KEGG   PATHWAY: hai04024
Entry
hai04024                    Pathway                                
Name
cAMP signaling pathway - Hipposideros armiger (great roundleaf bat)
Description
cAMP is one of the most common and universal second messengers, and its formation is promoted by adenylyl cyclase (AC) activation after ligation of G protein-coupled receptors (GPCRs) by ligands including hormones, neurotransmitters, and other signaling molecules. cAMP regulates pivotal physiologic processes including metabolism, secretion, calcium homeostasis, muscle contraction, cell fate, and gene transcription. cAMP acts directly on three main targets: protein kinase A (PKA), the exchange protein activated by cAMP (Epac), and cyclic nucleotide-gated ion channels (CNGCs). PKA modulates, via phosphorylation, a number of cellular substrates, including transcription factors, ion channels, transporters, exchangers, intracellular Ca2+ -handling proteins, and the contractile machinery. Epac proteins function as guanine nucleotide exchange factors (GEFs) for both Rap1 and Rap2. Various effector proteins, including adaptor proteins implicated in modulation of the actin cytoskeleton, regulators of G proteins of the Rho family, and phospholipases, relay signaling downstream from Rap.
Class
Environmental Information Processing; Signal transduction
Pathway map
hai04024  cAMP signaling pathway
hai04024

Other DBs
GO: 0019933
Organism
Hipposideros armiger (great roundleaf bat) [GN:hai]
Gene
109371251  JUN; transcription factor AP-1 [KO:K04448]
109371257  [KO:K04448]
109371666  PLD1; phospholipase D1 [KO:K01115] [EC:3.1.4.4]
109371669  GHSR; growth hormone secretagogue receptor type 1 [KO:K04284]
109371710  HTR1F; 5-hydroxytryptamine receptor 1F [KO:K04153]
109371718  HTR1B; 5-hydroxytryptamine receptor 1B [KO:K04153]
109371751  ADRB2; beta-2 adrenergic receptor [KO:K04142]
109371860  CNGA1; cGMP-gated cation channel alpha-1 [KO:K04948]
109372041  [KO:K04328]
109372060  FXYD1; phospholemman [KO:K13360]
109372230  CALM3; calmodulin [KO:K02183]
109372359  ADCY8; adenylate cyclase type 8 [KO:K08048] [EC:4.6.1.1]
109372517  [KO:K08014]
109372541  NFKB1; nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580]
109372542  CAMK2G; calcium/calmodulin-dependent protein kinase type II subunit gamma isoform X1 [KO:K04515] [EC:2.7.11.17]
109372681  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
109372914  ACOX3; peroxisomal acyl-coenzyme A oxidase 3 [KO:K00232] [EC:1.3.3.6]
109372942  GRIA2; glutamate receptor 2 isoform X1 [KO:K05198]
109373011  ADCY1; adenylate cyclase type 1 [KO:K08041] [EC:4.6.1.1]
109373019  CAMK2B; calcium/calmodulin-dependent protein kinase type II subunit beta isoform X1 [KO:K04515] [EC:2.7.11.17]
109373346  GLI3; transcriptional activator GLI3 [KO:K06230]
109373404  ADCYAP1; pituitary adenylate cyclase-activating polypeptide [KO:K05262]
109373471  CREB3L4; cyclic AMP-responsive element-binding protein 3-like protein 4 isoform X1 [KO:K09048]
109373524  NPR1; atrial natriuretic peptide receptor 1 isoform X1 [KO:K12323] [EC:4.6.1.2]
109373546  RAP1A; ras-related protein Rap-1A isoform X1 [KO:K04353]
109373796  TNNI3; troponin I, cardiac muscle isoform X1 [KO:K12044]
109373811  PIK3R3; phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1 [KO:K02649]
109373922  PDE10A; cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A isoform X1 [KO:K18438] [EC:3.1.4.17 3.1.4.35]
109373962  [KO:K04962]
109374297  [KO:K05730]
109374451  LIPE; hormone-sensitive lipase isoform X1 [KO:K07188] [EC:3.1.1.79]
109374464  ATP1A3; sodium/potassium-transporting ATPase subunit alpha-3 isoform X1 [KO:K01539] [EC:7.2.2.13]
109374595  PLN; cardiac phospholamban [KO:K05852]
109374806  CACNA1F; voltage-dependent L-type calcium channel subunit alpha-1F isoform X1 [KO:K04853]
109374859  AKT2; RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
109375001  CAMK2A; calcium/calmodulin-dependent protein kinase type II subunit alpha isoform X1 [KO:K04515] [EC:2.7.11.17]
109375211  PPP1R12A; protein phosphatase 1 regulatory subunit 12A isoform X1 [KO:K06270]
109375288  GNAI3; guanine nucleotide-binding protein G(k) subunit alpha [KO:K04630]
109375338  BVES; blood vessel epicardial substance isoform X1 [KO:K21108]
109375342  POPDC3; popeye domain-containing protein 3 [KO:K26207]
109375381  [KO:K05730]
109375416  EDN1; endothelin-1 [KO:K16366]
109375847  GLP1R; glucagon-like peptide 1 receptor [KO:K04581]
109375885  HTR1D; 5-hydroxytryptamine receptor 1D [KO:K04153]
109375910  GPHB5; glycoprotein hormone beta-5 [KO:K25484]
109375976  ADCY2; adenylate cyclase type 2 [KO:K08042] [EC:4.6.1.1]
109376015  PAK1; serine/threonine-protein kinase PAK 1 [KO:K04409] [EC:2.7.11.1]
109376114  RHOA; transforming protein RhoA isoform X1 [KO:K04513]
109376309  CNGA2; cyclic nucleotide-gated olfactory channel [KO:K04949]
109376431  [KO:K05031] [EC:5.6.1.6]
109376631  CRH; corticoliberin [KO:K05256]
109377058  ATP1B4; LOW QUALITY PROTEIN: protein ATP1B4 [KO:K01540]
109377479  [KO:K04962]
109377665  GNAI2; guanine nucleotide-binding protein G(i) subunit alpha-2 [KO:K04630]
109377904  GABBR1; gamma-aminobutyric acid type B receptor subunit 1 [KO:K04615]
109377948  [KO:K04440] [EC:2.7.11.24]
109377995  VIP; VIP peptides isoform X1 [KO:K05264]
109378038  MC2R; adrenocorticotropic hormone receptor [KO:K04200]
109378054  VAV1; proto-oncogene vav [KO:K05730]
109378853  SUCNR1; succinate receptor 1 [KO:K10042]
109379086  KCNK2; potassium channel subfamily K member 2 isoform X1 [KO:K04913]
109379855  GCG; glucagon [KO:K05259]
109380009  EDN3; endothelin-3 [KO:K05227]
109380071  [KO:K04632]
109380072  [KO:K04632]
109380134  DRD1; D(1A) dopamine receptor [KO:K04144]
109380150  RAC1; ras-related C3 botulinum toxin substrate 1 [KO:K04392]
109380260  CRHR1; corticotropin-releasing factor receptor 1 [KO:K04578]
109380340  [KO:K02183]
109380439  CACNA1S; voltage-dependent L-type calcium channel subunit alpha-1S [KO:K04857]
109380484  ADORA1; adenosine receptor A1 isoform X1 [KO:K04265]
109380690  GIP; gastric inhibitory polypeptide [KO:K05258]
109380840  PPP1R1B; protein phosphatase 1 regulatory subunit 1B [KO:K15494]
109380957  [KO:K05860] [EC:3.1.4.11]
109381083  AKT1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
109381168  VAV2; guanine nucleotide exchange factor VAV2 isoform X1 [KO:K05730]
109381238  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform [KO:K00922] [EC:2.7.1.153]
109381245  NPPA; natriuretic peptides A [KO:K12334]
109381333  [KO:K04587]
109381352  CRHR2; corticotropin-releasing factor receptor 2 isoform X1 [KO:K04579]
109381368  CREB5; cyclic AMP-responsive element-binding protein 5 isoform X1 [KO:K09047]
109381526  FOS; proto-oncogene c-Fos [KO:K04379]
109381707  RAP1B; ras-related protein Rap-1b isoform X1 [KO:K07836]
109381883  F2R; proteinase-activated receptor 1 isoform X1 [KO:K03914]
109382420  PDE4C; cAMP-specific 3',5'-cyclic phosphodiesterase 4C isoform X1 [KO:K13293] [EC:3.1.4.53]
109382484  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
109382502  GRIN1; glutamate receptor ionotropic, NMDA 1 [KO:K05208]
109382670  CALM1; calmodulin [KO:K02183]
109383120  GRIN2B; glutamate receptor ionotropic, NMDA 2B [KO:K05210]
109383198  NFATC1; nuclear factor of activated T-cells, cytoplasmic 1 isoform X1 [KO:K04446]
109383261  ADCY7; adenylate cyclase type 7 isoform X1 [KO:K08047] [EC:4.6.1.1]
109383371  EDN2; endothelin-2 [KO:K16367]
109383627  GRIN2C; glutamate receptor ionotropic, NMDA 2C [KO:K05211]
109383700  ACOX1; peroxisomal acyl-coenzyme A oxidase 1 isoform X1 [KO:K00232] [EC:1.3.3.6]
109383794  [KO:K02183]
109383796  [KO:K02183]
109383860  NFKBIA; NF-kappa-B inhibitor alpha [KO:K04734]
109383864  SSTR1; somatostatin receptor type 1 isoform X1 [KO:K04217]
109384108  CHRM1; muscarinic acetylcholine receptor M1 [KO:K04129]
109384139  PPP1CA; serine/threonine-protein phosphatase PP1-alpha catalytic subunit [KO:K06269] [EC:3.1.3.16]
109384256  BAD; bcl2-associated agonist of cell death [KO:K02158]
109384308  GPHA2; glycoprotein hormone alpha-2 isoform X1 [KO:K25483]
109384322  RELA; transcription factor p65 isoform X1 [KO:K04735]
109384360  OXT; oxytocin-neurophysin 1 [KO:K05243]
109384486  PTGER2; prostaglandin E2 receptor EP2 subtype [KO:K04259]
109384530  ATP1B3; sodium/potassium-transporting ATPase subunit beta-3 [KO:K01540]
109384548  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
109384686  TSHR; thyrotropin receptor [KO:K04249]
109384957  PDE4B; cAMP-specific 3',5'-cyclic phosphodiesterase 4B isoform X1 [KO:K13293] [EC:3.1.4.53]
109385186  ADCY3; adenylate cyclase type 3 isoform X1 [KO:K08043] [EC:4.6.1.1]
109385252  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 isoform X1 [KO:K04368] [EC:2.7.12.2]
109385315  FXYD2; sodium/potassium-transporting ATPase subunit gamma isoform X1 [KO:K01538]
109385316  ATP1B1; sodium/potassium-transporting ATPase subunit beta-1 [KO:K01540]
109385353  AKT3; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
109385440  PRKACB; cAMP-dependent protein kinase catalytic subunit beta isoform X1 [KO:K04345] [EC:2.7.11.11]
109385672  [KO:K01540]
109385685  PPP1CB; serine/threonine-protein phosphatase PP1-beta catalytic subunit isoform X1 [KO:K06269] [EC:3.1.3.16]
109385702  PDE4D; cAMP-specific 3',5'-cyclic phosphodiesterase 4D isoform X1 [KO:K13293] [EC:3.1.4.53]
109385803  MAPK3; mitogen-activated protein kinase 3 isoform X1 [KO:K04371] [EC:2.7.11.24]
109385850  SSTR5; somatostatin receptor type 5 [KO:K04221]
109385859  ATP2A1; sarcoplasmic/endoplasmic reticulum calcium ATPase 1 isoform X1 [KO:K05853] [EC:7.2.2.10]
109385878  [KO:K04456] [EC:2.7.11.1]
109386023  [KO:K08402]
109386024  HCAR1; hydroxycarboxylic acid receptor 1 [KO:K08401]
109386055  ATP2A2; sarcoplasmic/endoplasmic reticulum calcium ATPase 2 [KO:K05853] [EC:7.2.2.10]
109386108  PPP1CC; serine/threonine-protein phosphatase PP1-gamma catalytic subunit isoform X1 [KO:K06269] [EC:3.1.3.16]
109386109  ORAI1; calcium release-activated calcium channel protein 1 isoform X1 [KO:K16056]
109386426  GABBR2; gamma-aminobutyric acid type B receptor subunit 2 [KO:K04615]
109386487  ATP2B4; plasma membrane calcium-transporting ATPase 4 isoform X1 [KO:K05850] [EC:7.2.2.10]
109386501  ATP1A2; sodium/potassium-transporting ATPase subunit alpha-2 [KO:K01539] [EC:7.2.2.13]
109386644  ROCK2; rho-associated protein kinase 2 [KO:K17388] [EC:2.7.11.1]
109386737  SLC9A1; sodium/hydrogen exchanger 1 [KO:K05742]
109386936  NPY1R; neuropeptide Y receptor type 1 [KO:K04204]
109387027  [KO:K05250]
109387036  BDNF; brain-derived neurotrophic factor isoform X1 [KO:K04355]
109387184  GRIN2A; glutamate receptor ionotropic, NMDA 2A [KO:K05209]
109387194  SOX9; transcription factor SOX-9 [KO:K18435]
109387200  ADCY5; adenylate cyclase type 5 [KO:K08045] [EC:4.6.1.1]
109387205  SSTR2; somatostatin receptor type 2 [KO:K04218]
109387267  GHRL; appetite-regulating hormone isoform X1 [KO:K05254]
109387270  OXTR; oxytocin receptor [KO:K04229]
109387285  ATP2B2; plasma membrane calcium-transporting ATPase 2 isoform X1 [KO:K05850] [EC:7.2.2.10]
109387570  CNGB3; cyclic nucleotide-gated cation channel beta-3 [KO:K04953]
109387625  PPARA; peroxisome proliferator-activated receptor alpha [KO:K07294]
109387857  NPY; pro-neuropeptide Y [KO:K05232]
109388043  HTR1A; 5-hydroxytryptamine receptor 1A [KO:K04153]
109388269  RRAS2; ras-related protein R-Ras2 [KO:K07830]
109388277  PDE3B; cGMP-inhibited 3',5'-cyclic phosphodiesterase B [KO:K13296] [EC:3.1.4.17]
109388316  CREB1; cyclic AMP-responsive element-binding protein 1 isoform X1 [KO:K05870]
109388427  POPDC2; popeye domain-containing protein 2 isoform X1 [KO:K26206]
109388507  PTGER3; prostaglandin E2 receptor EP3 subtype isoform X1 [KO:K04260]
109388532  CREB3L2; cyclic AMP-responsive element-binding protein 3-like protein 2 isoform X1 [KO:K09048]
109388540  CHRM2; muscarinic acetylcholine receptor M2 isoform X1 [KO:K04130]
109388626  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
109388636  CREB3L3; cyclic AMP-responsive element-binding protein 3-like protein 3 isoform X1 [KO:K09048]
109388735  RAPGEF4; rap guanine nucleotide exchange factor 4 isoform X1 [KO:K04351]
109388840  ROCK1; rho-associated protein kinase 1 isoform X1 [KO:K04514] [EC:2.7.11.1]
109388873  GPR119; glucose-dependent insulinotropic receptor [KO:K08424]
109388950  CACNA1C; voltage-dependent L-type calcium channel subunit alpha-1C isoform X1 [KO:K04850]
109389577  MYL9; myosin regulatory light polypeptide 9 [KO:K12755]
109389899  FSHR; follicle-stimulating hormone receptor isoform X1 [KO:K04247]
109389900  LHCGR; lutropin-choriogonadotropic hormone receptor [KO:K04248]
109389917  CALM2; calmodulin [KO:K02183]
109390233  CREB3L1; cyclic AMP-responsive element-binding protein 3-like protein 1 isoform X1 [KO:K09048]
109390284  CAMK2D; calcium/calmodulin-dependent protein kinase type II subunit delta isoform X1 [KO:K04515] [EC:2.7.11.17]
109390564  HCN2; potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2 [KO:K04955]
109390616  AMH; muellerian-inhibiting factor [KO:K04665]
109390640  GRIN3B; glutamate receptor ionotropic, NMDA 3B isoform X1 [KO:K05214]
109390708  GLI1; zinc finger protein GLI1 [KO:K16797]
109390802  GRIA1; glutamate receptor 1 isoform X1 [KO:K05197]
109390887  GRIA3; glutamate receptor 3 isoform X1 [KO:K05199]
109390975  GRIN2D; glutamate receptor ionotropic, NMDA 2D [KO:K05212]
109390979  [KO:K08521]
109391058  RRAS; ras-related protein R-Ras [KO:K07829]
109391149  CALML6; calmodulin-like protein 6 [KO:K02183]
109391519  VIPR2; vasoactive intestinal polypeptide receptor 2 isoform X1 [KO:K04590]
109391534  CAMK4; calcium/calmodulin-dependent protein kinase type IV [KO:K05869] [EC:2.7.11.17]
109391610  PDE4A; cAMP-specific 3',5'-cyclic phosphodiesterase 4A isoform X1 [KO:K13293] [EC:3.1.4.53]
109391697  AFDN; afadin isoform X1 [KO:K05702]
109391760  HCN4; potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 [KO:K04957]
109391912  ATP2A3; sarcoplasmic/endoplasmic reticulum calcium ATPase 3 isoform X1 [KO:K05853] [EC:7.2.2.10]
109392029  ADRB1; beta-1 adrenergic receptor [KO:K04141]
109392133  ADCY9; adenylate cyclase type 9 [KO:K08049] [EC:4.6.1.1]
109392135  CREBBP; CREB-binding protein isoform X1 [KO:K04498] [EC:2.3.1.48]
109392186  POMC; pro-opiomelanocortin [KO:K05228]
109392215  MAPK8; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
109392262  EP300; histone acetyltransferase p300 isoform X1 [KO:K04498] [EC:2.3.1.48]
109392584  [KO:K05840]
109392585  [KO:K05840]
109392738  EDNRA; endothelin-1 receptor [KO:K04197]
109392748  MAPK9; mitogen-activated protein kinase 9 [KO:K04440] [EC:2.7.11.24]
109392787  ATP2B1; plasma membrane calcium-transporting ATPase 1 [KO:K05850] [EC:7.2.2.10]
109392811  TSHB; thyrotropin subunit beta [KO:K05251]
109392813  ATP1A1; sodium/potassium-transporting ATPase subunit alpha-1 [KO:K01539] [EC:7.2.2.13]
109392892  GNAI1; guanine nucleotide-binding protein G(i) subunit alpha-1 [KO:K04630]
109392954  HTR1E; 5-hydroxytryptamine receptor 1E [KO:K04153]
109392979  PDE3A; cGMP-inhibited 3',5'-cyclic phosphodiesterase A isoform X1 [KO:K19021] [EC:3.1.4.17]
109393041  RAC3; ras-related C3 botulinum toxin substrate 3 isoform X1 [KO:K07861]
109393118  HHIP; hedgehog-interacting protein isoform X1 [KO:K06231]
109393238  ADCY6; adenylate cyclase type 6 isoform X1 [KO:K08046] [EC:4.6.1.1]
109393508  TIAM1; T-lymphoma invasion and metastasis-inducing protein 1 [KO:K05731]
109393593  ADCY4; adenylate cyclase type 4 [KO:K08044] [EC:4.6.1.1]
109393756  CREB3; cyclic AMP-responsive element-binding protein 3 [KO:K09048]
109393984  ARAP3; arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 3 [KO:K12490]
109394074  ABCC4; multidrug resistance-associated protein 4 [KO:K05673]
109394108  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922] [EC:2.7.1.153]
109394225  PRKACA; cAMP-dependent protein kinase catalytic subunit alpha isoform X1 [KO:K04345] [EC:2.7.11.11]
109394331  ATP2B3; plasma membrane calcium-transporting ATPase 3 isoform X1 [KO:K05850] [EC:7.2.2.10]
109394416  CNGB1; cyclic nucleotide-gated cation channel beta-1 [KO:K04952]
109394502  RAC2; ras-related C3 botulinum toxin substrate 2 [KO:K07860]
109394696  PLD2; phospholipase D2 isoform X1 [KO:K01115] [EC:3.1.4.4]
109394700  ATP1B2; sodium/potassium-transporting ATPase subunit beta-2 isoform X1 [KO:K01540]
109394776  DRD2; D(2) dopamine receptor isoform X1 [KO:K04145]
109394900  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
109394916  ADORA2A; adenosine receptor A2a [KO:K04266]
109395037  GRIN3A; glutamate receptor ionotropic, NMDA 3A [KO:K05213]
109395568  HTR6; 5-hydroxytryptamine receptor 6 isoform X1 [KO:K04162]
109395605  BRAF; serine/threonine-protein kinase B-raf isoform X1 [KO:K04365] [EC:2.7.11.1]
109395865  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
109395944  CACNA1D; voltage-dependent L-type calcium channel subunit alpha-1D isoform X1 [KO:K04851]
109396303  SST; somatostatin [KO:K05237]
109396480  CNGA4; cyclic nucleotide-gated cation channel alpha-4 isoform X1 [KO:K04951]
109396577  GRIA4; glutamate receptor 4 isoform X1 [KO:K05200]
109396730  PTCH1; protein patched homolog 1 isoform X1 [KO:K06225]
109396935  CNGA3; cyclic nucleotide-gated cation channel alpha-3 [KO:K04950]
Compound
C00020  AMP
C00042  Succinate
C00076  Calcium cation
C00080  H+
C00165  Diacylglycerol
C00186  (S)-Lactate
C00212  Adenosine
C00238  Potassium cation
C00288  HCO3-
C00334  4-Aminobutanoate
C00416  Phosphatidate
C00547  L-Noradrenaline
C00575  3',5'-Cyclic AMP
C00584  Prostaglandin E2
C00698  Cl-
C00780  Serotonin
C00788  L-Adrenaline
C01089  (R)-3-Hydroxybutanoate
C01245  D-myo-Inositol 1,4,5-trisphosphate
C01312  Prostaglandin I2
C01330  Sodium cation
C01996  Acetylcholine
C03758  Dopamine
C20792  Oleoylethanolamide
C20793  3-Hydroxyoctanoate
Reference
PMID:11493633
  Authors
Fimia GM, Sassone-Corsi P
  Title
Cyclic AMP signalling.
  Journal
J Cell Sci 114:1971-2 (2001)
Reference
PMID:18323530
  Authors
Serezani CH, Ballinger MN, Aronoff DM, Peters-Golden M
  Title
Cyclic AMP: master regulator of innate immune cell function.
  Journal
Am J Respir Cell Mol Biol 39:127-32 (2008)
DOI:10.1165/rcmb.2008-0091TR
Reference
PMID:24281338
  Authors
Oldenburger A, Maarsingh H, Schmidt M
  Title
Multiple facets of cAMP signalling and physiological impact: cAMP compartmentalization in the lung.
  Journal
Pharmaceuticals (Basel) 5:1291-331 (2012)
DOI:10.3390/ph5121291
Reference
PMID:24613710
  Authors
Ahuja M, Jha A, Maleth J, Park S, Muallem S
  Title
cAMP and Ca signaling in secretory epithelia: Crosstalk and synergism.
  Journal
Cell Calcium 55:385-393 (2014)
DOI:10.1016/j.ceca.2014.01.006
Reference
PMID:22082266
  Authors
Shirshev SV
  Title
Role of Epac proteins in mechanisms of cAMP-dependent immunoregulation.
  Journal
Biochemistry (Mosc) 76:981-98 (2011)
DOI:10.1134/S000629791109001X
Reference
PMID:18176800
  Authors
Roscioni SS, Elzinga CR, Schmidt M
  Title
Epac: effectors and biological functions.
  Journal
Naunyn Schmiedebergs Arch Pharmacol 377:345-57 (2008)
DOI:10.1007/s00210-007-0246-7
Reference
PMID:24450633
  Authors
Roberts OL, Dart C
  Title
cAMP signalling in the vasculature: the role of Epac (exchange protein directly activated by cAMP).
  Journal
Biochem Soc Trans 42:89-97 (2014)
DOI:10.1042/BST20130253
Reference
PMID:16765984
  Authors
Schaub MC, Hefti MA, Zaugg M
  Title
Integration of calcium with the signaling network in cardiac myocytes.
  Journal
J Mol Cell Cardiol 41:183-214 (2006)
DOI:10.1016/j.yjmcc.2006.04.005
Reference
PMID:19874988
  Authors
Triposkiadis F, Karayannis G, Giamouzis G, Skoularigis J, Louridas G, Butler J
  Title
The sympathetic nervous system in heart failure physiology, pathophysiology, and clinical implications.
  Journal
J Am Coll Cardiol 54:1747-62 (2009)
DOI:10.1016/j.jacc.2009.05.015
Reference
PMID:15142747
  Authors
Saucerman JJ, McCulloch AD
  Title
Mechanistic systems models of cell signaling networks: a case study of myocyte adrenergic regulation.
  Journal
Prog Biophys Mol Biol 85:261-78 (2004)
DOI:10.1016/j.pbiomolbio.2004.01.005
Reference
PMID:21212391
  Authors
Yang JH, Saucerman JJ
  Title
Computational models reduce complexity and accelerate insight into cardiac signaling networks.
  Journal
Circ Res 108:85-97 (2011)
DOI:10.1161/CIRCRESAHA.110.223602
Reference
PMID:22022314
  Authors
Taggart P, Boyett MR, Logantha S, Lambiase PD
  Title
Anger, emotion, and arrhythmias: from brain to heart.
  Journal
Front Physiol 2:67 (2011)
DOI:10.3389/fphys.2011.00067
Reference
PMID:21852968
  Authors
Bozzi Y, Dunleavy M, Henshall DC
  Title
Cell signaling underlying epileptic behavior.
  Journal
Front Behav Neurosci 5:45 (2011)
DOI:10.3389/fnbeh.2011.00045
Reference
PMID:10880354
  Authors
Lizcano JM, Morrice N, Cohen P
  Title
Regulation of BAD by cAMP-dependent protein kinase is mediated via phosphorylation of a novel site, Ser155.
  Journal
Biochem J 349:547-57 (2000)
DOI:10.1042/bj3490547
Reference
PMID:21744067
  Authors
Gerlo S, Kooijman R, Beck IM, Kolmus K, Spooren A, Haegeman G
  Title
Cyclic AMP: a selective modulator of NF-kappaB action.
  Journal
Cell Mol Life Sci 68:3823-41 (2011)
DOI:10.1007/s00018-011-0757-8
Reference
PMID:7688165
  Authors
Lauder JM
  Title
Neurotransmitters as growth regulatory signals: role of receptors and second messengers.
  Journal
Trends Neurosci 16:233-40 (1993)
DOI:10.1016/0166-2236(93)90162-F
Reference
PMID:17077866
  Authors
Voglis G, Tavernarakis N
  Title
The role of synaptic ion channels in synaptic plasticity.
  Journal
EMBO Rep 7:1104-10 (2006)
DOI:10.1038/sj.embor.7400830
Reference
PMID:21346730
  Authors
Altarejos JY, Montminy M
  Title
CREB and the CRTC co-activators: sensors for hormonal and metabolic signals.
  Journal
Nat Rev Mol Cell Biol 12:141-51 (2011)
DOI:10.1038/nrm3072
Reference
PMID:24062645
  Authors
Bozzi Y, Borrelli E
  Title
The role of dopamine signaling in epileptogenesis.
  Journal
Front Cell Neurosci 7:157 (2013)
DOI:10.3389/fncel.2013.00157
Reference
PMID:14715909
  Authors
Ceulemans H, Bollen M
  Title
Functional diversity of protein phosphatase-1, a cellular economizer and reset button.
  Journal
Physiol Rev 84:1-39 (2004)
DOI:10.1152/physrev.00013.2003
Reference
PMID:16571352
  Authors
Lipinski RJ, Gipp JJ, Zhang J, Doles JD, Bushman W
  Title
Unique and complimentary activities of the Gli transcription factors in Hedgehog signaling.
  Journal
Exp Cell Res 312:1925-38 (2006)
DOI:10.1016/j.yexcr.2006.02.019
Reference
PMID:21693691
  Authors
Lasala C, Schteingart HF, Arouche N, Bedecarras P, Grinspon RP, Picard JY, Josso N, di Clemente N, Rey RA
  Title
SOX9 and SF1 are involved in cyclic AMP-mediated upregulation of anti-Mullerian gene expression in the testicular prepubertal Sertoli cell line SMAT1.
  Journal
Am J Physiol Endocrinol Metab 301:E539-47 (2011)
DOI:10.1152/ajpendo.00187.2011
Reference
PMID:19460777
  Authors
Rosenkranz AC, Rauch BH, Freidel K, Schror K
  Title
Regulation of protease-activated receptor-1 by vasodilatory prostaglandins via NFAT.
  Journal
Cardiovasc Res 83:778-84 (2009)
DOI:10.1093/cvr/cvp163
Reference
PMID:11117527
  Authors
Lazennec G, Canaple L, Saugy D, Wahli W
  Title
Activation of peroxisome proliferator-activated receptors (PPARs) by their ligands and protein kinase A activators.
  Journal
Mol Endocrinol 14:1962-75 (2000)
DOI:10.1210/mend.14.12.0575
Reference
PMID:16460276
  Authors
Murthy KS
  Title
Signaling for contraction and relaxation in smooth muscle of the gut.
  Journal
Annu Rev Physiol 68:345-74 (2006)
DOI:10.1146/annurev.physiol.68.040504.094707
Reference
PMID:18064650
  Authors
Birukova AA, Zagranichnaya T, Alekseeva E, Bokoch GM, Birukov KG
  Title
Epac/Rap and PKA are novel mechanisms of ANP-induced Rac-mediated pulmonary endothelial barrier protection.
  Journal
J Cell Physiol 215:715-24 (2008)
DOI:10.1002/jcp.21354
Reference
PMID:9204709
  Authors
Houslay MD, Milligan G
  Title
Tailoring cAMP-signalling responses through isoform multiplicity.
  Journal
Trends Biochem Sci 22:217-24 (1997)
DOI:10.1016/S0968-0004(97)01050-5
Related
pathway
hai00071  Fatty acid degradation
hai04015  Rap1 signaling pathway
hai04020  Calcium signaling pathway
hai04151  PI3K-Akt signaling pathway
hai04210  Apoptosis
hai04260  Cardiac muscle contraction
hai04340  Hedgehog signaling pathway
hai04720  Long-term potentiation
hai04740  Olfactory transduction
hai04972  Pancreatic secretion
hai04976  Bile secretion
KO pathway
ko04024   

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