KEGG   PATHWAY: hme00630
Entry
hme00630                    Pathway                                
Name
Glyoxylate and dicarboxylate metabolism - Haloferax mediterranei
Class
Metabolism; Carbohydrate metabolism
Pathway map
hme00630  Glyoxylate and dicarboxylate metabolism
hme00630

Module
hme_M00012  Glyoxylate cycle [PATH:hme00630]
hme_M00621  Glycine cleavage system [PATH:hme00630]
hme_M00741  Propanoyl-CoA metabolism, propanoyl-CoA => succinyl-CoA [PATH:hme00630]
hme_M00968  Pentose bisphosphate pathway (nucleoside degradation), archaea, nucleoside/NMP => 3-PGA/glycerone phosphate [PATH:hme00630]
Other DBs
GO: 0046487 0043648
Organism
Haloferax mediterranei [GN:hme]
Gene
HFX_2079  aceA; isocitrate lyase [KO:K01637] [EC:4.1.3.1]
HFX_1242  acs; acyl-CoA synthetase [KO:K01895] [EC:6.2.1.1]
HFX_0870  acs; acyl-CoA synthetase [KO:K01895] [EC:6.2.1.1]
HFX_1643  acs; acyl-CoA synthetase [KO:K01895] [EC:6.2.1.1]
HFX_2150  acs4; acyl-CoA synthetase [KO:K01895] [EC:6.2.1.1]
HFX_5129  acs; acyl-CoA synthetase [KO:K01895] [EC:6.2.1.1]
HFX_5131  acs; acyl-CoA synthetase [KO:K01895] [EC:6.2.1.1]
HFX_3026  mdhA; malate dehydrogenase [KO:K00024] [EC:1.1.1.37]
HFX_0432  citZ; citrate (si)-synthase [KO:K01647] [EC:2.3.3.1]
HFX_6170  gltA; citrate (si)-synthase [KO:K01647] [EC:2.3.3.1]
HFX_0511  acnA; aconitate hydratase [KO:K01681] [EC:4.2.1.3]
HFX_2049  citB; aconitate hydratase [KO:K01681] [EC:4.2.1.3]
HFX_0804  paaJ; acetyl-CoA C-acyltransferase [KO:K00626] [EC:2.3.1.9]
HFX_1023  phaAa; PHA-specific beta-ketothiolase alpha subunit [KO:K00626] [EC:2.3.1.9]
HFX_6358  acaB2; acetyl-CoA C-acetyltransferase [KO:K00626] [EC:2.3.1.9]
HFX_6004  bktBa; PHA-specific beta-ketothiolase alpha subunit [KO:K00626] [EC:2.3.1.9]
HFX_6015  acaB; acetyl-CoA C-acetyltransferase [KO:K00626] [EC:2.3.1.9]
HFX_6051  yqeF; acetyl-CoA acetyltransferase [KO:K00626] [EC:2.3.1.9]
HFX_5217  maoC; enoyl-CoA hydratase [KO:K17865] [EC:4.2.1.55]
HFX_6362  gloA; methylmalonyl-CoA epimerase [KO:K05606] [EC:5.1.99.1]
HFX_1453  gloA; methylmalonyl-CoA epimerase [KO:K05606] [EC:5.1.99.1]
HFX_2490  accA2; biotin carboxylase [KO:K11263] [EC:6.4.1.2 6.4.1.3 6.3.4.14]
HFX_2478  accA; methylmalonyl-CoA decarboxylase alpha chain [KO:K19312] [EC:6.4.1.2 6.4.1.3 2.1.3.15]
HFX_2479  hypothetical protein [KO:K22568] [EC:6.4.1.2 6.4.1.3]
HFX_0800  mcmB; methylmalonyl-CoA mutase, subunit B (cobalamin-binding subunit) [KO:K01849] [EC:5.4.99.2]
HFX_0867  sbm; methylmalonyl-CoA mutase, N-terminal domain protein [KO:K01848] [EC:5.4.99.2]
HFX_1456  sbm; methylmalonyl-CoA mutase, N-terminal domain protein [KO:K01848] [EC:5.4.99.2]
HFX_2078  aceB; malate synthase [KO:K19282] [EC:4.1.3.24 3.1.2.30]
HFX_2317  gph; 3-phosphoglycerate kinase [KO:K01091] [EC:3.1.3.18]
HFX_1933  gph; haloacid dehalogenase superfamily enzyme, subfamily IA [KO:K01091] [EC:3.1.3.18]
HFX_2283  gph; HAD-superfamily hydrolase, subfamily IA, variant 1 [KO:K01091] [EC:3.1.3.18]
HFX_1597  cof; phosphoglycolate phosphatase [KO:K22223] [EC:3.1.3.18]
HFX_0967  rbcL; ribulose-bisphosphate carboxylase large chain [KO:K01601] [EC:4.1.1.39]
HFX_2689  aminotransferase class V [KO:K00830] [EC:2.6.1.44 2.6.1.45 2.6.1.51]
HFX_0844  gltS; glutamate synthase large subunit [KO:K00284] [EC:1.4.7.1]
HFX_0245  glnA; glutamine synthetase [KO:K01915] [EC:6.3.1.2]
HFX_1686  glnA; glutamate--ammonia ligase [KO:K01915] [EC:6.3.1.2]
HFX_2854  glyA; serine hydroxymethyltransferase [KO:K00600] [EC:2.1.2.1]
HFX_2408  gcvP1; glycine dehydrogenase subunit 1 [KO:K00282] [EC:1.4.4.2]
HFX_2407  gcvP; glycine dehydrogenase subunit 2 [KO:K00283] [EC:1.4.4.2]
HFX_0365  gcvT_2; aminomethyltransferase, glycine cleavage system T protein [KO:K00605] [EC:2.1.2.10]
HFX_2410  gcvT; aminomethyltransferase (glycine cleavage system protein T) [KO:K00605] [EC:2.1.2.10]
HFX_2955  pdhD; dihydrolipoamide dehydrogenase [KO:K00382] [EC:1.8.1.4]
HFX_2409  gcvH; glycine cleavage system H protein [KO:K02437]
HFX_1615  gckA; hydroxypyruvate reductase, glycerate kinase [KO:K11529] [EC:2.7.1.165]
HFX_0947  kdgA1; 2-dehydro-3-deoxyphosphogluconate aldolase (KDPG aldolase) [KO:K01625] [EC:4.1.2.14 4.1.3.42]
HFX_6183  kdgA3; 2-dehydro-3-deoxyphosphogluconate aldolase (KDPG aldolase) [KO:K01625] [EC:4.1.2.14 4.1.3.42]
HFX_2249  purU; formyltetrahydrofolate deformylase [KO:K01433] [EC:3.5.1.10]
Compound
C00007  Oxygen
C00011  CO2
C00014  Ammonia
C00022  Pyruvate
C00024  Acetyl-CoA
C00025  L-Glutamate
C00026  2-Oxoglutarate
C00027  Hydrogen peroxide
C00033  Acetate
C00036  Oxaloacetate
C00037  Glycine
C00042  Succinate
C00048  Glyoxylate
C00058  Formate
C00064  L-Glutamine
C00065  L-Serine
C00091  Succinyl-CoA
C00100  Propanoyl-CoA
C00111  Glycerone phosphate
C00136  Butanoyl-CoA
C00149  (S)-Malate
C00158  Citrate
C00160  Glycolate
C00168  Hydroxypyruvate
C00197  3-Phospho-D-glycerate
C00209  Oxalate
C00258  D-Glycerate
C00266  Glycolaldehyde
C00311  Isocitrate
C00313  Oxalyl-CoA
C00332  Acetoacetyl-CoA
C00417  cis-Aconitate
C00552  meso-Tartaric acid
C00631  2-Phospho-D-glycerate
C00683  (S)-Methylmalonyl-CoA
C00798  Formyl-CoA
C00877  Crotonoyl-CoA
C00888  Pentanoyl-CoA
C00898  (R,R)-Tartaric acid
C00975  Dihydroxyfumarate
C00988  2-Phosphoglycolate
C01127  4-Hydroxy-2-oxoglutarate
C01146  2-Hydroxy-3-oxopropanoate
C01182  D-Ribulose 1,5-bisphosphate
C01213  (R)-Methylmalonyl-CoA
C01380  Ethylene glycol
C01732  Mesaconate
C01989  3-Ethylmalate
C01990  3-Oxalomalate
C02123  3-Propylmalate
C02405  Formyl phosphate
C03217  2-Hydroxy-3-oxoadipate
C03459  2-Hydroxy-3-oxosuccinate
C03548  trans-2,3-Epoxysuccinate
C03561  (R)-3-Hydroxybutanoyl-CoA
C03618  L-threo-3-Methylaspartate
C04348  L-Malyl-CoA
C06027  L-erythro-3-Methylmalyl-CoA
C06028  2-Methylfumaryl-CoA
C06049  N-Formylderivatives
C18026  (2S)-Ethylmalonyl-CoA
C18324  (2S)-Methylsuccinyl-CoA
C20238  (2R)-Ethylmalonyl-CoA
C22337  D-Ribulose 1-phosphate
Reference
PMID:10978349
  Authors
Njau RK, Herndon CA, Hawes JW.
  Title
Novel beta-hydroxyacid dehydrogenases in Escherichia coli and Haemophilus influenzae.
  Journal
J Biol Chem 275:38780-6 (2000)
DOI:10.1074/jbc.M007432200
Reference
PMID:18065535
  Authors
Zarzycki J, Schlichting A, Strychalsky N, Muller M, Alber BE, Fuchs G
  Title
Mesaconyl-coenzyme A hydratase, a new enzyme of two central carbon metabolic pathways in bacteria.
  Journal
J Bacteriol 190:1366-74 (2008)
DOI:10.1128/JB.01621-07
Reference
PMID:18819910
  Authors
Erb TJ, Retey J, Fuchs G, Alber BE
  Title
Ethylmalonyl-CoA mutase from Rhodobacter sphaeroides defines a new subclade of coenzyme B12-dependent acyl-CoA mutases.
  Journal
J Biol Chem 283:32283-93 (2008)
DOI:10.1074/jbc.M805527200
Reference
PMID:9596633
  Authors
Coschigano KT, Melo-Oliveira R, Lim J, Coruzzi GM
  Title
Arabidopsis gls mutants and distinct Fd-GOGAT genes. Implications for photorespiration and primary nitrogen assimilation.
  Journal
Plant Cell 10:741-52 (1998)
DOI:10.1105/tpc.10.5.741
Reference
PMID:16407450
  Authors
Masclaux-Daubresse C, Reisdorf-Cren M, Pageau K, Lelandais M, Grandjean O, Kronenberger J, Valadier MH, Feraud M, Jouglet T, Suzuki A
  Title
Glutamine synthetase-glutamate synthase pathway and glutamate dehydrogenase play distinct roles in the sink-source nitrogen cycle in tobacco.
  Journal
Plant Physiol 140:444-56 (2006)
DOI:10.1104/pp.105.071910
Reference
PMID:21252347
  Authors
Khomyakova M, Bukmez O, Thomas LK, Erb TJ, Berg IA
  Title
A methylaspartate cycle in haloarchaea.
  Journal
Science 331:334-7 (2011)
DOI:10.1126/science.1196544
Reference
PMID:11513957
  Authors
Serrano JA, Bonete MJ
  Title
Sequencing, phylogenetic and transcriptional analysis of the glyoxylate bypass operon (ace) in the halophilic archaeon Haloferax volcanii.
  Journal
Biochim Biophys Acta 1520:154-62 (2001)
DOI:10.1016/S0167-4781(01)00263-9
Related
pathway
hme00010  Glycolysis / Gluconeogenesis
hme00020  Citrate cycle (TCA cycle)
hme00030  Pentose phosphate pathway
hme00071  Fatty acid degradation
hme00230  Purine metabolism
hme00250  Alanine, aspartate and glutamate metabolism
hme00260  Glycine, serine and threonine metabolism
hme00620  Pyruvate metabolism
hme00710  Carbon fixation by Calvin cycle
hme00750  Vitamin B6 metabolism
hme00910  Nitrogen metabolism
KO pathway
ko00630   
LinkDB

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