KEGG   PATHWAY: han00480
Entry
han00480                    Pathway                                
Name
Glutathione metabolism - Helianthus annuus (common sunflower)
Class
Metabolism; Metabolism of other amino acids
Pathway map
han00480  Glutathione metabolism
han00480

Module
han_M00118  Glutathione biosynthesis, glutamate => glutathione [PATH:han00480]
Other DBs
GO: 0006749
Organism
Helianthus annuus (common sunflower) [GN:han]
Gene
110893771  glutathione hydrolase 3 [KO:K18592] [EC:2.3.2.2 3.4.19.13 3.4.19.14]
110928508  glutathione hydrolase 3 [KO:K18592] [EC:2.3.2.2 3.4.19.13 3.4.19.14]
110899266  gamma-glutamylcyclotransferase 2-1 [KO:K22596] [EC:4.3.2.9]
110930152  gamma-glutamylcyclotransferase 2-1 [KO:K22596] [EC:4.3.2.9]
110885602  gamma-glutamylcyclotransferase 2-3 isoform X1 [KO:K22596] [EC:4.3.2.9]
110886525  5-oxoprolinase [KO:K01469] [EC:3.5.2.9]
110866076  glutamate--cysteine ligase, chloroplastic isoform X1 [KO:K01919] [EC:6.3.2.2]
110926229  glutamate--cysteine ligase, chloroplastic [KO:K01919] [EC:6.3.2.2]
110885127  glutathione synthetase, chloroplastic [KO:K21456] [EC:6.3.2.3]
110903719  glutathione synthetase, chloroplastic [KO:K21456] [EC:6.3.2.3]
110893953  leucine aminopeptidase 2, chloroplastic [KO:K01255] [EC:3.4.11.1]
110886593  leucine aminopeptidase 1 [KO:K01255] [EC:3.4.11.1]
110877601  leucine aminopeptidase 2, chloroplastic [KO:K01255] [EC:3.4.11.1]
110928826  leucine aminopeptidase 1 [KO:K01255] [EC:3.4.11.1]
110899584  puromycin-sensitive aminopeptidase isoform X1 [KO:K01256] [EC:3.4.11.2]
110930512  puromycin-sensitive aminopeptidase [KO:K01256] [EC:3.4.11.2]
110930513  puromycin-sensitive aminopeptidase [KO:K01256] [EC:3.4.11.2]
110864247  glutathione S-transferase [KO:K00799] [EC:2.5.1.18]
110865392  probable glutathione S-transferase [KO:K00799] [EC:2.5.1.18]
110865393  probable glutathione S-transferase [KO:K00799] [EC:2.5.1.18]
110865394  probable glutathione S-transferase [KO:K00799] [EC:2.5.1.18]
110865395  probable glutathione S-transferase [KO:K00799] [EC:2.5.1.18]
110865357  probable glutathione S-transferase [KO:K00799] [EC:2.5.1.18]
110865360  probable glutathione S-transferase [KO:K00799] [EC:2.5.1.18]
110865361  probable glutathione S-transferase [KO:K00799] [EC:2.5.1.18]
110865363  probable glutathione S-transferase [KO:K00799] [EC:2.5.1.18]
110865364  probable glutathione S-transferase [KO:K00799] [EC:2.5.1.18]
110866160  glutathione S-transferase T1 [KO:K00799] [EC:2.5.1.18]
110867687  glutathione S-transferase T1 [KO:K00799] [EC:2.5.1.18]
110894111  probable glutathione S-transferase [KO:K00799] [EC:2.5.1.18]
110886777  probable glutathione S-transferase parC [KO:K00799] [EC:2.5.1.18]
110894581  microsomal glutathione S-transferase 3 [KO:K00799] [EC:2.5.1.18]
110902609  glutathione S-transferase T1 [KO:K00799] [EC:2.5.1.18]
110915982  probable glutathione S-transferase [KO:K00799] [EC:2.5.1.18]
110902652  glutathione S-transferase T1 [KO:K00799] [EC:2.5.1.18]
110902688  glutathione S-transferase T1 [KO:K00799] [EC:2.5.1.18]
110909178  microsomal glutathione S-transferase 3 [KO:K00799] [EC:2.5.1.18]
110884697  glutathione S-transferase U19 [KO:K00799] [EC:2.5.1.18]
110884701  probable glutathione S-transferase [KO:K00799] [EC:2.5.1.18]
110884703  glutathione S-transferase U19 [KO:K00799] [EC:2.5.1.18]
110884705  glutathione S-transferase U19 [KO:K00799] [EC:2.5.1.18]
110907230  glutathione S-transferase U7 [KO:K00799] [EC:2.5.1.18]
110911671  glutathione S-transferase F9 [KO:K00799] [EC:2.5.1.18]
110875880  glutathione transferase GST 23 [KO:K00799] [EC:2.5.1.18]
110891165  probable glutathione S-transferase [KO:K00799] [EC:2.5.1.18]
110891167  probable glutathione S-transferase parC [KO:K00799] [EC:2.5.1.18]
110915728  probable glutathione S-transferase [KO:K00799] [EC:2.5.1.18]
110871932  glutathione S-transferase F11 [KO:K00799] [EC:2.5.1.18]
110897765  glutathione S-transferase T1 isoform X1 [KO:K00799] [EC:2.5.1.18]
110897766  glutathione S-transferase T1 [KO:K00799] [EC:2.5.1.18]
110897852  glutathione S-transferase T1 [KO:K00799] [EC:2.5.1.18]
110897853  glutathione S-transferase T1 [KO:K00799] [EC:2.5.1.18]
110898313  glutathione S-transferase L3 isoform X1 [KO:K00799] [EC:2.5.1.18]
110921552  glutathione S-transferase U17 [KO:K00799] [EC:2.5.1.18]
110904983  glutathione S-transferase L3 isoform X2 [KO:K00799] [EC:2.5.1.18]
110920668  glutathione S-transferase U17 [KO:K00799] [EC:2.5.1.18]
110918289  probable glutathione S-transferase parC [KO:K00799] [EC:2.5.1.18]
110937967  probable glutathione S-transferase [KO:K00799] [EC:2.5.1.18]
110937969  probable glutathione S-transferase [KO:K00799] [EC:2.5.1.18]
110937970  probable glutathione S-transferase isoform X1 [KO:K00799] [EC:2.5.1.18]
110945010  glutathione transferase GST 23 [KO:K00799] [EC:2.5.1.18]
110936681  glutathione S-transferase T1 [KO:K00799] [EC:2.5.1.18]
110942808  glutathione S-transferase-like [KO:K00799] [EC:2.5.1.18]
110942815  glutathione S-transferase [KO:K00799] [EC:2.5.1.18]
110942822  glutathione S-transferase-like [KO:K00799] [EC:2.5.1.18]
110942831  glutathione S-transferase APIC-like [KO:K00799] [EC:2.5.1.18]
110942839  glutathione S-transferase-like [KO:K00799] [EC:2.5.1.18]
110942861  glutathione S-transferase [KO:K00799] [EC:2.5.1.18]
110942869  glutathione S-transferase-like [KO:K00799] [EC:2.5.1.18]
110938216  probable glutathione S-transferase parC [KO:K00799] [EC:2.5.1.18]
110939191  glutathione transferase GST 23 [KO:K00799] [EC:2.5.1.18]
110937354  glutathione S-transferase [KO:K00799] [EC:2.5.1.18]
110937356  glutathione S-transferase [KO:K00799] [EC:2.5.1.18]
110937366  glutathione S-transferase APIC [KO:K00799] [EC:2.5.1.18]
110937367  glutathione S-transferase APIC [KO:K00799] [EC:2.5.1.18]
110937368  glutathione S-transferase [KO:K00799] [EC:2.5.1.18]
110940951  glutathione S-transferase F11 [KO:K00799] [EC:2.5.1.18]
110937506  glutathione transferase GST 23 [KO:K00799] [EC:2.5.1.18]
110888227  probable glutathione S-transferase DHAR2, chloroplastic [KO:K21888] [EC:1.8.5.1 2.5.1.18]
110893651  probable glutathione S-transferase DHAR2, chloroplastic [KO:K21888] [EC:1.8.5.1 2.5.1.18]
110872537  glutathione S-transferase DHAR2 [KO:K21888] [EC:1.8.5.1 2.5.1.18]
110896725  glutathione S-transferase DHAR2 [KO:K21888] [EC:1.8.5.1 2.5.1.18]
110909251  probable glutathione S-transferase DHAR2, chloroplastic [KO:K21888] [EC:1.8.5.1 2.5.1.18]
110933878  probable glutathione S-transferase DHAR2, chloroplastic [KO:K21888] [EC:1.8.5.1 2.5.1.18]
110890733  glutathione reductase, cytosolic [KO:K00383] [EC:1.8.1.7]
110877387  glutathione reductase, cytosolic [KO:K00383] [EC:1.8.1.7]
110884045  glutathione reductase, chloroplastic [KO:K00383] [EC:1.8.1.7]
110867916  isocitrate dehydrogenase [NADP] [KO:K00031] [EC:1.1.1.42]
110878314  isocitrate dehydrogenase [NADP] [KO:K00031] [EC:1.1.1.42]
110915602  isocitrate dehydrogenase [NADP] [KO:K00031] [EC:1.1.1.42]
110903846  6-phosphogluconate dehydrogenase, decarboxylating 2 [KO:K00033] [EC:1.1.1.44 1.1.1.343]
110868740  6-phosphogluconate dehydrogenase, decarboxylating 2 [KO:K00033] [EC:1.1.1.44 1.1.1.343]
110920292  6-phosphogluconate dehydrogenase, decarboxylating 3, chloroplastic [KO:K00033] [EC:1.1.1.44 1.1.1.343]
110889612  glucose-6-phosphate 1-dehydrogenase, chloroplastic isoform X1 [KO:K00036] [EC:1.1.1.49 1.1.1.363]
110926343  glucose-6-phosphate 1-dehydrogenase, chloroplastic [KO:K00036] [EC:1.1.1.49 1.1.1.363]
110926476  glucose-6-phosphate 1-dehydrogenase, cytoplasmic isoform [KO:K00036] [EC:1.1.1.49 1.1.1.363]
110912238  glucose-6-phosphate 1-dehydrogenase 6, cytoplasmic [KO:K00036] [EC:1.1.1.49 1.1.1.363]
110924990  glucose-6-phosphate 1-dehydrogenase, chloroplastic [KO:K00036] [EC:1.1.1.49 1.1.1.363]
110911244  glucose-6-phosphate 1-dehydrogenase, cytoplasmic isoform [KO:K00036] [EC:1.1.1.49 1.1.1.363]
110938106  glucose-6-phosphate 1-dehydrogenase, chloroplastic isoform X1 [KO:K00036] [EC:1.1.1.49 1.1.1.363]
110864403  probable phospholipid hydroperoxide glutathione peroxidase [KO:K00432] [EC:1.11.1.9]
110867889  probable glutathione peroxidase 8 [KO:K00432] [EC:1.11.1.9]
110867581  probable glutathione peroxidase 2 [KO:K00432] [EC:1.11.1.9]
110930172  probable phospholipid hydroperoxide glutathione peroxidase [KO:K00432] [EC:1.11.1.9]
110899597  probable phospholipid hydroperoxide glutathione peroxidase [KO:K00432] [EC:1.11.1.9]
110884145  probable glutathione peroxidase 4 [KO:K00432] [EC:1.11.1.9]
110930483  probable phospholipid hydroperoxide glutathione peroxidase [KO:K00432] [EC:1.11.1.9]
110930485  glutathione peroxidase 1 [KO:K00432] [EC:1.11.1.9]
110868247  1-Cys peroxiredoxin PER1 isoform X1 [KO:K11188] [EC:1.11.1.7 1.11.1.27 3.1.1.-]
110926184  spermidine synthase 1 [KO:K00797] [EC:2.5.1.16]
110895040  spermidine synthase 1 [KO:K00797] [EC:2.5.1.16]
110878171  spermine synthase [KO:K00797] [EC:2.5.1.16]
110897763  spermine synthase [KO:K00797] [EC:2.5.1.16]
110898546  putative L-ascorbate peroxidase 6 [KO:K00434] [EC:1.11.1.11]
110926092  probable L-ascorbate peroxidase 4, peroxisomal [KO:K00434] [EC:1.11.1.11]
110911573  L-ascorbate peroxidase 3 [KO:K00434] [EC:1.11.1.11]
110871293  L-ascorbate peroxidase, cytosolic [KO:K00434] [EC:1.11.1.11]
110911973  L-ascorbate peroxidase 3 [KO:K00434] [EC:1.11.1.11]
110918963  L-ascorbate peroxidase, cytosolic [KO:K00434] [EC:1.11.1.11]
110941205  probable L-ascorbate peroxidase 6, chloroplastic/mitochondrial isoform X1 [KO:K00434] [EC:1.11.1.11]
110939906  L-ascorbate peroxidase, cytosolic [KO:K00434] [EC:1.11.1.11]
110878239  ribonucleoside-diphosphate reductase large subunit isoform X1 [KO:K10807] [EC:1.17.4.1]
110912757  ribonucleoside-diphosphate reductase large subunit isoform X1 [KO:K10807] [EC:1.17.4.1]
110904092  ribonucleoside-diphosphate reductase small chain [KO:K10808] [EC:1.17.4.1]
110894096  ribonucleoside-diphosphate reductase small chain A [KO:K10808] [EC:1.17.4.1]
110911212  ribonucleoside-diphosphate reductase small chain [KO:K10808] [EC:1.17.4.1]
Compound
C00005  NADPH
C00006  NADP+
C00024  Acetyl-CoA
C00025  L-Glutamate
C00037  Glycine
C00051  Glutathione
C00072  Ascorbate
C00077  L-Ornithine
C00097  L-Cysteine
C00127  Glutathione disulfide
C00134  Putrescine
C00151  L-Amino acid
C00315  Spermidine
C00669  gamma-L-Glutamyl-L-cysteine
C00750  Spermine
C01322  RX
C01419  Cys-Gly
C01672  Cadaverine
C01879  5-Oxoproline
C02090  Trypanothione
C02320  R-S-Glutathione
C03170  Trypanothione disulfide
C03646  Bis-gamma-glutamylcystine
C03740  (5-L-Glutamyl)-L-amino acid
C05422  Dehydroascorbate
C05726  S-Substituted L-cysteine
C05727  S-Substituted N-acetyl-L-cysteine
C05729  R-S-Cysteinylglycine
C05730  Glutathionylspermidine
C16562  Glutathionylspermine
C16563  Bis(glutathionyl)spermine
C16564  Bis(glutathionyl)spermine disulfide
C16565  Aminopropylcadaverine
C16566  Glutathionylaminopropylcadaverine
C16567  Homotrypanothione
C16568  Homotrypanothione disulfide
C16663  Tryparedoxin
C16664  Tryparedoxin disulfide
Reference
  Authors
Josch C, Klotz LO, Sies H.
  Title
Identification of cytosolic leucyl aminopeptidase (EC 3.4.11.1) as the major cysteinylglycine-hydrolysing activity in rat liver.
  Journal
Biol Chem 384:213-8 (2003)
DOI:10.1515/BC.2003.023
Reference
  Authors
Chu L, Lai Y, Xu X, Eddy S, Yang S, Song L, Kolodrubetz D.
  Title
A 52-kDa leucyl aminopeptidase from treponema denticola is a cysteinylglycinase that mediates the second step of glutathione metabolism.
  Journal
J Biol Chem 283:19351-8 (2008)
DOI:10.1074/jbc.M801034200
Reference
  Authors
Cappiello M, Lazzarotti A, Buono F, Scaloni A, D'Ambrosio C, Amodeo P, Mendez BL, Pelosi P, Del Corso A, Mura U.
  Title
New role for leucyl aminopeptidase in glutathione turnover.
  Journal
Biochem J 378:35-44 (2004)
DOI:10.1042/BJ20031336
Reference
  Authors
Suzuki H, Kamatani S, Kim ES, Kumagai H.
  Title
Aminopeptidases A, B, and N and dipeptidase D are the four cysteinylglycinases of Escherichia coli K-12.
  Journal
J Bacteriol 183:1489-90 (2001)
DOI:10.1128/JB.183.4.1489-1490.2001
Reference
  Authors
Oza SL, Shaw MP, Wyllie S, Fairlamb AH.
  Title
Trypanothione biosynthesis in Leishmania major.
  Journal
Mol Biochem Parasitol 139:107-16 (2005)
DOI:10.1016/j.molbiopara.2004.10.004
Reference
  Authors
Oza SL, Ariyanayagam MR, Fairlamb AH.
  Title
Characterization of recombinant glutathionylspermidine synthetase/amidase from Crithidia fasciculata.
  Journal
Biochem J 364:679-86 (2002)
DOI:10.1042/BJ20011370
Reference
PMID:9677355
  Authors
Tetaud E, Manai F, Barrett MP, Nadeau K, Walsh CT, Fairlamb AH.
  Title
Cloning and characterization of the two enzymes responsible for trypanothione biosynthesis in Crithidia fasciculata.
  Journal
J Biol Chem 273:19383-90 (1998)
DOI:10.1074/jbc.273.31.19383
Reference
  Authors
Ariyanayagam MR, Oza SL, Mehlert A, Fairlamb AH.
  Title
Bis(glutathionyl)spermine and other novel trypanothione analogues in Trypanosoma cruzi.
  Journal
J Biol Chem 278:27612-9 (2003)
DOI:10.1074/jbc.M302750200
Reference
  Authors
Oza SL, Ariyanayagam MR, Aitcheson N, Fairlamb AH.
  Title
Properties of trypanothione synthetase from Trypanosoma brucei.
  Journal
Mol Biochem Parasitol 131:25-33 (2003)
DOI:10.1016/S0166-6851(03)00176-2
Reference
  Authors
Oza SL, Tetaud E, Ariyanayagam MR, Warnon SS, Fairlamb AH.
  Title
A single enzyme catalyses formation of Trypanothione from glutathione and spermidine in Trypanosoma cruzi.
  Journal
J Biol Chem 277:35853-61 (2002)
DOI:10.1074/jbc.M204403200
Reference
  Authors
Comini M, Menge U, Wissing J, Flohe L.
  Title
Trypanothione synthesis in crithidia revisited.
  Journal
J Biol Chem 280:6850-60 (2005)
DOI:10.1074/jbc.M404486200
Reference
PMID:7813456
  Authors
Hunter KJ, Le Quesne SA, Fairlamb AH.
  Title
Identification and biosynthesis of N1,N9-bis(glutathionyl)aminopropylcadaverine (homotrypanothione) in Trypanosoma cruzi.
  Journal
Eur J Biochem 226:1019-27 (1994)
DOI:10.1111/j.1432-1033.1994.t01-1-01019.x
Reference
  Authors
Krauth-Siegel RL, Meiering SK, Schmidt H.
  Title
The parasite-specific trypanothione metabolism of trypanosoma and leishmania.
  Journal
Biol Chem 384:539-49 (2003)
DOI:10.1515/BC.2003.062
Reference
  Authors
Krauth-Siegel RL, Comini MA.
  Title
Redox control in trypanosomatids, parasitic protozoa with trypanothione-based thiol metabolism.
  Journal
Biochim Biophys Acta 1780:1236-48 (2008)
DOI:10.1016/j.bbagen.2008.03.006
Reference
PMID:8892297
  Authors
Krauth-Siegel RL, Ludemann H.
  Title
Reduction of dehydroascorbate by trypanothione.
  Journal
Mol Biochem Parasitol 80:203-8 (1996)
DOI:10.1016/0166-6851(96)02689-8
Reference
  Authors
Dormeyer M, Reckenfelderbaumer N, Ludemann H, Krauth-Siegel RL.
  Title
Trypanothione-dependent synthesis of deoxyribonucleotides by Trypanosoma brucei ribonucleotide reductase.
  Journal
J Biol Chem 276:10602-6 (2001)
DOI:10.1074/jbc.M010352200
Reference
  Authors
Schmidt H, Krauth-Siegel RL.
  Title
Functional and physicochemical characterization of the thioredoxin system in Trypanosoma brucei.
  Journal
J Biol Chem 278:46329-36 (2003)
DOI:10.1074/jbc.M305338200
Reference
PMID:9851611
  Authors
Tetaud E, Fairlamb AH.
  Title
Cloning, expression and reconstitution of the trypanothione-dependent peroxidase system of Crithidia fasciculata.
  Journal
Mol Biochem Parasitol 96:111-23 (1998)
DOI:10.1016/S0166-6851(98)00120-0
Reference
  Authors
Castro H, Sousa C, Santos M, Cordeiro-da-Silva A, Flohe L, Tomas AM.
  Title
Complementary antioxidant defense by cytoplasmic and mitochondrial peroxiredoxins in Leishmania infantum.
  Journal
Free Radic Biol Med 33:1552-62 (2002)
DOI:10.1016/S0891-5849(02)01089-4
Reference
  Authors
Wilkinson SR, Temperton NJ, Mondragon A, Kelly JM.
  Title
Distinct mitochondrial and cytosolic enzymes mediate trypanothione-dependent peroxide metabolism in Trypanosoma cruzi.
  Journal
J Biol Chem 275:8220-5 (2000)
DOI:10.1074/jbc.275.11.8220
Reference
  Authors
Konig J, Fairlamb AH.
  Title
A comparative study of type I and type II tryparedoxin peroxidases in Leishmania major.
  Journal
FEBS J 274:5643-58 (2007)
DOI:10.1111/j.1742-4658.2007.06087.x
Reference
  Authors
Hillebrand H, Schmidt A, Krauth-Siegel RL.
  Title
A second class of peroxidases linked to the trypanothione metabolism.
  Journal
J Biol Chem 278:6809-15 (2003)
DOI:10.1074/jbc.M210392200
Reference
  Authors
Soksawatmaekhin W, Kuraishi A, Sakata K, Kashiwagi K, Igarashi K.
  Title
Excretion and uptake of cadaverine by CadB and its physiological functions in Escherichia coli.
  Journal
Mol Microbiol 51:1401-12 (2004)
DOI:10.1046/j.1365-2958.2003.03913.x
Reference
PMID:6798961
  Authors
Pegg AE, Shuttleworth K, Hibasami H.
  Title
Specificity of mammalian spermidine synthase and spermine synthase.
  Journal
Biochem J 197:315-20 (1981)
DOI:10.1042/bj1970315
Related
pathway
han00220  Arginine biosynthesis
han00250  Alanine, aspartate and glutamate metabolism
han00270  Cysteine and methionine metabolism
han00430  Taurine and hypotaurine metabolism
han00460  Cyanoamino acid metabolism
KO pathway
ko00480   
LinkDB

DBGET integrated database retrieval system