptor 51E2 [KO:K04257]
109377371  olfactory receptor 51D1 [KO:K04257]
109377372  olfactory receptor 52K1-like [KO:K04257]
109377373  olfactory receptor 51I2-like [KO:K04257]
109377374  olfactory receptor 52M1 [KO:K04257]
109377375  olfactory receptor 52K1 [KO:K04257]
109377378  olfactory receptor 52I2 [KO:K04257]
109377400  LOW QUALITY PROTEIN: olfactory receptor 2B11 [KO:K04257]
109386310  olfactory receptor 2AT4 [KO:K04257]
109374046  olfactory receptor 8B3-like [KO:K04257]
109374050  olfactory receptor 149-like [KO:K04257]
109374051  olfactory receptor 10G6 [KO:K04257]
109374053  olfactory receptor 6M1 [KO:K04257]
109374054  LOW QUALITY PROTEIN: olfactory receptor 6X1 [KO:K04257]
109374055  olfactory receptor 6T1 [KO:K04257]
109374057  olfactory receptor 8G1-like [KO:K04257]
109374058  olfactory receptor 149-like [KO:K04257]
109374060  LOW QUALITY PROTEIN: olfactory receptor 10S1 [KO:K04257]
109378276  olfactory receptor 3A1-like [KO:K04257]
109378279  olfactory receptor 3A1 [KO:K04257]
109378285  olfactory receptor-like protein OLF2 [KO:K04257]
109378286  olfactory receptor 5AS1-like [KO:K04257]
109378287  LOW QUALITY PROTEIN: olfactory receptor 5W2-like [KO:K04257]
109378288  LOW QUALITY PROTEIN: olfactory receptor 5AS1-like [KO:K04257]
109378290  olfactory receptor 5W2-like [KO:K04257]
109378292  LOW QUALITY PROTEIN: olfactory receptor 1L6-like [KO:K04257]
109378294  olfactory receptor 1361-like [KO:K04257]
109378295  olfactory receptor 1361-like [KO:K04257]
109378296  olfactory receptor 1L3 [KO:K04257]
109378297  olfactory receptor 1L6 [KO:K04257]
109378298  olfactory receptor 1361-like [KO:K04257]
109378317  olfactory receptor 8K3-like [KO:K04257]
109378318  LOW QUALITY PROTEIN: olfactory receptor 8K3-like [KO:K04257]
109378320  olfactory receptor 8K3-like [KO:K04257]
109372406  olfactory receptor 52B4-like [KO:K04257]
109372409  putative olfactory receptor 52P1 [KO:K04257]
109372413  olfactory receptor 52B4-like [KO:K04257]
109372414  olfactory receptor 52B4-like [KO:K04257]
109372417  olfactory receptor 52K1-like [KO:K04257]
109372425  olfactory receptor 51G2-like [KO:K04257]
109378321  olfactory receptor 5T1 [KO:K04257]
109378322  olfactory receptor 8K3-like [KO:K04257]
109378391  olfactory receptor 4C11-like [KO:K04257]
109378392  olfactory receptor 4C11-like [KO:K04257]
109378394  olfactory receptor 4C15 [KO:K04257]
109377961  olfactory receptor 51G2 [KO:K04257]
109377962  olfactory receptor 51S1 [KO:K04257]
109377963  olfactory receptor 51A7-like [KO:K04257]
109377964  olfactory receptor 51F2 [KO:K04257]
109377965  olfactory receptor 51T1 [KO:K04257]
109377966  olfactory receptor 51H1-like [KO:K04257]
109377979  olfactory receptor 8B12-like [KO:K04257]
109377981  olfactory receptor 8A1 [KO:K04257]
109377984  olfactory receptor 7A17-like [KO:K04257]
109377985  olfactory receptor 7A17-like [KO:K04257]
109377986  olfactory receptor 7A10-like [KO:K04257]
109377987  olfactory receptor 7A10-like [KO:K04257]
109377990  olfactory receptor 7A17-like [KO:K04257]
109377991  olfactory receptor 2Z1 [KO:K04257]
109378013  olfactory receptor 5L1-like [KO:K04257]
109378015  olfactory receptor 5D13-like [KO:K04257]
109378016  olfactory receptor 5D13-like [KO:K04257]
109378017  olfactory receptor 4P4 [KO:K04257]
109378018  olfactory receptor 4S2 [KO:K04257]
109378020  olfactory receptor 4C16 [KO:K04257]
109378021  olfactory receptor 5D14 [KO:K04257]
109393776  olfactory receptor 13C7-like [KO:K04257]
109393777  olfactory receptor 13J1-like [KO:K04257]
109376064  olfactory receptor 10T2-like [KO:K04257]
109376066  olfactory receptor 7A17-like [KO:K04257]
109376070  olfactory receptor 7C2-like [KO:K04257]
109378407  olfactory receptor 1020-like [KO:K04257]
109372527  LOW QUALITY PROTEIN: olfactory receptor 10AD1 [KO:K04257]
109388869  olfactory receptor 13H1 [KO:K04257]
109390180  olfactory receptor 4C5-like [KO:K04257]
109390182  LOW QUALITY PROTEIN: olfactory receptor 4C12-like [KO:K04257]
109390184  olfactory receptor 4C12-like [KO:K04257]
109390185  olfactory receptor 4A47-like [KO:K04257]
109390186  olfactory receptor 4C13-like [KO:K04257]
109390188  olfactory receptor 4A5-like [KO:K04257]
109390191  olfactory receptor 4A15-like [KO:K04257]
109390192  olfactory receptor 4C3 [KO:K04257]
109390193  olfactory receptor 4C45-like [KO:K04257]
109390194  olfactory receptor 4A15-like [KO:K04257]
109390195  olfactory receptor 4A15-like [KO:K04257]
109390197  olfactory receptor 4A15-like [KO:K04257]
109390198  olfactory receptor 4A15-like [KO:K04257]
109378094  olfactory receptor 2D3-like [KO:K04257]
109383353  olfactory receptor 2A12-like [KO:K04257]
109389989  LOW QUALITY PROTEIN: olfactory receptor 1440-like [KO:K04257]
109389996  olfactory receptor 1444 [KO:K04257]
109389997  olfactory receptor 5B3-like [KO:K04257]
109389998  olfactory receptor 5B17-like [KO:K04257]
109390000  olfactory receptor 5B12-like [KO:K04257]
109390001  olfactory receptor 9I1-like [KO:K04257]
109374969  olfactory receptor 1L8-like [KO:K04257]
109376333  olfactory receptor 10A4 [KO:K04257]
109376334  olfactory receptor 10A5 [KO:K04257]
109376335  olfactory receptor 226 [KO:K04257]
109376372  olfactory receptor 6V1 [KO:K04257]
109376376  olfactory receptor-like protein OLF3 [KO:K04257]
109376383  olfactory receptor 9A4 [KO:K04257]
109396481  olfactory receptor 52K1-like [KO:K04257]
109396482  LOW QUALITY PROTEIN: olfactory receptor 52L1-like [KO:K04257]
109396483  olfactory receptor 56A1 [KO:K04257]
109396484  olfactory receptor 56A3 [KO:K04257]
109396485  LOW QUALITY PROTEIN: olfactory receptor 56A3-like [KO:K04257]
109396486  LOW QUALITY PROTEIN: olfactory receptor 52E5-like [KO:K04257]
109396487  LOW QUALITY PROTEIN: olfactory receptor 52E8-like [KO:K04257]
109396488  olfactory receptor 52E8 [KO:K04257]
109396489  olfactory receptor 52E8-like [KO:K04257]
109396490  olfactory receptor 51H1-like [KO:K04257]
109396491  olfactory receptor 51H1-like [KO:K04257]
109396493  putative olfactory receptor 52P1 [KO:K04257]
109396496  olfactory receptor 52B2-like [KO:K04257]
109396497  olfactory receptor 52H1-like [KO:K04257]
109396502  olfactory receptor 51V1 [KO:K04257]
109396503  olfactory receptor 52A5-like [KO:K04257]
109396504  olfactory receptor 51V1-like [KO:K04257]
109396505  olfactory receptor 51V1-like [KO:K04257]
109396506  olfactory receptor 51G2-like [KO:K04257]
109396507  olfactory receptor 51G2-like [KO:K04257]
109396508  olfactory receptor 51G2-like [KO:K04257]
109396509  olfactory receptor 52Z1-like [KO:K04257]
109396510  olfactory receptor 52D1-like [KO:K04257]
109396511  olfactory receptor 52A1-like [KO:K04257]
109396512  olfactory receptor 52A1-like [KO:K04257]
109396513  olfactory receptor 52K2-like [KO:K04257]
109396514  LOW QUALITY PROTEIN: olfactory receptor 52E8-like [KO:K04257]
109396515  olfactory receptor 52E5 [KO:K04257]
109396516  olfactory receptor 52B2 [KO:K04257]
109396517  olfactory receptor 52B2-like [KO:K04257]
109396518  olfactory receptor 51I2-like [KO:K04257]
109396519  olfactory receptor 51I2 [KO:K04257]
109396520  olfactory receptor 52E2-like [KO:K04257]
109396521  olfactory receptor 52B6 [KO:K04257]
109396522  olfactory receptor 52E2-like [KO:K04257]
109396523  olfactory receptor 52J3 [KO:K04257]
109396524  olfactory receptor 52H1 [KO:K04257]
109396525  olfactory receptor 52J3-like [KO:K04257]
109396528  olfactory receptor 52D1 [KO:K04257]
109396529  olfactory receptor 52N4 [KO:K04257]
109396530  olfactory receptor 51B6-like [KO:K04257]
109396531  olfactory receptor 52N2 [KO:K04257]
109396532  olfactory receptor 51I1 [KO:K04257]
109396533  olfactory receptor 51B2-like [KO:K04257]
109396534  olfactory receptor 51B5-like [KO:K04257]
109396535  olfactory receptor 51B4 [KO:K04257]
109396536  olfactory receptor 52N2-like [KO:K04257]
109396538  olfactory receptor 52A1 [KO:K04257]
109396539  olfactory receptor 52Z1-like [KO:K04257]
109396540  olfactory receptor 51I2-like [KO:K04257]
109396542  olfactory receptor 52A5-like [KO:K04257]
109396543  olfactory receptor 51I1-like [KO:K04257]
109396544  olfactory receptor 52D1-like [KO:K04257]
109396545  olfactory receptor 51Q1-like [KO:K04257]
109396546  olfactory receptor 51L1 [KO:K04257]
109396547  olfactory receptor 52M1-like [KO:K04257]
109396548  olfactory receptor 51G2-like [KO:K04257]
109396549  olfactory receptor 52W1 [KO:K04257]
109396550  putative olfactory receptor 52P1 [KO:K04257]
109396551  olfactory receptor 51J1-like [KO:K04257]
109377562  LOW QUALITY PROTEIN: olfactory receptor 10J4-like [KO:K04257]
109377565  LOW QUALITY PROTEIN: olfactory receptor 10J1-like [KO:K04257]
109391795  LOW QUALITY PROTEIN: olfactory receptor 10A7-like [KO:K04257]
109391796  olfactory receptor 6C6-like [KO:K04257]
109391798  olfactory receptor 6C2-like [KO:K04257]
109391806  olfactory receptor 6C6 [KO:K04257]
109391807  olfactory receptor 6C6-like [KO:K04257]
109391808  olfactory receptor 6C3-like [KO:K04257]
109391809  olfactory receptor 6C74-like [KO:K04257]
109391810  olfactory receptor 6C6-like [KO:K04257]
109391811  LOW QUALITY PROTEIN: olfactory receptor 6C3-like [KO:K04257]
109391812  olfactory receptor 6C4-like [KO:K04257]
109391814  olfactory receptor 6C75 [KO:K04257]
109391821  LOW QUALITY PROTEIN: olfactory receptor 10C1-like [KO:K04257]
109391823  olfactory receptor 12 [KO:K04257]
109373565  GNAL; guanine nucleotide-binding protein G(olf) subunit alpha isoform X1 [KO:K04633]
109391171  GNB1; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 [KO:K04536]
109390646  GNG7; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7 [KO:K04543]
109385811  GNG13; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-13 [KO:K04547]
109385186  ADCY3; adenylate cyclase type 3 isoform X1 [KO:K08043] [EC:4.6.1.1]
109376309  CNGA2; cyclic nucleotide-gated olfactory channel [KO:K04949]
109396480  CNGA4; cyclic nucleotide-gated cation channel alpha-4 isoform X1 [KO:K04951]
109394416  CNGB1; cyclic nucleotide-gated cation channel beta-1 [KO:K04952]
109373316  ANO2; anoctamin-2 [KO:K19497]
109395113  GUCY2D; retinal guanylyl cyclase 1 [KO:K12321] [EC:4.6.1.2]
109396935  CNGA3; cyclic nucleotide-gated cation channel alpha-3 [KO:K04950]
109382803  NCALD; neurocalcin-delta [KO:K19695]
109387521  PRKG1; cGMP-dependent protein kinase 1 [KO:K07376] [EC:2.7.11.12]
109387927  PRKG2; cGMP-dependent protein kinase 2 isoform X1 [KO:K19477] [EC:2.7.11.12]
109382076  SLC8A3; sodium/calcium exchanger 3 isoform X1 [KO:K05849]
109385540  SLC8A1; sodium/calcium exchanger 1 isoform X1 [KO:K05849]
109372224  SLC8A2; sodium/calcium exchanger 2 isoform X1 [KO:K05849]
109376794  SLC24A4; sodium/potassium/calcium exchanger 4 isoform X1 [KO:K13752]
109384296  GRK2; beta-adrenergic receptor kinase 1 [KO:K00910] [EC:2.7.11.15]
109394134  GRK3; beta-adrenergic receptor kinase 2 [KO:K00910] [EC:2.7.11.15]
109394691  ARRB2; beta-arrestin-2 isoform X1 [KO:K04439]
109386336  ARRB1; beta-arrestin-1 isoform X1 [KO:K04439]
109380430  RGS2; regulator of G-protein signaling 2 [KO:K18154]
109385440  PRKACB; cAMP-dependent protein kinase catalytic subunit beta isoform X1 [KO:K04345] [EC:2.7.11.11]
109394225  PRKACA; cAMP-dependent protein kinase catalytic subunit alpha isoform X1 [KO:K04345] [EC:2.7.11.11]
109372542  CAMK2G; calcium/calmodulin-dependent protein kinase type II subunit gamma isoform X1 [KO:K04515] [EC:2.7.11.17]
109373019  CAMK2B; calcium/calmodulin-dependent protein kinase type II subunit beta isoform X1 [KO:K04515] [EC:2.7.11.17]
109375001  CAMK2A; calcium/calmodulin-dependent protein kinase type II subunit alpha isoform X1 [KO:K04515] [EC:2.7.11.17]
109390284  CAMK2D; calcium/calmodulin-dependent protein kinase type II subunit delta isoform X1 [KO:K04515] [EC:2.7.11.17]
109382670  CALM1; calmodulin [KO:K02183]
109380340  calmodulin-like [KO:K02183]
109391149  CALML6; calmodulin-like protein 6 [KO:K02183]
109383794  calmodulin-like protein 3 [KO:K02183]
109383796  calmodulin-like [KO:K02183]
109372230  CALM3; calmodulin [KO:K02183]
109389917  CALM2; calmodulin [KO:K02183]
109374306  PDE1C; calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C [KO:K13755] [EC:3.1.4.17]
109392611  PDE1A; calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A isoform X1 [KO:K13755] [EC:3.1.4.17]
109391854  PDE1B; calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B isoform X1 [KO:K13755] [EC:3.1.4.17]
109386300  PDE2A; cGMP-dependent 3',5'-cyclic phosphodiesterase [KO:K18283] [EC:3.1.4.17]
Compound
C00020  AMP
C00076  Calcium cation
C00144  GMP
C00238  Potassium cation
C00575  3',5'-Cyclic AMP
C00698  Cl-
C00942  3',5'-Cyclic GMP
C01330  Sodium cation
Reference
PMID:20145624
  Authors
Kaupp UB
  Title
Olfactory signalling in vertebrates and insects: differences and commonalities.
  Journal
Nat Rev Neurosci 11:188-200 (2010)
DOI:10.1038/nrn2789
Reference
PMID:24733839
  Authors
Peterlin Z, Firestein S, Rogers ME
  Title
The state of the art of odorant receptor deorphanization: a report from the orphanage.
  Journal
J Gen Physiol 143:527-42 (2014)
DOI:10.1085/jgp.201311151
Reference
PMID:19652915
  Authors
Kato A, Touhara K
  Title
Mammalian olfactory receptors: pharmacology, G protein coupling and desensitization.
  Journal
Cell Mol Life Sci 66:3743-53 (2009)
DOI:10.1007/s00018-009-0111-6
Reference
PMID:11557990
  Authors
Firestein S.
  Title
How the olfactory system makes sense of scents.
  Journal
Nature 413:211-8 (2001)
DOI:10.1038/35093026
Reference
PMID:16269360
  Authors
Ache BW, Young JM.
  Title
Olfaction: diverse species, conserved principles.
  Journal
Neuron 48:417-30 (2005)
DOI:10.1016/j.neuron.2005.10.022
Reference
PMID:10944513
  Authors
Zufall F, Leinders-Zufall T.
  Title
The cellular and molecular basis of odor adaptation.
  Journal
Chem Senses 25:473-81 (2000)
DOI:10.1093/chemse/25.4.473
Reference
PMID:22875451
  Authors
Lodovichi C, Belluscio L
  Title
Odorant receptors in the formation of the olfactory bulb circuitry.
  Journal
Physiology (Bethesda) 27:200-12 (2012)
DOI:10.1152/physiol.00015.2012
Reference
PMID:12488531
  Authors
Kohout TA, Lefkowitz RJ.
  Title
Regulation of G protein-coupled receptor kinases and arrestins during receptor desensitization.
  Journal
Mol Pharmacol 63:9-18 (2003)
DOI:10.1124/mol.63.1.9
Reference
PMID:22735517
  Authors
De Palo G, Boccaccio A, Miri A, Menini A, Altafini C
  Title
A dynamical feedback model for adaptation in the olfactory transduction pathway.
  Journal
Biophys J 102:2677-86 (2012)
DOI:10.1016/j.bpj.2012.04.040
Reference
PMID:19941039
  Authors
Zufall F, Munger SD
  Title
Receptor guanylyl cyclases in mammalian olfactory function.
  Journal
Mol Cell Biochem 334:191-7 (2010)
DOI:10.1007/s11010-009-0325-9
Reference
PMID:19306880
  Authors
Duda T, Sharma RK
  Title
Ca2+-modulated ONE-GC odorant signal transduction.
  Journal
FEBS Lett 583:1327-30 (2009)
DOI:10.1016/j.febslet.2009.03.036
Related
pathway
hai00230  Purine metabolism
hai04024  cAMP signaling pathway
KO pathway
ko04740   
LinkDB

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