KEGG   PATHWAY: hale00630
Entry
hale00630                   Pathway                                
Name
Glyoxylate and dicarboxylate metabolism - Haloferax alexandrinus
Class
Metabolism; Carbohydrate metabolism
Pathway map
hale00630  Glyoxylate and dicarboxylate metabolism
hale00630

Module
hale_M00012  Glyoxylate cycle [PATH:hale00630]
hale_M00621  Glycine cleavage system [PATH:hale00630]
hale_M00741  Propanoyl-CoA metabolism, propanoyl-CoA => succinyl-CoA [PATH:hale00630]
hale_M00968  Pentose bisphosphate pathway (nucleoside degradation), archaea, nucleoside/NMP => 3-PGA/glycerone phosphate [PATH:hale00630]
Other DBs
GO: 0046487 0043648
Organism
Haloferax alexandrinus [GN:hale]
Gene
G3A49_12905  isocitrate lyase/PEP mutase family protein [KO:K01637] [EC:4.1.3.1]
G3A49_11045  AMP-binding protein [KO:K01895] [EC:6.2.1.1]
G3A49_04475  acs; acetate--CoA ligase [KO:K01895] [EC:6.2.1.1]
G3A49_05190  acs; acetate--CoA ligase [KO:K01895] [EC:6.2.1.1]
G3A49_05200  acs; acetate--CoA ligase [KO:K01895] [EC:6.2.1.1]
G3A49_09375  acyl--CoA ligase [KO:K01895] [EC:6.2.1.1]
G3A49_00355  malate dehydrogenase [KO:K00024] [EC:1.1.1.37]
G3A49_02415  citrate synthase [KO:K01647] [EC:2.3.3.1]
G3A49_12765  aconitate hydratase [KO:K01681] [EC:4.2.1.3]
G3A49_02760  aconitate hydratase [KO:K01681] [EC:4.2.1.3]
G3A49_04200  thiolase domain-containing protein [KO:K00626] [EC:2.3.1.9]
G3A49_05715  thiolase domain-containing protein [KO:K00626] [EC:2.3.1.9]
G3A49_08355  thiolase family protein [KO:K00626] [EC:2.3.1.9]
G3A49_05695  VOC family protein [KO:K05606] [EC:5.1.99.1]
G3A49_10085  mce; methylmalonyl-CoA epimerase [KO:K05606] [EC:5.1.99.1]
G3A49_15655  acetyl-CoA carboxylase biotin carboxylase subunit [KO:K11263] [EC:6.4.1.2 6.4.1.3 6.3.4.14]
G3A49_15580  acyl-CoA carboxylase subunit beta [KO:K19312] [EC:6.4.1.2 6.4.1.3 2.1.3.15]
G3A49_15585  acc operon protein [KO:K22568] [EC:6.4.1.2 6.4.1.3]
G3A49_04180  cobalamin B12-binding domain-containing protein [KO:K01849] [EC:5.4.99.2]
G3A49_04470  methylmalonyl-CoA mutase family protein [KO:K01848] [EC:5.4.99.2]
G3A49_10105  methylmalonyl-CoA mutase family protein [KO:K01848] [EC:5.4.99.2]
G3A49_12900  malate synthase [KO:K19282] [EC:4.1.3.24 3.1.2.30]
G3A49_07690  malate synthase [KO:K19282] [EC:4.1.3.24 3.1.2.30]
G3A49_12260  HAD family hydrolase [KO:K01091] [EC:3.1.3.18]
G3A49_14750  HAD family hydrolase [KO:K01091] [EC:3.1.3.18]
G3A49_17265  HAD family hydrolase [KO:K01091] [EC:3.1.3.18]
G3A49_10800  phosphoglycolate phosphatase [KO:K22223] [EC:3.1.3.18]
G3A49_04835  rbcL; type III ribulose-bisphosphate carboxylase [KO:K01601] [EC:4.1.1.39]
G3A49_17060  alanine--glyoxylate aminotransferase family protein [KO:K00830] [EC:2.6.1.44 2.6.1.45 2.6.1.51]
G3A49_04365  gltB; glutamate synthase large subunit [KO:K00284] [EC:1.4.7.1]
G3A49_01555  glnA; type I glutamate--ammonia ligase [KO:K01915] [EC:6.3.1.2]
G3A49_17905  serine hydroxymethyltransferase [KO:K00600] [EC:2.1.2.1]
G3A49_07155  serine hydroxymethyltransferase [KO:K00600] [EC:2.1.2.1]
G3A49_15225  aminomethyl-transferring glycine dehydrogenase subunit GcvPA [KO:K00282] [EC:1.4.4.2]
G3A49_15220  glycine dehydrogenase subunit 2 [KO:K00283] [EC:1.4.4.2]
G3A49_15235  gcvT; glycine cleavage system aminomethyltransferase GcvT [KO:K00605] [EC:2.1.2.10]
G3A49_02080  aminomethyl transferase family protein [KO:K00605] [EC:2.1.2.10]
G3A49_00100  lpdA; dihydrolipoyl dehydrogenase [KO:K00382] [EC:1.8.1.4]
G3A49_15230  gcvH; glycine cleavage system protein GcvH [KO:K02437]
G3A49_10885  DUF4147 domain-containing protein [KO:K11529] [EC:2.7.1.165]
G3A49_04720  eda; bifunctional 4-hydroxy-2-oxoglutarate aldolase/2-dehydro-3-deoxy-phosphogluconate aldolase [KO:K01625] [EC:4.1.2.14 4.1.3.42]
G3A49_05320  bifunctional 4-hydroxy-2-oxoglutarate aldolase/2-dehydro-3-deoxy-phosphogluconate aldolase [KO:K01625] [EC:4.1.2.14 4.1.3.42]
G3A49_07830  eda; bifunctional 4-hydroxy-2-oxoglutarate aldolase/2-dehydro-3-deoxy-phosphogluconate aldolase [KO:K01625] [EC:4.1.2.14 4.1.3.42]
G3A49_07630  fdhF; formate dehydrogenase subunit alpha [KO:K00123] [EC:1.17.1.9]
G3A49_14400  formyltetrahydrofolate deformylase [KO:K01433] [EC:3.5.1.10]
Compound
C00007  Oxygen
C00011  CO2
C00014  Ammonia
C00022  Pyruvate
C00024  Acetyl-CoA
C00025  L-Glutamate
C00026  2-Oxoglutarate
C00027  Hydrogen peroxide
C00033  Acetate
C00036  Oxaloacetate
C00037  Glycine
C00042  Succinate
C00048  Glyoxylate
C00058  Formate
C00064  L-Glutamine
C00065  L-Serine
C00091  Succinyl-CoA
C00100  Propanoyl-CoA
C00111  Glycerone phosphate
C00136  Butanoyl-CoA
C00149  (S)-Malate
C00158  Citrate
C00160  Glycolate
C00168  Hydroxypyruvate
C00197  3-Phospho-D-glycerate
C00209  Oxalate
C00258  D-Glycerate
C00266  Glycolaldehyde
C00311  Isocitrate
C00313  Oxalyl-CoA
C00332  Acetoacetyl-CoA
C00417  cis-Aconitate
C00552  meso-Tartaric acid
C00631  2-Phospho-D-glycerate
C00683  (S)-Methylmalonyl-CoA
C00798  Formyl-CoA
C00877  Crotonoyl-CoA
C00888  Pentanoyl-CoA
C00898  (R,R)-Tartaric acid
C00975  Dihydroxyfumarate
C00988  2-Phosphoglycolate
C01127  4-Hydroxy-2-oxoglutarate
C01146  2-Hydroxy-3-oxopropanoate
C01182  D-Ribulose 1,5-bisphosphate
C01213  (R)-Methylmalonyl-CoA
C01380  Ethylene glycol
C01732  Mesaconate
C01989  3-Ethylmalate
C01990  3-Oxalomalate
C02123  3-Propylmalate
C02405  Formyl phosphate
C03217  2-Hydroxy-3-oxoadipate
C03459  2-Hydroxy-3-oxosuccinate
C03548  trans-2,3-Epoxysuccinate
C03561  (R)-3-Hydroxybutanoyl-CoA
C03618  L-threo-3-Methylaspartate
C04348  L-Malyl-CoA
C06027  L-erythro-3-Methylmalyl-CoA
C06028  2-Methylfumaryl-CoA
C06049  N-Formylderivatives
C18026  (2S)-Ethylmalonyl-CoA
C18324  (2S)-Methylsuccinyl-CoA
C20238  (2R)-Ethylmalonyl-CoA
C22337  D-Ribulose 1-phosphate
Reference
PMID:10978349
  Authors
Njau RK, Herndon CA, Hawes JW.
  Title
Novel beta-hydroxyacid dehydrogenases in Escherichia coli and Haemophilus influenzae.
  Journal
J Biol Chem 275:38780-6 (2000)
DOI:10.1074/jbc.M007432200
Reference
PMID:18065535
  Authors
Zarzycki J, Schlichting A, Strychalsky N, Muller M, Alber BE, Fuchs G
  Title
Mesaconyl-coenzyme A hydratase, a new enzyme of two central carbon metabolic pathways in bacteria.
  Journal
J Bacteriol 190:1366-74 (2008)
DOI:10.1128/JB.01621-07
Reference
PMID:18819910
  Authors
Erb TJ, Retey J, Fuchs G, Alber BE
  Title
Ethylmalonyl-CoA mutase from Rhodobacter sphaeroides defines a new subclade of coenzyme B12-dependent acyl-CoA mutases.
  Journal
J Biol Chem 283:32283-93 (2008)
DOI:10.1074/jbc.M805527200
Reference
PMID:9596633
  Authors
Coschigano KT, Melo-Oliveira R, Lim J, Coruzzi GM
  Title
Arabidopsis gls mutants and distinct Fd-GOGAT genes. Implications for photorespiration and primary nitrogen assimilation.
  Journal
Plant Cell 10:741-52 (1998)
DOI:10.1105/tpc.10.5.741
Reference
PMID:16407450
  Authors
Masclaux-Daubresse C, Reisdorf-Cren M, Pageau K, Lelandais M, Grandjean O, Kronenberger J, Valadier MH, Feraud M, Jouglet T, Suzuki A
  Title
Glutamine synthetase-glutamate synthase pathway and glutamate dehydrogenase play distinct roles in the sink-source nitrogen cycle in tobacco.
  Journal
Plant Physiol 140:444-56 (2006)
DOI:10.1104/pp.105.071910
Reference
PMID:21252347
  Authors
Khomyakova M, Bukmez O, Thomas LK, Erb TJ, Berg IA
  Title
A methylaspartate cycle in haloarchaea.
  Journal
Science 331:334-7 (2011)
DOI:10.1126/science.1196544
Reference
PMID:11513957
  Authors
Serrano JA, Bonete MJ
  Title
Sequencing, phylogenetic and transcriptional analysis of the glyoxylate bypass operon (ace) in the halophilic archaeon Haloferax volcanii.
  Journal
Biochim Biophys Acta 1520:154-62 (2001)
DOI:10.1016/S0167-4781(01)00263-9
Related
pathway
hale00010  Glycolysis / Gluconeogenesis
hale00020  Citrate cycle (TCA cycle)
hale00030  Pentose phosphate pathway
hale00053  Ascorbate and aldarate metabolism
hale00071  Fatty acid degradation
hale00230  Purine metabolism
hale00250  Alanine, aspartate and glutamate metabolism
hale00260  Glycine, serine and threonine metabolism
hale00620  Pyruvate metabolism
hale00710  Carbon fixation by Calvin cycle
hale00750  Vitamin B6 metabolism
hale00910  Nitrogen metabolism
KO pathway
ko00630   
LinkDB

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