PATHWAY: hsyr00020 Help
Entry
Name
Citrate cycle (TCA cycle) - Hibiscus syriacus (Rose-of-Sharon)
Description
The citrate cycle (TCA cycle, Krebs cycle) is an important aerobic pathway for the final steps of the oxidation of carbohydrates and fatty acids. The cycle starts with acetyl-CoA, the activated form of acetate, derived from glycolysis and pyruvate oxidation for carbohydrates and from beta oxidation of fatty acids. The two-carbon acetyl group in acetyl-CoA is transferred to the four-carbon compound of oxaloacetate to form the six-carbon compound of citrate. In a series of reactions two carbons in citrate are oxidized to CO2 and the reaction pathway supplies NADH for use in the oxidative phosphorylation and other metabolic processes. The pathway also supplies important precursor metabolites including 2-oxoglutarate. At the end of the cycle the remaining four-carbon part is transformed back to oxaloacetate. According to the genome sequence data, many organisms seem to lack genes for the full cycle [MD:
M00009 ], but contain genes for specific segments [MD:
M00010 M00011 ].
Class
Metabolism; Carbohydrate metabolism
BRITE hierarchy
Pathway map
Ortholog table
Module
Other DBs
Organism
Hibiscus syriacus (Rose-of-Sharon) [GN:
hsyr ]
Gene
120169981 LOW QUALITY PROTEIN: isocitrate dehydrogenase [NADP], chloroplastic/mitochondrial-like [KO:K00031 ] [EC:1.1.1.42 ]
120132337 isocitrate dehydrogenase [NAD] regulatory subunit 1, mitochondrial-like isoform X1 [KO:K00030 ] [EC:1.1.1.41 ]
120180917 LOW QUALITY PROTEIN: isocitrate dehydrogenase [NAD] catalytic subunit 5, mitochondrial-like [KO:K00030 ] [EC:1.1.1.41 ]
120129584 dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex 1, mitochondrial-like [KO:K00658 ] [EC:2.3.1.61 ]
120197782 dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex 2, mitochondrial-like isoform X1 [KO:K00658 ] [EC:2.3.1.61 ]
120202431 dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex 2, mitochondrial-like [KO:K00658 ] [EC:2.3.1.61 ]
120170370 dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex 1, mitochondrial-like [KO:K00658 ] [EC:2.3.1.61 ]
120189411 dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex 1, mitochondrial-like [KO:K00658 ] [EC:2.3.1.61 ]
120160461 dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex 2, mitochondrial-like isoform X1 [KO:K00658 ] [EC:2.3.1.61 ]
120130920 succinate dehydrogenase [ubiquinone] flavoprotein subunit 1, mitochondrial-like [KO:K00234 ] [EC:1.3.5.1 ]
120152465 succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial-like [KO:K00234 ] [EC:1.3.5.1 ]
120153144 LOW QUALITY PROTEIN: succinate dehydrogenase [ubiquinone] flavoprotein subunit 1, mitochondrial-like [KO:K00234 ] [EC:1.3.5.1 ]
120121682 succinate dehydrogenase [ubiquinone] iron-sulfur subunit 2, mitochondrial-like [KO:K00235 ] [EC:1.3.5.1 ]
120195743 succinate dehydrogenase [ubiquinone] iron-sulfur subunit 2, mitochondrial-like [KO:K00235 ] [EC:1.3.5.1 ]
120162624 succinate dehydrogenase subunit 3-1, mitochondrial-like [KO:K00236 ]
120116736 succinate dehydrogenase subunit 3-1, mitochondrial-like [KO:K00236 ]
120185436 succinate dehydrogenase subunit 3-1, mitochondrial-like [KO:K00236 ]
120149470 pyruvate dehydrogenase E1 component subunit alpha-1, mitochondrial isoform X1 [KO:K00161 ] [EC:1.2.4.1 ]
120213217 dihydrolipoyllysine-residue acetyltransferase component 1 of pyruvate dehydrogenase complex, mitochondrial-like isoform X1 [KO:K00627 ] [EC:2.3.1.12 ]
120180699 dihydrolipoyllysine-residue acetyltransferase component 5 of pyruvate dehydrogenase complex, chloroplastic-like [KO:K00627 ] [EC:2.3.1.12 ]
120197685 dihydrolipoyllysine-residue acetyltransferase component 4 of pyruvate dehydrogenase complex, chloroplastic-like [KO:K00627 ] [EC:2.3.1.12 ]
120131612 dihydrolipoyllysine-residue acetyltransferase component 2 of pyruvate dehydrogenase complex, mitochondrial-like isoform X1 [KO:K00627 ] [EC:2.3.1.12 ]
120148526 dihydrolipoyllysine-residue acetyltransferase component 2 of pyruvate dehydrogenase complex, mitochondrial-like isoform X1 [KO:K00627 ] [EC:2.3.1.12 ]
120133350 dihydrolipoyllysine-residue acetyltransferase component 2 of pyruvate dehydrogenase complex, mitochondrial-like [KO:K00627 ] [EC:2.3.1.12 ]
120217067 dihydrolipoyllysine-residue acetyltransferase component 5 of pyruvate dehydrogenase complex, chloroplastic-like [KO:K00627 ] [EC:2.3.1.12 ]
120156247 dihydrolipoyllysine-residue acetyltransferase component 1 of pyruvate dehydrogenase complex, mitochondrial-like isoform X1 [KO:K00627 ] [EC:2.3.1.12 ]
120190271 dihydrolipoyllysine-residue acetyltransferase component 2 of pyruvate dehydrogenase complex, mitochondrial-like [KO:K00627 ] [EC:2.3.1.12 ]
120174727 dihydrolipoyllysine-residue acetyltransferase component 1 of pyruvate dehydrogenase complex, mitochondrial-like [KO:K00627 ] [EC:2.3.1.12 ]
Compound
C05125 2-(alpha-Hydroxyethyl)thiamine diphosphate
C05381 3-Carboxy-1-hydroxypropyl-ThPP
C15972 Enzyme N6-(lipoyl)lysine
C15973 Enzyme N6-(dihydrolipoyl)lysine
C16254 [Dihydrolipoyllysine-residue succinyltransferase] S-succinyldihydrolipoyllysine
C16255 [Dihydrolipoyllysine-residue acetyltransferase] S-acetyldihydrolipoyllysine
Reference
Authors
Nishizuka Y (ed).
Title
[Metabolic Maps] (In Japanese)
Journal
Tokyo Kagaku Dojin (1980)
Reference
Authors
Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).
Title
[Cellular Functions and Metabolic Maps] (In Japanese)
Journal
Tokyo Kagaku Dojin (1997)
Reference
Authors
Michal G.
Title
Biochemical Pathways
Journal
Wiley (1999)
Related pathway
hsyr00250 Alanine, aspartate and glutamate metabolism
hsyr00280 Valine, leucine and isoleucine degradation
hsyr00630 Glyoxylate and dicarboxylate metabolism
KO pathway
LinkDB
All DBs